Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in Mice

Choi, Jun-Ho,Kim, Dong-Wook,Yun, Nari,Choi, Jae-Sue,Islam, Md. Nurul,Kim, Yeong-Shik,Lee, Sun-Mee American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.5

<P>In this study, the hepatoprotective effects of hyperoside (<B>1</B>), a flavonoid glycoside isolated from <I>Artemisia capillaris</I>, have been examined against carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with vehicle or <B>1</B> (50, 100, and 200 mg·kg<SUP>−1</SUP>) 30 min before and 2 h after CCl<SUB>4</SUB> (20 μL·kg<SUP>−1</SUP>) injection. Levels of serum aminotransferases were increased 24 h after CCl<SUB>4</SUB> injection, and these increases were attenuated by <B>1</B>. Histological analysis showed that <B>1</B> prevented portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia. Lipid peroxidation was increased and hepatic glutathione content was decreased significantly after CCl<SUB>4</SUB> treatment, and these changes were reduced by administration of <B>1</B>. Protein and mRNA expression of tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) and nuclear protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2) significantly increased after CCl<SUB>4</SUB> injection. Compound <B>1</B> suppressed TNF-α, iNOS, and COX-2 protein and mRNA expression and augmented HO-1 protein and mRNA expression and Nrf2 nuclear protein expression. These results suggest that <B>1</B> has protective effects against CCl<SUB>4</SUB>-induced acute liver injury, and this protection is likely due to enhancement of the antioxidative defense system and suppression of the inflammatory response.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-5/np200001x/production/images/medium/np-2011-00001x_0006.gif'></P>

혈액투석 환자의 가성 고칼륨혈증

최창렬,조형도,강태영,이준수,한호,정청일,이동규,유준호,한상웅,김호중 대한신장학회 2001 대한신장학회잡지 Vol.20 No.5

7두의 개에서 배설성 요로조영술을 통한 신장 기능 평가

최윤정,이기자,최형준,이용진,박성준,송근호,정성목,최호정,이영원 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

Excretory urography is a type of contrast study used to verify and localize upper urinary tract disease. It is an inexpensive and easy way to visualize of anatomic and functional status of the kidney and has been used as a primary imaging modality for the evaluation of urinary tract abnormalities. We describe urological signs of 7 dogs who examined with excretory urography and ultrasonography. Six cases were referred to veterinary medical teaching hospital. Chungnam national university (VMTH, CNU) to evaluate renal function after the treatment for renal failure and one case was referred showing hematuria. In case 1, 2 and 4, blood test and urinalysis was normal and the results of excretory urography presented that renal function were normal range. In case 3, the results of urinalysis, ultrasonography, and excretory urography except blood test presented abnormal kidney and hydronephrosis was diagnosed. In case 5 and 6, blood test, urinalysis, ultrasonography and excretory urography indicated renal failure. In case 7, blood test, urinalysis and ultrasonography presented partially abnormal signs, however, the results of excretory urography was normal range.

단기간의 금연과 일회성 유산소 운동이 흡연자의 심혈관 반응에 미치는 영향

송준경(Jun Kyung·choi),최현민(Hyun Min Choi),김종경(Jong Kyung Kim),노호성(Ho Sung Nho) 한국사회체육학회 2012 한국사회체육학회지 Vol.0 No.48

The purpose of this study was to investigate cardiovascular responses to a bout of aerobic exercise and acute smoking cessation in smoker. nine collegiate male smoker who have been smoking(duration of smoking: 7.5 ± 0.9yrs; number of cigarettes per day: 15.5 ± 1.5) participated in this study. All subjects performed PEI to stimulate Group IV metaboreceptor at immediately after smoking, 24hours after smoking cessation and smoking after a bout of aerobic exercise. they were measured SBP, DBP, HR, SV, CO, TVC using by finometer(FMS co, Netherland). As a result, compared to immediately after smoking, SBP, DBP, and MAP were significantly decreased 24-hours after smoking cessation at rest and PEI(p<0.05). In addition, smoking after a bout of aerobic exercise caused by post-exercise hypotension indicated that SBP was significantly decreased compared to immediately after smoking(p<0.05). also, the changes in DBP and MAP at rest and handgrip exercise were significantly smaller compared to immediately after smoking(p<0.05). Thus, the results showed that smoking cessation during 24-hours and a bout of aerobic exercise relieve excess blood pressure response and enhanced arterial baroreflex in collegiate male smoker. It is concluded that caused exercise pressor reflex by stimulated Group IV may be effective to improve excess blood pressure responses.

간 이식 환자에서 발생한 파종성 Scedosporium apiospermum 감염 1예

박현구,최성호,강호석,송주형,정지훈,소민욱,최상호,김양수,우준희 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

저자들은 다발성 뇌 농양을 동반한 치명적인 파종성 S. apiospermum 감염이 발생한 간 이식 환자를 경험하였다. 본 증례의 환자는 voriconazole로 치료하는 호전경과를 보이다가 진균성 뇌 동맥류 파열로 사망하였다. S. apio-spermum은 비교적 드문 진균으로 병리학적으로 Aspergillus spp.와 매우 유사하고 amphotericin B에 내성을 나타내므로 진단과 치료가 적절하게 이루어지지 못할 가능성이 많고 면역 기능 저하 환자에서 혈행성 전파를 통한 파종성 감염이 용이하게 발생하므로 높은 사망률을 나타낸다. 이식 환자를 비롯한 면역 기능 저하 환자에서 진균감염이 의심될 때 S. apiospermum과 같은 드문 진균에 의한 감염증도 감별진단에 포함해야 하겠다. Sedosporium apiospermum is a saprophytic fungus commonly found in soil and polluted water. This organism is known as a cause of mycetoma, which may occur in immunocompetent hosts following trauma. However, in immunocompromised patients, S. apiospermum can also cause life-threatening invasive disease, including central nervous system infection or disseminated infection. We report a fatal case of disseminated S. apiospermum infection in a 46-year-old woman after liver transplantation. Eight days postoperatively, she developed pneumonia, followed by altered mentality in the 15 days. A head CT demonstrated multiple brain abscesses. Sputum and stereotactic-aspirated brain abscess culture yielded S. apiospermum. Despite treatment with voriconazole, the patient died of intracranial hemorrhage.

해수유동모델 결과의 3차원 가시화를 위한 GUI 구현

최우정,박성은,이원찬,구준호,서영상,김태현 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.3

해수유동모델 결과를 3차원적으로 가시화하기 위한 그래픽 유저 인터페이스를 구축하는 과정에서 지리정보시스템(GIS) 기술을 활용하였다. 연안역 관리에서 GIS 기법은 산재되어 있는 방대한 자료들을 저장하고 이를 3차원으로 가시화하는 기능을 제공하며 해석적, 통계적, 모델링 도구로써 주어진 상황에 적합한 데이터 변환이 가능하도록 해준다. 해수유동모델은 개방경계에서 조석, 바람, 수온, 염분, 강물 유입 및 태양복사 등과 같은 모델입력값을 부여함으로써 구동되며 대상해역은 진해만으로 하였다. 녈 연구에서는 국산 GIS 소프트웨어인 GeoMania (v2.5)를 사용하여 진해만을 대상으로 시뮬레이션된 해수유동모델 결과의 3차원 가시화 모듈을 구축하였다. This study presents an application of GIS technologies to construct the graphic user interface for 3-dimensional exhibition of the results obtained by ocean hydrodynamic model. In coastal management studies, GIS provide a receptacle for scattered data from diverse sources and an improvement of the 3D visualization of such data. Within the frame of a GIS a variety of analytical, statistical and modeling tools can be applied to transform data and make them suitable for a given application. A 3D hydrodynamic model was driven by time-dependent external forcing such as tide, wind velocity, temperature, salinity, river discharge, and solar radiation under the open boundary condition. The Jinhae bay was selected as a case study. Here, we have used GeoMania v2. 5 GIS software and its 3D Analyst extension module to visualize hydrodynamic model result that were simulated around the Jinhae bay.

CGI 프로그램에서 클라이언트와 서버의 자동화된 상태정보 전달

최준용,유진호,장종표,방만원 木浦大學校 情報産業硏究所 1997 情報産業硏究誌 Vol.5 No.-

The HTTP Protocol composed of WWW's client/server model is unconnected and not keep state, so, there is one connection for one request. In this condition, it has no guarantee to memory which is needed in sequential processing, and HTTP Protocol has no choices to transfer the information from client to server's CGI or the information exchange. This paper uses the word 'key' instead of this 'state information'. We studied the key which creates automatically the HTML document for data search hierarchically in WWW environment and to confirm applied this to multimedia order and sale system of agricultural and marine products.

복합 치아종에 관한 증례보고

최형준,최병재,손흥규,양호정 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.2

The odontoma is relatively a common odontogenic tumor. It has come to mean as a growth in which both the epithelial and the mesenchymal cell exhibit complete differentiation, with the result that functional ameloblast and odontoblast form enamel and dentin. The etiology of it is unknown, but it has been suggested that local trauma or infection may lead to the production of such a lesion. Odontma is divided into 2 types. One is compound odontoma that is at least superficial anatomic simiarity to normal teeth, and the other is complex odontoma, that calcified dental tissues are simply an irregular mass bearing no morphologic similarity even to rudimentary teeth. Somtimes this malformation is not easily identified because its lacking of calcification. So, if permanant tooth is delayed to erupt, one should take a careful look the radiographic film to find that whether the cause of it is odontoma or not. In this case report, 3 patients with odontoma who visited Dept. of Pediatric Dentistry in Yonsei Dental College, were treated by means of surgical removal. The obtained results were as follows: 1. The odontoma is usually related to impacted tooth, and it is occurred neighboring to the crown of impacted tooth that have normally developed. So, in the case of missing tooth and delayed eruption, its presence should be investigated. 2. The odontoma can be seen vaguely radiographically, so, it is difficulty to make diagnosis. 3. The treatment of odontoma is a surgical removal. And, if it is completely removed, its occurrence is rare. 4. In the case of impacted tooth being associated with compound odontoma, continuous management is necessary for the eruption of impacted tooth after the surgical extraction of odontoma. 5. It resembles the ameloblastic odontoma radigraphically, and if it is the case, the treatment may vary, so the confirmation through histologic examination after removal of mass is necessary.

성인들의 사회인구학적 특성에 따른 체육활동 욕구에 관한 연구

최종삼,문준혁,박경호 龍仁大學校 體育科學硏究所 2001 體育科學硏究論叢 Vol.11 No.1

To investigate adults' desire for sport activities in accordance with their socio-demographic features, we selected a population of (a total of 600 persons) adult males and females who engage in physical activities at physical facility in Yongin, Gyeonggi Among them, those who were finally surveyed were 552 persons, and as a result of analyzing the collected data, we drew the following conclusion. First, for adults' desire for physical activities according to sex, all the seven factors showed statistical differences, and adult male, compared to adult female, showed higher desire for the subordinate factors of physical activities, such as achievement, ecstasy, pursuit, social motivation, healthy physical strength, purification, and adventure. Secondly, adults' desire for physical activities according to age showed statistically significant difference in all the seven factors. Those over 20 old years showed higher desire for physical molding, pursuit of joy and adventure, achievement, and healthy physical strength, those over 30 showed a high average as a whole, and those over 40 showed higher desire in the factors including healthy physical strength, physical molding, and pursuit of ecstasy. Thirdly, for adults' desire for physical activities in accordance with their education level, it showed statistically significant difference in terms of achievement, pursuit of ecstasy, social motivation, motivation, healthy physical strength, pursuit of adventure, and physical molding. Those with diploma less than the high-school showed high desire for physical activities in terms of healthy physical strength, social motivation, pursuit of joy, and physical molding, and those with diploma over the high-school and university showed high desire for physical activities, except for purification. Fourthly, adults' desire for physical activities in accordance with life standard showed statistically significant difference in such factors as achievement, pursuit of ecstasy, social motivation, healthy physical strength, purification, and physical molding. Upper class showed high desire for physical activities in all the seven factors; middle class showed low desire for physical activities in social motivation and purification; and lower class showed high desire for physical activities in healthy physical strength, pursuit of ecstasy and adventure, and purification.

IMT-2000 송신기 RF 시스템 설계 및 성능 분석

최호준,지만구,김학선 한밭대학교 산업과학기술연구소 2001 논문집 Vol.5 No.-

In this paper, the RF system of IMT-2000 transmitter is designed and analyzed. We derived RF system requirements of minimum performance for IMT-2000 transmitter from analysis of test condition in 3GPP standard(3GPP TS 34.121(v.3.2.0)) and 3GPP2 standard (TIA/EIA/IS-98-C). Using RF system requirements of minimum performance, RF system of W-CDMA and cdma2000 transmitter is designed. Maximum and minimum output power test, spurious emission test, intermodulation test is simulated to a performance analysis. and then, we performed optimization on the parameter value of power amplifier that severely affect the system performance. Simulation results for W-CDMA and cdma2000 are presented.