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Jun Sung Kim,LEESUBIN,Seung Wan Suh,Jong Bin Bae,Ji Hyun Han,Seonjeong Byun,Ji Won Han,Jae Hyoung Kim,Ki Woong Kim 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.1
Background and Purpose Both hypertension and hypotension increase cerebral white matter hyperintensities. However, the effects of hypotension in individuals with treated hypertension are unknown. We analyzed the association of low blood pressure with the location and amount of white matter hyperintensities between elderly individuals with controlled hypertension and those without hypertension. Methods We enrolled 505 community-dwelling, cognitively normal elderly individuals from the participants of the Korean Longitudinal Study on Cognitive Aging and Dementia. We measured blood pressure three times in a sitting position using a mercury sphygmomanometer and defined low systolic and diastolic blood pressure as ≤110 and ≤60 mm Hg, respectively. We segmented and quantified the periventricular and deep white matter hyperintensities from 3.0 Tesla fluidattenuated inversion recovery magnetic resonance images. Results Low systolic blood pressure was independently associated with larger volume of periventricular white matter hyperintensity (P=0.049). The interaction between low systolic blood pressure and hypertension was observed on the volume of periventricular white matter hyperintensity (P=0.005). Low systolic blood pressure was associated with the volume of periventricular white matter hyperintensity in individuals with controlled hypertension (F1,248=6.750, P=0.010), but not in those without hypertension (P=0.380). Low diastolic blood pressure was not associated with the volumes of white matter hyperintensities regardless of presence of controlled hypertension. Conclusions Low systolic blood pressure seems to be associated with larger volume of periventricular white matter hyperintensity in the individuals with a history of hypertension but not in those without hypertension.
Jun Sung Kim,Jae Hang Lee,Hyoung Woo Chang,김경환 대한흉부외과학회 2011 Journal of Chest Surgery (J Chest Surg) Vol.44 No.1
Background: We evaluated the efficacy of Cox-maze IV procedure using bipolar irrigated radiofrequency ablation and cryothermy in chronic atrial fibrillation associated with valvular heart disease. Material and Methods: From November 2005 to June 2009, ninety four patients have undergone valvular heart surgery with Cox-maze IV procedure. Preoperative duration of atrial fibrillation was 7.6±6.5 years and follow-up duration was 22.7±12.3months. Results: There were two (2.1%) postoperative deaths not related to maze procedure. Two cerebrovascular accidents, five low cardiac output syndromes and two permanent pacemaker implantations have occurred after surgery. Preoperative ejection fraction on echocardiography was 55.3±8.1% and ejection fraction of postoperative six month was 54.7±6.5%. Left atrial size of preoperative and postoperative were 61.5±11.6 mm and 53.1±8.4 mm at each. Freedom from atrial fibrillation rate at postoperative six-month was 80.7% and the cases of recurrence of atrial fibrillation after six months were three (3.3%). Risk factors for failure or recurrence of maze procedure were old age (p=.010) and preoperative moderate or severe tricuspid regurgitation (p=.033). Conclusion: The Cox-maze IV procedure using RFBP2 and cryothermy is quite safe and freedom from atrial fibrillation at postoperative 6month was 82.5%. Risk factors for failure or recurrence of atrial fibrillation after Cox-maze IV were old age and preoperative over moderate tricuspid regurgitation.
Jun-Sung Kim,Jin Hong Park,Sung-Jin Park,Hyun Woo Kim,Jin Hua,Hyun Sun Cho,Soon Kyung Hwang,Seung Hee Chang,Arash Minai Tehrani,Myung Haing Cho 한국독성학회 2005 Toxicological Research Vol.21 No.4
Eukaryotic initiation factor 4E (eIF4E) is a key element for cap-dependent protein translation controlled by affinity between eIF4E and 4E-binding protein 1 (4E-BP1). Rapamycin can also affect protein translation by regulating 4E-BP1 phosphorylation. Tobacco-specific nitrosamine, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a strong lung carcinogen, but its precise lung cancer induction mechanism remains unknown. Relative roles of cap-dependent and -independent protein translation in terms of NNK-induced lung carcinogenesis were elucidated using normal human bronchial epithelial cells. NNK concentrations applied in this study did not decrease cell viability. Addition of NNK restored rapamycin-induced decrease of protein synthesis and rapamycininduced phosphorylation of 4E-BP1, and increased expression levels of mTOR, ERK1/AFG₁, p70S6K, and Raf-1 in a concentration-dependent manner. NNK also caused perturbation of normal cell cycle progression. Taken together, NNK might cause toxicity through the combination of restoration of 4EBP1 phosphorylation and increase of eIF4E as well as mTOR protein expression, interruption of Raf1/ERK as well as the cyclin G-associated p53 network. Our data could be applied towards elucidation of the molecular basis for lung cancer treatment.
인문,사회과학편 : 체육의 부정적 인식 형성에 관한 담론 분석
김준성(JunSungKim),한만석(ManSeokHan),류태호(TaeHoYu) 한국체육학회 2014 한국체육학회지 Vol.53 No.6
본 연구는 대중이 갖는 체육에 대한 부정적 인식의 원인을 규명하고 이로 인해 파생되는 여러 가지 사회현상을 고찰하는데 그 목적이 있다. 이를 위해 페어클로의 비판적 담론 분석(Critical Discourse Analysis)을 활용하였으며 귀납적범주분석의 개념을 적극적으로 차용하여 담론의 범주를 나누고 그 구조를 밝히고자 하였다. 이를 위해 학교교육, 학원스포츠, 스포츠 조직, 직업(계층), 일탈행위, 젠더논리의 6가지 분야를 연구 영역으로 설정하였으며 2000년대 이후192개의 신문기사 중 기사의 반복성, 대표성, 신뢰성을 검토하여 내부 기준에 부합하는 95개 기사를 원자료로 사용하였다. 연구결과 체육담론은 신문을 대표로 하는 미디어의 제도적 장치를 통하여 사람들에게 유포되었고 체육인 및대중 등 관련자들이 해당 담론 내 특정 위치에서 사회를 해석함으로써 실제 체육을 둘러싼 상황을 악화시켰다고 볼수 있다. 이를 통해 담론은 사회를 형성하고 구성하는 동시에, 사회적으로 형성되고 구성됨을 발견할 수 있었다. The purpose of the study is to investigate reasons behind the negative perceptions on physical education and explore relatedsocial phenomena. The study was conducted in the six major areas in sport, where negative news are often reported: physicaleducation, interscholastic sports, sport organizations and governments, classes and strata, deviant behaviors, and gender issues. After reviewing 192 news articles in these six areas, published since 2000, 95 news articles were selected based on importance,repeatability, reprehensibility, and reliability for further analysis. The results show that after the effects of media on theconstruction of negative perception in physical education, the relationships between the discoursive practices and the existinghegemony were investigated. By doing so, the roles of media which interprets and delivers the discourses to people andaggravates the negative perceptions were shown. It was confirmed that the media creates the discourses and recreates thenegative perceptions.