네모나프라이드의 유효성 및 추체외로 부작용 : Haloperidol 및 Risperidone과의 자연관찰적 개방형 비교연구 A Naturalistic Open Comparative Study with Haloperidol and Risperidone

서영수,김용관,신동환,공보금,이정구,박정환,윤성환,정치영,이상경,김영훈 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : This open prospective study was performed in order to evaluate the efficacy and extrapyramidal adverse effects of nemonapride in the schizophrenic patients, and was compared wit one of typical antipshchotics. haloperidol and one of atypical antipsychotics, risperidone. Methods : Thirty male and female schizophrenic patients(DSM-Ⅳ) were treated for 12 weeks with haloperidol(n=10), risperidone(n=10) and nemonapride(n=10). The overall efficacy was assessed at baseline, 1st week, 2nd week, 4th week, 8th week, and 12th week by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS). Also the overall safety was assessed in the same time period by the Extrapyramidal Symptom Rating Scale(ESRS). Results : There were no significant differences in PANSS scores(total, positive, negative, and general psycho­pathology subscale) among haloperidol, risperidone, and nemonapride groups, Treatment responders, defined as at least 20% reduction of baseline total PANSS score, were achieved by 8 patients(80%) in haloperidol group, 10 patients(100%) in risperidone group, and 8 patients(80%) in nemonapride group. And there were no significant differences in ESRS total scores among haloperidol, risperidone, and nemonapride group. Inter-group comparison among haloperidol, risperidone and nemonapride group, as assessed by the ESRS, revealed no significant differences in the shifts to the maximum score, 9.4(±9.4), 6.2(±8.4), and 11.3(±8.1) respectively, and also revealed no significant differences in the mean time reaching the maximum score, 4.5(±4.5) week, 7.8(±4.8) week, and 4.6(±4.4) week, respectivily. Conclusion : There wee no significant differences in the efficacy and extrapyramidal adverse effects among haloperidal, rispecridone and nemonapride groups. These results suggest that nemonapride was as efficacious and safe in he treatment of schizophrenia, as well known and widely used antipsychotics, haloperidol and risperidone.

암처리 엽수와 기간이 들깨의 생육 및 개화에 미치는 영향

최영훈,최영환,이영근,김용균,손병구,강점순,김근기 밀양대학교 농업기술개발연구소 2000 農業技術開發硏究所報 Vol.4 No.1

The lower leaves shading in upper leaves is unknown to be reduced significantly due to the early differentiation of flower-bud by dark treatment of leaves when growing perilla for harvesting the leaves in the greenhouse during the winter. This study analyzed the effect of dark treatment of leaves on the growth and regulation of flowering, which are closely related with differentiation of flower and amount of leaves. One leaf and 3 leaves per plant were dark treated for 0, 5, 10 days. Plant hight was reduced in 3 leaves treatment, but there was no difference in 1 leaf treatment. Stem diameter was reduced in both 1 leaf and 3 leaves treatments, which was more significant in 3 leaves treatment. Leaf area was reduced when 1 leaf was treated for 10 days, but there was no difference when 1 leaf was treated for 5 days. When 3 leaves were treated, leaf area was no difference between treatments. However, leaf area which 3 leaves were treated was reduced more significantly than that 1 leaf was treated. Seed weight was remarkably decreased when 1 leaf was treated for 10 days, and it was decreased when 3 leaves were treated for more than 5 days.

Performance Analysis of the Modified Symmetric Banyan Network(MSBN)

금영욱 聖潔大學校 情報産業技術硏究所 1997 情報産業技術論叢 Vol.2 No.-

SBN은 결함 허용 능력을 지닌 고성능 베이년 상호연결망이다. SBN은 3개의 결함을 허용하는데 SBN의 라우팅 알고리즘은 결함이 존재해도 매우 간단하다. 이 논문에서 SBN의 마지막 단을 수정한MSBN을 제안하여 향상된 성능을 보인다. 또한 MSBN의 성능 측정을 위한 분석 모델을 개발하여 다른 망들과 성능 비교를 한다. 분석 결과는 MSBN이 SBN보다 11%의 성능 향상을 보인다.

2-Acetylaminofluorene으로 유발된 실험적 간암의 세포 동태학적 연구

금주섭,고영혜,이중달 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.2

Kinetics of hepatocytes in various precancerous and cancer iesions during hepatocarcinorenesis was evaluated in 38 Sprague-Dawley rats fed with 0.075% 2-acetylaminofluorene diet. The rats were sacrificed after 4, 7, 10 days. 2, 3, 4, 6, 8 weeks, and 3, 4, 5, 6, 7, 8 months of the experiment. The lesions were divided as altered cell lesions (clear cell focus, acidophilic cell focus, and basophilic cell focus). regenerating nodules. neoplastic nodules, and hepatocellular carcinomas. Cell kinetics was studied by intraperitoneal bromodexyuridine(BrdU) injection 2 hours before sacrifice. After detection of the BrdU-incorporated nuclei with monoclonal antibody kit, the BrdU labelling index(BLI) was measured as percentage of BrdU labelled cells among about 1000 cells. The liver cells in the altered cell lesions showed significantly increased BLI(clear cell 1.66: acidophilic 2.39: basophilic 2.41) in comparion with normal control(0. 18) or non-lesional hepatocytic lobules (0. 47), and lower BLI than hepatocellular carcinoma(8.61∼27.07) (P<0.05). Regenerating and neoplastic nodules did not differ in their BLI (1.54 and 1.70), and were significantly lower in their proliferating kinetics than acidophilic or basophilic cell foci (P<0.05). It was suggested from this study that the altered cell lesion should be true premalignant lesion, which was composed of at least initiated cells by the chemical carcinogen. The basophilic and acidophilic foci in altered cell lesions were suggestive of close correlation with the hepatocellular carcinoma in that they had greatest proliferative cell kinetics of all the lesions occurred before cancer developed.

대장안 조직에서 cDNA Microarray의 초기경험

금충수,이령아,홍영준,홍석일,황대용 대한대장항문학회 2003 Annals of Coloproctolgy Vol.19 No.6

素問·氣交變大論에 對한 硏究

蔡英?,鄭憲瑩,琴坰樹,朴炅 대한한의진단학회 1998 大韓韓醫診斷學會誌 Vol.2 No.2

The contents of Ki Kyo Byun Dae Ron(氣交燮大論) are explained on the basis of the so-called "Five elements motion and six kinds of natural factorsc(五運大氣)" theory. The relevant adaptation of the human body to natural enviroment is one of the basic theoties in Oriental medicine, according to which the physical structure and physiological phenomena of human body as well as the physiological changes are in adaptative confirmity with the variations of the natural environment, and hence in diagnosis and treatment the influences of environmental factors such as climatic conditions, geographical localities, etc., should be considered. The theory of Fve Circuit Phases and Six Atomsphric Influences is based on this thought. Summeriiing the contents of the Ki Kyo Byun Dae Ron(氣交燮大論) in reference to the contents of successive generation note, the contents were as follows; What attract our attention in chapter Ⅰ are climatic changes and pathologic explanations on the diseases which are invited by a certain excessive circuit phase. What attract our attention in chapter Ⅱ are climatic changes and pathologic explanations on the diseases which are invited by a certain insufficient circuit phase. The main point of chapter Ⅲ is the promoting and counteracting relations of the five circuit phases taken as a whole, which forms a self-limiting balanced process. What attract our attention in chapter Ⅳ, Ⅴ is the change of five planets brigtness which is invited by excessive or insufficient circuit phase.

척수강내 Bupivavacain에 첨가한 소량의 Neostigmin의 진통효과와 부작용

소금영,정종달,김병철,유벙식,안태훈,김훈정,임경준 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background : Spinal cholinergic receptor has been shown to have a antinociceptive action, an effect that can be mimicked by spinal cholinesterase inhibitor. Intrathecal injection of neostigmine cause analgesia and adverse effect in a dose-dependent pattern in the patients. The purpose of this study was to determine whether small doses of intrathecal neostigmine (10, 25 and 50 ㎍) produce analgesia and any side effects. Method : After getting informed consents, 60 patients scheduled for orthopedic surgery of lower extremities under spinal anesthesia were randomly assigned to one of four groups. Using dose-ranging design, patients received either normal saline or neostigmine l0, 25 or 50 ㎍ in a 1-㎎ solution of 5% glucose in normal saline with heavy bupivacaine 12 ㎎. Heart rate, blood pressure, degree of motor and sensory block were recorded. The assessment of postoperative analgesia included time to first rescue, total number of rescue medication and pain score on visual analog scale (VAS) at 1, 3, 6, 9, 12, 24 hour. Nausea and vomiting were assessed by using the visual analog scale at 24 hr postperatively and the incidence of them was recorded postoperatively. Result : There were no significant differences among the four groups in characteristics of spinal blocks. Compared to saline, neostigmine groups significantly prolonged time to first rescue medication and decreased total number of rescue medication and pain visual analog scale score, but incidence of nausea and 24hr nausea VAS score were not increased in neostigmine group compared to control group. Conclusion : These data in patients injected intrathecal neostigmine suggest that analgesia may occur at doses less than neostigmine 50 ㎍ and neostigmine 50㎍ has a better analgesia effect with fewer side effects than other doses for postoperative analgesia.

가족여가를 통한 가족자원봉사 활성화방안에 관한 연구

정영금 가톨릭대학교 생활과학연구소 2009 생활과학연구논집 Vol.29 No.1

Recently, the importance of the leisure and leisure time are increasing, but most of leisure time is spending in TV watching. So, the purpose of this study is to suggest the importance and method for activating the family volunteer activity through family leisure. For this purpose, this study shows the importance of family leisure and leisure time. And the significance of voluntary activities and the time survey results about them are demonstrated. Especially, this study focused the importance of family voluntary activities and the contribution to their families and society. Finally, the legislations relating to the voluntary activities are listed. So, many communities and family service centers, specially healthy family support center, can activate and increase family voluntary activities by participating to the implementation of these laws.

上場企業의 轉煥社債發行과 株式轉煥에 관한 硏究

李一琴,洪永哲 진주여자전문대학 1996 論文集 Vol.19 No.-

In this paper, We reviewed and discussed on convertible bonds, and explained effects for convertible bonds. As discussed above, convertible bonds is to conver into issuing company stock by an intension of stock owner. In issuing convertible bonds, repayment and external interest rate, conversion cost and issuing condition, no connection with company size, grade credit, stock trends, are uniformly determined. To promotion non guarnteed convertible bond issuing, nonguranteed bond issuing rather than guaranteed bond are profitable to the issuing company.

요실금이 있는 중년여성의 일상생활불편감 및 우울에 관한 연구

김금순,이윤정,서문자,박영숙 서울대학교 간호대학 간호과학연구소 1999 간호학 논문집 Vol.13 No.1

The purpose of this study was to explore the relating factors, discomfort and depression due to urinary incontinence in middle-aged women. The subjects were 215 women in the age 35-65 years old who dewelled in community. The data were collected from August to December in 1996 with interview using structured questionaire composing of items of general characteristics, obsteric characterisitcs, disease charactteristics, situation of experiencing urinary incontinence, discomfort, and terapeutic method, and Beck's depression inventory. The data were analysed using SPSS/PC+ program; Cronbach's, frequency, percentage, Spearman's or pearson's coefficient correlation. The results of this study were as follows: 1) The mean duration of experiencing the urinary incontinence was 36.16 moths and the 60.9% of the respondents experienced a few frequency of urinary incontinence and the 77.2% was somewhat small expressed as "wetting their clothes". 2) The urinary incontinence induced situations were coughing, sneezing, hasty, and ascending abdominal pressure. 3) The ost common situations of discomforts associated with hrinary incontinence were diversional activity such as exercise, long period journey, and interpersonal relations. 4) The 80.5% of ascending abdominal pressure experienced the urinary incontinence, and the most common symptom of urinary incontinence was the frequent urine(43.3%) 5) The urinary incontinence correlated with menopause, age of menopause(p<.05) and age group(p<.01) significantly. 6) The 89.7% of urinary incontinence were not treated, but they wanted to try noninvasive methods such as the herb medicine(27.4%), pelvic muscle exercise(27.0%), and biofeeback(4.2%). 7) situation of experiencing urinary incontinence, discomfort and symptoms of depression correlated with urinary incontinence significantly(p<.05). In conclusion, we need to develop and provide various nursing interventions such as the pelvic muscle exericse, biofeedback and stress & depresion management program in middle-aged women who dewells in community in view of quality of life, health maintenance and promotion.