Management of Psoriasis through Unani Medicine: a Case Study

Khatoon, Faiza,Uddin, Qamar,Jabeen, Arzeena,Azahar, Mohd,Alam, Md Aftab,Munim, Abdul Cellmed Orthocellular Medicine and Pharmaceutical 2021 셀메드 (CellMed) Vol.11 No.2

Psoriasis is a chronic inflammatory skin disease clinically characterized by erythematous, sharply demarcated papules and rounded plaques covered by silvery white micaceous scales. It affects about 1-3% of the world's population. Although considerable advances have been made in the management of psoriasis in recent years, the disease remains incurable. Current treatment does not affect disease activity, and relapse occurs quickly after cessation of treatment. Moreover, topical and systemic conventional therapies used in the management of psoriasis are associated with adverse effects. In Unani system of medicine, psoriasis is known as Taqashshur al-Jild, which is caused by predominance of black bile and characterised by scaling of skin. Various topical as well as systemic Unani formulations are effectively used in the management of psoriasis. This case study was aimed to evaluate the efficacy of Unani formulations, Itrīfal Shāhtra and Marham Ḥinā in the management of psoriasis. A 49-year-old male patient presenting with psoriasis came to the OPD of National Research Institute of Unani Medicine for Skin Disorders, Hyderabad. Treatment was given to the patient for a period of 12 weeks. PASI score was significantly reduced from 40.5 at baseline to 2.2 after treatment. Unani formulations were found safe and effective in the management of Psoriasis as assessed by validated scales.

Zwitterionic mesoporous nanoparticles with a bioresponsive gatekeeper for cancer therapy

Khatoon, S.,Han, H.S.,Lee, M.,Lee, H.,Jung, D.W.,Thambi, T.,Ikram, M.,Kang, Y.M.,Yi, G.R.,Park, J.H. Elsevier BV 2016 ACTA BIOMATERIALIA Vol.40 No.-

To enhance cellular uptake and site-specific drug release in the tumor microenvironment, zwitterionic mesoporous silica nanoparticles (Z-MSN) were prepared by introducing a bioresponsive gatekeeper composed of negatively charged carboxylic groups and positively charged quaternary amine groups. When these Z-MSN encountered a mildly acidic environment, their surface charge readily switched from negative to positive by cleavage of an acid-labile maleic amide linkage, thus allowing for effective cellular uptake into tumor tissue. Doxorubicin (DOX) encapsulated in Z-MSN was not significantly released in physiological conditions (pH 7.4), whereas the release rate of DOX remarkably increased in mildly acidic conditions through disintegration of the gatekeeper. The antitumor efficacy of DOX-loaded Z-MSN (DOX-Z-MSN) was evaluated after their systemic administration to tumor-bearing mice. Compared to free DOX and DOX-loaded MSN without the gatekeeper, DOX-Z-MSN exhibited much higher antitumor efficacy in vivo. Overall, these results demonstrated that the hydrophilic negative surface of Z-MSN, with their closed gate, allowed for their effective accumulation in tumor tissue after systemic administration, and that their charge-swapping and gate-opening in the tumor environment enhanced their cellular uptake and drug release rate simultaneously, implying a highly promising potential for development of Z-MSN as a drug carrier for cancer therapy. Statement of Significance: In an attempt to address the issues of enhanced cellular uptake and site-specific drug release of nanoparticles, we herein report on zwitterionic MSN (Z-MSN) with a pH-responsive gatekeeper which can be internalized into cancer cells via switching their surface charge from negative, in physiological conditions, to positive, in the tumor microenvironment. We hypothesized that the hydrophilic negative surface of Z-MSN with a closed gate allows for their accumulation into tumor tissue after systemic administration, whereas their charge-swapping and gate-opening in the tumor environment enhance cellular uptake and drug release rate simultaneously. Overall, Z-MSN constitute a promising drug delivery carrier for cancer therapy.

A comprehensive review on Tukhme Kunjud (Sesamum indicum Linn.) with special reference to Unani System of Medicine.

Khatoon, Rizwana,Abbasi, Hana,Aslam, Mohammad,Chaudhary, Shahid Shah Cellmed Orthocellular Medicine and Pharmaceutical 2019 셀메드 (CellMed) Vol.9 No.3

Sesame (Sesamum indicum L.) is a rich source of edible oil most commonly it is used as a food product mainly in bakeries and also use as a common source of oil in daily kitchen needs. Due to the presence of some special phytochemicals like proteins, fibers, oil, minerals and antioxidants it is highly used for medicinal and therapeutic purposes. It is a good source of energy and act as an antiaging agent. Its seeds are used as Anti-helmintic, antihypertensive, antimicrobial, cytotoxic and Hepatoprotective but its seed coat which is a byproduct of sesame and a cherished source of fibers is normally use for animal feedstuff. In Unani system of medicine it is used both as drug & diet (dawa wa ghida). In classical Unani literature it is indicated in various disorders like Asthma, Dry Cough, Gastritis (due to any drug, excessive use of alcohol), Dryness of Intestine, Dryness in throat, Renal Stone, Bleeding Piles, Amenorrhea, Retention of urine, Dysuria, Orchitis, Sexual Debility, Anorexia. The present review article, an attempt have been made to compile all the pharmacological and Pharmacognostical characters of Sesamum indicum with special reference to Unani literature.

Naphthaquinones from some Boraginaceous Taxa-A Chemical Review

Khatoon, Sayyada,Mehrotra, Shanta The Korean Society of Pharmacognosy 1996 Natural Product Sciences Vol.2 No.2

The naphthaquinones-isohexenylnaphthazarins-are mostly found in the ceratenchymatous cells of the roots of some boraginaceous taxa. A total of 34 naphthazarins and their derivatives have been isolated from these taxa till date.

Thermodynamic analysis of two evaporator vapor compression refrigeration system with low GWP refrigerants in automobiles

Khatoon Salma,Karimi Munawar Nawab 대한설비공학회 2023 International Journal of Air-Conditioning and Refr Vol.31 No.1

Due to the growing demand for refrigerators and air conditioners in automobiles, there is a need for an innovative and efficient design to achieve both refrigeration and air conditioning. To address this, the present work has evaluated a two-evaporator vapor compression system to eliminate the requirement for separate refrigeration and air conditioning units. Theoretical energy and exergy performance assessment of the same is carried out along with the variation in the condenser and evaporators temperature. Various low GWP refrigerants such as R1234yf, HFO1336mzz(Z), R513A, and R450A are compared against high GWP R134a and R452A. The results reveal that maximum exergy efficiency and COP and lowest compressor power of 31.50%, 2.47, and 6.304 kW, respectively, are obtained with HFO1336mzz(Z). After HFO1336mzz(Z), R134a shows the highest exergy efficiency and COP of 30.56% and 2.41, respectively, and the lowest compressor power of 5.61kW. HFO1336mzz(Z) exhibits the optimum performance, whereas R452A shows the worst thermodynamic performance in the system. It is also found that the performance of R450, R513A, R450A, and R1234yf is approximately equivalent to each other. Moreover, component-wise exergy destruction analyses indicate that the efficiency of the compressor needs to be improved as the maximum destruction of 61.84–56.00% occurs in the compressor while the minimum exergy destruction of 0.42–0.54% occurs in the expansion valve. This study proposes the two-evaporator system for both refrigeration and air conditioning in automobiles. It is also found that R450A, R1234yf, R513A, and HFO1336mzz(Z) can be the potential alternative to R134a.

A Review of the Flashover Performance of High Voltage Insulators Constructed with Modern Insulating Materials

Khatoon, Shabana,Khan, Asfar Ali,Singh, Sakshi The Korean Institute of Electrical and Electronic 2017 Transactions on Electrical and Electronic Material Vol.18 No.5

Pollution flashover of outdoor insulators is a common risk, which affects the safe operation of overhead transmission networks. Early electrical power systems, which feature insulators made from ceramic materials have been used all over the world with good performance. At present, non-ceramic insulators are in common use, as a result of their good electrical as well as mechanical properties. The aim of this paper is to discuss and compare the flashover performance of insulators typically used in power lines, such as, porcelain, ethylene-propylene-diene-monomer (EPDM) rubber, room temperature vulcanized (RTV) and high temperature vulcanized (HTV) coated silicone rubber. The effect of various parameters, including the severity of pollution, ice accumulation, and shade profile, are considered.. From the studies reviewed it was concluded that there is a distinct difference in the flashover voltages of different types of insulators, and the silicone provides the best flashover performance of all insulating materials.

A review on conducting polymer reinforced polyurethane composites

Halima Khatoon,Sharif Ahmad 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-

With the endless efforts in the development of polymer composite materials, conducting polymer reinforced in polyurethane (CP/PU) composites are gaining tremendous attention of scientific community in the past few years. Conducting polymers as a reinforcement, offers exceptional properties when it combines with the thermoplastic polyurethane matrix. In view of this, we critically highlight the development of different types of conducting polymers reinforced in polyurethane composites, with a detailed discussion on their method of synthesis and various characterizations techniques. Furthermore, the promising applications of CP/PU composites have also been discussed. Finally, we attempted to assemble the existing challenges and the possible future perspectives.

A Review of the Flashover Performance of High Voltage Insulators Constructed with Modern Insulating Materials

Shabana Khatoon,Asfar Ali Khan,Sakshi Singh 한국전기전자재료학회 2017 Transactions on Electrical and Electronic Material Vol.18 No.5

Pollution flashover of outdoor insulators is a common risk, which affects the safe operation of overhead transmission networks. Early electrical power systems, which feature insulators made from ceramic materials have been used all over the world with good performance. At present, non-ceramic insulators are in common use, as a result of their good electrical as well as mechanical properties. The aim of this paper is to discuss and compare the flashover performance of insulators typically used in power lines, such as, porcelain, ethylene-propylene-diene-monomer (EPDM) rubber, room temperature vulcanized (RTV) and high temperature vulcanized (HTV) coated silicone rubber. The effect of various parameters, including the severity of pollution, ice accumulation, and shade profile, are considered.. From the studies reviewed it was concluded that there is a distinct difference in the flashover voltages of different types of insulators, and the silicone provides the best flashover performance of all insulating materials.

A Pairing-Free Identity-Based Authenticated Key Agreement Protocol for MANET

Shaheena Khatoon 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.6

Providing a suitable authenticated key establishment protocol in MANETs is challenging due to all the characteristics of networks, such as communication capability, computation capability and storage resources. This paper presents an efficient and flexible authenticated key agreement protocol without bilinear pairings for MANET. Our proposed protocol not only provides mutual authentication between users and servers but also supports session key agreement. In addition, in our protocol the user does not need to perform the expansive bilinear operations, so it reduces the computation loads.

Exploratory investigation of semantic reasoning in oneM2M

Nargis Khatoon,Naqqash Dilshad,JaeSeung Song 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.6

Today important challenges in the Internet of Things (IoT) include; providing interoperability among IoT data, interpreting data generated by IoT devices, and assisting developers in accomplishing these tasks by defining rules. Current standard development organizations such as oneM2M have a vital role to design the semantic-based IoT architecture to address such challenges. Semantic reasoning is introduced by oneM2M, which is a potential capability that oneM2M-compliant IoT instances have. This paper did an exploratory investigation of semantic reasoning in the oneM2M, which is a global initiative that develops specifications to ensure the most efficient deployment of Machine-to-Machine (M2M) communications systems and the Internet of Things (IoT)