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殘留應力을 考慮한 鎔接材의 疲勞龜裂 進展擧動에 關한 硏究
최병기,이을호,국중민,기준호,임선빈,정장만 朝鮮大學校 機械技術硏究所 2000 機械技術硏究 Vol.3 No.1
The effect of welding residual stress on the initiation and propagation of fatigue crack is investigated so as to study the fatigue behavior in welding residual stress field. Especially, the relation between welding residual stress and fatigue crack opening behavior is investigated and the redistribution of residual stress as a fatigue crack propagates is examined. Following results are obtained. 1) In case of the load range is constant, as the stress ratio is changing to 0.1, 0.33, 0.5 the propagation life is constant but the growth life decreases. And than, when maximum load or minimum load is constant, as the stress ratio increases the growth life and propagation life increase. 2) The fatigue crack propagations rate da/dN appears to accelerate when the stress intensity factor range ΔK is less than 15MPa-m^1/2. 3) The residual stress that is appeared by welding decreases after cutting. 4) Fatigue crack propagation ratio is affected by tensional and compressible residual stress at the initial time, but it's similar to the original in the more than 20mm of crack length.
Newly Developed Multiple Myeloma in a Patient with Primary T-Cell Lymphoma of Bone
Jun Eul Hwang,조상희,Ok Ki Kim,Hyun Jeong Shim,Se Ryeon Lee,Jae Sook Ahn,양덕환,김여경,이제중,김형준,정익주 대한의학회 2008 Journal of Korean medical science Vol.23 No.3
Primary non-Hodgkin’s lymphoma of bone (PLB) is rare, and generally presents as a single extensive and destructive bone lesion. Histopathologically, most cases present as diffuse large B-cell lymphoma, and T-cell lymphoma is rare. By contrast, multiple myeloma is a disease defined as the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. We report a case of multiple myeloma that developed during treatment of PLB in a type of T-cell. A 48-yr-old man was diagnosed as T-cell PLB, stage IE, 18 months ago. The patient received the chemoradiotherapy and salvage chemotherapy for PLB. However, the lymphoma progressed with generalized bone pain, and laboratory findings showed bicytopenia and acute renal failure. On bone marrow biopsy, the patient was diagnosed as having multiple myeloma newly developed with primary T-cell lymphoma of bone. In spite of chemotherapy, the patient died of renal failure.
Jun Eul Hwang,Ju-Young Yoon,Woo Kyun Bae,Hyun Jeong Shim,Ik Joo Chung 대한부인종양학회 2012 Journal of Gynecologic Oncology Vol.23 No.1
Cancers of an unknown primary site are heterogenous with respect to their clinical and pathologic features. They are generally very aggressive, but specific favorable subsets have a better prognosis. For these favorable subsets, taxane based chemotherapy is very effective for a subset of woman with papillary serous peritoneal adenocarcinoma. A 52 year-old woman underwent [^(18)F]- FDG PET/CT for routine health screening. On PET/CT, multiple hypermetabolic lymph nodes were detected in the paraaortic spaces, and there were no other hypermetabolic abnormalities. The patient was diagnosed with an unknown primary cancer that probably originated from the ovary or peritoneum, according to clinical studies and biopsy results. This was not a typical case of a favorable subset of cancer of an unknown primary site, but the tumor showed complete biologic response to taxane based chemotherapy as revealed by PET/CT, and necrotic tumor cells were confirmed by surgery.
전병을(Jun Byung-Eul),박동조(Park Dong-Jo) 대한전자공학회 1992 대한전자공학회 학술대회 Vol.1992 No.10
A novel steepest descent adaptive filter algorithm, which uses the instantaneous stochastic gradient for the steepest descent direction, is derived from a newly devised performance index function. The performance function for the new algorithm is improved from that for the LMS in consideration that the stochastic steepest descent method is utilized to minimize the performance index iterativly. Through mathmatical analysis and computer simulations, it is verified that there are substantial improvements in convergence and misadjustments even though the computational simplicity and the robustness of the LMS algorithm are hardly sacrificed. On the other hand, the new algorithm can be interpreted as a variable step size adaptive filter, and in this respect a heuristic method is proposed in order to reduce the noise caused by. the step size fluctuation.
황준일 ( Jun Eul Hwang ),우학 ( Hak Woo ),김상호 ( Sang Ho Kim ),이우석 ( Woo Seok Lee ),황재하 ( Jae Ha Hwang ),김정철 ( Jung Chul Kim ),조덕 ( Duck Cho ),박정진 ( Jeong Jin Park ),이신석 ( Shin Seok Lee ),박용욱 ( Yong Wook Pa 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.2
Necrotizing fasciitis is a life-threatening soft tissue infection involving skin, subcutaneous tissue, and superficial fascia. We report a case of necrotizing fasciitis that developed in a 76-year-old female patient taking low-dose methotrexate and prednisolone for rheumatoid arthritis (RA). A computed tomography scan of the neck during the initial work-up showed soft tissue swelling, loss of fat planes, and mild heterogeneous enhancement in the right lateral neck, suggesting cellulitis. The lesions were associated with skin necrosis and multiple bullae rapidly expanded to the right anterior chest in spite of empirical antibiotic therapy. Surgical debridement was immediately performed, and soft tissue biopsy from the lesions showed the pathologic finding consistent with necrotizing fasciitis. The skin wound defect was reconstructed by a flap operation with split-thickness skin graft. This case shows the development of necrotizing fasciitis in a elderly patient taking methotrexate and low-dose steroid for RA and highlights early recognition and prompt surgical debridement for successful management.
Byung-Eul Jun 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10
The dynamics of rolling airframes with a single plane of control surfaces shows periodic properties. This paper introduces an acceleration control law for the rolling airframes. An analysis shows that the nonlinear part of the proposed control law works as an effective integrator on acceleration errors in the sense of averaging cycles of rolling. The control law can be considered as a type of repetitive control, but it does not need any a priori information on the period of control signals. Simulations for an example confirm the performance of the control systems.
혈액종양 : 암 환자에서 염산히드로모르폰 서방정의 효과와 내약성에 대한 연구
황준일 ( Jun Eul Hwang ),김대은 ( Dae Eun Kim ),김하나 ( Ha Na Kim ),윤주영 ( Ju Young Yoon ),배우균 ( Woo Kyun Bae ),심현정 ( Hyun Jeong Shim ),조상희 ( Sang Hee Cho ),정익주 ( Ik Joo Chung ) 대한내과학회 2011 대한내과학회지 Vol.80 No.3
목적: 암성통증은 흔한 증상 중 하나로 진통제를 이용한 통증 조절은 환자의 통증 강도에 따른 적절한 약물 선택이 중요하다. 염산히드로모르폰 서방정은 합성 마약성 진통제의 하나로 2006년에 개발된 1일 1회의 강한 마약성 진통제이며, 현재까지 기존의 마약성 진통제를 사용하던 환자를 대상으로 진행된 임상 연구 결과는 있으나, 마약성 진통제 투약 경험이 없는 환자에게서 염산히드로모르폰 서방정을 이용한 암성 통증 조절에 대한 임상 자료는 없다. 그러므로 강한 마약성 진통제 투약 경험이 없는 암환자에 대한 염산히드로 모르폰 서방정의 유효성과 안전성을 알아보고자 하였다. 방법: 20세 이상의 중등도(NRS 4) 이상의 통증을 호소하며 최근 한달 이내에 강한 마약성 진통제 투약 경험이 없는 환자를 대상으로 염산하이드로모르폰서방정 8 mg으로 투약을 시작한다. 용량 조절은 매 2일 간격으로 하며 지난 24시간 동안 4회 이상의 돌발성 통증 치료제 투약이 있었던 경우 시험약의 용량을 증량한다. 다만 이상 반응으로 인해 용량의 증가가 의학적으로 바람직하지 않다고 판단될 경우 현재 투약 중인 용량을 유지하거나 중단 혹은 낮출 수 있다. 돌발성 통증 치료제 이외의 다른 마약성 진통제는 사용하지 않는다. 평가 변수로 1차 방문과 마지막 방문에서의 지난 24시간 NRS 감소정도(%) (baseline에서 NRS minus 마지막 방문에서의 NRS/baseline에서 NRS), 연구기간 동안 지난 24시간 NRS 변화 추이, 1차 방문 이후 안정적인 통증 조절에 도달하는 피험자 비율(안정적인 통증 조절: 연속 2일 동안 지난 24시간 평균 통증 강도가 NRS 3 이하로 유지되고 돌발성 통증 마약성 진통제 투약 횟수가 3회 이하인 경우) 등을 보고자 하였다. 또한 부작용, 피험자 만족도, 연구자의 평가 등도 알아보고자 하였다. 결과: 총 23명의 고형암 환자가 참여하였고, 그 중 3명이 탈락 되었다. 22명(95.7%)의 환자가 4기 환자였다. 1차 방문과 마지막 방문에서의 지난 24시간 NRS 감소정도(%)는 59%로 현저한 감소를 보였다. 연구기간 동안 지난 24시간 NRS 변화 추이도 1차 방문시 4.4에서 3차 방문 시 1.8로 감소를 보였다. 또한 1차 방문 이후 안정적인 통증 조절에 도달하는 피험자 비율은 100%였다. 부작용은 여느 다른 마약성 진통제의 부작용과 유사하였으며, 통증 치료에 대한 피험자의 만족도는 매우 만족 26.1%, 만족 47.8%를 보였고, 시험자의 전반적인 평가 또한 대단히 효과적 43.5%, 효과적 30.4%를 보였다. 결론: 염산히드로모르폰 서방정은 1일 1회 복용의 마약성 진통제로 강한 마약성 진통제 투약경험이 없는 환자에서 암성 통증 조절에 매우 유효하고 안전하다고 하겠다. Background/Aims: OROS hydromorphone is a synthetic opioid agent. While clinical studies have tested its effectiveness at controlling cancer-associated pain in patients who have received other strong opioids, no clinical studies have tested its effectiveness at managing cancer pain in strong opioid-naive patients. We performed the present study to evaluate the efficacy and tolerability of OROS hydromorphone in strong opioid-naive cancer patients. Methods: We administered OROS hydromorphone to patients who had not received strong opioids during the previous month. The starting dose was 8 mg/day. The dose was increased every 2 days in patients who experienced more than four episodes of breakthrough pain per day (more than four times in patients being treated with short-acting opioids). We evaluated the efficacy, safety and tolerability of ORS hydromorphone. We also evaluated patient satisfaction and investigators` global assessments. Results: We enrolled 23 patients to the study. The decrease in the numeric rating scale (NRS) was 59%. NRS variation had decreased markedly during the previous 24 h. All patients achieved stable pain control. The side effects were similar to those of other strong opioids. In total, 26% of patients were very satisfied with the treatment and 47% satisfied, and 74% of the investigators deemed OROS hydromorphone to be very effective or effective at controlling cancer pain. Conclusions: OROS hydromorphone is an osmotically driven, controlled-release preparation that is very effective and safe when administered once daily to strong opioid-naive cancer patients. (Korean J Med 2011;80:317-322)
인삼으로 오인하여 섭취한 후 발생한 자리공 뿌리 중독 4례
배준호 ( Jun Ho Bae ),김가을 ( Ga Eul Kim ),김기중 ( Gi Joong Kim ),이두현 ( Doo Hyun Lee ),이준열 ( Jun Yeol Lee ),정대진 ( Dae Jin Jeong ),김윤성 ( Yoon Seong Kim ),박찬우 ( Chan Woo Park ),이희영 ( Hui Young Lee ),조준휘 ( Jun 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.2
Poisoning by Phytolacca esculenta commonly occurs by misidentification as other edible plants. The root of Phytolacca esculenta is similar to other roots, such as kudzu, balloon flower, codonopsis lanceolata, and ginseng. The author experienced four cases of Phytolacca esculenta intoxication due to misidentification as a ginseng. We report on these cases with a review of the literature.