Acute Heart Failure Management

Kamilė Čerlinskaitė,Tuija Javanainen,Raphaël Cinotti,Alexandre Mebazaa,Global Research on Acute Conditions Team (GREAT) Network 대한심장학회 2018 Korean Circulation Journal Vol.48 No.6

Acute heart failure (AHF) is a life-threatening medical condition, where urgent diagnostic and treatment methods are of key importance. However, there are few evidence-based treatment methods. Interestingly, despite relatively similar ways of management of AHF throughout the globe, mid-term outcome in East Asia, including South Korea is more favorable than in Europe. Yet, most of the treatment methods are symptomatic. The cornerstone of AHF management is identifying precipitating factors and specific phenotype. Multidisciplinary approach is important in AHF, which can be caused or aggravated by both cardiac and non-cardiac causes. The main pathophysiological mechanism in AHF is congestion, both systemic and inside the organs (lung, kidney, or liver). Cardiac output is often preserved in AHF except in a few cases of advanced heart failure. This paper provides guidance on AHF management in a time-based approach. Treatment strategies, criteria for triage, admission to hospital and discharge are described.

Reactivation of Human Brain Homogenate Cholinesterases Inhibited by Tabun using Newly Developed Oximes K117 and K127

Kuca, Kamil,Cabal, Jiri,Jung, Yung Sik,Musilek, Kamil,Soukup, Ondrej,Jun, Daniel,Pohanka, Miroslav,Musilova, Lucie,Karasová,, Jana,Novotný,, Ladislav,Hrabinova, Martina Blackwell Publishing Ltd 2009 Basic & clinical pharmacology & toxicology Vol.105 No.3

<P>Abstract: </P><P>Newly developed acetylcholinesterase reactivators K117 [1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxapentane dichloride] and K127 [(1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxapentane dibromide)] were tested for their potency to reactivate tabun-inhibited human brain cholinesterases. Pralidoxime and trimedoxime were chosen as standard reference reactivators. Human tissue was used, as that was closer on the real treatment of human beings. As a result, oxime K127 was found as the best tested reactivator according to the constant <I>k</I><SUB>r</SUB>, characterizing the overall reactivation process. On the contrary, the maximal reactivation ability expressed as percentage of reactivation was the best for trimedoxime. This differences were caused as a result of using the enzyme from different species. Due to this, experiments on human tissue should be conducted after <I>in vitro</I> and <I>in vivo</I> tests on animals to eliminate such important failures of promising oximes.</P>

Evaluating the bond strength between concrete substrate and repair mortars with full-factorial analysis

Kamile Tosun Felekoglu,Burcu Felekoglu,A. Serdar Tasan,Burak Felekoglu 사단법인 한국계산역학회 2013 Computers and Concrete, An International Journal Vol.12 No.5

Concrete structures need repairing due to various reasons such as deteriorative effects, overloading, poor quality of workmanship and design failures. Cement based repair mortars are the most widely used solutions for concrete repair applications. Various factors may affect the bond strength between concrete substrate and repair mortars. In this paper, the effects of polymer additives, strength of the concrete substrate, surface roughness, surface wetness and aging on the bond between concrete substrate and repair mortar has been investigated. Full factorial experimental design is employed to investigate the main and interaction effects of these factors on the bond strength. Analysis of variance (ANOVA) under design of experiments (DOE) in Minitab 14 Statistical Software is used for the analysis. Results showed that the interaction bond strength is higher when the application surface is wet and strength of the concrete substrate is comparatively high. According to the results obtained from the analysis, the most effective repair mortar additive in terms of bonding efficiency was styrene butadiene rubber (SBR) within the investigated polymers and test conditions. This bonding ability improvement can be attributed to the self-flowing ability, high flexural strength and comparatively low air content of SBR modified repair mortars. On the other hand, styrene acrylate rubber (SAR) modified mortars was found incompatible with the concrete substrate.

A KOROVKIN TYPE APPROXIMATION THEOREM FOR DOUBLE SEQUENCES OF POSITIVE LINEAR OPERATORS OF TWO VARIABLES IN A-STATISTICAL SENSE

Kamil Demirci,Fadime Dirik 대한수학회 2010 대한수학회보 Vol.47 No.4

In this paper, we obtain a Korovkin type approximation theorem for double sequences of positive linear operators of two variables from Hw (K) to C (K) via A-statistical convergence. Also, we construct an example such that our new approximation result works but its classical case does not work. Furthermore, we study the rates of A-statistical convergence by means of the modulus of continuity.

민족어 대매체 교과목소프트웨어의 개발과 설계

Kamil Moydin 한국어정보학회 2002 한국어정보학 Vol.5ㆍ6 No.-

ON SEMI-ARMENDARIZ MATRIX RINGS

Kamil Kozlowski,Ryszard Mazurek 대한수학회 2015 대한수학회지 Vol.52 No.4

Given a positive integer n, a ring R is said to be n-semi- Armendariz if whenever ∫n = 0 for a polynomial ∫ in one indeterminate over R, then the product (possibly with repetitions) of any n coefficients of ∫ is equal to zero. A ring R is said to be semi-Armendariz if R is n-semi-Armendariz for every positive integer n. Semi-Armendariz rings are a generalization of Armendariz rings. We characterize when certain important matrix rings are n-semi-Armendariz, generalizing some results of Jeon, Lee and Ryu from their paper (J. Korean Math. Soc. 47 (2010), 719–733), and we answer a problem left open in that paper.

Role of liver support systems in the management of post hepatectomy liver failure: A systematic review of the literature

Kamil Pufal,Alexander Lawson,James Hodson,Mansoor Bangash,Jaimin Patel,Chris Weston,Thomas van Gulik,Bobby VM Dasari 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.2

Backgrounds/Aims: Post-hepatectomy liver failure (PHLF) is a serious complication following liver resection, with limited treatment options, and is associated with high mortality. There is a need to evaluate the role of systems that support the function of the liver after PHLF. Aims: The aim of this study was to review the literature and summarize the role of liver support systems (LSS) in the management of PHLF. Publications of interest were identified using systematically designed searches. Following screening, data from the relevant publications was extracted, and pooled where possible. Findings: Systematic review identified nine studies, which used either Plasma Exchange (PE) or Molecular Adsorbent Recirculating System (MARS) as LSS after PHLF. Across all studies, the pooled 90-day mortality rate was 38% (95% CI: 9-70%). However, there was substantial heterogeneity, likely since studies used a variety of definitions for PHLF, and had different selection criteria for patient eligibility for LSS treatment. Conclusions: The current evidence is insufficient to recommend LSS for the routine management of severe PHLF, with the current literature consisting of only a limited number of studies. There is a definite need for larger, multicenter, prospective studies, evaluating the conventional and newer modalities of support systems, with a view to improve the outcomes in this group of patients.

Observer-based friction compensation in heavy-duty parallel robot control

Kamil Vedat Sancak,Zeki Yagiz Bayraktaroglu 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.8

This paper presents an experimental study on friction compensation for the high-precision tracking control of parallel manipulators. A Luenberger-like observer (LLO) and an extended state observer (ESO) are designed and implemented in real-time control of a 6-DoF heavy-duty Stewart-Gough platform (SGP). The dynamic Lu-Gre model is used in the identification of friction. Performances of the proposed observer-based friction compensators are compared to those of a model-based compensator in computed torque control. Experimental results show that the observer-based compensators significantly improve the tracking performances in high speed motions. Among the investigated observers, the ESO results in minimum RMS error in position tracking. Improvement in position tracking at velocity reversals of the individual leg motions is also observed with the contribution of observer-based compensation. The observer error dynamics is exponentially stable, and the convergence rate can be arbitrarily increased by tuning the observer gain.

The Use of Contrast in Caudal Epidural Injections under Image Intensifier Guidance: Is It Necessary?

Kamil Naidoo,Sulaiman Alazzawi,Alexander Montgomery 대한정형외과학회 2017 Clinics in Orthopedic Surgery Vol.9 No.2

Background: We investigated the value of using contrast as an additional aid to confirm the accuracy of needle placement for caudal epidural injections under intraoperative image intensifier guidance. Methods: A total of 252 consecutive patients were included in this study. Their mean age was 46.7 years (range, 32 to 76 years). There were 133 males (53%) and 119 females (47%) over a 12-month period. Results: Of the 252 consecutive procedures, the contrast enhanced image intensifier confirmed accurate needle placement on first attempt in 252 cases (100%). Needle resiting following the infiltration of contrast was required in 0 case. Conclusions: The results from this study demonstrate that a surgeon beyond the learning curve can accurately place caudal epidural injections using image intensification only, without the use of contrast.

Design methodology of standing-wave thermoacoustic refrigerator: theoretical analysis

Kamil Mohanad Q.,Yahya Samir Gh.,Azzawi Itimad D. J. 대한설비공학회 2023 International Journal of Air-Conditioning and Refr Vol.31 No.1

Thermoacoustic refrigeration systems are one of the best alternative solutions for conventional refrigeration systems that are harmful to the environment and humans due to global warming and ozone layer depletion issues. Thermoacoustic technology can be considered a renewable and clean technology with a promising future for its many advantages. A thermoacoustic refrigerator converts acoustic energy to thermal energy (creating a cooling effect). In the present research, the focus is on the design of a standing-wave thermoacoustic refrigerator driven by an ordinary loudspeaker using the numerical simulation program DELTAEC with the concern of building the apparatus at a low cost. In addition, investigating the influence of some crucial parameters on cooling power and thermal/overall performance. Hence, the designed thermoacoustic refrigerator performed well in respect of cooling power and coefficient of performance. It has achieved a cooling power of 134.34 W with a temperature difference between the ambient and cold heat exchangers of 25 K at a COP of 1.956 and the overall efficiency (electrical power converted into cooling power) amounted to 113.43%. The achieved cooling power and COP could be significant when compared to others’ results.