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벼 품종의 백엽고병 필리핀 균계에 대한 저항성 유전분석
이규성,구뎁에스쿠쉬 한국국제농업개발학회 2000 韓國國際農業開發學會誌 Vol.12 No.4
본 실험은 인디카 벼 4품종을 필리핀 흰잎마름병 6개 레이스 중 레이스 6에 대한 저항성 유전양식과 대립검정을 통한 기존 및 새로운 유전자를 밝히기 위하여 1999년 건기 및 우기에 필리핀 국제미작연구소 식물육종과 흰잎마름병 실험포장에서 수행하였다. 저항성 유전양식은 4품종 모두 필리핀 레이스 6을 지배하는 열성유전자를 갖고 있었으며, 이 유전자는 기존에 밝혀진 저항성 열성 유전자인 xa13과 비 대립관계인 것으로 나타났다. 한편 똑 같은 레이스 6을 지배하는 저항성 열성 유전자이나 xa13과 비 대립간에 있는 것으로 최근 밝혀진 xa24(t) 와의 대립검정에서도 4개 품종 중 ARC5756, Bazail 414 그리고 Bazail 980은 유전자의 비 대립간으로 밝혀졌으며, Bhadoia 648은 대립간으로 나타나 xa24(t)와 같은 유전자로 나타났다. 따라서, 3개 품종은 레이스 6을 지배하는 새로운 유전자일 가능성이 컸으며, 확인 검정을 위한 F₃후대 검정이 이루어지고 있다. The mode of inheritance and allelic relationship of the genes for resistance to bacterial blight using Philippine races of Xanthomonas oryzae pv. oryzae(Xoo) in four cultivars were studied. The results showed that four cultivars have at least a single recessive gene for resistance to race 6. Test for allelism of the genes revealed that a recessive gene conferring resistance to race 6 in four cultivars is non-allelic to xa 13. The allelic test of four cultivars with DV85 carrying xa24(t) showed that ARC5756, Bazai1414, and Bazai1980 are non-allelic while Bhadoia 648 is allelic to xa24(t). The further confirmation of new gene conferring resistance to race 6 is now being investigated.
Baloch, Abdul Hameed,Khosa, Ahmad Nawaz,Bangulzai, Nasrullah,Shuja, Jamila,Naseeb, Hafiz Khush,Jan, Mohammad,Marghazani, Illahi Bakhsh,Kakar, Masood-ul-Haq,Baloch, Dost Mohammad,Cheema, Abdul Majeed,A Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Breast cancer is very common and the leading cause of cancer deaths among women globally. Hereditary cases account for 5-10% of the total burden and CHEK2, which plays crucial role in response to DNA damage to promote cell cycle arrest and repair or induce apoptosis, is considered as a moderate penetrance breast cancer risk gene. Our objective in the current study was to analyze mutations in related to breast cancer. A total of 271 individuals including breast cancer patients and normal subjects were enrolled and all 14 exons of CHEK2 were amplified and sequenced. The majority of the patients (>95%) were affected with invasive ductal carcinoma (IDC), 52.1% were diagnosed with grade III tumors and 56.2% and 27.5% with advanced stages III and IV. Two novel nonsense variants i.e. c.58C>T (P.Q20X) and c.256G>T (p.E85X) at exon 1 and 2 in two breast cancer patients were identified, both novel and not reported elsewhere.
Baloch, Abdul Hameed,Khosa, Ahmad Nawaz,Bangulzai, Nasrullah,Shuja, Jamila,Naseeb, Hafiz Khush,Jan, Mohammad,Marghazani, Illahi Bakhsh,Kakar, Masood-ul-Haq,Baloch, Dost Mohammad,Cheema, Abdul Majeed,A Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Breast cancer is the most commonly occurring and leading cause of cancer deaths among women globally. Hereditary cases account 5-10% of all the cases and CHEK2 is considered as a moderate penetrance breast cancer risk gene. CHEK2 plays a crucial role in response to DNA damage to promote cell cycle arrest and repair DNA damage or induce apoptosis. Our objective in the current study was to analyze mutations in the CHEK2 gene related to breast cancer in Balochistan. A total of 271 individuals including breast cancer patients and normal subjects were enrolled. All 14 exons of CHEK2 were amplified and sequenced. The majority of the patients (>95%) had invasive ductal carcinomas (IDCs), 52.1% were diagnosed with tumor grade III and 56.1% and 27.5% were diagnosed with advance stages III and IV. Two novel nonsense variants i.e. c.58C>T (P.Q20X) and c.256G>T (p.E85X) at exon 1 and 2 in two breast cancer patients were identified in the current study. Both the variants identified were novel and have not been reported elsewhere.
Genetic and Molecular Insights into the Enhancement of Rice Yield Potential
Jeon, Jong-Seong,Jung, Ki-Hong,Kim, Hyun-Bi,Suh, Jung-Pil,Khush, Gurdev S. 한국식물학회 2011 Journal of Plant Biology Vol.54 No.1
Rice is one of the most important global food crops and a primary source of calories for more than half of the world's population. Rice production increased steadily during the green revolution era primarily as a result of introducing high-yielding rice varieties. World rice production increased at a rate of 2.3-2.5% per year during 1970s and 1980s, but this rate of growth was only 1.5% per year during the 1990s. The yield growth rate for rice has further declined during the first decade of this century. However, the populations in the major rice-consuming countries continue to grow at a rate of more than 1.5% per year. According to various estimates, world rice production must increase at the rate of 2 million tons per year. To meet this challenge, rice varieties with higher yield potential and greater yield stability are needed. Various strategies for increasing the yield potential of rice include; (1) conventional hybridization and selection, (2) $F_1$ hybrid breeding, (3) modification of plant architecture, and (4) enhancement of photosynthesis. Many genes and QTLs have recently been identified which will assist with rice breeding objectives.
Various Aspects, Patterns and Risk Factors in Breast Cancer Patients of Balochistan
Baloch, Abdul Hameed,Shuja, Jameela,Daud, Shakeela,Ahmed, Muneer,Ahmad, Adeel,Tareen, Mehrullah,Khan, Farah,Kakar, Muhammad Azam,Baloch, Dost Mohammad,Kakar, Naseebullah,Naseeb, Hafiz Khush,Ahmad, Jam Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Purpose: Breast cancer is the commonest malignancy of females throughout the world with one million new cases each year. In Pakistan, the burden of breast cancer disease is high with late stage presentation being a common feature, more than half being stage III or stage IV. The objective of this study was to study various aspects, patterns and risk factors in breast cancer patients of Balochistan. Method: Present study was performed on 134 patients of breast cancer who were registered in CENAR. The patients were interviewed by providing a questionnaire. Informed consent was taken from all the patients who took part in this study after explanation of the study aims. Body mass index (BMI) was calculated andbiopsy reports were obtained from patients files. All the cases were classified with respect to age, gender, ethnic group (Baloch, Pashtoon, Punjabi, Afghani, Hazara) BMI, cancer type, cancer grade, hormonal status, side of the cancer, fertility and marital status. Results: Out of 134 patients, the most common ethnic group was Pashtoon with a total of 42 and the common age group was 41-50 years with a total of 51. Invasive ductal carcinoma (IDC) was the most common type, accounting for in 128 patients (95.5%) followed by invasive lobular carcinoma (ILC). Conclusion: Pashtoon was the most common ethnic group, IDC was common type and most of the patients had an ER/PR positive hormonal status.