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Jyun-Pei Jhou,Se-Jie Chen,Ho-Yin Huang,Wan-Wan Lin,Duen-Yi Huang,Shiang-Jong Tzeng 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Resveratrol, an anti-inflammatory agent, can inhibit pro-inflammatory mediators by activating Sirt1, which is a class III histone deacetylase. However, whether resveratrol can regulate inhibitory or anti-inflammatory molecules has been less studied. FcγRIIB, a receptor for IgG, is an essential inhibitory receptor of B cells for blocking B-cell receptor-mediated activation and for directly inducing apoptosis of B cells. Because mice deficient in either Sirt1 or FcγRIIB develop lupus-like diseases, we investigated whether resveratrol can alleviate lupus through FcγRIIB. We found that resveratrol enhanced the expression of FcγRIIB in B cells, resulting in a marked depletion of plasma cells in the spleen and notably in the bone marrow, thereby decreasing serum autoantibody titers in MRL/lpr mice. The upregulation of FcγRIIB by resveratrol involved an increase of Sirt1 protein and deacetylation of p65 NF-κB (K310). Moreover, increased binding of phosphor-p65 NF-κB (S536) but decreased association of acetylated p65 NF-κB (K310) and phosphor-p65 NF-κB (S468) to the − 480 promoter region of Fcgr2b gene was responsible for the resveratrol-mediated enhancement of FcγRIIB gene transcription. Consequently, B cells, especially plasma cells, were considerably reduced in MRL/lpr mice, leading to improvement of nephritis and prolonged survival. Taken together, we provide evidence that pharmacological upregulation of FcγRIIB expression in B cells via resveratrol can selectively reduce B cells, decrease serum autoantibodies and ameliorate lupus nephritis. Our findings lead us to propose FcγRIIB as a new target for therapeutic exploitation, particularly for lupus patients whose FcγRIIB expression levels in B cells are downregulated.
Yi-Wen Lin,Chih-Hsiang Fang,Ya-Jyun Liang,Ching-Yun Yang,Wei-Ting Kuo,Feng-Huei Lin 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Alzheimer’s disease is a neurodegenerative disorder, and Aβ aggregation is considered to be the central process implicated in its pathogenesis. Current treatments are faced by challenges such as serious side effects and reduced drug bioavailability. In this study, we developed a drug delivery system for intramuscular injection that uses cellular activity to achieve constant and long-term drug release. Methods Synthesized mesoporous hydroxyapatite (SHAP) was prepared via co-precipitation, and hydrophobic surface modification using stearic acid was then used to load clenbuterol by physical absorption, thus creating the drug delivery system. Clenbuterol release was achieved through cellular activity, with macrophage uptake triggering lysosome/endosome disruption, cytoplasmic release, extracellular exocytosis, and subsequent systemic circulation. Results We found that clenbuterol-loaded SHAP enabled sustained release for more than 2 weeks and effectively modulated inflammation, reduced Aβ oligomer-induced toxicity, and prevented Aβ aggregation. Conclusions Our findings suggest that treatment with clenbuterol loaded in this SHAP delivery system could be a promising strategy for treating Alzheimer’s disease.
Dehydrochlorination of Plyvinylchloride on the Al-containing Gaphitic-C<sub>3</sub>N<sub>4</sub>
( Song Yi Bae ),( Sung Ho Jyun ),( Dong Hyun Lee ),( Hyeong San Kye ),( Jong Wook Bae ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 3RINCs초록집 Vol.2015 No.-
Polyvinylchloride(PVC) is one of the general-purpose polymers with a lower production cost and it also has an excellent processing characteristics to be properly utilized in the products such as the building timbers and household goods through calendaring and extrusion processes. The lower thermal stability of the waste PVC can generate chlorinated products through the unzipping degradation mechanisms, which can cause severe corrosion problems of equipments during the incineration process. One of the possible chemical recycling routes of the waste PVC is the dehydrochlorination reaction using an environmentally benign solvent. In the present study, graphitic carbon nitrides (g-C<sub>3</sub>N<sub>4</sub>) having abundant Lewis acid sites were prepared by melem-based synthesis method and they were further modified with alumina during the preparation step to verify the activity of dehydrochlorination of waste PVC. The metal-free Al-modified g-C<sub>3</sub>N<sub>4</sub> was found to be stable during dehydrochlorination reaction in the PEG400 medium, and the activity of PVC degradation on the Al-modified g-C<sub>3</sub>N<sub>4</sub> was found to be higher on the 10wt%Al-modifed g-C<sub>3</sub>N<sub>4</sub> due to the proper amount of acid sites by producing HCl selectively.
Unfolding the European Sovereign Debt Crisis
( Chih Mei Luo ),( Jyun Yi Lee ) 한국EU학회 2013 Asia-Pacific Journal of EU Studies Vol.11 No.2
The European sovereign debt crisis emerged from a few euro members being stuck with highdeficits and high-indebtedness, and thus is oversimplified to be referred to as the euro debt crisis. It, in fact, consists of several individual crises with different causes. The Greek crisis was a governance crisis that lacks of fiscal disciple by nature; the Irish and Spanish crises were the bubble crisis of the property sector and banking crisis caused by the US sub-prime crisis; the Italian and Portuguese crises involve more structural and long-term growth crisis. Accordingly, the austerity and the fiscal compact that Germany promoted can only offer partial answers to the end of the crisis. The implementation of fiscal discipline and the resolution of the crisis depend on the provision of economic growth and jobs as well as the establishment of a full-blown fiscal union. With the absence of expansionary fiscal policy and fiscal transfer at the EU level, this paper suggests that the crisis countries should be granted with the manoeuvre of expanding/contracting government spending according to the changes in growth and jobs. The crisis reveals five characteristics: the centrality of Franco-German axis; the specialty of the Greek case; national governments’ triumph over supranational institutions; the convergence of the EU’s economic governance with the German model; the need to address non-fiscal dimensions.
A 3-Gb/s Equalizer with an Adaptive Swing Controller for TFT-LCD Interfaces
Miao-Shan Li,Yen-Chen Lin,Chai-Chi Liu,Ching-Rong Chang,Jyun-Yi Li,You-Sheng Lin,Ching-Yuan Yang 대한전자공학회 2019 Journal of semiconductor technology and science Vol.19 No.1
A 0.18-μm CMOS 3-Gb/s equalizer with an adaptive swing controller is presented for 4K2K large display panels to compensate a 24-dB channel loss. Employing the output-swing control technique, we propose the adaptive loop for the equalizer to improve adaptation accuracy without degrading the boost tuning and input swing ranges. Besides, cascading two bandpass filters (BPF) measured energy in a narrow range is much more accuracy than conventional highpass filters (HPF). The measured jitter of 3-Gb/s and 1.5-Gb/s data are 0.23-UI and 0.356-UI for 1.23-m FR4 board, respectively. The core area occupies 0.12-㎟ and the power consumption is 27-mW at 3 Gb/s from a 1.8-V supply.
Neuroprotective Activity of Vitis thunbergii var. taiwaniana Extracts In Vitro and In Vivo
Chung-Kwe Wang,Lih-Geeng Chen,Chi-Luan Wen,Wen-Chi Hou,Ling-Fang Hung,Shish-Jung Yen,Yi-Jyun Shen,Shyr-Yi Lin,Yu-Chih Liang 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
Vitis thunbergii var. taiwaniana (VTT) is a wild grape native to Taiwan, where it has been used as a folk medicine. In this study, we found that the branch and leaf ethanol extracts of VTT significantly inhibited the inducible nitric oxide (NO) synthase protein expression and NO production in BV2 microglia. Using primary neuronal cells, kainic acid (KA) significantly increased hydrogen peroxide production in a dose-dependent manner. All four ethanol extracts of VTT significantly decreased hydrogen peroxide production. However, only root and branch ethanol extracts were able to prevent the neuronal cell death induced by KA in vitro. In the animal study, administration of all four plant part extracts of VTT delayed the onset of seizure and decreased the hippocampus neuronal cell loss, and the neuroprotective activity could be ranked as follows: branchleaf>root>trunk. The results suggest that VTT extracts have a potential to prevent neurodegeneration through the antioxidative activity by their ability to inhibit NO and hydrogen peroxide production.