Possible clinical implications of prostate capsule thickness and glandular epithelial cell density in benign prostate hyperplasia

Katherine G. Holder,Bernardo Galvan,Andrew S. Knight,Freedom Ha,Reagan Collins,Preston E. Weaver,Luis Brandi,Werner T. de Riese 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.4

Purpose: The negative correlation between BPH-size and incidence of prostate cancer (PCa) is well-documented in the literature, however the exact mechanism is not well-understood. The present study uses histo-anatomical imaging to study prostate volume in correlation to prostate capsule thickness, and glandular epithelial cell density within the peripheral zone (PZ). Materials and Methods: Specimens were selected from radical prostatectomies ranging from 20 to 160 mL based on ease of anatomical reconstruction by the slides. A total of 60 patients were selected and underwent quantitative measurements of prostate capsule thickness and glandular epithelial density within the PZ using computer-based imaging software. Pearson's correlation and a stepwise multiple linear regression analysis was conducted to determine the relationship between these measured parameters and the clinical characteristic of these patients. Results: Pearson's correlation analysis revealed a strongly significant, negative correlation between prostate volume and glandular epithelial cell density (r(58)=−0.554, p<0.001), and a strongly significant, positive correlation between prostate volume and average capsule thickness (r(58)=0.462, p<0.001). Results of multiple regression analysis showed that average glandular epithelial cell density added statistically to this prediction (p<0.05). Conclusions: The results suggest that growth of the transition zone in BPH causes increased fibrosis of the PZ, leading to atrophy and fibrosis of glandular cells. As 80% of PCa originates from the glandular epithelium within the PZ, this observed phenomenon may explain the inverse correlation between BPH and PCa that is well-documented in the literature.

Pushing the envelope: expanding fertility sparing treatment of endometrial cancer

Katherine Ikard Stewart,Melinda S. Yates,Shannon N. Westin 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.5

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Prioritization of Realignment Associated With Superior Clinical Outcomes for Cervical Deformity Patients

Katherine E. Pierce,Peter G. Passias,Avery E. Brown,Cole A. Bortz,Haddy Alas,Lara Passfall,Oscar Krol,Nicholas Kummer,Renaud Lafage,Dean Chou,Douglas C. Burton,Breton Line,Eric Klineberg,Robert Hart,J 대한척추신경외과학회 2021 Neurospine Vol.18 No.3

Objective: To prioritize the cervical parameter targets for alignment. Methods: Included: cervical deformity (CD) patients (C2–7 Cobb angle>10°, cervical lordosis>10°, cervical sagittal vertical axis [cSVA]>4 cm, or chin-brow vertical angle>25°) with full baseline (BL) and 1-year (1Y) radiographic parameters and Neck Disability Index (NDI) scores; patients with cervical [C] or cervicothoracic [CT] Primary Driver Ames type. Patients with BL Ames classified as low CD for both parameters of cSVA (<4 cm) and T1 slope minus cervical lordosis (TS–CL) (<15°) were excluded. Patients assessed: meeting minimum clinically important differences (MCID) for NDI (<-15 ΔNDI). Ratios of correction were found for regional parameters categorized by primary Ames driver (C or CT). Decision tree analysis assessed cutoffs for differences associated with meeting NDI MCID at 1Y. Results: Seventy-seven CD patients (mean age, 62.1 years; 64% female; body mass index, 28.8 kg/m2). Forty-one point six percent of patients met MCID for NDI. A backwards linear regression model including radiographic differences as predictors from BL to 1Y for meeting MCID for NDI demonstrated an R2 of 0.820 (p=0.032) included TS–CL, cSVA, McGregor’s slope (MGS), C2 sacral slope, C2–T3 angle, C2–T3 SVA, cervical lordosis. By primary Ames driver, 67.5% of patients were C, and 32.5% CT. Ratios of change in predictors for MCID NDI patients for C and CT were not significant between the 2 groups (p> 0.050). Decision tree analysis determined cutoffs for radiographic change, prioritizing in the following order: ≥42.5° C2–T3 angle, >35.4° cervical lordosis, <-31.76° C2 slope, <-11.57-mm cSVA, <-2.16° MGS, >-30.8-mm C2–T3 SVA, and ≤-33.6° TS–CL. Conclusion: Certain ratios of correction of cervical parameters contribute to improving neck disability. Prioritizing these radiographic alignment parameters may help optimize patient-reported outcomes for patients undergoing CD surgery.

흑인과 백인이라고 생각하지 않음: Q 방법 분석을 적용한 테네시 멤피스 내의 인종 인식 식별에 대한 연구

( Katherine Mae Wiederhold ) 한국주관성연구학회 2009 Journal of Human Subjectivity Vol.7 No.1

Total knee arthroplasty in patients with severe obesity: outcomes of standard keeled tibial components versus stemmed universal base plates

( Katherine L. Elcock ),( Deborah J. Macdonald ),( Nick D. Clement ),( Chloe E. H. Scott ) 대한슬관절학회 2023 대한슬관절학회지 Vol.35 No.-

Background Patients with severe obesity [body mass index (BMI) ≥ 40 kg/m²] potentially overload the tibial component after total knee arthroplasty (TKA), risking tibial subsidence. Using a cemented single-radius cruciate-retaining TKA design, this study compared the outcomes of two tibial baseplate geometries in patients with BMI ≥ 40 kg/m²: standard keeled (SK) or universal base plate (UBP), which incorporates a stem. Methods This was a retrospective, single-centre cohort study with minimum 2 years follow-up of 111 TKA patients with BMI ≥ 40 kg/m²: mean age 62.2 ± 8.0 (44-87) years, mean BMI 44.3 ± 4.6 (40-65.7) kg/m² and 82 (73.9%) females. Perioperative complications, reoperations, alignment and patient-reported outcomes (PROMS): EQ-5D, Oxford Knee Score (OKS), Visual Analogue Scale (VAS) pain score and satisfaction were collected preoperatively, and at 1 year and final follow-up postoperatively. Results Mean follow-up was 4.9 years. SK tibial baseplates were performed in 57 and UBP in 54. There were no significant differences in baseline patient characteristics, post-operative alignment, post-operative PROMs, reoperations or revisions between the groups. Three early failures requiring revision occurred: two septic failures in the UBP group and one early tibial loosening in the SK group. Five-year Kaplan-Meier survival for the endpoint mechanical tibial failure was SK 98.1 [94.4-100 95% confidence interval (CI)] and UBP 100% (p = 0.391). Overall varus alignment of the limb (p = 0.005) or the tibial component (p = 0.031) was significantly associated with revision and return to theatre. Conclusions At early to mid-term follow-up, no significant differences in outcomes were found between standard and UBP tibial components in patients with BMI ≥ 40 kg/m². Varus alignment of either tibial component or the limb was associated with revision and return to theatre.

Retail place attachment: a qualitative study of apparel shoppers

Katherine Shaw,Pauline Sullivan 한국마케팅과학회 2013 Journal of Global Fashion Marketing Vol.4 No.4

This exploratory study proposes an empirical look at the meaning of place attachmentfor the retail consumer and studies its role in online shopping patronage. A theoreticalframework was developed from a review of the literature, and guides this research. Thedependent variable in this study was retail place attachment. The aim of the study wasto validate constructs of retail place attachment and identify its influence on onlineretail patronage. A total of 429 participants were randomly chosen from a social-networking databaseand two professional organization databases using the snowball sampling technique. Inclusion criteria for this sample included gender, age range of 18 and up, and all ethnicbackgrounds. Survey participants were recruited from Facebook, a social-networkingdatabase, and two professional organization databases. Identifying that consumers value both hedonic and utilitarian aspects of theirshopping experience, this study assists in understanding the meaning of the term “retailplace attachment.” Retailers should focus on increasing both the emotional and socialbond to their stores while offering quality merchandise at affordable prices.

Women in Food Advertisements : An Analysis of Women’s Portrayal in Food Advertisements on Instagram

Katherine Wayles,Jee Young Chung 한국외국어대학교 미디어커뮤니케이션연구소 2021 東西言路 Vol.52 No.-

본 연구의 목적은 미국 식/음료 글로벌 브랜드의 인스타그램 광고에 나타난 여성의 성적 대상화를 탐 색해 보는 것이다. 구체적으로, 미디어가 여성을 성적 대상으로 표현하는 대상화 이론 (objectification theory)에 근거하여, 본 연구는 12 개 식/음료 글로벌 브랜드의 미국 어카운트에 나타난 698인스타그램 광고 포스팅을 내용 분석하였다. 분석 결과는 다음과 같다. 첫째, 여성 역할의 고정관념 (stereo type)이 “대접하는 사람 (the server)” 에서 “먹는 사람 (the eater)” 과 “다이어트 하는 사람 (the dieter)”으로 변화 되었다는 점은 주목할 만한 변화이다. 둘째, 약 30% 정도의 식/음료 광고에 나타난 여성들은 성적인 매력을 표현하였다. 결론적으로, 식/음료 광고의 여성 모델들이 성적 매력을 강하게 소구하지 않는다는 점과 음식에 대한 주체적인 행동을 보이는 점이 본 연구에서 새롭게 제시하는 논의이다. The purpose of this paper is to examine the way women are presented in food and beverage advertisements of 12 global brands on Instagram. By applying objectification theory, which asserts that women are represented as sexual objects and their bodies are used to sell products primarily to men, this study examined the prevalence of food advertisements and the stereotypical, foodrelated relationships and expectations they example for women, analyzing 698 Instagram food advertisements in the U.S. The results suggested that women were depicted as “the eater” and “the dieter,” rather than “the server,” which was the most popular depiction in the past. Also, almost onethird of the advertisements featured models in sexually appealing situations, both through their clothing and gaze.

포브스를 통해 보는 세계

KATHERINE LOVE,GIGI ZAMORA 중앙일보에스 2024 Forbes Korea = 포브스 코리아 Vol.2024 No.3

Cutaneous T-Cell Lymphoma with Nasal Necrosis

Katherine Shaum,Joyce Aycock 대한성형외과학회 2015 Archives of Plastic Surgery Vol.42 No.2

Not So Black and White: Using Q‐Method Analysis to Identify Racial Perceptions in Memphis, Tennessee

Katherine Mae Wiederhold 한국주관성연구학회 2009 Journal of Human Subjectivity Vol.7 No.1

The purpose of this project is to decipher the current racial perceptions of Memphians on the media’s representation of race in the city. Using a Q‐Method analysis, audience member perceptions were gauged. Perceptions were compared to and contrasted with those with similar and varying ethnographic and demographic information, with the researcher looking for similarities among individuals. By analyzing the Q‐deck card sort, audience members’ ideas, values, and perceptions became apparent, and certain conclusions concerning their reactions and subjective perceptions ―individually, racially, and collectively― were made. Each of the factors was made of up a very diverse group of respondents. Their views on crime and race in Memphis vary by each factor. Overall, this research has shown that people of various ages, genders, races, cultures can and do share outlooks on the world.