Improved Equations for the Profile of a Vertical Air-Core Vortex

Kerem Taştan,Nevzat Yıldırım 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.5

The available formulas for the profile of a vertical non-air-entraining vortex are not practical because they involve unknown parameters and need measurements of the local viscous-core radii across the height of the air-core vortex. Also, these formulas can not be used for the air-entraining vortices. In the present study, the available formulas involving unknown parameters were further improved. Findings are as follows. 1) the magnitudes of the unknown parameters vary across the height of the profile of the air-core vortex and they are the function of the ratio of the height of the air-core vortex to the submergence of the intake; 2) simple charts and formulas were obtained for the variations of the unknown parameters for the air-core vortices with and without an intake; 3) in lieu of the local viscous-core radius, the radius at the half-depth of the profile of the air-core vortex was used; 4) no laborious work of measurements are needed to determine the local viscous-core radii along the profile of the vortex; and 5) the improved formulas are in good agreement with available test data for the profiles of both the non-air-entraining and the air-entraining vortices with or without a vertically flowing downward intake.

Pleomorphic Carcinoma of the Lung with High Serum Betahuman Chorionic Gonadotropin Level and Gynecomastia

Kerem Okutur,Baris Hasbal,Kubra Aydin,Mustafa Bozkurt,Esat Namal,Buge Oz,Kamil Kaynak,Gokhan Demir 대한의학회 2010 Journal of Korean medical science Vol.25 No.12

Although gynecomastia is a well-defined paraneoplastic syndrome in patients with nonsmall cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. βhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG. Serum βhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.

On Elliptic trigonometry

Kerem BASOL,Omer Faruk TAL,Ismail Naci CANGUL 장전수학회 2019 Proceedings of the Jangjeon mathematical society Vol.22 No.4

The ordinary trigonometric functions are defined by means of angles and lengths on the unit circle. There are several derivatives of classical trigonometric functions such as hyperbolic, polar, spherical, Fourier, inverse, log, complex, q-versions etc. In this paper, we add this list a new version of trigonometry which will be consistently called as elliptic trigonometry by working on an ellipse instead of a circle. Although the definitions of elliptic trigonometric functions remind us the classical trigonometry, there are several interesting differences between the two whence the relations and expansions are considered. Also as ellipses has applications in engineering, medicine, astronomy, architecture, etc., it is expected that this new notion will have new applications or improve the existing applications in these and other areas.

Effective Intake for Critical Submergence in the Case of More Than One Intake

Kerem Ta tan,Nevzat Yildirim 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.3

The available potential flow solution methods over-estimate the number of effective intake for the prediction of critical submergence in the case of multiple intakes of identical level without partition walls located on the longitudinal line of the canal, because they cannot establish an upper limiting value for the distance between the centers of the intakes. To address this, tests were conducted on dual intakes of identical level located on the longitudinal line of the canal in a cross-flow. In practice, by means of the chart obtained from the experimental results, one can determine the upper limiting value of the distance between the centers of dual intakes beyond which the effect of the intake on the critical submergence of the other intake is negligible. Such an intake is considered a non-effective intake and is disregarded in the prediction of critical submergence. In addition, the effective intake relating to multiple intakes sited in a still-water reservoir is explained.

Cranially-based nasolabial flaps for the reconstruction of nasal surgical defects

Kerem, Hakan,Bali, Ulas,Sonmez, Erhan,Evrenos, Mustafa Kursat Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.2

Background Cranially-based nasolabial flaps are a good alternative for the reconstruction of nasal defects. Methods A cranially-based nasolabial flap was used in 18 patients to reconstruct defects of the nose from 2010 to 2016, and the long-term results are presented in this report. Results Fifteen of the flaps completely survived. All the patients had a bulky appearance, but they did not want to undergo a second operation for cosmesis. The dissection of the flap took approximately 20 minutes, and the total operation lasted for 1 hour. The patients were hospitalized for 1-7 days, and the postoperative follow-up period was 1-28 months (mean, 17 months). Conclusions The cranially-based nasolabial flap possesses all the advantages of the traditional forehead flap, and can safely be used in selected cases.

Comparison Of Human Dermal Graft (HDG) And Tensor Fascia Lata Autograft (TFL) In Superior Capsule Reconstruction (SCR) Of The Shoulder: A Biomechanical And Histological Study In Rabbit Models

Kerem Bilsel,Fatih Yildiz,Anil Pulatkan,Mehmet Kapicioglu,Gokcer Uzer 대한견주관절의학회 2019 대한견주관절학회 학술대회논문집 Vol.2019 No.3

Predictive and Prognostic Significance of p27, Akt, PTEN and PI3K Expression in HER2-Positive Metastatic Breast Cancer

Okutur, Kerem,Bassulu, Nuray,Dalar, Levent,Aydin, Kubra,Bozkurt, Mustafa,Pilanci, Kezban Nur,Dogusoy, Gulen Bulbul,Tecimer, Coskun,Mandel, Nil Molinas,Demir, Gokhan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

Background: The phosphatidylinositol 3'-kinase/Akt (PI3K/Akt) pathway is a key regulator for HER2-overexpressing breast cancer, but data about whether activation of PI3K/Akt is associated with poor prognosis and resistance to trastuzumab therapy is controversial. In this study we investigated predictive and prognostic significance of expression of p27, Akt, PTEN and PI3K, which are components of the PI3K/Akt signaling pathway, in HER2-positive metastatic breast cancer (MBC), retrospectively. Materials and Methods: Fifty-four HER2-positive MBC patients who had received first-line trastuzumab-based therapy were recruited for the study group. All of the patient's breast tissue samples were examined for p27 and Akt expression. In addition, twenty-five patients with sufficient amount of tumor tissue were also examined for PTEN and PI3K expression. p27, Akt, PTEN and PI3K were evaluated by immunohistochemistry and their relationship with patient demographic features, tumor characteristics, response to trastuzumab-based treatment and survival outcomes were analyzed. Results: p27, Akt, PTEN and PI3K were positive in 25.9%, 70.4%, 24% and 96% of the cases, respectively. Nomne were significantly associated with response to trastuzumab and time to progression (TTP). A trend toward statistical significance for longer overall survival (OS) was found for PTEN-positive patients (p=0.058); there was no significant relationship between the other immunohistochemical variables and OS. When we analyzed groups regarding co-expression, the PTEN-negative/Akt-negative group had a significantly lower objective response rate (ORR) (20% vs 80%, p=0.023) and the PTEN-negative/p27-negative and PTEN-negative/Akt-negative groups had significantly lower median OS compared to other patients (26.4 months vs 76.1 months, p=0.005 and 25.6 months vs 52.0 months, p=0.007, respectively). Conclusions: p27, Akt, PTEN and PI3K expression is not statistically significantly associated with ORR, TTP and OS, individually. However, the combined evaluation of p27, Akt and PTEN could be helpful to predict the response to trastuzumab-based therapy and prognosis in HER2-positive MBC.

개발 도상민주주의 국가 정당들의 후견주의적 및 프로그래매틱 전략변화 - 터키 공화인민당 (Cumhuriyet Halk Partisi)

케렘클러츠다르옥루 ( Kerem Kılıcdaroglu ) 한국외국어대학교 중동연구소 2016 중동연구 Vol.35 No.2

본 연구는 개발 도상민주주의 국가의 정당들이 후견주의에서 프로그래매틱 전략 변화의 원인을 밝히는 데 목적을 두고 있다. 다음과 같은 주요문제점으로는 어떤 조건 하에서 정당들이 후견주의에서 프로그래매틱 전략을 채택하는지? 전략변화는 정당조직에 어느 정도의 영향을 미치는지? 정당 유권자들과 관해서는 터키의 이스탄불에서 진행된 현장 조사에 기반을 두어 투표자들의 요구와 정당들의 국가 자원 접근이 전략변략에 미치는 영향이 논의된다. 정당들은 덜 개발 지역에서 후견주의적 전략을 따르나 개발된 지역에서는 프로그래매틱 전략 추세를 보인다. 또한, 정당이 연립 정부와 관련이 있다면, 정당은 더 후견주의적 전략 추세인다. 정반대로, 야당이라면 프로그래매틱 전략의 추세를 보인다. 전체적인 전략변화를 관찰하기 위하여, 투표 동원 전략, 당의 재정, 당내 민주주의, 당 파벌주의 및 당 충성심* 등 5가지 지표를 통하여 정당 후견주의 지수(Party Clientelism Index, PCI)를 개발하였다. 주장을 강조하기 위하여 본 연구에서, 공화인민당의 3분기 (1991년~1995년 및 2002년~2015년) 와 정당 전략에 초점 두어 이스탄불에서 에센레르 (저개발 지역)와 카드쿄이 (중진 지역)을 관찰한다.

Cranially-based nasolabial flaps for the reconstruction of nasal surgical defects

Hakan Kerem,Ulaş Bali,Erhan Sönmez,Mustafa Kürşat Evrenos 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.2

Background Cranially-based nasolabial flaps are a good alternative for the reconstruction of nasal defects. Methods A cranially-based nasolabial flap was used in 18 patients to reconstruct defects of the nose from 2010 to 2016, and the long-term results are presented in this report. Results Fifteen of the flaps completely survived. All the patients had a bulky appearance, but they did not want to undergo a second operation for cosmesis. The dissection of the flap took approximately 20 minutes, and the total operation lasted for 1 hour. The patients were hospitalized for 1–7 days, and the postoperative follow-up period was 1–28 months (mean, 17 months). Conclusions The cranially-based nasolabial flap possesses all the advantages of the traditional forehead flap, and can safely be used in selected cases.

The Anti-Inflammatory and Antioxidant Effects of Salvia officinalis on Lipopolysaccharide-Induced Inflammation in Rats

Umut Kerem Kolac,Mehmet Cengiz Ustuner,Neslihan Tekin,Derya Ustuner,Emine Colak,Emre Entok 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.12

Salvia officinalis, which has a high phenolic acid and flavonoid content, is a powerful antioxidant and anti-inflammatory herb. Inflammation plays an important role in the pathophysiology of many diseases and could cause damage by means of oxidative stress. The aim of this study was to investigate the anti-inflammatory and antioxidant activity of S. officinalis formed lipopolysaccharide (LPS)-induced experimental inflammation model. Four- to five-month-old 42 female Wistar albino rats were divided into six groups. Three groups were administered intraperitoneally 1 mg/kg LPS. Twenty-four hours after injection of LPS, 10 and 30 mg/kg S. officinalis extract were given orally to treatment groups. Pulmonary and hepatic 18F-fluoro-deoxy-D-glucose (18F-FDG) uptake was calculated to determine the status of inflammation by 18F-fluoro-deoxy-D-glucose-positron emission tomography (18FDG-PET) scan. Antioxidant enzyme activities and nitric oxide (NO) and malondialdehyde (MDA) levels were determined. Nuclear factor-kappa B (NF-κB) and tumor necrosis factor-alpha (TNF-α) levels were also detected in serum. As a result, lung and liver 18F-FDG uptake was found to be higher in the inflammation group than control group. MDA levels in erythrocyte and all tissue samples (liver, lung, and kidney) were found to be significantly higher compared to treatment groups. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase activities of the inflammation group in the liver, lung, kidney tissues, and erythrocyte SOD and CAT activities were determined to significantly lower than groups treated with S. officinalis. Increased NO, NF-κB, and TNF-α levels were found in the inflammation group. S. officinalis has been observed to have useful effects on LPS-induced inflammation and oxidative stress in rats.