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- 저자 : Khalilah (검색결과 3 건)
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Khalilah Zakariya,Dr. Sue Anne Ware 세계문화관광학회 2010 Conference Proceedings Vol.11 No.0
Temporary markets can be considered as everyday spaces in the city. There is something unpretentious about walking through a night market or a weekly bazaar, and yet, there is also something spectacular and festive about experiencing these informal, temporary event spaces. They are often a common feature in guide books for cities, enticing visitors to engage and experience the local life. Temporary markets may look similar at a glance or through photographs, but a conscious experience through them generates a richer and more complex understanding of their similarities and differences, how they operate as part of the city, and how places in the city are interconnected. This paper presents a collection of walking experiences through different temporary markets in Kuala Lumpur, Malaysia, ranging from less formal to more formal ones, while exploring their qualities and senses. The study employs an ethnographic approach through my own personal walking experience, engaging in the experiences of others, observations and conversations with vendors and visitors, mapping, and photo-documentation. The discussion from the findings challenges us to rethink the complexities of temporary markets as both ordinary and extra-ordinary spaces, and shares how we can engage with a rich phenomenon.
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Expression Profile of Genes Modulated by Aloe emodin in Human U87 Glioblastoma Cells
Haris, Khalilah,Ismail, Samhani,Idris, Zamzuri,Abdullah, Jafri Malin,Yusoff, Abdul Aziz Mohamed Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Glioblastoma, the most aggressive and malignant form of glioma, appears to be resistant to various chemotherapeutic agents. Hence, approaches have been intensively investigated to targeti specific molecular pathways involved in glioblastoma development and progression. Aloe emodin is believed to modulate the expression of several genes in cancer cells. We aimed to understand the molecular mechanisms underlying the therapeutic effect of Aloe emodin on gene expression profiles in the human U87 glioblastoma cell line utilizing microarray technology. The gene expression analysis revealed that a total of 8,226 gene alterations out of 28,869 genes were detected after treatment with $58.6{\mu}g/ml$ for 24 hours. Out of this total, 34 genes demonstrated statistically significant change (p<0.05) ranging from 1.07 to 1.87 fold. The results revealed that 22 genes were up-regulated and 12 genes were down-regulated in response to Aloe emodin treatment. These genes were then grouped into several clusters based on their biological functions, revealing induction of expression of genes involved in apoptosis (programmed cell death) and tissue remodelling in U87 cells (p<0.01). Several genes with significant changes of the expression level e.g. SHARPIN, BCAP31, FIS1, RAC1 and TGM2 from the apoptotic cluster were confirmed by quantitative real-time PCR (qRT-PCR). These results could serve as guidance for further studies in order to discover molecular targets for the cancer therapy based on Aloe emodin treatment.
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Che Aishah Nazariah Ismail,Rapeah Suppian,Che Badariah Abd Aziz,Khalilah Haris,Idris Long 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.2
Background: This study investigated the role of NR2B in a modulated pain process in the painful diabetic neuropathy (PDN) rat using various pain stimuli. Methods: Thirty-two Sprague-Dawley male rats were randomly allocated into four groups (n=8): control, diabetes mellitus (DM) rats and diabetic rats treated with ifenprodil at a lower dose (0.5 μg/day) (I 0.5) or higher dose (1.0 μg/day) (I 1.0). DM was induced by a single injection of streptozotocin at 60 mg/kg on day 0 of experimentation. Diabetic status was assessed on day 3 of the experimentation. The responses on both tactile and thermal stimuli were assessed on day 0 (baseline), day 14 (pre-intervention), and day 22 (post-intervention). Ifenprodil was given intrathecally for 7 days from day 15 until day 21. On day 23, 5% formalin was injected into the rats’ hind paw and the nociceptive responses were recorded for 1 hour. The rats were sacrificed 72 hours postformalin injection and an analysis of the spinal NR2B expression was performed. Results: DM rats showed a significant reduction in pain threshold in response to the tactile and thermal stimuli and higher nociceptive response during the formalin test accompanied by the higher expression of phosphorylated spinal NR2B in both sides of the spinal cord. Ifenprodil treatment for both doses showed anti-allodynic and anti-nociceptive effects with lower expression of phosphorylated and total spinal NR2B. Conclusion: We suggest that the pain process in the streptozotocin-induced diabetic rat that has been modulated is associated with the higher phosphorylation of the spinal NR2B expression in the development of PDN, which is similar to other models of neuropathic rats.
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