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- 저자 : Karakelleoglu (검색결과 2 건)
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Selami Demirelli,Sule Karakelleoglu,Fuat Gündog˘du,Muhammed Hakan Tas,Ahmet Kaya,Hakan Duman,Hüsnü Deg˘irmenci,Hikmet Hamur,Ziya Simsek 대한심장학회 2013 Korean Circulation Journal Vol.43 No.7
Background and Objectives: The aim of this study was to investigate the impact of treatment with oral trimetazidine (TMZ) applied before and after percutaneous coronary interventions (PCI) on short-term left ventricular functions and plasma brain natriuretic peptide (BNP) levels in patients with non-ST segment elevation myocardial infarction (NSTEMI) undergoing PCI. Subjects and Methods: The study included 45 patients who were undergoing PCI with the diagnosis of NSTEMI. The patients were ran-domized into two groups. The first group (n=22) of the patients hospitalized with the diagnosis of NSTEMI was given conventional therapy plus 60 mg TMZ just prior to PCI. Treatment with TMZ was continued for one month after the procedure. TMZ treatment was not given to the second group (n=23). Echocardiography images were recorded and plasma BNP levels were measured just prior to the PCI and on the 1st and 30th days after PCI. Results: The myocardial performance index (MPI) was greater in the second group (p=0.02). In the comparison of BNP levels, they signifi-cantly decreased in both of the groups during the 30-day follow-up period (29.0±8 and 50.6±33, p<0.01 respectively). However, decreasing of BNP levels was higher in the group administered with TMZ. The decrease of left ventriclular end-diastolic volume was observed in all groups at 30 days after intervention, but was higher in the group administered with TMZ (p=0.01). Conclusion: Trimetazidine treatment commencing prior to PCI and continued after PCI in patients with NSTEMI provides improvements in MPI, left ventricular end diastolic volume and a decrease in BNP levels.
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Muhammed Hakan Tas,Enbiya Aksakal,Yekta Gurlertop,Ziya Simsek,Fuat Gundogdu,Serdar Sevimli,Eftal Murat Bakirci,Sule Karakelleoglu 대한심장학회 2013 Korean Circulation Journal Vol.43 No.6
Background and Objectives: Dobutamine stress echocardiography (DSE) is an important non-invasive imaging method for evaluating ischemia. However, wall motion interpretation can be impaired by the experience level of the interpreter and the subjectivity of the visual assessment. In our study we aimed to combine DSE and tissue syncronisation imaging to increase sensitivity for detecting ischemia. Subjects and Methods: 50 patients with indications for DSE were included in the study. In 25 patients we found DSE positive for isch-emia and in the other 25 patients we found it to be negative. The negative group was accepted as the control group. There was no signifi-cant difference in terms of risk factors and echocardiographic parameters between the two groups, except for wall motion scores. In both groups, left ventricular dyssychrony was accepted as the difference between time to peak systolic velocity (Ts) in the reciprocal four cou-ple of non-apical segments at rest and during peak stress. Timings were corrected for heart rate. We compared the differences of the dys-synchronisation value at rest and during peak stress to determine the distinctions within the groups and between the groups of DSE pos-itive and negative patients. Results: We found that stress and ischemia did not create any significant difference over the left intraventricular dyssynchrony with DSE,although at the segmenter level it prolonged the time to peak systolic velocity (p<0.05). These alterations did not show any significant difference between positive and negative DSE groups. Conclusion: As a result, this segmenter dyssynchrony and the time to peak systolic velocity, which is corrected for heart rate, did not en-hance any new value over DSE for detecting ischemia.
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