입원 중인 베트남 참전 군인의 삶의 만족도와 관련된 요인

김애리,박종,김율,노희송,박광희,김은숙,김형철,홍강식,류소연,강명근,김기순 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background and Objectives: The aim of the study was to identify the factors associated with life satisfaction of hospitalized Vietnam veterans. Material and Methods: The data were collected from 200 hospitalized Vietnam veterans of 5 veterans hospitals in Korea from September 13 to 23, 2004. Information of general characteristics, health behavior, disease history, family function, depression and life satisfaction were collected by structured questionnaire. Results: The mean of life satisfaction was 21.48(±6.03), and the mean of depression was 53.10(±9.64). The prevalence of depression was mild depression 24.0%, moderate depression 43.5% and severe depression 25.0%. Depression was associated with life satisfaction and depression was higher, life satisfaction was lower. Family function and age were positively associated with life satisfaction, Conclusion: Life satisfaction was affected by depression and family function in hospitalized Vietnam veterans. Therefore, it was thought that psychosocial approaches such as improve depression and family function in care of hospitalized Vietnam veterans is required.

水泳一스트레스에 의한 血裝 Corticosterone 증가에 미치는 水溫, Clonidine 및 Bromazepam의 영향

金炯健,申炅浩,金庚旭,全普權,千然淑 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.2

Recently, many reports suggested that warm water swim-stress induces an opioid-analgesia, while cold water swim-stress produces a nonopioid form of analgesia. And Hong et. al. reported that the increase of plasma corticosterone (p-CS) in response to swim-stress at 20℃(20-SS) was significantly attenuated by swim-stress at 4℃ (4-SS) was affected by CL but markedly suppressed by BA. In this paper, the influences of CL-500㎍/㎏ and BA-5㎎/㎏ on the change of p-CS in response to 20-SS or 4-SS were studied in male mice comparing with those of morphine and naloxone. The 20-SS induced increase of p-CS was significantly inhibited by CL and BA, respectively, while the 4-SS induced increase was not affected by CL but markedly inhibited by BA. And the 20-SS or 4-SS induced increase of p-CS was slightly inhibited by naloxone,2mg/kg but not affected by morphine, 2㎎/㎏. The increase of p-SS in response to three times repeated 20-SS or 4-SS with one hour interval was little affected by B-pretreatment, but CL-pretreatment slightly attenuated the 4-SS induced increase of p-CS and significantly inhibited the 20-SS induced increase. The increase of p-CS induced by the repeated SS was little affected by the treatment of BA 30 minutes before the last SS, but the such treatment of CL slightly attenuated the p-CS increase induced by the repeated 20-SS but significantly enhanced the p-CS increase by the repeated the repeated 4-SS. And during the experiment of repeated 4-SS, 55.6% of mice pretreated with BA were drowned. The results demonstrate that there are some pharmacological differences between the mechanisms of hypothalamo-adenohypophysial responses to 20-SS and 4-SS, respectively.

A rare case of extensive papillary muscle calcification in senile cardiac calcification syndrome

김은진;송봉근;강민호;손형래;홍수민;박동원;허승혜;김계연;최석구 인제대학교 2011 仁濟醫學 Vol.32 No.-

광범위 유두근 석회화는 흔하지 앉으며, 원인과 임상적 중요성에 관한 문헌만 드물게 찾아볼 수 있다. 반면에 작은 석회 침착은 노인에서 흔하며 심장 첨부에 주로 나타난다. 유두근 석회화는 관상동맥질환, 확장성 심근병증, 승모관 질환, 고칼슘혈증, 그리고 말기신부전에서 인산칼슘의 중가와 연관성이 있다. 저자는 심장초옴파와 MDCT를 통해 진단된 전외측 유두근의 광범위 석회화의 드문 사례가 있어 보고한다.

후두 편평세포암종에서 Galectin-1 및 -7의 발현 의의

김건형,강차영,윤혁수,도남용,조성일,임성철 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background and Objectives: The role of different Galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of Galectin-1 and -7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Methods: Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007, were immunohistochemically stained for Galectin-1 and -7. Results: Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion: Expression of Galectin-1 and -7 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.

활성탄 및 자외선에 의한 세균제거에 관한 연구

김경진,김형석,이호근 慶熙大學校 地球環境硏究所 1998 지구환경논문집 Vol.9 No.-

The environment of the earth has been changed worse by human activities. There are lots of waterborne diseases which are caused by bacteria, virus, and protozoan. Microorganisms pose a serious threat to the safety of the world's drinking water. At least 25 millon people in the world die because of the waterborne diseases. The major symptoms are diarriah, vomite, stomach pain, and headache. Some diseases kill patients who are especially immuno compromised such as cholera, typhoid, etc. Many cases of this kind of diseases are the important issue throughout the world. Therefore international academic conferences are holding frequently. One of the recommentation was announced in Guayaquil, Ecuador in 1995, which is related with control of waterborne diseases. We know that water pollution by E.coli indicate fecal contamination in water system. We are drinking about 2 liters of drinking water every day. There are several kinds of drinkind water, e.g., tap water, bottled water, purifier passed water, groundwater, etc. The city tap water is most widely using drinking water source. But owing to the corrosion of water supplying pipe lines and storage tank contamination in buildings, the tap water quality has some problems of bacteria and other contaminants. Throughout the world, water purifiers are using in many countries, but there are few reports on bacteria behavior in water purifiers. Authors studied the bacteria reduction and removal effects through activated carbon and UV lamp in water purifier, and got some interesting results.

TiN 박막 형성에 미치는 ion beam 조사 효과

안병건,추관식,문두수,안정식,김영대,김형자,이규용 釜慶大學校 2002 釜慶大學校 論文集 Vol.7 No.-

Low energy high current N_2 ion beam was used to modify the morphology and chemical composition of cemented carbide WC-Co(Co:10 wt%, TiC + TaC:15 wt%, WC:bal) hard material surface for the fabrication of the TiN thin film by sol-gel method. The effects of ion beam treatment on preparation of the TiN thin film by sol-gel mothod were investigated by XPS, SEM, AFM and GXRD. According to the N_2 ion beam bombardment, the surface roughness was increased and TiC binders in WC were dissolved. The dissolved Ti was recombind with nitrogen ion to form the TiN nucleuses which were acted as seeds for the forming of the TiN thin film on the cemented WC-Co surface. Besides, the sputter deposited Ti interlayer prevented the diffusion of TiO_2 sol into the porous WC-Co during the formation of TiN thin film.

Swim-Stress에 의한 血漿 Corticosterone 增加와 腦 Monoamine 性 神經系의 關聯性에 대한 硏究

徐聖祚,金炯健,全普權 고려대학교 의과대학 1988 고려대 의대 잡지 Vol.25 No.1

There are many evidences suggesting that central, alpha-adrenergic but not beta-adrenergic or dopaminergic, pathways inhibit ACTH-corticosteroid secretion caused by various stimuli in a variety of animal species. But noradrenenergic activation has been reported to cause no change, inhibition, or stimulation of ACTH secretion. O'Conner and Chipkin reported that the response to warm swim-stress might involve central opioid pathway, whereas the response to cold swim-stress appeared not to be opioid mediated. In this paper, the influence of clonidine on the increase of plasma corticosterone level occurred by swim-stress at 4℃ or 20℃ was studied in male mice. The results obtained were summarized as follows: 1. The increase of plasma corticosterone (CS) occurred by swim-stress at 4℃ was not affected by clonidine, 500㎍/㎏, but the increase occurred by swim-stress at 20℃ (20-SS) was significantly inhibited by clonidine. 2. The increase of plasma CS occurred by 20-SS was not affected by prazosin, phenoxybenzamine, yohimbine. propranolol and haloperidol. But the inhibitory effect of clonidine on 20-SS induced increase of plasma CS was significantly antagonized by yohimbine and phenoxybenzamine but not affected by prazosin, propranolol, and haloperidol. 3. The increase of plasma CS occurred by 20-SS was significantly inhibited by reserpine, alpha-methyl-p-tyrosine, and p-chlorophenylalanine but not affected by iproniazid. And the inhibitory effect of clonidine on the increase of plasma CS occurred by 20-SS was not affected by ipronizid, reserpine, alpha-methyl-p-tyrosine, and p-chlorophenylalanine. 4. Clonidine increased plasma corticosterone level, and the increasing effect of clonidine was moderately enhanced by reserpine and alpha-methyl-p-tyrosine but not affected by the above adrenoceptor blockades. The results suggest that the increase of plasma corticosterone level occurred by 20-SS may be mediated by hypothalamic noradrenergic and serotonergic neurons and inhibited by clonidine via presynaptic α₂-adrenoceptor.

흰쥐에서 음경발기 평가의 척도로서 음경해면체내압측정술 확립

송윤섭,김용준,이광우,김준모,문기혁,박영호,민영기,유형균,김형건 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Because studies about the control of penile erection at the entral nervous system was dependent on the animal experiments, establishment of measuring penile erection is important to evaluate the effects changes at the central nervous system on the penile erection. Intracavernous pressure measurement in rats has been introduced as a suitable index for the evaluation of penile erection but this method is invasive and technically difficult. So, we established the intracavernous pressure measurement in rats as the experimental index for penile erection. Materials and Methods: 42 male adult Sprague-Dawley rats (250-300gm) were divided to saline or papaverine treated group. Rats were placed on a heating table to maintain their body temparature and anesthetized with 50mg/kg of pentobarbital sodium by intraperitoneal injection. A cannula was inserted to the left carotid artery to measure systemic blood pressure. Saline (0.05, 0.1ml), papaverine(0.05, 0.1, 0.25, 0.5, 1.0, 2.0mg) were injected intracavernously via 26 guage needle filled with saline or papaverine which connected to pressure transducer and polygraph was inserted into the corpus cavernosum on one side to inject the drug and to measure intracavernous presure. Results: Properly executed insertion and intracavernous administration produced a instantaneous but transient rise in intracavernous pressure that substantially stabilized and maintained at 5.4±0.4mmHg. Intracavernous pressure and duration of penile blood flow following intracavernous injection of papaverine are increased comared to those of saline. Conclusions: Monitoring intracavernous pressure in rats represents a suitable index for the evaluation of penile erection in small laboratory animals.

甲狀腺홀몬-處置 마우스에서 스트레스에 의한 腦 Noradrenaline代謝 및 血漿 Corticosterone値의 變動에 關한 硏究

洪起堵,金炯健,全普權 고려대학교 의과대학 1988 고려대 의대 잡지 Vol.25 No.3

The role of brain noradrenergic neurons in the suppressive activity of clonidine and bromazepam on the swim stress-induced increase of plasma corticosterone level was investigated in male mice pretreated with thyroxine, The obtained results were summarized as follows; 1. The plasma corticosterone level (P-CS) was significantly increased after the pretreatment with thyroxine, 4mg/kg/day for 3 days (T4-3d). And the P-CS was moderately increased by clonidine, 500ug/kg(CD) but markedly decreased by bromazepam, 10mg/kg (BA). 2. The increase of P-CS induced by swim stress at 20℃ (20-SS) was markedly suppressed by CD and BA, respectively. The 20-SS induced increase of P-CS in mice pretreated with T4-3d was not affected by CD but significantly suppressed by BA. 3. The increase of P-CS induced by swim stress at 4℃ (4-SS) was not affected by CD but markedly suppressed by BA. And the suppressive effect of BA was significantly attenuated by the pretreatment with 74-3d. 4. The decorticated brain contents of tyrosine (T), noradrenaline (NA), and 3-methoxy-4-hydroxy-phenylglycol (MHPG) were not significantly affected by 74-3d, 20-SS, and 4-SS, respectively. 5. CD significantly decreased brain MHPG and MHPG/NA ratio in normal and T4-3d pretreated mice. However, CD did net decrease brain MHPG and significantly increased brain NA in mice exposed to20-SS and 4-SS, respectively. 6. BA moderately decreased brain T in normal and T4-3d pretreated mice. But the brain content of T in mice exposed to 20-55 and 4-55, respectively, was not affected by BA.These results suggest that the suppressive effect of clonidine and bromazepam on the swim stressinduced increase of plasma corticosterone level may not be mediated by presynaptic regulation via alpha-2adrenoceptors of brain noradrenergic neurons.

수영-스트레스에 의한 腦 Catecholamine 代謝의 變動에 있어서 甲狀腺-機能의 役割에 關한 硏究

洪起男,申炅浩,金炯健,全普權 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.3

Effects of hyper-and hypothyroidism in the swim-stress(SS) induced changes of plasma corticosterone(CS) level and brain norepinephrine(NE) metabolism were studied in male mice pretreated with 1-thyroxine sodium(4㎎/㎏, i.p. inj. once a day for 5 days; T₄) and propylthiouracil (fed ad lib in 0.01% drinking water for 5 weeks : PTU). The circadian rhythm of spotaneous motor activity was not significantly altered by T₄ and PTU, respectively. The plasma thyroxine level was markedly increased by T₄ but reduced by PTU and the plasma thyrotropin level was markedly increased by PTU but decreased by T₄. The plasma CS level was not changed by PTU but moderately increased by T₄ Clonidine slightly increased the plasma CS level, but the clonidine effect was significantly enhanced by T₄-pretreatment. The brain NE and 3-methoxy-4-hydroxyphenylglycol(MHPG) contents were little affected by T₄ but significantly decreased by PTU. ThE SS-induced increase of plasma CS level was moderately decreased by PTU but increased by T₄. However, clonidine significantly inhibited the SS-induced increase, and the inhibitory effect of clonidine was little significantly affected by PTU and T₄ respectively. The brain MHPG content and MHPG/NE ratio were significantly decreased by clonidine bur increased by SS. THe clonidine-induced decrease of brain MHPG/NE ratio were not altered by PYTU or T₄. The SS-induced, and the inhibitory effect of clonidine was not affected by PTU and T₄ respectively. These results suggest 1) that the alteration of thyroidal function little affects the changes of brain NE in responses to swim-stress, but the stress-induced change of plasma corticosterone level may be somewhat modulated by the thyroidal function, and 2) that the hypothalamo-pituitary-adrenocortical stimulation in response to swim-stress seems to be mediated via hypothalamic noradrenergic activation, and the stress response may inhibited by the agonistic activity of clonidine on the presynaptic α₂-adrenoceptor.