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Keishi Maruo,Toshiya Tachibana,Shinichi Inoue,Fumihiro Arizumi,Shinichi Yoshiya 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.5
Study Design: A retrospective case review. Purpose: To assess the clinical and radiographic outcomes and identify the predictive factors associated with poor clinical outcomes after lumbar spinous process-splitting laminectomy (LSPSL) for lumbar spinal stenosis (LSS). Overview of Literature: LSPSL is an effective surgical treatment for LSS. Special care should be taken in patients with degenerative lumbar scoliosis (DLS). Methods: A consecutive retrospective case review of patients undergoing LSPSL for LSS with a minimum 2-year follow-up was performed. Mild DLS and mild degenerative spondylolisthesis (DS) were included in the study. The Japanese Orthopedic Association (JOA) score and recovery rate were reviewed. Poor clinical outcome was defined as a recovery rate <50% using Hirabayashi’s method. Results: A total of 52 patients (mean age, 72 years) met the inclusion criteria and had a mean follow-up of 2.6 years (range, 2–4.5 years). The preoperative diagnosis was LSS in 19, DS in 19, and DLS in 14 cases. The mean JOA score significantly increased from 14.6 to 23.2 at the final follow-up. The overall mean recovery rate was 60.1%. Thirteen patients (25%) were assigned to the poor outcome group. A higher rate of pre-existing DLS was observed in the poor outcome (poor) group (good, 15%; poor, 62%; p =0.003) than in the good outcome (good) group. None of the patient factors examined were associated with a poor outcome. A progression of slippage ≥5 mm was found in 8 of 24 patients (33%) in the DS group. A progression of curvature ≥5° was found in 5 of 14 patients (36%) in the DLS group. The progression of scoliosis and slippage did not influence the clinical outcome. Conclusions: The clinical and radiographic outcomes of LSPSL for LSS were favorable. Pre-existing DLS was significantly associated with poor clinical outcome.
Method for Reduction of Metal Artifacts in Dental CT Images by Use of Frequency Analysis
Keishi Mito,Hyoungseop Kim,Joo Kooi Tan,Seiji Ishikawa,Tatsuro Tanaka,Yasuhiro Morimoto 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
CAD (Computer Aided Diagnosis) system that has 3-D viewer function to display the DICOM (Digital Imaging and Communication in Medicine) image has been developed in recent years. Now, the function of CAD system for artificial implant to which development is advanced includes the removal of artifact in the input DICOM image, region extraction of bone, major vessel, and nerve and mounting of function to presume place where implant is stricken. However, it is still required a software with high performance because of taking the processing time to do a series of operation before simulating by the strike of the implant on the operation on a clinical site. In this paper, we propose the function to extract the area of bone separately for teeth and mandibles automatically as addition to the system that can do a series of operation before simulating by the strike of the implant. In addition, we proposed also the function to extract each tooth separately. The main aim of this paper is to develop the integrative system for the dental screening that can be operated in a personal computer.
Keishi Maruo,Toshiya Tachibana,Fumihiro Arizumi,Kazuki Kusuyama,Kazuya Kishima,Shinichi Yoshiya 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.2
Study Design: Retrospective case review. Purpose: To assess the incidence and effect of teriparatide (TP) on subsequent vertebral fractures following a long-instrumented fusion surgery for osteoporotic vertebral fractures (OVFs). Overview of Literature: TP treatment may be a useful strategy for patients with OVFs treated with a long-instrumented surgery. Methods: Overall, 47 patients who underwent long-instrumented fusion surgery (≥3 levels) for OVFs with neurological deficits between 2010 and 2013 were enrolled. The mean age of the subjects was 76 years; the study population comprised 20 males and 27 females. The mean follow-up duration was 23 months. The average of fused vertebrae was 4.9. TP was used for 19 patients who comprised the TP group. The incidence of subsequent VFs was estimated with Kaplan–Meier analyses and compared between the TP and non-TP groups using the log-rank test. Risk factors were evaluated using a Cox proportional hazards model. Results: A total of 38% (18/47 cases) of the subjects were identified with subsequent VFs. There were no significant differences in the age, sex, fused levels, presence of prevalent fractures, and correction loss of the two groups. The occurrence of subsequent VFs was lower in the TP group than in the non-TP group (16% vs. 54%, p=0.014). The log-rank test revealed that the TP treatment significantly reduced the risk of subsequent VFs (p=0.048). A Cox proportional hazards model revealed that preoperative TP treatment is only a protective factor of subsequent VFs after instrumented fusion surgery for OVFs (hazard ratio, 0.281; p=0.047). Conclusions: In this retrospective study, pre- and postoperative TP treatment significantly reduced the incidence of subsequent VFs after instrumented fusion surgery for OVFs. A prospective randomized study is warranted to determine the efficacy of TP treatments.
Tacrolimus Differentially Regulates the Proliferation of Conventional and Regulatory CD4+ T Cells
Keishi Fujio,Kazue Kogina,Hirofumi Shoda,Yumi Yamaguchi,Nelson H Tsuno,Koki Takahashi,Kazuhiko Yamamoto 한국분자세포생물학회 2009 Molecules and cells Vol.28 No.2
Tacrolimus is a widely used T cell targeted immunosuppressive drug, known as a calcineurin inhibitor. However, the exact pharmacological effects of tacrolimus on CD4+ T cells have yet to be elucidated. This study investigated the effects of tacrolimus on CD4+ T cell subsets. Mouse or human CD4+ T cells were cultured with immobilized anti-CD3/CD28 antibodies in the presence of tacrolimus. The cell division of CD4+ T cells was analyzed using a flow cytometer according to the expression of Foxp3. The gene expression patterns of tacrolimus-exposed T cells were examined by quantitative PCR. In the case of conventional CD4+ T cells (Tconv cells), tacrolimus inhibited T cell receptor stimulation-induced cell division. In contrast, the cell division of regulatory CD4+ T cells (Treg cells) was even promoted in the presence of tacrolimus, especially in humans. Tacrolimus did not promote conversion of Tconv to Treg cells in mice. Furthermore, tacrolimus modified the expression levels of Foxp3-regulated T cell receptor signal related-genes, PTPN22 and Itk, in human Treg cells. Immunosuppressive effect of tacrolimus may be attributed to the relatively enhanced proliferation of Treg cells in association with altered gene expression levels of TCR signaling molecules.
Preparation and Properties of Inorganic-organic Hybrid $Li^+$ Ion Conductor by Sol-gel Process
Nishio, Keishi,Miyazawa, Tsutomu,Watanabe, Yuichi,Tsuchiya, Toshio The Korean Ceramic Society 2001 The Korean journal of ceramics Vol.7 No.1
Inorganic-organic hybrid Li$^+$ ion conductors were prepared by the sol-gel process. Tetramethyl orthosilicate (TMOS), polyethylene glycol 200 (PEG$_200$) and lithium bis (trifluoro-methylsulfony) imide were used as raw materials and $H_2O$ was used as a solvent. Hybrid Li$^+$ ion conductor prepared by the sol-gel process showed very high ion conductivities of log${\sigma}_R.T$(S/cm)=-3.73, log${\sigma}_60$(S/cm)=-3.00 at room temperature and $60^{\circ}C$, respectivery. Decomposition voltage was 3.1 V.
紫田惠司,孫泰俊 濟州大學校海洋硏究所 1994 해양과환경연구소 연구논문집 Vol.18 No.-
Since the pre-history era of japan. many literatures and techniques highly developedin in China.i.e.. rice plantation. Chinese letters. Buddism. ironworks. silk textiles. and so on had been imported via land passages of Korean Peninsular and sea routes between Korea and Japan. Japanese envoyes to Cjina in the weil Sui and tong Dynasties had often passed these routes or acrossed the east China Sea and the Yellow Sea and Chinese envoyes also came to Korea and Japan. The triffic routes have been changed due to developments of triffic boits in the above countries during long histories.