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수종의 피부종양에서 Proliferating Cell Nuclear Antigen과 Ki - 67 의 표현에 관한 비교 연구
황선욱(Sun Wook Hwang),원영호(Young Ho Won),전인기(Inn Ki Chun),박창수(Chang Soo Park) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.3
Background : Both PCNA and Ki-67 have been used as marker for cellular proliferation. The drawback of Ki-67 antibody in immunohistochemistry was that it can be labelled only on fresh tissue, however, MIB1 is a newly developed Ki-67 antiboc which can be labelled on formalin-fixed tissue. Objective : The purpase of the present study is to compir the stainability of the Ki-67 antibody with that of the ICNA antibody on formalin-fixed, para fin embedded tissues. Methods : Using MIE1, the newly developed Ki-67 antibody and PC10(PCNA antibody), speci mens of squamous cell carcinoma(SCC), Bowens disease(BL), actinic keratosis(AK) and basal cell epithelioma(BCE) were stained by one hour immunocytial, mistry using a Microprobe immuno/DNA stainer. Results : The labelling indices (LI) of MIB1 were 82.6%, 37.4%, 38.3% & 81.1% respectively in SCC, BD, AK & BC, while the LI of PC10 were 77.69%, 26.6% & 64.4%. The labelled cells of both antibodies differed in distribution patterns on turmor tissues. Conclusion : MIBI cain be used to be an alternative m.rl r for proliferating cells. MIBI PC10, when used together, will be mutually compensatory the study of proliferating cell kinetics. (Kor J Dermatol 1995;33(3): 453-458)
동창의 임상 및 병리조직학적 소견과 Ki-67 발현 양상
서기석(Ki Seuk Suh),김상태(Sang Tae Kim),이기욱(Ki Wook Lee) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9
N/A Background : Pernio or chilblain is an abnormal reaction to damp cold air, resulting in pruritic erythematous swellings on acral skin. The histologic features are subepidermal edema, diffuse fluffy edema of endothelial cell, and superficial or superficial and deep perivascular lymphocytic infiltrates. Many studies with a large sample size have been conducted in western countries, but there were no collective studies of pernio that have been reported in Korea. Objective : The purpose of this study was to clarify the clinical and histopathologic features of pernio in Korea. Methods : We reviewed the clinical and histopathologic findings in ten patients with pernio who visited the Department of Dermatology, Kosin Medical College Gaspel Hospital during the 10 year period from 1988 to 1997. Results : The results were as follows. 1. The age distribution was in the range of 6∼50 year old. The prevalance was heighest in the third and fourth decade. Sex ratio was 1 : 4 (2 males : 8 females). The duration of symptoms ranged from 4 days to 30 years. All patients developed skin lesions on the acral area. Two male patients developed skin lesions on the hand associated with cold exposure and outdoor works. All patient had itching and burning papules and/or plaques, and one had a painful hard nodule. Laboratory studies were all negative and within normal ranges. 2. Histopathologic features revealed subepidermal edema, diffuse fluffy edema of endothelial cell, and superficial or superficial and deep perivascular lymphocytic infiltrates in all specimens. 3. Treatment includes prophylatic measures against cold and nifedipine(calcium channel inhibiting drug). In more severe cases, pentoxifylline might be helpful. Conclusion : Our study suggests that pernio commonly occurs in twenty to forty year old females during fall and winter. Upon exposure to cold temperatures, the acral skin develops pruritic erythematous papules and plaques. If these lesions persisit for a long time or recur, they may progress to vesicle and ulceration and possibly develop vasculitis which does not respond to therapy well. Thus, a thorough understanding of clinical and histopathologic features of pernio is vital in making a diagnosis, a treatment plan and determining the prognosis. (Korean J Dermatol 1999;37(9) : 1254∼1260)
소화불량(消化不良)과 과심상(過心傷)의 상관성(相關性)에 대(對)한 고찰(考察) -스트레스, 기울(氣鬱), 비병증(脾病證)의 평가(評價)를 통(通)해-
김진성,윤상협,류봉하,류기원,이상욱,Kim, Jin-Sung,Yoon, Sang-Hyub,Ryu, Bong-Ha,Ryu, Ki-Won,Lee, Sang-Wook 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4
Background & Object : Dyspepsia for which no organic causes are disclosed is referred to as functional dyspepsia. Functional dyspepsia is here studied in connection with a biopsychosocial model. From the aspect of individual response to external environment, in connection with stress response, functional dyspepsia is studied by both the psychology department and the internal medicine departments. The disease is taken as approachable from the aspect of internal injury due to seven emotions and stress as differentiated by Oriental medicine. Materials and Methods : Targeted at 223 patients underwent medical checks and endoscopy at Kangnam Korean Hospital, Kyunghee University. They agreed to join this clinical experiment. Stress response inventory, GARS (global assessment of recent stress scale), GSRS (gastrointestinal symptom rating scale), diagnostic scores for Ki-depression, and Spleen Disease Differentiation of Syndromes were all measured and evaluated. The test group was comprised of functional dyspepsia patients. The control group was comprised of nonsymptomatic chronic gastritis patients who were found to suffer from chronical gastritis in endoscopy and thus could be diagnosed with functional dyspepsia if symptoms would arise, but did not complain of subjective symptoms. Results showed these corelations: Functional dyspepsia patients were found to have more serious Ki-depression compared to nonsymptomatic chronic gastritis patients. The more serious Ki-depression the more serious the dyspepsia symptoms. The higher the stress response inventory the more serious the dyspepsia. Deficiency of spleen Eum, and Deficiency and Sinking of spleen Gi were found to coincide with serious Ki-depression.
RYU, Seung-Hee,KANG, Ki Mun,MOON, Soo Young,CHAI, Gyu Young,HONG, Joon Pio,CHO, Kyoung-Oh,KANG, Mun-Il,CHOI, Eun Kyung,LEE, Sang-wook Journal of Radiation Research Editorial Committee 2010 JOURNAL OF RADIATION RESEARCH Vol.51 No.5
<P>Concurrent chemotherapy with radiotherapy (CCRT) has been applied for the treatment of advanced stage of head and neck cancer patients. However CCRT is associated with several complications including mucositis, dermatitis, stomatitis, etc. This study was conducted to evaluate the therapeutic effect of systemically administrated recombinant human epidermal growth factor (rhEGF) in CCRT-induced oral mucositis in a mouse model. Oral mucositis was induced in male BALB/c mice through combination treatment with cisplatin (11 mg/kg, i.p.) and irradiation (17 Gy) of the head and neck area. rhEGF (1.0 mg/kg/day for consecutive 3 days) was administered systemically, and the therapeutic effect was determined by histological evaluation of the oral mucosa. To elucidate optimal dose of rhEGF on CCRT-induced mucositis, various concentrations (0.04–3 mg/kg) of rhEGF were injected for 3 days. Systemic rhEGF administration accelerated the recovery of body weight. Histologically, rhEGF-treated mice showed significantly increased epithelial cell layer thickness, basal cell number, and expression of Ki-67 compared to control mice. Most effective dose was 1 mg/kg among other doses tested. Systemic administration of 1 mg/kg of rhEGF reduces the severity of oral mucositis induced by CCRT in a mouse model, suggesting that rhEGF can be used for treating CCRT-induced mucositis during the cancer treatment.</P>
이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
일측 요관폐쇄에 의한 실험적 수신증에서 신조직내 MCP-1 및 TNF-α유전자 발현
나가량,황평주,김종학,구영선,강민규,서광선,이강욱,신영태 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2
Early cellular and molecular derangements have been suggested as potential pivotal factors for the development of renal injury, such as interstitial fibrosis after the experimental hydronephrosis. Several recent studies have been demonstrating that one of the initial events taking place in the progressive renal injury process is the mononuclear cell infiltration in the glomeruli and tubulointerstitiuim. In order to evaluate the renal light microscopic findings as well as the renal cortical MCP-1 and TNF-α gene expressions which are modulating inflammatory process and the recruitment of mononuclear cells in many experimental models of renal injury, Sprague-Dawley rats underwent unilateral ureteral obstruction (UUO) and sham operation under the thiopental sodium anesthesia(50 mg/kg intraperitoneal injection). Three and 7 days after surgery, rats were sacrificed. By the competitive RT-PCR, the levels of TNF-α and MCP-1 mRNA in renal cortical tissues were measured. The magnitude of mononuclear cell infiltration and interstitial widening were evaluated by standard point counting method. The level of MCP-1 gene expression was significantly increased in UUO group compared to sham group at 3 and 7 days after surgery(UUO 3 days 8.99 ± 0.45, UUO 7 days 11.2 ± 0.26, sham 3 days 1.00 ± 0.08, sham 7 days 0.94 ± 0.05, p < 0.01, p < 0.01, mean ± SEM, respectively). The level of MCP-1 mRNA at 7 days after surgery was significantly higher than that at 3 days in UUO group. The TNF-α gene expression level of UUO group was also significantly higher than that of sham group at 3 and 7 days after surgery(UUO 3 days 1.73 ± 0.16, UUO 7 days 2.03 ± 0.21, sham 3 days : 1.00 ± 0.06, sham 7 days 1.09 ± 0.03, p < 0.01, p < 0.01, respectively). But there was no significant difference between the levels at 3 and 7 days after surgery in UUO group(p>0.05). On the light microscopic examination, the relative volume of interstitium (RVI) and the total count of infiltrated mononuclear cells(MCC) at 3 and 7 days after surgery in UUO group were also significantly higher than those of sham group(RVI ; UUO 7 days 14.9±1.0%,sham 6.0±0.7%, MCC; UUO 7days 34.0± 1.6, sham 3.7± 0.6, p < 0.01, p < 0.01, respectively). In conclusion, we speculated that the early up-regulation of MCP-1 and TNF-α genes of renal cortical tissue in this experimental hydronephrosis model is closely related to the mononuclear cell infiltration and tubulointerstitial fibrosis.
엄기욱,박인아 한국사회복지정책학회 2005 사회복지정책 Vol.21 No.-
본 연구의 목적은 시행 4년을 지나는 일본 개호보험제도의 정책목표인 ① 이용자 중심 서비스로의 개혁 ② 재가보호의 추진 ③ 지방분권의 추진이 어느 정도 달성되었는가 즉, 제도의 효과성을 살펴보고, 그 결과가 한국에 주는 시사점을 제시하는데 있다 연구결과 이용자 중심 서비스로의 개혁은 서비스 이용자, 서비스 제공기관 및 서비스의 수가 지속적으로 증가하고 있어 어느 정도 긍정적으로 평가 할 수 있으나 시설입소신청자 중 입소에예향형의 비중이 높고, 제공기관의 지정취소 사례가 증가하는 등양적·질적으로 미흡하였다. 둘째, 재가보호의 추진은 재가서비스 이용자의 절대 수와 전체에서 차지하는 비율이 증가하고 있어 긍정적으로 평가할 수 있으나 요개호 수준이 높을수록 여전히 시설서비스를 선호하고 있어 한계를 지니고 있는 것으로 평가할 수 있다. 셋째, 지방분권의 추진은 제도 운영의 주체는 시·정·촌이면서 서비스 공급량 조정권한은 도·도·부·현에 있으며, 지역간 보험료 기준액의 격차가 심화되는 등 부정적인 측면이 더 많은 것으로 평가되었다. 이러한 평가결과가 주는 시사점으로 우선 이용자 중심의 서데스를 제공하기 위해서는 양적·질적으로 충분한 서비스 제공 뿐 아니라 이용자가 적절한 서데스를 선택할 수 있는 정보제공체계가 마련되어야 하며, 재가보호 중심의 서비스 운영을 위해서는 서비스의 내용과 지원체계가 이용자의 욕구에 부합되어야 하며, 급여 및 비용부담에서 시설서비스와의 형평성이 고려되어야 하고, 지방분권을 추진하기 위해서는 지역간 형평성과 이를 위한 지역 특성과 역량을 고려한 중앙정부의 지원과 적정규모의 지역을 단위로 한 제도운영과 서비스 공급체계가 마련되어야 함을 제시하였다. The present study purposed to examine the efficiency of the long-term care insurance system in Japan, which began four years ago, focused on the achievement of its policy goals - ① reform to user-centered services; ② the promotion of community-based care; and ③ the promotion of decentralization - and to suggest the implications of the outcome for Korea. According to the result of this study, reform to user-centered services has been attained to some degree considering the steady increase of the numbers of users, services and service providing institutions, but still quantitative and qualitative shortages exist as shown by the high percentage of users reserving admission in applicants for facility admission and the increasing number of cancellations of designation as service providers. Second, the promotion of community-based care may be evaluated positively in that the absolute number of home service users and their percentage in the entire service users have increased but those who are badly in need of long-term care still appear to prefer facility services. Third, the promotion of decentralization has troubles because the main operators of the system are towns and villages while the right to control the supply of services lies in provinces and the gap of base insurance premium among localities is getting larger. These show that there are many limitations in promoting decentralization. The results of evaluation as presented above imply that services must be sufficiently quantitatively and qualitatively to make the system user-centered and that there must be an information service system so that users can choose appropriate services. In addition, for the operation of services centering on community-based care, the contents of services and the support system must meet users' needs, and equity with facility service users in insurance coverage and the bearing of expenses must be considered. Lastly, for the promotion of localization, balance among localities is a prerequisite. For this, this study suggests the central government's support in consideration of the characteristics and capacity of each locality, the operation of the system in units of appropriate size, and the establishment of a service supply system.
유산소 운동과 복합 운동 프로그램이 비만 중년 여성의 건강 관련 체력에 미치는 영향
권기욱,백광현 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6
In this research fourteen obese middle-aged women were divided into two groups of Aerobic & Combined Training. After twelve weeks of training, the effects on the body composition, plasma lipids, and strength conditioning of the subjects were evaluated. The results of this study were as follows: 1. While the group of aerobic exercise showed the tendency to decrease in the areas of weight, fat weight and lean body mass, the other group showed the tendency to increase in all the areas. 2. Whereas there wasn't any significant change for the group of aerobic exercise in the fitness factors such as power(sargent jump), muscular endurance(push-ups, sit-ups), agility (side-step, reflex movement), balance(stork stand), flexibility (bend over reach, back- stretch), the group of combined exercise showed significant increase in all the areas. 3. In an isokinetic strength test, the group of aerobic exercise showed the tendency to increase in quadriceps, but tended to decrease in hamstrings. However, the group of combined exercise significantly increased in quadriceps and tended to increase in hamstrings. 4. For the density of plasma lipids, both groups showed the tendency to increase in TC(total cholesterol), to decrease in TG(triglyceride) and both significantly increased in HDL-C(high density lipoprotein cholesterol). The group of aerobic exercise tended to increase in LDL-C(low density lipoprotein cholesterol) but the group of combined exercise tended to decrease. With regards to the changes of the body composition, fitness factors, muscular strength, plasma lipids that have occurred in the obese middle-aged women in this research, a conclusion can be reached that combined training, rather than only an aerobic exercise, is a more effective way of improving fitness factors and muscular strengthas well as losing weight and reducing the risk of coronary disorder.
金基元,文点東,金哲旭 진주산업대학교 1983 論文集 Vol.21 No.-
The status of artificial insemination of Korean cattle, Dairy cattle and Pig was surveyed at Animal farms located Gyeongnam ares during 2 years from Jan. 1981 to Dec. 1982 and The results obtained were summarized as follows: 1. No. head of A. I. by breeds were high in the order of Korean cattle. Dairy cattle and Pig. 2. No. head of A. I. by months were higher than the other months with 42.44% of Korean cattle at 79 months 29.0% Dairy cattle at 1012 months and each 29.7 and 27.28%, Pig at 46 and 1012 months. 3. No. head of A. I. by years were gradually increased as the year passed and these of Korean cattle were incrased with 1.2 times and Dairy cattle 1.1 times, but Pig decreased 4. The conception rate of Korean cattle was 78.46%, Pig 78.38% and Dairy cattle 72.71 and Korean cattle was superior to the others. 5. All the conception rates of the animal surveyed were superior at 46 and 1012 months, but 79 months was lower than the other months.