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Katsuhiko Ono,Hirohide Takebayashi,Kazuhiro Ikenaka 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.4
Olig2 transcription factor is widely expressed throughout the central nervous system; therefore, it is considered to have multiple functions in the developing, mature and injured brain. In this mini-review, we focus on Olig2 in the forebrain (telencephalon and diencephalon) and discuss the functional significance of Olig2 and the differentiation properties of Olig2-expressing progenitors in the development and injured states. Short- and long-term lineage analysis in the developing forebrain elucidated that not all late Olig2+ cells are direct cohorts of early cells and that Olig2 lineage cells differentiate into neurons or glial cells in a region- and stage-dependent manner. Olig2-deficient mice revealed large elimination of oligodendrocyte precursor cells and a decreased number of astrocyte progenitors in the dorsal cortex, whereas no reduction in the number of GABAergic neurons. In addition to Olig2 function in the developing cortex, Olig2 is also reported to be important for glial scar formation after injury. Thus, Olig2 can be essential for glial differentiation during development and after injury.
Japanese EMRs and IT in Medicine: Expansion, Integration, and Reuse of Data
Katsuhiko Takabayashi,Shunsuke Doi,Takahiro Suzuki 대한의료정보학회 2011 Healthcare Informatics Research Vol.17 No.3
Objectives: The prevalence of electronic medical record in Japan varies according to the size of the hospital which is 62.5% in major hospitals, 21.7% in medium, 9.1% in small size hospitals, and 16.5% in clinics. The complete paperless system is very limited, though some major hospitals are aiming at this system. Several regional network systems which connect different platforms of EMRs, have been developing in many districts, while the final picture of a regional network has not been clearly proposed. To develop a whole electronic health record or personal health records system from the regional network data, we have several obstacles to overcome such as standardization, a privacy act, unique national health number. Methods: Some experimental trials have just been started. The reuse of the accumulated data has also just been initiated. We exploited text mining systems (term frequency-inverse document frequency method) to find similar cases and auto-audit Japanese diagnosis related group (DRG) coding by using discharge summaries. Results: The same or even a more extreme phenomenon of huge data accumulation is occurring in genetic research and confluence of multi-disciplines of informatics is the next step,which has an enormous accumulation of data and discoveries of the relations beyond the dimension of each informatics. Conclusions: We need another approach to science apart from the conventional method, and data-driven approach with data mining techniques must be brought in for each field. Informaticians have new important roles as coordinators to link up numerous phenomena over dimensions.
Neutrino burst and gravitational wave from supernova explosions
Katsuhiko Sato,Kei Kotake,Keitaro Takahashi,Shin'ichiro Ando 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.1
The time prole and energy spectrum of a neutrino burst from supernovae is greatly modied by the eect of neutrino oscillations. We review how these conversions happen in a supernova mantle and how the burst could be detected by SK (Super-Kamiokande) and SNO (Sudbury Neutrino Observatory). We show that implications for neutrino parameters (mass hierarchy and the mixing angle between mass eigenstate 1; 3), can be obtained if a supernova appears at the Galactic Center. We also discuss the eects of neutrino oscillation on the supernova relic neutrino observations. In the end, we discuss the gravitational radiation from the rotating stellar cores, which will give us the information of the angular momentum distribution for evolved massive stars.
Katsuhiko HAYASHI,네모토 토시요리 한국해운물류학회 2010 The Asian journal of shipping and Logistics Vol.26 No.1
The procurement of automotive parts efficiently from remote suppliers under poor logistics infrastructure conditions has become a critical issue for car manufacturers located in inland China. This study explores how Japanese auto manufactures located in Sichuan, China have established its automotive parts procurement network and improve its distribution system to cope with severe logistics infrastructure conditions in the area. An analysis on the viability of ship transport in the Yangtze River as a means for long-distance transportation was also performed.