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Synthesis and Antimicrobial Activities of Some New Nitroimidazole Derivatives
Benkli, Kadriye,Karaburun, Ahmet-Cagrl,Gundogdu-Karaburun, Nalan,Demirayak, Seref,Guven, Klymet The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.10
In this study, some new nitroimidazole derivatives were obtained from 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethylamine dihydrochloride (4) and 1-(2-bromoethyl)-2-methyl-5-nitroimidazole (5), which were prepared using metronidazole. Compound 4 was reacted with arylisothiocyanates (6) to obtain 1-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]-3-arylthioureas (7) and the latter with $\alpha$-bromoacetophenones (8) to give -3-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]-2-arylimino-4-aryl-4-thiazolines (9). Also 1-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]-2-phenyl-4-arylideneimidazolin-5-ones (11) were prepared by reaction of 4 with 2-phenyl-4-arylidene-5-oxazolones (10). The reaction of the other starting material 5 with 5-arylidenethiazolidin-2,4-dione (12) gave 3-[2-(2-methyl-5-nitroimidazol-1-yl)ethyl]-5-arylidenethiazolidin-2,4-dione (13) derivatives. Structural elucidation of the compounds was performed by IR, $^1H-NMR$ and MASS spectroscopic data and elemental analysis results. Antimicrobial activities of the compounds were examined and moderate activity was obtained.
Synthesis and Antifungal Activities of Some Aryl (3-Methyl-Benzofuran-2-yl) Ketoximes
Benkli, Kadriye,Gundogdu-Karaburun, Nalan,Karaburun, Ahmet-Cagrl,Ucucu, Umit,Demirayak, Seref,Kiraz, Nuri The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.3
In this study, some aryl (3-methyl-benzofuran-2-yl) ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, $^1H-NMR$, MASS spectroscopy and elemental analyses. Antifungal activities of the compounds were examined and moderate activity was obtained.
Some Pyridazinone and Phthalazinone Derivatives and Their Vasodilator Activities
Seref Demirayak,Ahmet Cagri Karaburun,Ismail Kayagil,Kevser Erol,Basar Sirmagul 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.1
In this study, 6-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 4-(4- aminophenyl)-1(2H)-phthalazinone compound with different 4-arylidene-2-phenyl-5(4H)- oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.