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최준식,유재신,박용채,이진환 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2
This study was attempted to investigate the pharmacokinetic interaction between sodium valproate (4. 8. 16 ㎎/㎏. i.v.) and phenytoin (4 ㎎/㎏. i.v) in rabbits. The plasma concentration and area under the curve (AUC) of phenytoin were increased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (4. 8. 16 ㎎/㎏) in rabbits. The volume of distribution and total body clearance of phenytoin were decreased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (8. 16 ㎎/㎏) in rabbit. From the results of this experiment. it is desirable that dosage regimen of phenytoin should be adjusted and therapeutic drug monitoring should be performed for reduction of side or toxic effect when phenytoin will be coadministered with sodium valproate in clinical use.
최준식,문홍섭,최인,범진필 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2
The purpose of this investigation was to determine pharmacokinetic parameter of gentamicin using nonlinear least square regression(NLSR) and Bayesian analysis in Korea normal volunteers and gastrointestinal surgical patients. Nonparametric expected maximum(NPEM) method for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were 0.226±0.032, 0.231±0.063 L/㎏ and 0.357± 0.024, 0.337±0.041 hr^-1 for normal volunteers and gastrointestinal surgical patients using NLSR analysis. Population pharmacokinetic parameters. KS and VS were 0.00344±0.00049(hr·mL/min/1.73㎡)^-1 and 0.214±0.0502 L/㎏ for gastronintestinal surgical patients using NPEM method. The V and K were 0.216±0.048 L/㎏ and 0.336±0.043 hr^-1 for gastrointestinal surgical patients using Bayesian analysis. There were no differences in gentamicin pharmacokinetic between NLSR and Bayesian analysis in gastrointestinal surgical patient.
전자상거래 서비스품질과 사전이용경험이 이용자 만족 및 구매의사에 미치는 영향
정형식,황준하 한국정보전략학회 2000 한국정보전략학회지 Vol.3 No.1
The objectives of this research are to investigate major factors of Service Quality(SQ), Questionnaires for user interface satisfaction(QUIS), and the effects of these factors, and an interaction effect of prior internet experience on satisfaction and purchase intention. A survey was conducted to collected the data with the questionnaires, 193 questionnaires were used for the analyses. The study results show that consumer perceived SQ and QUIS, and the judgements of a specific shopping mall's product and service in the processes from information search to afterservice affect consumer satisfaction and behavioral intention as hypothesized. Consumers' Internet shopping experience was found to affect behavioral intention interactively with satisfaction. Tangibility and reliability dimensions of service quality were found to be the major factors affecting consumer satisfaction. Also, the dimension of interaction between service provider and consumer in QUIS was a major factor for the satisfaction and behavioral intention. In sum, the results of this research appear to explain consumers' Internet shopping mall behavior. This research offers several implications for Internet marketers and academics.
사례연구: 인터넷 방송의 스트리밍 기술을 이용한 실시간 원격학습 코스웨어 구현
류준식,김상운 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-
In this paper, we design and implement a preliminary system of web-based real-time interactive courseware on a RealServer system by using the webcasting streaming technology and the Javascript language in order to increase of learning effects and its efficiency. From the experiments, it is known that internet service suppliers and client users could interact with each other efficiently in real-time through the implemented courseware.
사질토지반 앵커식 널말뚝 설계를 위한 흙막이 해석법 적용에 관한 연구
양우식,김기웅,장준환 東新大學校 工業技術硏究所 1999 工業技術硏究 Vol.5 No.-
The sheet-pile wall has been generally used as a temporary retaining structure when the underground excavation is performed. The design parameters of sheet-pile wall are penetration depth, anchor pull and maximum bending moment. It was compared the methods of conventional design, using the design charts and bracing system design by analyzing and estimating the design parameters of sheet-pile wall in sand. It was suggested that can be applied the bracing system analysis method to the designing the sheet-pile wall.
성인원외폐렴의 원인미생물에대한 전향적 다기관 연구 : 성인원외폐렴의 원인으로 세균의 역할을 중심으로
우준희,강재명,김양수,신완식,류진홍,최정현,김양리,정희진,어수택,박춘식,정문현,정기석,이찬주,류지소 대한감염학회 2001 감염 Vol.33 No.1
Background : Communite-acquired peumonia (CAP) is one of the leading causes of mortality and morbidity. Despite progress in diagnostic techniques and treatments, management of pneumonia remains challenging, because the precise etiology remains uncertain in as many as 49% of cases. The limitaions of identifying etiologic agents make it necessary to use empiric antibiotics in almost all patients, and furthermore emergence of antibiotic-resistant organisms pose difficulties to the selection of an empiric antibiotic regimen. For the optimal choice of empirical antibiotics, we should know the frequency of etiologic agents and antimicrobial resistance rates in the community. Methods : A prospective multicenter study of community-acquired pneumonia in Korea was carried out between May 1997 and April 2000. The microbiologic diagnosis was based on the results of sputum culture, blood culture and pleural culture. Results : Five hundred eighty eight cases of community-acquired peumonia in 562 patients admitted to the hospitals. The mean age was 59.9 with male predominance (58.3%), and 370 (63%) had underlyin gillness. The etiologic agents were identified in 38.3%, and the list of individual agents, in decreasing order, was Streprococcus pneumoniae (21.7%), Klebsiella pneumoniae (14.8%) Pseudomonas aeruginosa (9.8%), Staphylococcus aureus (9.5%), viridans group streptococci (5.7%), Enterobacter cloacae (4.2%), Hemophillus Influenza (3.8%), The rates of admission to the intensive care unit was 10.4%. The motality was 7.1%. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Forty percents of S. aureus were methicillin-resistant S. aureus. K. penumoniae were susceptible to cephalosporin and quinolone. Conclusion : In Korea, S.pneumoniae is the most important agent causing community-acquired pneumonia. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Gram negative bacteria such as K. pneumoniae, P. aeruginosa showed high incidence when compared with that of other countries. Most of them had underlying diseases including bronchiectasis and chronic obstructive pulmonary diseases. (Korean J Infect Dis 33:1∼7, 2001)
한용식,김명배,최준석 韓國火災ㆍ消防學會 1998 한국화재소방학회논문지 Vol.12 No.3
액체연료들의 열발생율이 산소 소모법에 의해 측정되었다. 산소 소모법은 화재 시에 경험되어지는 대부분의 연료에 대해서 소모된 산소단위 질량당 발생된 열량이 근사적으로 같다는 원리에 기초하고 있다. 산소농도의 측정에는 상자성 방식의 가스 분석기가 사용되었고, CO_2 및 CO가스 농도 측정은 적외선 방식의 분석기에 의해 이루어졌다. 가스 분석기들의 시간지연은 고려하지 않았다. 배기가스 측정방법에 따른 결과들을 비교 검토하였다. The heat release rate of liquid fuels is estimated by oxygen consumption technique. This method is based on the generalization that the heat release rate of combustion per unit of oxygen consumed are approximately the same for most fuels commonly encountered in fires. The oxygen concentration is measured by analyzer of paramagnetic type. The concentrations of CO_2 and CO gas are measured by analyzer of Infra-Red type. Time delays of analyzers are ignored. Results acqired from measuring techniques of exhaust gas concentrations are compared with each other.