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Lee, Sang-Han,Kim,Keh-Young,Kim,Chang-Se,Cho,Man-Hee 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1
본 연구는 high density lipoprotein의 구성 단백질인 아포단백A-I에 특이적인 single chain Fv(scFv)항체를 대장균 세포에서 발현할 목적으로 먼저 단일클론항체 A-I4를 제조하였다. 단일클론항체 A-I4의 항원과의 결합특이성은 Western blot 분석에 의해 결정하였으며, 항원 항체반응의 해리상수(Kd) 치는 enzyme linked immunosorbent assay(ELISA)로 측정한 결과 2.15 ×10의 마이너스8승M 이었다. 단일클론항체 A-I4를 분비하는 융합세포로 부터 poly(A)+ RNA를 제조한후 이를 이용하여 cDNA 합성과 클로닝을 수행하였다. Heavy chain과 light chain의 다변부위를 coding하는 cDNA의 염기서열 분석 결과 Heavy chain은 subgroup Ⅱ(A), light chain은 subgroup Ⅱ에 속하는 항체임을 밝혔으며, GenBank에 수록된 생쥐의 항체유전자 서열과 비교한 바 아직까지 보고되지 않은 유전자 서열임을 확인하였다.
人大腦 帶狀回(Brodmann 第24皮質分野)皮質의 細胞構築學的 硏究
康承桂 최신의학사 1974 最新醫學 Vol.17 No.8
The authors have made a study of the quantitative changes in the development of human brain with special growth and cytoarchitectonics of cerebral cortex in the anterior part of the cingulate gyrus (Br odmann's area 24) in a sample of 149 Korean brains (83 of male & 66 of female), of which the age ranged from the newborns to the old age. The thickness of the total cortex and each. cortical layer, the relative neuron density and the relative glia density in (100u)3 of each cortical layer and the relative total neuron and glia densities of the cortex were observed and the results were summerized as follows; 1. The mean thickness of the cortex in the 0-1 year group was 80% of the adult and it increased very rapidly during 2-5 years and it was 96% of the adult. In the 16-20 year group it was maximun thick and thereafter it decreased gradually. The mean thicknes of the adult cortex was 2.13mm. The mean thickness of the cortex increased rapidly until the 1,100-1,199gm stage of the brain weight and increased slowly until the 1, 400-1, 499gm stage of the brain weight and thereafter it had a tendency of slow decreasing as the brain weight increased. 2. The relative neuron density was highest in the 0-1 year group and it decreased very rapidly in the 2-5 year group and it decreased slowly until the 11-15 year group and at this time it was eaqual as the adult mean value. Thereafter it was relatively stable. As the relation between the neuron density and the brain weight, it was highest in 300-500gm stage of the brain weight and it decreased rapidly until the 500-699gm stage of brain weight and it decreased slowly until the brain weight was 900-1,099gm stage and in this stage it became eaqual as the adult mean value. Thereafter it had a tendency to derease slowly as the brain weight increased. The mean valuee of thee neuron density of the adult was 292-309. 3. The relative glia density was high in the 0-1 year group and' it decreased rapidly in the 2-5 year group and was minimum value which was lower than the adult mean value and thereafter it increased gradually as the age increased. The mean value of the relative glia density of the adult was 501-536 which is higher than that of the adult neuron density (292-309). -During the 300-499gm,stage of the brain weight the relative glia density was high and it decreased gradually to the minimum value (406-472) until the 1,100-1,199gm stage of the brain weight and thereafter it increased gradually as the brain weight incrceaged. 4. The neuron density and glia density had no sexual difference and left-right difference.
愛生園 愛樂園 在園患者를 中心으로한 慶北道內 癩患의 疫學的 考察
金重明,李相準,河桂子,金在植 慶北大學校 醫科大學 1959 慶北醫大誌 Vol.2 No.1
During the period of November 1957 and September 1958, the epidemiological studies on lepers in Aerack and Aeseng leprosaria were made. The number of in-patients were 1,205, and that of the ambulatory patients were 2,788. It had been estimated that 0.12 percent of the population was affected by leprosy, but the male adults between 31 and 40 years of age had been more frequently enountered. For the convenience sake, we divided Kynugsang pook-do into five subareas in order to estmate their geographycal distribution, i. e., Central Area (Andong, Eisung, Chungsong, Youngchun, Guni, Sunsan, and Chilkock District) Western Area (Sangju, kimnung, Sungju District and Kimchon City) Southern Area (Taegu City, KyungSan, Talsung, Koryong, Chungdo District) Northern Area (Yongyang, Bongwha, Yechon and Munkyong District) Eastern Area (Yongduck, Yongil, Wolsung District and Kyungju City) The patient/s geographycal distribution in Kyungsang pook-do were as follows:there were 1,129 patients in Central Area, 556 lepers in southern Area, in Eastern Area three were 434 patients, in Western Area 395, and in Northern Area 269. Eisung District was found to have the largest numbers of patients and in Yongyang District the lepers were less abundant. The tuberculoid type of leprosy had been more commonly met than the other types. And it was showen that the negative results of Wades Skin Test was slightly higher in incidence.
The development of Taiwan Fracture Liaison Service network
Lo-Yu Chang,Keh-Sung Tsai,Jen-Kuei Peng,Chung-Hwan Chen,Gau-Tyan Lin,Chin-Hsueh Lin,Shih-Te Tu,I-Chieh Mao,Yih-Lan Gau,Hsusan-Chih Liu,Chi-Chien Niu,Min-Hong Hsieh,Jui-Teng Chien,Wei-Chieh Hung,Rong-S 대한골다공증학회 2018 Osteoporosis and Sarcopenia Vol.4 No.2
Osteoporosis and its associated fragility fractures are becoming a severe burden in the healthcare system globally. In the Asian-Pacific (AP) region, the rapidly increasing in aging population is the main reason accounting for the burden. Moreover, the paucity of quality care for osteoporosis continues to be an ongoing challenge. The Fracture Liaison Service (FLS) is a program promoted by International Osteoporosis Foundation (IOF) with a goal to improve quality of postfracture care and prevention of secondary fractures. In this review article, we would like to introduce the Taiwan FLS network. The first 2 programs were initiated in 2014 at the National Taiwan University Hospital and its affiliated Bei-Hu branch. Since then, the Taiwan FLS program has continued to grow exponentially. Through FLS workshops promoted by the Taiwanese Osteoporosis Association (TOA), program mentors have been able to share their valuable knowledge and clinical experience in order to promote establishments of additional programs. With 22 FLS sites including 11 successfully accredited on the best practice map, Taiwan remains as one of the highest FLS coverage countries in the AP region, and was also granted the IOF Best Secondary Fracture Prevention Promotion award in 2017. Despite challenges faced by the TOA, we strive to promote more FLS sites in Taiwan with a main goal of ameliorating further health burden in managing osteoporotic patients.
乾燥 BCG-Vaccin에 依한 Lepromin 反應의 影響에 對해서
崔在圭,金重明,李相準,河桂子,卞東吉,崔炳吉,徐舜鳳 慶北大學校 醫科大學 1958 慶北醫大誌 Vol.1 No.1
Since 1939, Fernandez had reported on the tuberculin and lepromin test, prophylaxy of leprosy by inocculating with BCG was also suggssted by him, and Azulay, Rosenberg, Neyra, Ramirez, Convit, Bundiansky and others were agreable by their furthermore invstigation, but some othsrs discussed. Recently in Japan, Mayama showed that a fraction of serum protein induced from human and rat leprosy has been an inhibitory growing factor of tubercle bacilli. On the other hand Gawaguch said that the haemoagglutination test was to be stronger positive not only with tuberculous patient's serum, cut with serums of human and rat leprosy. From Feb. to Sept. in 1957, we inocculated with dry BCG Vaccine to 116 cases of untainned children of leprosy at Sam Hyuck Preventorium in Taegu city, and observed the influences of lepromin reaction by vaccination of dry BCG, and dividing A.B. and C group of all cases according to its given conditions observed results are as follow;. In the A group (53 casss), 13 cases of the lepromin negative 3 cases of them were turned to be lepromin positive by firs vaccination of BCG. After 2 months later, and lepromin positives increased to 2 cases by second inocculation, after 5 months later. And there were 15 cases of the leptomin negative in the B group, (52 casss) 4 cases of them covnerted to be lepromin positive by vaccination of BCG after 5 months later. In the C group (11 case) 3 cases were negative, one case of them turned to be positive. Of the total cases, there were some cases which a lepromin positive reactor inverted to be negative and which a lepromin negative fixed parmanentely for the negative nevertheless. Generally, the lepromin negative reactors were 31 cases in total (116 casss), 10 cases of them (31 cases) converted to be lepromin positive. As above, Vaccination of BCG enables the lepromin negative to convert to be lepromin positive. Especially, it is most important things to in occulats with BCG to the untainned children for prevention of leprosy and tuberculosis.