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      • 가상공간의 가공 공정과 상태 구현에 관한 연구

        이수훈,김봉석,홍민성,김종민,JUN NI,박상호,송준엽,이창우,하태호 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

        This paper presents virtual machining system in order to realize turning process in virtual space. A reliable virtual turning process simulation was developed based on the surface shaping system which is capable of considering geometric model, thermal error model, and vibration model. Accuracy of surface shape resulting from proposed machining simulator was verified experimentally. This paper also developed the watchdog agent that continuously assessed, diagnosed, and predicted performance of products and machines in machining. The Watchdog agent extracted feature signal using time-frequency analysis among various signals from multi-sensor and evaluated machining condition using performance confidence value.

      • KCI등재

        전통시장 시설현대화사업이 전통시장 활성화에 미치는 영향 분석

        이준호(Lee, Jun-Ho),김영(Kim, Yeong),김경훈(Kim, Kyoung-hun) 한국지역개발학회 2013 韓國地域開發學會誌 Vol.25 No.1

        After full opening of distribution market in 1996, its competitiveness was lost and declined due to the emergence of a variety of distribution types, change of customers consumption habits, and purchase patterns. Therefore, Korean government began to support the modernization projects of traditional markets through the establishment of law for the activation of existing traditional markets. In this regard, this study attempts to diagnose the problems of facility modernization projects through substantial and concrete effect analysis on facility modernization projects to provide the activation methods effectively. To achieve this goal, we analyzed the overall satisfaction and substantial effect of facility modernization projects for traditional markes by carrying out questionnaire surveys on merchants at Jun-gang Yudeung Market in Jinju. As a result of questionnaire survey, customers were generally satisfied with the facility modernization project, the market environment was improved and the customer numbers and sales amount which show the actual improvement also increased after implementing the projects. Also, it was proved that customer numbers and the sales amount after the facility modernization project of traditional markets increased and the degree in the increase was low level of 5~20%. Therefore, it was analyzed that sub-project items of the facility modernization project, which have a significant effect on the activation of traditional markets, had a low level of influence.

      • SCOPUSKCI등재

        In vivo transduction of ETV2 improves cardiac function and induces vascular regeneration following myocardial infarction

        Lee, Sunghun,Lee, Dong Hun,Park, Bong-Woo,Kim, Riyoun,Hoang, Anh Duc,Woo, Sang-Keun,Xiong, Wenjun,Lee, Yong Jin,Ban, Kiwon,Park, Hun-Jun Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.2

        <▼1><P>Vascular regeneration in ischemic hearts has been considered a target for new therapeutic strategies. It has been reported that ETV2 is essential for vascular development, injury-induced neovascularization and direct cell reprogramming of non-endothelial cells into endothelial cells. Thus, the objective of this study was to explore the therapeutic potential of ETV2 in murine models of myocardial infarction in vivo. Direct myocardial delivery of lentiviral ETV2 into rodents undergoing myocardial infarction dramatically upregulated the expression of markers for angiogenesis as well as anti-fibrosis and anti-inflammatory factors in vivo. Consistent with these findings, echocardiography showed significantly improved cardiac function in hearts with induced myocardial infarction upon ETV2 injection compared to that in the control virus-injected group as determined by enhanced ejection fraction and fractional shortening. In addition, ETV2-injected hearts were protected against massive fibrosis with a remarkable increase in capillary density. Interestingly, major fractions of capillaries were stained positive for ETV2. In addition, ECs infected with ETV2 showed enhanced proliferation, suggesting a direct role of ETV2 in vascular regeneration in diseased hearts. Furthermore, culture media from ETV2-overexpressing cardiac fibroblasts promoted endothelial cell migration based on scratch assay. Importantly, intramyocardial injection of the adeno-associated virus form of ETV2 into rat hearts with induced myocardial infarction designed for clinical applicability consistently resulted in significant augmentation of cardiac function. We provide compelling evidence that ETV2 has a robust effect on vascular regeneration and enhanced cardiac repair after myocardial infarction, highlighting a potential therapeutic function of ETV2 as an efficient means to treat failing hearts.</P></▼1><▼2><P><B>Cardiovascular disease: New hope for healing the heart</B></P><P>A gene therapy strategy that stimulates cardiovascular repair could improve recovery for heart attack patients. Heart attacks inflict severe damage on the heart and blood vessels, tissues with limited capacity for self-repair. Researchers led by Kiwon Ban of the City University of Hong Kong and Hun-Jun Park of the Catholic University of Korea, Seoul, have now demonstrated that a gene responsible for cardiovascular development can also efficiently stimulate heart repair. They used viruses to deliver the gene into a mouse model of heart attack, and showed that treated heart tissues exhibited strong recovery relative to untreated controls. The treatment reduced scar tissue formation and promoted proliferation of the cells lining blood vessels and blood vessel formation, measurably improving heart function. This approach could lay the groundwork for treating a common potentially fatal event.</P></▼2>

      • SCIESCOPUSKCI등재
      • SCIESCOPUSKCI등재
      • KCI등재
      • 국내에서 분리된 Aujeszky's Disease Virus의 면역원성 : Ⅰ. Aluminum Hydroxide겔 흡착 불활화 Aujeszky's Disease Virus항원의 면역원성 Ⅰ. Immunogenicity of the Inactivated Aujeszky's Disease Virus with Aluminum Hydroxide Gel Adjuvant

        전무형,이헌준,박정우,안수환 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

        Aujeszky's disease virus(ADV), NYJ-1 strain, isolated from the diseased piglets in Korea was inactivated with binary ethyleneimine or formalin and absorbed in aluminum hydroxide gel. Safety and humoral and cellular immunogenicity of the antigens were investigated in mouse, guinea pig and piglets. In mouse inoculation test, the antigens showed 100% of safety and induced a significant level of ADV antibody. The protective potency following intracerebral challenge with the virulent ADV at 10^7.5TCID_50/0.2㎖ were 60% to 64.3%. In guinea pig inoculation test, it was found that the antigens were quite safe, inducing 63.2 to 124.9 of virus neutralization(VN) titers at the 5th week post inoculation(pi). The protectivity of the antigens against the challenge of the virulent ADV were 62.5% to 75.0%. In piglet inoculation test, the antigens were quite safe after the primary and booster injections, and induced 28.7 to 39.1 of VN titers at the 5th week pi. The high levels of ADV antibodies were also recognized by agar gel precipitation test, latex agglutination test and immunoenzyme assays. Leucocyte adherence inhibition(LAI) test for the piglets revealed 22.3±3.8% to 32.8±6.9% of LAI index at the 4th week pi, and the evident reactions of delayed type hypersensitivity was observed in subcutaneous inoculation of the antigen to the immunized piglets. Following the challenge, the immunized piglets showed none of specific clinical signs of AD and revealed the higher gain of body weight, and the lower secretion of ADV from the nasal cavity as compared with the control group.

      • 초등학교 교사의 창의적 행동기능 요인 인식 연구

        전헌선,박순길 大邱大學校 師範大學 附設 敎育硏究所 2010 學校敎育硏究 Vol.6 No.1

        본 연구는 초등학교 교사들이 창의적인 성격 및 동기 요소에 대하여 유전, 성격, 그리고 사회적 요인에 따라 어떻게 인식하고 있는가를 알아보고, 나아가 창의적 성격 및 동기 형성 요소에 대한 요인별 인식의 특징을 알아보는데 목적이 있었다. 연구의 대상은 D광역시 초등학교 교사 34명 이었고, 연구의 도구는 “창의적 행동 기능 요인 인식” 설문지를 활용하였다. 연구의 결과와 해석을 토대로 얻어진 결론은 다음과 같다. 첫째, 초등학교 교사들은 창의적 행동 특성이 성격 요인, 사회적 요인, 그리고 유전 요인의 순으로 영향을 미친다고 보고 있다. 둘째, 초등학교 교사들은 창의적 성격과 동기 요소 중에서 유전요인은 “열성적, 정력적, 철저함”요소를 높게 인식하고, “독립심, 반항심, 자신감”요소를 낮게 인식하고 있다. The purpose of this study was to investigate the factor recognition for the creative behavior skills of the elementary school teachers. The subjects of this study were 34 elementary school teachers in Daegu. The collected data were analyzed by SPSS/12 versions program. The t, F and x2 test were applied to analyze the data. The results of this study were as follows; First, elementary school teachers were to recognized according to personality factor, social factor, and heredity factor for the creative behavior skills. Second, elementary school teachers were to recognized higher to the “hearty, vigorous, through”, and lower to the “independent spirit, rebellious spirit, self-confidence” in the creative personality and motivation factor.

      • KCI등재

        재택·순회 교육의 동향과 교수-학습 방법의 모색

        전헌선 대구대학교 특수교육재활과학연구소 2000 특수교육재활과학연구 Vol.39 No.2

        본 연구는 중도·중복 장애아를 위한 교육권 확보와 교육의 적절성 보장이란 시대적 가치를 실현하는데 목표를 둔 재택·순회 교육의 최근 동향을 분석하고, 중도·중복 장애 아동이 필요로 하는 최소한의 행동 기능을 훈련하는 재택·순회 교욱의 효율적인 방안을 모색하는데 목적이 있다. 연구의 결과와 고찰을 통하여 다음과 같은 결론을 도출하였다. 첫째, 중도·중복 장애아 재택·순회 교육의 목표는 학교 복귀에 있다. 둘째, 중도·중복 장애아에게 필요한 교육 내용은 학교가 필요로 하는 '최소한의 행동 기능'이다. 셋째, 중도·중복 장애아 재택·순회 교육은 치료 교육 활동 중심으로 교육 과정이 운영되어야 한다. 넷째, 재택·순회 교육은 사례 연구 중심의 교육 방법이 적용되어야 한다. The purpose of this study was to investigate the trend and teaching - learning method of the children with severe - multiple disabilities for residential and itinerant education. The results of this study were as follows ; First, the objective of residential and itinerant education for the severe - multiple disabilities was return to school. Second, the specail education needs of the severe - multiple disabilities were least behavior skills of school living. Finally, residential and itinerant education was to apply educational method of the case study oriented.

      • 선택적 치료 교육 활동의 실행 방안

        전현선 大邱大學校 特殊敎育·再活科學硏究所 2000 特殊敎育硏究 Vol.23 No.1

        본 연구는 선택적 치료 교육 활동의 실행 방안을 모색하기 위하여 학생 중심, 수요자 중심, 수행 능력 중심의 치료 교육 활동의 구성 체제, 전개 방안, 그리고 운영 방안을 알아보는데 목적이 있었다. 연구의 결과와 논의를 토대로 내린 결론은 다음과 같다. 첫째, 학생 중심의 치료 교육 활동은 이들의 독특한 교육적 욕구를 충족시켜 주는 가장 적절한 수업을 보장하는 교육 체제이어야 한다. 둘째, 수요자 중심의 선택적 치료 교육 활동을 전개하기 위해서는 개별화 교육 계획, 개별화수업 계획이 수립되어 수요자의 선택이 보장되는 교육 체제이어야 한다. 셋째, 수행 능력 중심의 선택적 치료 교육 활동은 개인 학생의 능력을 토대로 계속적인 성공감이 보장되는 교육 체재이어야 한다. Therapeutic educational service is activity promoting education for the whole man, maintainenance of unlimited life, recovery of physiological self-control function, supplement of disability and recovery of life skills. The purpose of this study was to investigate execution plan of selected therapeutic educational service for the student with disabilities. The results of this study were as follows ; First, therapeutic educational service of student centered were promoting education for the whole man and appropriate subject lesson activity and special activity to students with' unique educational needs' in order to practice an idea. Second, therapeutic educational service of consumer centered should be performed selectively according to individual character of student with disability. Finally, therapeutic educational service of competence centered should be able to perform competence centered selected therapeutic educational service according to feature and degree of severity. Therefore, Therapeutic educational service was education activity. Teacher should practice it through play, exercise, and occupation according to character of student, and carry out instruction slowly, safely, and naturally.

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