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Juhari, Wan Khairunnisa Wan,Rahman, Wan Faiziah Wan Abdul,Sidek, Ahmad Shanwani Mohd,Hassan, Muhammad Radzi Abu,Noordin, Khairul Bariah Ahmad Amin,Zakaria, Andee Dzulkarnaen,Macrae, Finlay,Zilfalil, B Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Lynch syndrome (LS) is an inherited predisposition to colorectal, endometrial (uterine) and other cancers. Although most cancers are not inherited, about 5 percent (%) of people who have colorectal or endometrial cancer have the Lynch syndrome. It involves the alteration of mismatch repair (MMR) genes; MLH1, MSH2, MSH6 or PMS2. In this study, we analyzed the expression of MMR proteins in colorectal cancer in a Malay cohort by immunohistochemistry. Materials and Methods: A total of 17 patients were selected fulfilling one of the Bethesda criteria: colorectal cancer diagnosed in a patient aged less than 50 years old, having synchronous and metachronous colorectal cancer or with a strong family history. Immunohistochemical staining was performed on paraffin embedded tumour tissue samples using four antibodies: MLH1, MSH2, MSH6 and PMS2. Results: Twelve out of 17 patients (70.6%) were noted to have a family history. A total of 41% (n=7) of the patients had abnormal immunohistochemical staining with one or more of the four antibodies. Loss of expression were noted in 13 tumour tissues with a negative staining score <4. Of 13 tumour tissues, four showed loss expression of MLH1. For PMS2, loss of expression were noted in five cases. Both MSH2 and MSH6 showed loss of expression in two tumour tissues respectively. Conclusions: Revised Bethesda criteria and immunohistochemical analysis constituted a convenient approach and is recommended to be a first-line screening for Lynch syndrome in Malay cohorts.
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Competency Prole of Managers in the Singapore Logistics Industry
Vinh V. THAI,Khairunnisa Binte IBRAHIM,Vidya RAMANI,Hong-Yuan HUANG 한국해운물류학회 2012 The Asian journal of shipping and Logistics Vol.28 No.2
In this paper, we aim to explore what competencies are essential for logistics managers to be successful in the future by developing a conceptual framework of competency profile of logistics managers based on the existing BLM model and some newly proposed competencies, taking into account changes in the business environment. A survey was conducted in Singapore with logistics managers from 350 rms. A total of 52 returned questionnaires were received, representing a response rate of 14.8%. We found that the proposed framework of 103 business-, logistics- and management-related competencies are essential for logistics managers to be successful, although management-related competencies were perceived as more important than the others. Although being based on the existing BLM framework, this research also proposed and validated new competencies into the existing BLM framework to reect the necessary response to changes in the business environment. This research also contributes to management practice and serves as another effort to map out the critical competency prole for logistics managers of the future.
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Feda Anisah Makkiyah,Tasya Anggraini Sinaga,Namira Khairunnisa 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.2
Objective : Low back pain (LBP) is a global health problem that affects the productivity of the patients. Several factors such as individual, occupational, and psychosocial factors increase the risk of LBP. However, only a few studies investigated those factors, especially in middle adulthood in Indonesia. Indonesia is a country with a young population that has been rapidly developing in recent years. This study was conducted to find out the factors associated with LBP in middle adulthood. Methods : This study is a cross-sectional observational analytic study using a convenience sampling method with a total sample of 3005 respondents. Data were collected using a questionnaire which was then analyzed using the chi-square test, Kolmogorovsmirnov, Spearman’s Rank, and logistic regression test. Results : From the result of this study, it was found that the 12-month prevalence of LBP in middle-aged adults was 44,29%. Female (odds ratio [OR], 1.3; 95% confidence interval [Cl], 1.098–1.545; p=0.002), lack of physical exercises (OR, 0.87; 95% Cl, 0.794–0.959; p=0.005), high body mass index (OR, 1.09; 95% Cl, 1.009–1.187; p=0.002), stress level (OR, 1.26; 95% Cl, 1.088–1.458; p=0.002), and years of work experience (OR, 1.1; 95% Cl, 1.001–1.225; p=0.047) were determined as risk factors that significantly associated with LBP. Conclusion : LBP is quite common among middle-aged adults in Indonesia. Female gender, higher body mass index, lack of physical activity, stress level, and years of work experience were all potential risk factors for LBP in middle-aged adults. Middle-aged adults in Indonesia should be aware of LBP and avoid disabilities by identifying risk factors that may worsen LBP in the future.
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Harisun Yaakob,Nor Rashidah Ahmed,Siti Khairunnisa Daud,Roslinda Abd Malek,Roshanida Abdul Rahman 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.4
In this study, response surface methodology (RSM) was employed to optimize the ingredient formulation and processing parameters of coconut milk yogurt production such as temperature, time, and amount of starter culture on the sensory evaluation responses. Besides, the physicochemical properties such as pH, titratable acidity, and viscosity of the yogurt were also analysed. The analyses show that the coconut yogurts have a pH from 4.01 to 5.79, acidity from 0.461 to 2.079 (%), and viscosity from 433 to 21,833 cp during the optimization process. From the analysis of variance, the R2 of all response variables is more than 0.73that indicates that a high proportion of variability was explained by the model. Based on the response surface 3D plot of the sensory evaluation, the optimum acceptability of the coconut yogurt processing parameter are at temperature of 37oC, 8 h of the fermentation duration, and 3%(w/w) of the starter culture.
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Franchising for Global Distribution: A Systematic Review
Nurul Ashykin ABD AZIZ,Mohamad Rohieszan RAMDAN,Khairunnisa ABDUL AZIZ,Hasif Rafidee HASBOLLAH,Noreen Noor ABD AZIZ,Nik Syuhailah NIK HUSSIN,Md Zaki MUHAMAD HASAN 한국유통과학회 2023 유통과학연구 Vol.21 No.10
Purpose: The purpose of this study is to explore areas that have been studied extensively in previous studies related to franchising as a platform for global distribution. Furthermore, franchising is a strategic distribution method that gives entrepreneurs the opportunity to replicate an established business model. In addition, franchisees benefit from the use of established branding and receive support from the franchisor. Research design, data, and methodology: This study used the Preferred Reporting Items Systematics Review and Meta- Analyses (PRISMA) method to analyse data from 2003 to 2023 in the Web of Science and Scopus databases. Results: A total of 79 articles were identified and analysed to see trends and related themes such as product distribution, business distribution, business strategy, emerging market, and franchising relationship. Also, publication trends by year related to franchises are also presented. Conclusions: Overall, the research trend related to franchising as a global distribution is well seen, and every year, many researchers begin to explore the topic of franchising as a method of distribution that can be explored from various aspects either quantitatively or qualitatively. Lastly, limitations and recommendations are made to provide guidance for future studies related to the topic broadly and deeply in enriching the findings.
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