Palmes Tube를 이용한 실내외 NO₂농도 측정

정갑열,김정만,김용규,김준연 동아대학교 의과대학 부설 산업의학연구소 1992 산업의학연구소 논총 Vol.- No.1

실내 공기오염의 주요인자의 하나인 NO₂에 대하여 부산의 도심지역(중구의 남포동, 광복동, 창선동)과 외곽지역(서구, 사하구)의 사무실, 식당, 다방(150개소)을 대상으로 하여 NO₂에 의한 실내외 공기오염의 정도를 파악하고 NO₂에 농도에 영향을 미칠 가능성이 있는 몇가지 인자에 대하여 조사함으로써 NO₂에 의한 인체장해의 예방대책을 수립하기 위한 기초 자료를 얻고자 본 연구를 실시하였다. 조사기간은 1988년 12월부터 1989년 2월까지 동계 3개월간이었고 NO₂에측정은 Palmes method 에 의하였으며 그 결과는 다음과 같다. 1. 도심지역의 NO₂평균농도; 1) 사무실의 홀 : 0.045±0.032 ppm, 2) 식당의 주방 : 0.106±0.049 ppm, 홀 : 0.076±0.030 ppm, 3) 다방의 주방 : 0.082±0.033 ppm, 홀 : 0.077±0.041 ppm 및 4) 옥외 : 0.031±0.009 ppm이었다. 2. 외곽지역의 NO₂평균농도; 1) 사무실의 홀 : 0.036±0.019 ppm, 2) 식당의 주방 : 0.079±0.045 ppm, 홀 : 0.056±0.034 ppm, 3) 다방의 주방 : 0.054±0.024 ppm, 홀 : 0.042±0.024 ppm 및 4) 옥외 : 0.021±0.007 ppm이었다. 3.1일 연료 소비량별 홀의 NO₂농도는 5L 미만 0.037±0.017 ppm, 5∼ 10L 미만 0.047±0.027 ppm, 10∼ 20 L 미만 0.065±0.042 ppm으로 연료 소비량이 증가할수록 홀의 NO₂농도는 유의하게 증가하였다. (p<0.01). 4. 환기를 실시하지 않는 홀의 NO₂농도는가 환기를 실시하는 홀의 NO₂농도 및 옥의 NO₂농도보다 유의하게 높았고(p<0.001), 환기를 실시하는 홀의 NO₂농도는 옥외 농도와 유사하여 인공환기시 홀의 NO₂농도는 상당히 감소하였다. Recently nitrogen dioxide(NO₂) has been regarded as one of the main elements among indoor air pollutants. For the purpose of preparing the fundamental data for evaluation and control on the health effect relevant to NO₂levels, the authors measured the indoor and outdoor NO₂levels by the type of subject(office, restaurant, coffee shop) with some factors related to the indoor NO₂levels. The level of NO₂was measured by Palmes method, and this survey was carried out to 150 subjects in the Pusan area from December, 1988 to Feburary, 1989. The obtained results were as follows; 1. The mean indoor and outdoor NO₂levels at down-town 1) Hall of office : 0.045±0.032 ppm, 2) Hall of restaurant : 0.076±0.030 ppm, Kitchen of restaurant : 0.106±0.049 ppm, 3) Hall of coffee shop : 0.077±0.041 ppm, Kitchen of coffee shop : 0.082±0.033 ppm, and 4) Outdoor : 0.031±0.009 ppm 2. The mean indoor and outdoor NO₂levels at outskirt 1) Hall of office : 0.036±0.019 ppm, 2) Hall of restaurant : 0.056±0.034 ppm, Kitchen of restaurant : 0.079±0.045 ppm, 3) Hall of coffee shop : 0.042±0.024 ppm, Kitchen of coffee sho : 0.054±0.024 ppm, and 4) Outdoor : 0.021±0.007 ppm 3. The NO₂levels of Hall by daily fuel consumption were; 1) ∼5L: 0.037±0.017 ppm, 2) 5 ∼ 10L : 0.047±0.027 ppm, and 3) 10 ∼ 20L : 0.065±0.042 ppm The NO₂levels of Hall were significantly increased with the daily fuel consumption amount. 4. The NO₂levels of vented Hall was significantly lower than the NO₂levels of unvented Hall, which decreased when artificial ventilation was conducted, and the NO₂levels of vented Hall was similar to the outdoor NO₂level.

釜山·慶南地域의 2, 3次 醫療機關의 基本形 設定을 爲한 基本調査硏究

鄭甲烈 동아대학교 부설 산업의학연구소 1995 산업의학연구소 논총 Vol.- No.2

의료전달체계와 의료자원의 공급 등에 대한 여러 연구자들의 성적과 현재의 상황을 토대로 하여 부산·경남지역 2,3차의료기관의 기본형을 개발하고 이에 따른 개설진료과목, 소요의료인력 및 투자예산 등을 추정할 수 있는 기본자료를 얻고자 본 연구를 시도하였다. 부산과 경남지역의 입원의료수요는 1996년에 연간 1,000명당 각 798.9일 및 773.9일 이었고 외래의료수요는 일인당 연간 외래방문횟수가 각각 8.71회 및 7.89회로 1993년에 비해 약 10% 내외 증가될 것으로 추계되었다. 병상수요는 1996년에 각각 11,727병상 및 9,718병상으로 1990년 12월 당시의 병상수를 기준으로 할때 부산지역은 1995년 부터, 경남지역은 1994년 부터 병상부족현상이 초래될 것으로 추계되었다. 의료기관별 적정소요인력 추정치는 2차의료기관인 경우는 병상당 1.162-1.249명, 3차의료기관인 경우는 대학병원 1.365명, 비대학병원 1.196명으로 추정되었다. 적정개설진료과목수는 2차의료기관인 경우는 병상수별 유형에 따라 4-17개의 필수과와 1-6개의 임의권장과를 두고 3차의료기관은 23개 내외의 진료과목을 두는 것이 좋을 것으로 판단되었다. 대지구입비를 제외한 투자예산의 추정치는 2차의료기관인 경우는 병상당 3,000-5,910만원, 3차의료기관인 경우는 7,710만원 정도가 적당한 것으로 추정되었다. This study was conducted to obtain the basic data on the estimated inpatient and ambulatory care utilization amounts, number of beds requirements, proper installing medical departments, proper hospital manpower requirements and investment budget requirements based on the current circumstances and previous investigator's results for developing the basic model of secondary and tertiary medical facilities in Pusan and Kyung-Nam area. In Pusan and Kyung-Nam area, eatimated inpatient days per 1,000 population in a year were 798.9 and 773.9 days in 1996, respectively. And estimated number of visits per person for ambulatory care utilization in a year were 8.71 and 7.89 times in 1996, respectively. The estimated numbre of beds requirements in 1996 were 11,727 and 9,718 beds, respectively. And the bed-deficit situation will be led from 1995 in Pusan and 1994 in Kyung-Nam area comparing the current number of beds in December, 1990. Proper hospital manpower requirements per bed were estimated as 1.122-1.249 persons in secondary medical facilities, 1.365 persons in university hospital and 1.079 persons in non-university hospital. Proper number of installing medical departments will be judged as a good thing that setting up 4-17 necessary departments and 1-6 optional encouraging departments according to the number of hospital beds types in secondary medical facilities. And it was judged that about 23 departments were proper in tertiary medical facilities. Proper investment budget requirements except site purchase price per bed were estimated 30-59.1 million won in secondary medical facilities and 77.1 million won in tertiary medical facilities.

熱量組成에 따른 白鼠의 Sodium 代謝에 關한 硏究

李琦烈,金甲英,申泰善 연세대학교 대학원 1974 延世論叢 Vol.11 No.1

Albino male rats, weighing from 290-300g, were divided into four dietary groups according to the amounts of carbohydrate, protein and fat in the basal diet. Diet I was a control diet, Diet II, low protein, Diet III, low protein and low fat diet and Diet IV, low fat diet. All rats were provided with 3% sodium chloride solution. The experiment was carried out for 9 weeks during which time the body weight, the food intake, and 3% sodium chloride solution consumption were determined. At the 9th week, the balance study was carried to the analysis of sodium and potassium and other chemical studies. The rats were sacrificed and the kidney, adrenal, liver and spleen were measured, and observed changes of the pathological tissue in the kidney and adrenal. The results were summarized as follows: 1) There was no significant difference found between the experimental Diets II, III, and IV for growth rate, food intakes. 2) The concentration of sodium and potassium in the blood were within the normal range in all diets. 3) The amount of sodium chloride in the urine was signficantly greater in Diets II, III and IV than in the control diet. Diets II, III, IV had a largey amount of sodium solution consumption. 4) Observation of pathological tissue in the experimental diets found a cell proliferation in the glomerlulus of the kidney, while such change was not found in the control diet.

인체의 장기조직중 Dieldrin의 잔류량에 관한 조사

양승림,정갑열 부산대학교 환경문제 연구소 1986 環境硏究報 Vol.4 No.-

Dieldrin is belongs to the organochlorine pesticide compounds, but it's pharmacodynamic action and metabolic mechanism are different to the other organochlorine compounds. So this study was conducted to investigate the amounts of dieldrin residues in human organ tissues of 52 autopsy cases which were caried out in Pusan and Kyung-nam area. The obtained results were as follows; 1. The residues of dieldrin in each tissue were 20.19±14.97ppb in liver, 10.37±6.84ppb in kidney, 14.79±8.67ppb in heart, 3.27±1.98ppb in lung and 12.21±7.25ppb in pancreas. 2. Although there was no statistical significance, the values of dieldrin residues in male were generally higher than in female. 3. The residues of dieldrin in all tissues were showed increasing tendency with the age. 4. The frequency distribution type of dieldrin residues in liver and kidney showed as like "L" type, right-skewed distributed type in heart and pancreas and irregular pattern in lung tissue.

판별분석법을 이용한 관상동맥질환 고위험군의 예측

김성률,김기현,정갑열,김정만,박경일,김준연,이상주,김원술 동아대학교 부설 산업의학연구소 1995 산업의학연구소 논총 Vol.- No.2

The objective of this study is to predict the high risk group of coronary artery disease from body mass index, blood pressure, fasting blood sugar and serum lipids level using the method of discriminant analysis. Variables with significant difference between coronary artery disease group and normal group were HDS-C, LDL-C/HDL-C, LDL-C, and TG. But the acuity did not exceed 70% in any single variable. As the results of discriminant analysis, statistically significant discriminant variables were HDL-C, T-chol, FBS and TG. The discriminant equation was(Y) = -0.06759(HDL-C) + 0.01498(T-chol),+0.01923(FBS) - 0.01421(TG) + 0.5187, and the overall discriminant power using the above 4 variables was 79.3%

職業性 鉛暴露가 血壓에 미치는 影響에 關한 調査硏究

鄭甲烈 大韓産業醫學會 1989 대한직업환경의학회지 Vol.1 No.1

연폭로로 인한 건강장애의 예방대책을 수립하고 생물학적 정보관리에 도움이 되는 자료를 얻을 목적으로 우리나라의 연취급 산업장여성근로자(연폭로군)192명과 일반사무직여성근로자(비폭로군) 126명을 대상으로 일반적 특성외에 연폭로에 관련된 수종의 생물학적지표(연폭로관련지표)들을 조사함과 동시에 이들 요인들이 혈압에 미치는 영향의 정도를 조사한 결과를 요약하면 다음과 같다. 1. 연폭로군과 비폭로군간에 일반적특성치에는 차이가 없었으나 연폭로관련지표인 요중 coproporphyrin배설량, 요중 σ-aminolevuoinic acid배설량, 요중연량 및 혈중연량에는 유의한 차이가 있었다. 2. 연폭로군중 저혈중연량군(혈중연량 30㎍/㎗미만)과 고혈중연량군(혈중연량 30㎍/㎗)간에는 수축기 및 이완기혈압, 요중 coproporphyrin배설량, 요중연량 및 혈중연량에 유의한 차이가 있었다. 3. 연폭로군중 요중 coproporphyrin배설량, 요중연량 및 혈중연령의 농도별분포는 연폭로군과 비폭로군 모두 정규분표 형을 보였으나 요중 σ-aminolevulinic acid배설량의 경우는 2봉형을 보였고 연폭로군을 저혈중연량군 및 고혈중연량군으로 구분시는 4종류 모두 불규칙한 분포양상을 나타내었다. 4. 혈압과의 유의한 관련성을 나타낸 연폭로관련지표는 비폭로군에서는 없었으나 고혈중연량군에서는 이완기혈압과 요중연량 및 혈중연량간에 통계적으로 유의한 단순상관관계가 있었다. 5. 연폭로관련지표의 농도별 혈압치의 분포는 비폭로군에서는 특별한 양상이 없었으나 연록폭로군에서는 대체적으로 농도가 높아짐에 따라 혈압치도 증가되는 경향이 있었으며 특히 고혈중연량군의 요중연량 및 혈중연량의 경우에 더욱 현저하였다. 6. 4종류의 연폭로관련지표로서 혈압치를 설명해 줄수 있는 정도는 비폭로군의5.3-6.1%에 비해 연폭로군에서는 11.0-12.6%였으며 특히 고혈중 연량군에서는 12.0-15.4%로서 유의하게 높았다. For the purpose of establishing the preventive program against the health consequences of lead exposure and obtaining the effective biological monitoring data, the author investigated the values of biological parameters relating to lead exposure and the degree of influences on blood pressure level by these parameters including general characteristics in 192 female industrial workers dealing with lead(lead-exposed group) and 126 female official workers(non-exposed group). The summarized results were as follows; 1. Between the lead-exposed group and non-exposed group, the significant differences were showed in urinary coproporphyrin, urinary delta-aminolevulinic acid, urinary lead and blood lead amount. 2. Between the low blood lead group(less than 30㎍/㎗) and high blood lead group(more than 30㎍/㎗) in lead-exposed group, there were significant differences in systolic and diastolic blood pressure, urinary coproporphyrin, urinary lead and blood lead. 3. Among the parameters relating to lead exposure, the distribution of concentration of urinary coproporphyrin, urinary lead and blood lead showed normal distributed type in lead-exposed and non-exposed group. But the case of urinary delta-aminolevulinic acid showed bimodal type. On the other hand, dividing the lead-exposed group into low blood lead and high blood lead group, irregular distributed type were showed in all 4 kinds of parameters. 4. The parameters relating to lead exposure which showed significant correlation to blood pressure were absent in non-exposed group, but there were statistically significant simple correlation among the diastolic blood pressure and urinary lead and blood lead in high blood lead group. 5. The distribution of blood pressure by the concentration of parameters relating to lead exposure were not showed specific mode in non-exposed group, but there was increasing tendency with the higher concentration of parameters relating to lead exposure in lead-exposed group. Especially in high blood lead group, the increasing tendency of blood pressure with the level of urinary lead and blood lead were predominant. 6. The opportunity to explain variation of each blood pressure by the 4 kinds of parameters relating to lead exposure were 11.0-12.6% in lead exposed group and 12.0-15.4% in high blood lead group comparing to 5.3-6.1% in non-exposed group.

건강한 일부 도시지역 주민의 혈중 연 및 Zinc protoporphyrin 농도

정갑열,김준연,김동일,장형심,김용규,최안홍,이영호,김정만 동아대학교 부설 산업의학연구소 1995 산업의학연구소 논총 Vol.- No.2

1991년 5월 1일부터 약 6개월 동안 남자 1,193명 및 여자 658명을 대상으로 우리나라 도시 거주자들의 혈중 혈색소치, ZPP치 및 연농도를 성별, 연령별로 측정한 결과 아래와 같은 결과를 얻었다. 1. 혈색소의 평균치는 남자 14.55±1.82g/dl, 여자 12.61±1.18g/dl이었으며, 20세 이상 군에서는 남자가 여자보다 유의하게 높았다(p<0.05). 2. 혈중 ZPP치는 32.54±9.88(32.09~32.99㎍/dl, 95% C.I.)㎍/dl이었으며 7세 미만 소아의 혈중 ZPP치는 남아 및 여아가 37.49±13.31㎍/dl 및 35.77±11.85㎍/dl로 7세 이상군의 남자 및 여자의 31.91±8.23㎍/dl 및 30.11±9.11㎍/dl보다 유의하게 높았다(p<0.05). 3. 혈중 연농도는 23.84±4.58(23.55~24.14, 95% C.I.)㎍/dl이었으며, 7세 미만 소아의 혈중 연농도는 남아 및 여아가 25.10±5.21㎍/dl 및 24.45±4.18㎍/dl로 7세 이상군의 남자 및 여자의 24.28±3.00㎍/dl 및 21.99±5.05㎍/dl보다 유의하게 높았다(p<0.05). 이상의 결과를 요약하면 우리나라 도시 거주인은 남녀 모두 전연령에 걸쳐 높은 혈중 ZPP치 및 연농도를 나타내었으며 이러한 현상은 학동기전 소아에서 더욱 현저하므로 이들에 대한 관리대책 수립이 필요하다고 사료된다. Hemoglobin(Hb), zinc protoporphyrin(ZPP) and blood lead(PbB) levels were determined for 1,851 blood samples collected from healthy urban population to establish reliable baselines for Hb, ZPP and PbB levels by age and sex. ZPP values were analyzed with a hematofluorometer and PbB determinations were concurrently carried out using flameless atomic absorption spectrophotometry. The blood sampling period was about 6 months from May, 1991 and the summarized results were as follows: 1. The mean value of Hb in male and female were 14.55±1.81g/dl and 12.6±1.18g/dl respectively and there was statistically significant defference(p<0.05). 2. The mean value of ZPP in pre-schoolchildren was 37.49±13.31㎍/dl for male, 35.77±11.85㎍/dl for female and that of ZPP in after 7 years groups was 31.91±98.23㎍/dl for male, 30.11±9.11㎍/dl for female and there was statistically significant difference(p<0.05). 3. The mean value of PbB in pre-schoolchildren was 25.10±5.21㎍/dl for male, 24.45±4.18㎍/dl for female and that of PbB in after 7 years groups was 24.28±3.00㎍/dl for male, 21.99±5.05㎍/dl for female and there was statistically significant difference(p<0.05).

食餌組成에 따른 食塩攝取量에 關한 硏究

金甲英(Kap Young Kim),李琦烈(Ki Yull Lee),申泰善(Tai Sun Shin) 韓國營養學會 1973 Journal of Nutrition and Health Vol.6 No.4

Isolation and Characterization of Bacteroides fragilis

Kag Hyun Kim,Kyu Yull Hwang,Kap Jun Yoon,Hyung Hoan Lee 한국미생물생명공학회(구 한국산업미생물학회) 1991 한국미생물생명공학회 학술발표초록집 Vol.1991 No.1

개인용 공기포집기를 이용한 기중 연농도와 생물학적 연 폭로지표와의 관련성

김정만,정갑열,김준연,이행렬 동아대학교 부설 산업의학연구소 1995 산업의학연구소 논총 Vol.- No.2

This study was carried out to evaluate the relationship between the biological lead exposure indices and air lead concentrations measured by personal air samplers. The 72 occupationally lead exposed workers were observed and the biological lead exposure indices chosen for this study were blood lead(PbB), urine lead(PbU), zinc protoporphyrin in whole blood(ZPP), δ-aminolevulinic acid in urine(ALAU), δaminolevulinic acid dehydratase activity(ALAD), coproporphyrin urine(CPU) and hemoglobin(Hb). The workers were divided into four groups by air lead concentration : Group Ⅰ;under 0.05㎎/㎥, Group Ⅱ;0.05-0.10㎎/㎥, Group Ⅲ ;0.10-0.15㎎/㎥ and GroupⅣ ; and over 0.15㎎/㎥. For evaluation the relationship between the biol-ogical lead exposure indices and air lead concentrations was used as correlation coefficients. The results obtained were as follows: 1. In GroupⅠ, Ⅱ, Ⅲ and Ⅳ, the mean value of PbB were 25.45 ± 1.84㎍/㎗, 27.87 ± 3.53㎍/㎗, 31.21 ± 1.76㎍/㎗ and 47.02 ± 13.96㎍/㎗. Between Group Ⅳ and other groups showed statistically significant difference(p<0.05). 2. There was an increasing tendency of PbB, PbU, ALAU and ZPP according to the increase the mean air lead concentration, while ALAD has decreasing tendency. CPU and Hb did not show any constant tendency. 3. Correlation coefficients between PbB, ZPP,ALAU, ALAD, CPU, Hb and air lead concentration were 0.95, 0.83, 0.89, 0.72, -0.83, 0.51 and -0.45 respectively, and regression coefficient between PbB(Y) and PbA(X) was Y=126.8746X + 16.9996(P<0.01).