내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

물질주의가 과시소비, 충동구매와 삶의 만족 및 부정적 감정에 미치는 영향

윤성욱(Yoon, Sung-wook),강아롱(Kang, A-rong) 한국경영교육학회 2021 경영교육연구 Vol.36 No.1

[연구목적] 물질주의의 부정적인 영향에 대한 선행연구들은 이루어져 왔지만, 물질주의가 과시소비 및 충동구매에 영향을 미치고 이러한 비합리적인 소비가 삶의 만족 및 부정적 감정에 미치는 전체 변수들 간의 연구는 전무했기에 본 연구에서 이러한 관계들이 동시에 미치는 영향을 살펴보고자 한다. [연구방법] 본 연구는 자료 분석을 위해 신뢰도분석, 탐색적 요인분석, 확인적 요인분석을 실시한 후 측정모델의 적합도를 평가하였고, 이를 바탕으로 측정모형과 구조모델을 동시에 측정하는 구조방정식 검증을 실시하였다. [연구결과] 본 연구를 통한 결과는 다음과 같다. 물질주의가 높을수록 과시소비와 충동구매를 더 하는 것으로 나타났다. 그리고 과시소비 성향이 높을수록 삶의 만족도는 낮아지며, 부정적 감정은 높았다. 마지막으로 충동구매 성향이 높을수록 부정적 감정은 높았지만, 삶의 만족도에는 영향을 미치지 않는 것으로 나타났다. [연구의 시사점] 본 연구의 결과를 토대로 청소년들의 올바른 가치관과 소비 형태를 정립할 수 있는 교육 자료로 활용할 수 있을 것이라 본다. 그리고 물질주의를 통한 올바르지 못한 구매들이 부정적인 감정을 높이고 삶의 만족을 떨어뜨릴 수 있음을 공익광고를 통해 건전한 인식 전환을 시도해 볼 수 있을 것이며, 구매 후에 느낄 수 있는 부정적 감정들에 대해서는 과시를 통한 우월감, 만족감으로 대신하거나, 실용적인 측면들을 내세워 소비에 대한 정당성을 확보하여 부정적 감정들을 완화 시킬 수 있을 것으로 본다. [Purpose] Previous studies on the negative effects of materialism have been carried out, there has been no study of materialism’s effects on conspicuous consumption and impulse buying nor the study of entire variables between the effects of irrational consumption and satisfaction with life and negative emotions. In this context, this study examines the simultaneous effects of the relationships. [Methodology] This study evaluated the measuring model’s fitness after performing a reliability analysis, an exploratory factor analysis, and a confirmatory factor analysis. Based on this, the verification of the structural equation model simultaneously measuring the measuring model and the structural model was performed. [Findings] The results of this study are as follows: As materialism was higher, conspicuous consumption and impulse buying were higher. As conspicuous consumption was higher, satisfaction with life became lower but negative emotions were higher. Lastly, as the impulse buying disposition was higher, negative emotions were higher, but it did not affect satisfaction with life. [Implications] The result of this study can be used for educational data to establish adolescents’ proper values and behavioral patterns. A sound awareness shift that improper buying can elevate negative emotions and lower satisfaction with life can be attempted through public service advertisement. Negative emotions can be eased by securing legitimacy on consumption by replacing negative emotions with sense of superiority and satisfaction or by presenting the practical aspect.

경상대학교 사회봉사활동 활성화 방안

강욱모 경상대학교 1997 學生生活硏究所報 Vol.23 No.-

The purpose of this study is to identify the problems of the voluntary activities and to develop strategies encoraging more voluntary activities in the Gyeongsang National Unversity. For this purpose, a survey interview for the students was conducted to identify their characteristics, duration and continuation of action, motivation, and attitudes. The survey found that volunteers are not reliable work sources yet, because only 37.9 percent of students were experienced in voluntary action, and their participations are not on the regular bases and do not last long enough. This finding suggests that if systematic supporting body is established in the university, many students may better participate in the voluntary activities Based on these findings, some policy recommendations are suggested as follows; 1)The volunteer support regulation should be legislated as soon as possible. The regulation should include such regulations as establishment of volunteer center, curriculum, and supporting systems such as insurance, incentives, and approval of career. 2) The centralized supporting organization, so-called "Gyeongsang Voluntary Center" should be established. In order to establish effective center that provide organized, coordinated and well-managed service efforts, a broad and sustainable foundation of support is necessary. Most importantly, it requires the building of genuine relationship across the student body, academic discipines, community boundaries, administrative departments. 3) Voluntary coordinators should be trained so that they can play a variety of professional roles in managing volunteer programs. 4) Various voluntary action programmes should be developed. 5) In order to increase the efficiency in voluntary activities, database and computerization should be developed. 7) Against accidents during voluntary activities, a social insurance system should

두경부 종양세포주에 대한 Mithramycin A의 세포자멸사 유도성 및Cisplatin 항암작용 증가효과

이강대,손성환,박종욱,김영록,이봉주,김주연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Background and Objectives : Cisplatin (CP) is a major chemotherapeutic agent for head and neck cancer. However, cancer cells can get drug resistance through recovering the DNA damage by CP. Mithramycin A (MA) can inhibit gene expression of multidrug resistance gene 1, c-myc or h-ras. The goal of this study is to evaluate the therapeutic effect of MA alone and combination of MA and CP on head and neck cancer cell lines. Materials and Methods : Two head and neck cancer cell lines (AMC-HN4, AMC-HN7) were treated with MA. The cellular proliferation, apoptosis and protein expression were measured with XTT assay, FACS analysis, and western blotting, respectively after MA treatment in cell lines. In order to know the combination effect of MA with CP, the cancer cell lines were treated with MA, CP, and MA/CP combination, and cellular proliferation, apoptosis and expression of apoptosis-associated proteins were measured. Results : MA inhibited the proliferation of head and neck cancer cells and induce dapoptosis. Increase of caspase activation, PLC-?1 fragmentation and percent apoptosis by MA treatment was blocked by z-VAD-fms, but not blocked by N-Acetyl Cystein. Combination of MA and CP significantly inhibited cancer cell growth and increased apoptosis compared to MA and CP alone, and it also suppressed the expression of anti-apoptotic proteins such as XIAP and Mcl-1. Conclusions : The present study suggests that MA alone andMA/CP combination chemotherapy could be a potential regiment for the control of the head and neck cancer.

신장질환과 동반된 고혈압 환자에서 Cicletanine HCl이 신기능에 미치는 영향에 관한 연구

이강욱,신영태 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Cicletanine HCl is the first delivative of the furopyridines, a new class of antihypertensive agents. The properties of cicletanin HCl involve increased prostacycline release, vascular H_1, H_3, receptor antagonism and modulation of intracytosolic free calcium. In order to evaluate the effect of cicletanine HC1 to renal function in hypertensive patients with renal disease, we examined twenty one patients with hypertension and renal disease in Chungnamnam National University Hospital, before and four weeks after administration of cicletanine HCl 100 mg per day . The results were as follows : 1. Mean age of patients was 50 years and man was 1.3 times more than woman. 2. Eight with hypertensive nephropathy, 7 with unknown cause chronic renal failure and 6 patients with diabetic nephropathy were included. 3. Systolic, diastolic and mean blood pressure of all patients decreased significantly, and 62 % of patients showed normalized blood pressure at end point of study 4. Parameters of renal function such as BUN, serum creatinine and creatinine clearence were not changed. 5. Amounts of 24 hour uninary protein excretion in patients goup with massive proteinuria ( >3.0 g/day,n = 13 ) decreased significantly, 4 weeks after cicletanine HCl administration. 6. Serum cholesterol, triglyceride, ALT, AST, uric acid, muscle enzyme and serum electrolytes shch as sodium, potassium, calcium and phosphorus remained unchanged. 7. There was no significant side effect during 4 weeks course of cicletanine HCI administration. With results above, we think that cicletanm HCl can be used safely in hypertensive patients with renal disease.

유로 변경식 고도하수처리 공정의 최적 제어 알고리즘에 관한 연구

조욱상,강성욱,허형우 한국공업화학회 2004 응용화학 Vol.8 No.2

ZnO 투명전도막의 전기적 특성에 미치는 Al₂O₃의 도핑 농도의 효과

박강일,김병섭,이성욱,김현수,이세종,곽동주 경성대학교 공학기술연구소 2003 공학기술연구지 Vol.10 No.-

Al doped Zinc Oxide(ZnO:AI) films, which is widely used as a transparent conductor in optoelectronic devices such as solar cell, liquid crystal display, plasma display panel, thermal heater, and other sensors, were prepared by using the capacitively coupled DC magnetron sputtering method. In this paper the effect of doping amounts of Al₂0₃ on the electrical, optical and morphological properties were investigated experimentally. The results show that the structural and electrical properties of the film are highly affected by the doping. The optimum growth conditions were obtained for films doped with 2 wt% of indium which exhibit a resistivity of 8.5×10^(-4)Ω-cm associated with a transmittance of 91.7 % for 840 nm in film thickness in the wavelength range of the visible spectrum.

활성탄관에 포집된 2MEA와 2EEA의 에스테르화가 2MEA와 2EEA 분석에 미치는 영향

김현욱,김강윤,최호춘 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

This study was performed to find an appropriate desorbing solution for 2MEA and 2EEA collected activated charcoal. The desorbing solution should be transesterification-free and have reliable desorption efficiency. Anumber of desorbing solutions were tested against CS2 and MeOH/ methylene chloride(5/95, v/v, 5MeOH) which were normally used as desorbing solutions. Transesterfication of 2MEA and 2EEA on dry charcoal by 5MeOH was also verified. A GC/MSD was used for verification of transesterification. Desorption effciencies of several desorbing solutions were measured by GC/FID, As desorbing solutions, CS2, 5MeOH, DMF/CS2(1/99, v/v, 1DMF), and DMF/cs2(3/97,v/v, 3DMF)were selected. Desorption effciencies of 2MEA and 2EEA were 97.3% and 99.2% by 5MeOH, respectively, and 100.8% and 101.4% by 3DMF, respectively. No significant difference between 5MeOH and 3DMF was found for both 2MEA and 2EEA(p〈0.05), Transesterification of 2MEA and 2EEA on dry charcoal at≥10 ppm was confirmed when 5MeOH was used as the desorbing solution, However, when 3DMF was used, no transestserification of 2MEA and 2MEEA on dry charcoal was found. This study found that 3DMF (DMF/CS@, 3/97, v/v)was the desorbing solvent of choice for 2MEA and 2EEA collected on coconut shell charcoal tube With the solutiom, no transesterification was found with nearly 100% desorption efficiency.

韓牛 卵巢의 生物 統計學値 및 卵巢 疾患에 관한 硏究

李康郁,李元暢,尹快炳 건국대학교 1972 學術誌 Vol.13 No.1

Korean native cow 2567 slaughtared in abattoir were investigated fur studying the incidence of ovarian disease and biostatistical value of ovaries. The result obtained in the experiment are summarized as follows : 1) The average length of the ovary; 3.63±0.57cm ... right. 3.41±0.71 cm... left, The average width of the ovary; 2.36±0.49cm ... right. 2.02±0.54cm... left, According to the result the right ovary is bigger then the left. 2) The average waight of the ovary: 6.80±2.05g ... right. 5.40±2.69g ... left. According to the result is that the right ovary is heavier than the left by 1.40g Observation on the correlation between the ovary length and the weight was carried out as follows; r=0.568 ... right ovary. r=0.721 ... left ovary. The result shows that the correlation between two is close. 3) The average diameter of the corpus luteum; 1.15±0.43 cm ... right. 1.17±0.39 cm ... left, The average deep of the corpus luteum 1.34±0.06 ... right. 1.87±0.07 ... left. The result shows that the left is more diameter and deep then the right. 4) The average surface area of the ovary; 11.79±0.24 cm ... right. 11.68±0.25cm ... left. The result shows that the right is more wide then the left. 5) The incedence attributed to the ovarian disease was about 5.36% which includes; 3.11% of follicular cyst, 0.39% of lutein cyst, 1.22% of atrophic ovary and 0.36% agenesis of ovary. 6) Among the incidence, ovarian disease on both side occupied 32.35% whereas 41.9% right side, 25.17% left side, 67.64% was observed on any one side. 7) The average size of cystic ovary was 1.5-2.0 cm in diameter and then followed the size of 3.1-4.0 cm. 8) In 136 case 9, or 2.86%, occurred in cattle from 1 to 3 years outage; 21 or,5.46% in four; 54 or, 10.76% in five; 23 or,7.08% in six; 21 Or, 314 of in 7 to 9; and 2 or, 1.9% occurred over 10 years of age.

姙娠乳牛 血液像에 關한 硏究

李康郁 건국대학교 1974 學術誌 Vol.18 No.1

Hemogram of pregnant dairy cow were studied and the results obtained as follow: 1.Number of erythrocyte, hemoglobin concentration and hematocrit value in pregnant dairy cow was unchanged until the two month of pregnancy but highly significant dicrease was found at the four, sixth, eight, and tenth month of gestation. 1 month after delivers showed the normal value. 2.Mean corpuscular hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin concentration of pregnant dairy cow revealed the tendancy of decrease as gestation progress and 1 month after delivery the value was returned to normal, and highly significant decrease was observed at the sixth and eight month, but no difference were observed at the other period of gestation, 1 month postpartum and sterlity dairy cow. 3.Total leucocyte of pregnant dairy cow increased continuously as gestation and 1 month postpartum the values were returned to normal. Highly significant changes were observed in the sixth and eighth month of pregnancy.