관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

도로시설물 설치를 위한 정착장치의 구조특성에 관한 기초적 연구

성기태,이승용,한영두 韓國交通大學校 2013 한국교통대학교 논문집 Vol.48 No.-

The high strength anchor for asphalt pavement, applied on this study, is the system with settling nut anchors after boring asphalt surface to subbase and inject epoxy without separate concrete base. The enough bearing force is necessary to use these anchor system as a base of road facility installation. Therefore, this study implemented static drawing experiment with the variables such as reclamation depth of anchor, pavement thickness, diameter of anchor, type of anchor, experiment temperature, and type of epoxy for the verification of the bearing force of high strength anchor system for asphalt road. As a result, the major factor of asphalt anchor maximum weight is shear strength of base in the subbase. Meanwhile, the effective settlement depth of anchor is 50mm point under the subbase for the stability. Also, the effective diameter of anchor is bigger than 25mm based on the consideration of shear strength and stability of settlement bolt.

이동통신 시스템의 채널 시뮬레이션

김명기,백정기,임영도,김두영 동아대학교 공과대학 부설 한국자원개발연구소 1992 硏究報告 Vol.16 No.1

Land-mobile-radio signals are affected severely by multipath phenomena. Multipath fading may be classified into envelope fading, FM noise, and delay spread. For a bit rate of 16 kbps or higher, the effects of delay spread cannot be neglected. In this paper, BER performances of QDPSK, MSK, GMSK, and TCM-8PSK are analyzed by computer simulation under the time-selective and/or frequency-selective fading environments.

병렬처리가 가능한 고속 라벨링 알고리즘

박용기,정광웅,김두영 동아대학교 공과대학 부설 한국자원개발연구소 1992 硏究報告 Vol.16 No.1

A high speed algorithm for seperating the regions and numbering the each region, so called region labelling, is presented. In this algorithm, A new technique is included for the solving the problems of conventional raster scan algorithm. Numbers of provisional label and the amount of memories for connectivity search is reduced by the region enlargement and sub-image dividing which is proper for high speed and parallel processing.

다양한 구조특성에 따른 비선형 약산법들의 비교

신기영,강병두,김재웅 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

In performance-based design methods, it is clear that the evaluation of the nonlinear response is required. Some codes proposed the capacity spectrum method(CSM) based on the nonlinear static analysis to determine earthquake induced demand given the structure pushover curve. This procedure is conceptually simple but iterative and time consuming with some errors. The nonlinear direct spectrum method(NDSM) is proposed and studied to evaluate nonlinear response of structures, without iterative computations, given by the structural linear vibration period and yield strength from the pushover analysis, especially for shear buildings system. The purpose of this paper is to compare accuracy of approximate nonlinear methods with respect to various structure characteristics.

차신호의 적응적 블록 분할을 이용한 프랙탈 동영상 부호화

박용기,고기영,박철우,김두영 東亞大學校 附設 情報通信硏究所 1998 情報通信硏究所論文誌 Vol.6 No.1

This paper presents a compression technique based on fractal theory for fast encoding and decoding image sequences for very low bit-rates image communication instead of DCT coding which is a standard compression method of moving image used in the H.261, or MPEG. We calculated RMS values by blocks between the first adn the second frames. We chose two threshold values, i.e. The first threshold is Th1 and second threshold is Th2. We found blocks with movement and found fractal coefficients by comparing RMS values and two threshold values. Experimental results show that the compression rate is improved compare to liner approximation and PSNR reduced from 1dB to 1.2dB, but the sbjective fidelity remained almost unchanged.

척수 손상 환자의 우울에 대한 정신과적 고찰

김문두,신태균,심기범,신지남 최신의학사 2003 最新醫學 Vol.46 No.9-10

하순 및 하악골 정중열의 치험례

차두원,김현수,백상흠,김진수,변기정 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3

Median cleft of the lower lip and/or mandible is a rare congenital anomaly, first mentioned by Couronne in 1819. Monroe(1966), Fujino(1970), Ranta(1984) and Oostrom(1996) conducted comprehensive reviews and list cases in literature. Median cleft varies greatly, from a simple vermilion notch to a complete cleft of the lip involving the tongue, the chin, the mandible, the supporting structures of the median of the neck, and the manubrium sterni. The associated anomalies include ankyloglossia, cleft tongue, neck contraction, heart lesion, absence of hyoid bone, and so on. The etiology of median cleft is unknown. Various possibilities, such as failure of mesodermal penetration into the midline, failure of fusion of mandibular processes, external factors apart from the embryogenic pattern such as prensure, position in utero, circulatory failure caused placental adhesion, diseases in pregnancy, and so on, have been discussed. A 8-year-old girl was referred to the Dept. of Oral & Maxillofacial Surgery, Kyungpook National University Hospital and had been aware of the fact that at birth "she had something wrong with her mouth." Shortly after birth she had been examined by a plastic surgeon and at that time surgical procedure had been performed to release the tongue from the lower jaw and lip at local hospital. On admission, she had a slight notching of lower lip and two fibrous frenum ran from the lip along the ventral surface of the tongue, diastema between her mandibular central incisors, and slightly constricted bifid mandible associated independent movement of the two halves of mandible. The patient had autogenous iliac bone graft to reconstruct the mandibular midline defect. The postoperative result was uneventful. In future, the correction of the soft tissue deformities such as notching of the lower lip and partial ankyloglossia will be required for the esthetic and functional improvement.

초음파 및 Phased Array를 이용한 터빈 블레이드 루트부 건전성 평가에 관한 연구

길두송,박상기,조용상,이상국,허광범 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

Power plant is consisted of many component parts for the generation of the electricity, and occasionally, turbine equipment may be caused in break-down because of the damage of the blade root. Phased array ultrasonic testing system has become available for practical application in complicated geometry such as turbine blade root, tenon, disc in power industry, This research describes the characteristics of phased array ultrasonic testing signal for various type of blade roots in thermal Power Plant turbines. This application of Phased array ultrasonic testing system has been promoted mainly to save inspection time and labor cost of turbine inspection. The characteristic of phased array ultrasonic testing signal for power plant component in very simple to understand but to difficult for perform the inspection. This paper is focused on the safety of the turbine equipment by the ultrasonic measurement and phased array analysis. As a result of the test through ultrasonic and phased array method, we have concluded that the main damage in these turbine blade root parts could be generated by the concentrated stress and centrifugal force.