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여러 질환에서의 Antinuclear Antibody(ANA) Test 에 관한 연구
조준구,김현숙,홍천수,조철호,권오현,김현만,이수곤,허갑범,전상일 대한내과학회 1987 대한내과학회지 Vol.32 No.2
Antinuclear antibodies are autoantibodies that are usually detected by indirect immunofluorescence and are directed against components of human and other mammalian cell nuclei. Between January 1982 and December 1984, we retrospectively reviewed the records of 238 patients with a positive ANA test. The following results were obtained from this review. 1) Among 238 ANA positive specimens, 98 (41.2%) were connective tissue disorders, 43 (18.0%) immune disorders and 97 (40.8%) other disorders. 2) Among 238 ANA positive specimens, 135 (57%) were low, 26 (11%) intermediate and 77 (32%) high titers. Sixty three of 98 (64.2%) sera from patients with connective tissue disorders and 44 of 53 (83%) sera from patients with SLE had ANA titers of 1:80 or more. Thirty two of 42 (74.4%) sera from patients with immune disorders and 68 of 97 (70.1%) sera from patients with other disorders had ANA titers of 1: 20. 3) Among 238 ANA positive specimens, immunofluorescent patterns showed that 105 (44%) were homogeneous, 102 (43%) speckled, 13 (5.5%) mixed, 12 (5%) peripheral and 6(2.5%) nucleolar pattern. 4) In 53 SLE patients, 41 (77%) were high titers in ANA test and homogeneous and speckled patterns were 26 (55.5%) and 20 (37.7%) respectively. Thirty of 37 (81%) SLE patients had positive anti-DNA test and 16cases (43%) were high titers. 5) Nineteen patients (13.6%) of 140 nonrheumatic disorders showed high ANA titers. Among nine patients with idipathic thrombocytopenic purpura, three patients showed high ANA titers (1:160 1). In conclusion ANA test was useful to diagnose various rheumatic disease. Some nonrheumatic patients also revealed positive ANA test. ANA titers were high in rheumatic disorders, but some non-rheumatic patients with high ANA titers should be followed to look for evolving rheumatic disorders.
Pipeline Subranging 아날로그 - 디지탈 변환기에 관한 연구
김종대,차균현,조현묵,백경갑,백인천 고려대학교 공학기술연구소 1992 고려대학교 생산기술연구소 생기연논문집 Vol.28 No.1
In this thesis, the design of high speed pipeline subranging A/D converter is presented. The A/D converter has the subranging structure in which the 8 bits are partitioned into higher 4 bits and lower 4 bits. The pipeline method is utilized to maintain the conversion speed as fast as that of flash structure. The error correction circuit is added to detect and correct the errors within ±8 LSB error range that may be generated in the 1st comparator. The converter has been designed using a double metal 1.5 ㎛ BiCMOS technology of Samsung Electronics Co. The performance of designed converter was evaluated by using AWB(Analog Work Branch) and SPICE simulator. Results shows a conversion speed of higher than 20 ㎒ and dissipates 390 ㎽ with 5 V single power supply. Its differential nonlinearity error (DNL) is below 1 LSB and integrator nonlinearity error (INL) is below 3.2 LSB for ±2 LSB error detection range and below 2.4 LSB for ±4 LSB error detection range.
이승택,Ji-Hyun Kim,Ho-Kap Choi,Haeyul Lee,Hyun Young Park,Jeong-Ho Kim,Jong-Won Kim,Hyon J. Kim 한국분자세포생물학회 2004 Molecules and cells Vol.18 No.1
We have identified 16 different mutations of the lowdensity lipoprotein receptor (LDLR) gene in 25 unrelated Korean patients with heterozygous familial hypercholesterolemia (FH), including five novel mutations, C83Y, 661del17, 1705insCTAG, C675X, and 941- 1G>A. The 1705insCTAG mutation in which the four 3′-terminal nucleotides of exon 11 are duplicated was found to prevent splicing of exon 11 and would therefore generate a truncated polypeptide. The in-frame 36-bp deletion (1591del36) in exon 11, which had been reported only in one Korean FH patient, was also found. We showed that this change affects transport of the LDL receptor from the endoplasmic reticulum to the cell surface. In addition, we found 8 mutations (- 136C>T, E119K, E207K, E207X, F382L, R574Q, 1846- 1G>A, and P664L) that had been described in other ethnic groups but not in Koreans, and 2 mutations (R94H and D200N) that had been described in Koreans as well as other ethnic groups. 5 mutations (1591del36, E119K, E207X, E207K, and P664L) were found more than once in the Korean FH samples. Identification of the novel and recurring LDLR mutations in Korean FH patients should facilitate prenatal and early diagnosis in families at high risk of FH.
박정환,한갑현,Bahk, Jong-Hwan,Han, Kap-Hyon 대한화학회 1961 대한화학회지 Vol.5 No.1
The hydroxydation of the saturated fatty acids in order to prepare hydroxy fatty acids in the presence of catalysts was reported by several workers. The considering commercial applications of this reaction, authors studied on the hydroxydation of natural fats composed of nonhydroxy saturated fatty acids. Tallow and stearic acid were tested with manganese dioxide as catalyst, $110 {\pm}3^{\circ}C,$ and under atmospheric oxygen. The highest hydroxyl values were obtained at 20 hours for tallow, 107.6 and at 14 hours for stearic add, 116.0.