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대장에 발생한 샘암종에서 MUC1과 MUC2 점소 발현의 의의
이윤경,이주호,이용,심재영,박정훈,오수섭,박진실,기근홍 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2
Background : Mucins possess the unique function of protecting and lubricating the epithelial surface and other important functions such as call growth, direct implication in the fetal development, the epithelial renewal and differentiation, the epithelial integrity, carcinogenesis, immune regulation, cellular adhesion and metastasis. Purpose : This study was done to provide the significance of alteration of MUC1 and MUC2 expression in colorectal adenocarcinoma, A series of 131 colorectal adenocarcinomas including 11 mucinous carcinomas were screened immunohistochemically for their expression of MUCI and MUC2, Materials and mehtods : Of 131 carcinomas, 76 (58,5%) were MUCI positive and 91 (68, 9%) were MUC2 positive, In normal colonic goblet cells, MUCl was not expressed but MUC2 was expressed in cytoplasm, Conclusion There were up-regulation of MUCI and down-regulation of MUC2 in colorectal carcinomas, The frequency of MUC2 positivity according to differentiation was statistically reliable. (p=0.0001)
Novel Peak-Power Tracking Algorithm for Photovoltaic Conversion System
Sil-Keun Kim,Soon-Ill Hong,Jeng-Pyo Hong 한국조명·전기설비학회 2007 조명·전기설비학회논문지 Vol.21 No.9
In this parer, a novel MPPT (Maximum Power Point Tracking) algorithm for power of PV (Photovoltaic) systems is presented using a boost converter for a connected single phase inverter. On the basic principle of power generation for the PV (photovoltaic) module, the model of a PV system is presented. On the basis of this model, simulation of this PV system and algorithms for maximum power point tracking are described by utilizing a boost converter to adjust the output voltage of the PV module. Based on output power of a boost converter, single phase inverter uses predicted current control to control four IGBT's switch in full bridge. Furthermore, a low cost control system for solar energy conversion using the DSP is developed, based on the boost converter to adjust the output voltage of the PV module. The effectiveness of the proposed inverter system is confirmed experimentally and by means of simulation. Finally, experimental results confirm the superior performance of the proposed method.
Novel Peak-Power Tracking Algorithm for Photovoltaic Conversion System
Kim, Sil-Keun,Hong, Soon-Ill,Hong, Jeng-Pyo The Korean Institute of IIIuminating and Electrica 2007 조명·전기설비학회논문지 Vol.21 No.9
In this paper, a novel MPPT(Maximum Power Point Tracking) algorithm for power of PV(Photovoltaic) systems is presented using a boost converter for a connected single phase inverter. On the basic principle of power generation for the PV(photovoltaic) module, the model of a PV system is presented. On the basis of this model, simulation of this PV system and algorithms for maximum power point tracking are described by utilizing a boost converter to adjust the output voltage of the PV module. Based on output power of a boost converter, single phase inverter uses predicted current control to control four IGBT#s switch in full bridge. Furthermore, a low cost control system for solar energy conversion using the DSP is developed, based on the boost converter to adjust the output voltage of the PV module. The effectiveness of the proposed inverter system is confirmed experimentally and by means of simulation. Finally, experimental results confirm the superior performance of the proposed method.
간질 환아에서 항경련제의 임의 중단 후 관찰된 임상 소견
임근희(Keun Hee Lim),이은실(Eun Sil Lee),문한구(Han Ku Moon) 대한소아신경학회 1999 대한소아신경학회지 Vol.7 No.1
목 적 : 본 연구는 간질 환아 중 보호자나 환아가 임의로 항경련제의 복용을 중단한 후 추적 관찰된 경우에서 임의 중단 후 발생한 경련은 어떤 형태로 나타나며, 임의 중단이 간질 중첩증의 발생과 직접적인 인과관계가 있는지에 대해 알아보기 위하여 시행되었다. 방 법 : 1995년 1월부터 1997년 6월까지 2년 6개월 동안 영남대학교 부속병원 소아과 소아신경클리닉에서 추적 관찰되고 있던 간질 환아 425명 중 항경련제의 복용을 갑자기 임의 중단했던 72명, 88증례를 대상으로 항경련제의 임의 중단 후 간질 의 종류 및 항경련제의 종류에 따른 경련의 발생 여부와 발생한 경련의 형태와 정도를 분석하고, 임의 중단과 간질 중첩증의 발생과의 연관성을 의무 기록지를 검토하는 후향적 연구로 시행하였다 결 과 : 1) 항경련제가 임의 중단된 88 증례 중 추적시 기존 경련 재발군에 속한 경우가 42례(47.7%), 경련의 발생이 없던 군이 18례(20.5%) 그리고 14례(16.0%)는 경련 횟수 증가군에 속했으며, 경련 횟수나 정도의 변화가 없던 경우가 3례(3.4%), 경련의 횟수나 정도가 감소한 경우가 2례(2.3%)였다. 2) 임의 중단 후 기존 경련 재발, 경련 횟수 증가, 경련 정도 악화 및 간질 중첩증의 소견을 보인 경우는 국소 간질의 경우 71례 중 55례(77.5%), 전신성 간질의 경우 17례 중 9례(52.9%)로서 국서 간질에서 많았으며(P=0.041), 이와 같은 소견이 임의 중단 4주 이내에 관찰된 예는 국소 간질의 경우 55례 중 36례(65.5%), 전신성 간질의 경우는 9례 중 3례(30.0%)로서 이 역소 국소 간질에서 많았으나 통계학적으로는 유의하지 않았다(P=0.137). 3) 항경련제별로 임의 중단 후 기존 경련의 개발, 횟수 증가, 경련 정도의 악화 및 간질 중첩증 발생의 소견을 보인 경우는 carbamazepine 사용군 26례 중 18례(69.2%), phenobarbital 사용군은 16례 중 15례(93.8%), 다약제군의 34례 중 24례(70.6%)였으나 통계학적으로 유의한 차이를 얻을 수 없었고(P=0.143), 이러한 소견이 임의 중단 4주 이내에 발생한 예에서 약제간의 차이도 유의하지 않았다(P=0.122). 4) 간질 중첩증은 4명, 4례(4.5%)에서 발생하였으며 모두 국소 간질 환아였고 항경련제의 임의 중단 4개월(2례), 5개월(1례), 23개월(1례) 후에 발생하였다. 결 론 : 간질 환아에서 항경련제의 복용이 임의로 중단되는 경우가 많으므로 이에 대한 환아 및 부모의 교육이 강화되어야 하겠다. 간질 환아의 간질 중첩증의 발생기전에 대해 항경련제의 임의 중단 외의 다른 요인에 보다 많은 연구가 필요할 것으로 생각된다. 간질 환아에서 항경련제의 처방 후 효과 뿐만 아니고 역효과에 대해서도 세심항 관찰이 필요하다고 생각된다. Purpose : The effects of arbiturary acute anticonvulsants withdrawal in epileptic children were studied and relationship between status epilepticus and anticonvulsant withdrawal was analysed. Methods : Medical records of 88 withdrawal episodes in 72 active epileptic children were analysed retrospectively according to the types of epilepsies, anticonvulsants. Results : 1) When followed up after withdrawal, 42 cases(47.7%) had a recurrence of habitual seizure, 18 cases(20.5%) had no seizure and increased seizure frequency were found in 14 cases(16.0%). Three cases(3.4%) had no change in seizure frequency or severity and in 2 cases(2.3%) the frequency or severity of seizure were decreased after withdrawal. 2) Recurrence of habitual seizure, increased seizure frequency, more intense seizure or status epilepticus were noted in 55 of 71 withdrawal episodes in focal epilepsies(77.5%), in 9 of 7 withdrawal episodes(52.9%) in generalized epilepsies(P=0.041). These changes occurred in 36 of 55 cases(65.5%) in focal epilepsies, 3 of 9 cases(30.0%) in generalized epilepsies within 4 weeks after withdrawal(P=0.137). 3) Recurrence of habitual seizure, increased seizure frequency, development of more intense seizure or status epilepticus were found in 18 of 26 cases(69.2%) in carbamazepine monotherapy, 15 of 16 cases(93.%) in phenobarbital monotherapy, 24 of 34 cases(70.6%) in polypharmacy(P=0.143). These changes occurred in 14 of 18 cases(77.8%) in carbamazepine monotherapy, 7 of 15 cases(46.7%) in phenobarbital monotherapy and 18 of 24 cases(75.0%) in polypharmacy within 4 weeks after withdrawal(P=0.122). 4) Four cases(4.5%) of status epilepticus occurred in 4 patients with focal epilepsies at 4 months(2 cases), 5 months, 23 months later after acute anticonvulsant withdrawal. Conclusion : Arbiturary acute anticonvulsants withdrawal in epileptic children wrer more common than expectation and councelling to avoid arbiturary anticonvulsant withdrawal must be entensified. Approximately half of the cases with anticonvulsant withdrawal showed a recurrence of habitual seizure abd status epilepticus occurred in 4.5% of cases only. Other factors besides acute anticonvulsant withdrawal must be investigated to clarify the underlying mechanism of status epilepticus. A quarter of cases showed no seizure and even decrease in seizure frequency or severity after anticonvulsant withdrawal. These results suggest more considerated prescription of anticonvulsant is needed in practice.
Optimization of Radiotherapy Treatment Plan for Hepatic Tumor
( Jin Sil Seong ),( Kyoung Keun Jeong ),( Su Jung Shim ),( Sei Hwan You ),( Kwang Hwan Cho ) 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)
Purpose/Objective: Radiotherapy treatment plans for hepatic tumor are significantly limited by the adjacent normal organs at risk (OAR), which become major restriction on the total dose of the target. In this study, we try to find the optimal treatment pl