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Some Pyridazinone and Phthalazinone Derivatives and Their Vasodilator Activities
Seref Demirayak,Ahmet Cagri Karaburun,Ismail Kayagil,Kevser Erol,Basar Sirmagul 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.1
In this study, 6-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 4-(4- aminophenyl)-1(2H)-phthalazinone compound with different 4-arylidene-2-phenyl-5(4H)- oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.