3大營養素가 흰쥐 十二指腸의 Goblet Cell에 미치는 影響

노영복,정주현,문정석 順天鄕大學校 1979 의대논문집 Vol.4 No.-

In our experiments we made use of male and female Swiss albino rats weighing about 60gm each for the sake of investigating the duodenal goblet cells which mostly bring about secretory work. The mice fed on three unbalanced diets consisting mostly of carbohydrate, protein and fat were the chief objects of study. on the 20th day after feeding, and after one or three-day fasting, Specimens were taken from the upper, middle and lower portions of the duodenum. tne specimens were fixed in 10% formalin and made into paraffin sections of 5μ and stainings were done with Hematoxylin-eosin. all of the goblet cells in each 20 crypts and villi, baths of which were cut in the axial directions were counted and averaged numbers were considered as total relative number of one animal. The results were gained as follows: 1. The relative number of the goblet cells in the duodenum of the mice fed 'on normal food averaged 22.5. these cells were found more in the villi than in the crypts. 2. The relative number of the goblet cells in the mice fed on fat was larger than the normal value, and was tne largest in the three groups fed on unbalanced diets. 3. The protein diet group was the smallest value among three groups. 4. The group's goblet cells fasting 1-day increased a little in number relative to the normal. 5. The group's goblet cells fasting 3-days increased the most in number of all groups.

3大營養素가 흰쥐 十二指腸의 Goblet Cell에 미치는 影響

노영복,정주현,문정석 朝鮮大學校 醫學硏究所 1979 The Medical Journal of Chosun University Vol.- No.-

In our experiments we made use of male and female Swiss albiro rats weighing about 60gm each for the sake of investigating the duodenal goblet cells which mostly bring about secretory work. The mice fed on three unbalanced diets consisting mostly of carbohydrate. protein and fat were the chief objects of study. on the 20th day after feeding, and after one or three day fasting, Specimens were taken from the upper, middle and lower portions of the duodenum the specimens were fixed in 10% formalir and made into paraffin secuions of 5μ and stainings were done with Hematoxylm-eosin. all or the goblet cells in each 20 crypts and villi, boths of which were cut in the axial directions were counted and averaged numbers were considered as total relative number of one animal. The result were gained as follows 1 The relative number of the goblet cells in the duodenum of the mice fed on food averaged 22. 5. these cells were found more in the villi than in the crypts. 2. The relative number of the goblet cells in the mice fed on fat was larger than the normal value, and was the largest in the three groups fed on unbalanced diets. 3. The protein diet group was the smallest value among three groups. 4. The group's goblet cells fasting 1-day increased a little in number relative to the normal. 5. The group's goblet cells fasting 3-days increased the most in number of all groups.

이명 여부와 소음성 청력손실에 따른 변조 이음향 검사 연구

송주복,김정일,김병권,김준연 가톨릭대학산업의학센타 산업의학연구소 2003 韓國의 産業醫學 Vol.42 No.2

This study was performed to investigate the characteristics of distortion product otoacoustic emission (DPOAE) audiogram in noise exposed workers who were classified by hearing loss and noise-induced tinnitus (NIT). 7,204 noise exposed workers who had participated in noise-specific health examination in ship yard were surveyed to the tinnitus questionnaire and were conducted on the hearing threshold by pure tone audiometry. Of 7,204 noise exposed workers, 288 ears of 144 subjects selected by stratified random sampling according to hearing loss and NIT, and those were conducted on DPOAE audiogram. All examinee with known external or middle ear disorders were excluded. In DPOAE audiogram, distortion product and noise floor were elicited from L1=50 ㏈ SPL, L2=40 ㏈ SPL and F2/F1 ratio was set at 1.22. The averaged D/N ratio gram of normal hearing group was significantly different from that of high frequency hearing loss group and sensory hearing loss group. In multiple comparison test, average D/N ratio of normal hearing group was significantly different from that of high frequency hearing loss group and sensory hearing loss group at 1, 2, 4 ㎑. Significant decreases in average D/N ratio at 8000 ㎐ and averaged D/N ratio grams were observed between normal hearing group with tinnitus and normal hearing group without tinnitus(p<0.01). The data support that DPOAE audiogram of noise induced hearing loss and NIT may be useful in diagnosis and management of noise induced hearing loss and NIT noise exposed population and encourage noise exposed population to cooperate more actively in a hearing conservation program.

비선형해석에 의한 RCSF 외부접합공법으로 내진보강 된 중ㆍ저층 R/C 건물의 내진보강 효과의 검증

정주성(Jung, Jue Sung),이강석(Lee, Kang Seok),김상구(Kim, Sang Gu),이복기(Lee, Bok Gi) 한국콘크리트학회 2016 한국콘크리트학회 학술대회 논문집 Vol.28 No.1

악성 흉막액에 대한 흉막강내 OK - 432 주입의 치료 효과

방영주(Yung Jue Bang),서철원(Chol Won Seo),이재훈(Jae Hoon Lee),신동복(Dong Bok Shin),강윤구(Yoon Koo Kang),박근칠(Keun Chil Park),김노경(Noe Kyeong Kim) 대한내과학회 1989 대한내과학회지 Vol.36 No.4

N/A OK-432 has been shown to have antitumor activity in cancer patients, and intrapleural injection of OK-432 had also been shown to cause reduction or disappearance of pleural effusions and/or tumor cells in pleural effusions of cancer patients. Forty patients with malignant pleural effusions were treated with intrapleural administration of OK-432. Their age ranged from 20 to 80 years with a median of 56 years, and the male to female ratio was 24:16. Primary tumor sites were lung in 30 patients, stomach in 3, colon in 1, ovary in 1, and 5 patients had adenocarcinoma of unknown primary site. Cytologic examinations of pleural fluid were positive in 30 patients, and 10 patients without cytologic proof had exudative effusions with elevated levels of carcinoembryonic antigen. Their performance status was ECOG grade 1 in 9, 2 in 18, and 3 in 13 patients. One to three courses of intrapleural injection of OK-432 were tried weekly (mean 1.3 courses) without any concomitant anticancer treatment. The responses were categorized as objective response or failure. Seven patients were not evaluable for response because of early death without pleural effusion in two, protocol violation in one, and lost to follow-up in four. Twenty-four patients (72.7%) achieved objective responses among 33 evaluable patients. Response duration ranged from 4+ to 59 weeks with a median of 52 weeks. Common toxicities included fever and chill (38/52 courses), and pleuritic chest pain (24/52), but those symptoms were tolerable. These results show that intrapleural administration of OK-432 appears to be effective in the control of malignant pleural effusions with acceptable toxicity.

Prevalence of Hepatitis C Virus Genotype as a Risk Factor of Hepatocellular Carcinoma in Pusan, Korea

SHIN,Hai-Rim,SONG,Jue-Bok,SHIN,Woo-Won,JUNG,Kap-Yeol 동아대학교 부설 산업의학연구소 1999 산업의학연구소 논총 Vol.- No.4

최근 노년기에 간암을 일으키는 주요원인으로 보고된 C형 간염 바이러스(Hepatitis C virus : HCV)의 각종 간질환에서의 genotype 분포와 간염의 위험요인들과의 연관성을 알아보고자 본 연구를 시행하였다. 연구대상자들은 동아대학병원 건강관리과에서 종합건강진단을 받기 위하여 내원한 검진자 중에서 anti-HCV 양성인 사람(28명), anti-HCV 양성인 헌혈자(7명) [35명, Carrier군] 및 동병원 내과에 입원하였던 만성간질환 환자들 [만성간염과 간경화증 환자 93명 (Chronic liver disease: CLD군), 간세포암 환자 78명(Hepatocellular carcinoma: HCC군)]이었다. 연구방법은 각각의 연구대상자군별로 연령 및 B형 간염 표식자, anti-HCV 양성률을 비교하였으며, 또한 간질환의 위험요인의 양성률의 차이를 비교하였다. 전제 anti-HCV 양성인 연구대상자 중에서 40명의 혈청에서 genotyping ELISA방법으로 HCV genotype을 조사하였다. CLD군과 HCC군 모두에서 anti-HCV 음성인 경우 anti-HCV 양성인 환자들에 비해 HBsAg 양성률이 높았으며, anti-HBs 양성률은 더 낮았다. HBsAg 양성인 환자들의 평균 연령은 CLD군 43.8세, HCC군에 53.4세로 anti-HCV 양성인 환자들의 평균연령보다 낮았다 (CLD군 49.6세, HCC군 62.8세). 간 질환의 위험요인이라고 알려진 과거 수술력, 수혈력, 침을 맞은 과거력들은 Carrier, CLD, HCC군 모두에서 유의한 차이가 없었다. 40명의 anti-HCV 양성인 사람들을 대상으로 HCV genotype을 조사한 결과 SG-1 type이 47.5%로 가장 많았으며, SG-2 type은 35.0%였다. SG-1/2 type은 7.5%, SG-ud는 10.0%를 차지하였다. 이들에 대해서는 polymerase chain reaction, HCV RNA sequencing 등을 통한 분석이 더 필요하다고 하겠다. 위의 결과들을 종합하면 만성간염, 간경화에서 간세포암으로의 진행에 유의한 영향을 미치는 요인은 연령이라고 할 수 있으며, 부산지역의 C형 간염 바이러스 중에서 SG-1형이 가장 많았다. 앞으로 간염 표식자들이 양성인 사람들에 있어서는 정기적인 추적조사로 간세포암으로의 진행을 조기 발견하도록 하여야 할 것이며, HCV genotype과 간세포암과의 관계에 대해서는 더 많은 연구가 있어야 할 것이다. The epidemiologic study was conducted to determine the hepatitis C virus(HCV) genotype and to evaluate the association of known risk factors and chronic liver diseases in Pusan, Korea. The blood donors(n=7) and health check-up examinees(n=28) with positive anti-HCV were recruited as carrier group(carrier, n=35). Those who took anti-HCV test(ELISA, Lucky HCD 3.0) among in patients from September, 1995 at December, 1996 at Dong-A University Hospital were divided into chronic liver disease group(CLD, n=93) and hepatocellular carcinoma group(HCC, n=78). Among anti-HCV negative subjects, the hepatitis B surface antigen(HBsAg) positive rates(73.7% in CLD, 80.0% in HCC) were higher than those of anti-HCV positive subjects(11.4% in CLD, 7.1% in HCC). The average age was younger in HBsAg positive cases(43.8 years in CLD, 53.4 years in HCC) than in anti-HCV positive cases(49.6 years in CLD, 62.8 years in HCC) The Positive rates of past histories of surgical operation, acupuncture, and transfusion among anti-HCV positive cases were higher than those of negative cases(p<0.01). Most prevalent HCV genotype tested by genotyping ELISA was SG-1(47.5%). The mean ages of each HCV genotype were not significantly different (p>0.05). Most prevalent risk factor among each HCV genotype was acupuncture history. From this study, HCV genotype SG-1 was found to predominate in Korean patients with type C hepatitis. There were no significant association between the risk factors and HCV genotype. More research to evaluate the HCV genotype and the role of liver diseases, especially of the hepatocellular carcinoma are needed.

Nephropathy in Chronic Lead Poisoning

LEE,Haeng Ryeol,SONG,Jue Bok,KIM,Won Sul,RHA,Seo Hee,KIM,Byoung Gwon,KIM,Sung Hwan,KIM,Joon Youn,JUNG,Kap Yeol 동아대학교 부설 산업의학연구소 1999 산업의학연구소 논총 Vol.- No.4

This case is that of a 43 year-old male who had worked at a secondary lead smelter for 14 years. lead poisoning was suspected at a staturory health check in 1991 After the diagnosis, he received regular health checks twice each year.

대퇴골두 골괴사를 가진 환자에서의 조립식 대퇴주대를 이용한 무시멘트형 고관절 전치환술 -금속 금속 관절면과 세라믹 세라믹 관절면의 비교-

강번중 ( Bun Jung Kang ),이주희 ( Jue Hee Lee ),정영복 ( Young Bok Jung ),김진홍 ( Jin Hong Kim ),한용문 ( Yong Moon Han ),장의찬 ( Eui Chan Jang ),김경운 ( Kyoung Woon Kim ) 대한고관절학회 2011 Hip and Pelvis Vol.23 No.4

목적: 진행된 대퇴골두 골괴사증 환자에서 무시멘트형 조립식 대퇴주대를 이용한 고관절 치환술의 임상적 및 방사선학적 결과를 평가하였으며, 금속-금속 관절면을 사용한 군과 세라믹-세라믹 관절면을 사용한 군 간, 결과에 차이가 있는지를 확인하고자 하였다. 대상 및 방법: 2001년 1월부터 2004년 12월 까지 대퇴골두 골괴사증으로 조립식 대퇴주대를 이용하여 무시멘트형 고관절 치환술을 시행 받았으며, 5년 이상 추시관찰이 가능하였던 66명(78예)을 대상으로 하였고, 술 후 평균 추시 기간은 평균 77개월(60~122개월) 이었다. 결과: 임상적 평가로 술 전 평균 Harris 고관절 점수는 53점에서 최종 추시 시 88.5점으로 향상되었다. 방사선학적 검사 결과에서 대퇴주대의 안정도는 68예에서 골성고정을 얻었으며, 9예에서 섬유성 안정고정, 1예에서 불안정고정을 나타내었다. 재치환술은 3예에서 시행하였으며, 122개월 간 대퇴 스템의 생존율은 95.7%인 것으로 조사되었다. 결론: 진행된 대퇴골두 골괴사증에서 시행한 조립식 대퇴주대를 이용한 무시멘트형 고관절 전치환술은 5년 이상 추시 결과 금속-금속 관절면을 사용한 군과 세라믹-세라믹 관절면을 사용한군, 모두 만족한 만한 임상적 및 방사선학적 결과를 얻었다. Purpose: The purpose of this study was to evaluate the clinical and radiological outcomes after total hip arthroplasty using the S-ROM modular system for osteonecrosis of the femoral head, and to compare the results between the groups using metal-on-metal articulation and ceramic-on-ceramic articulation. Materials and Methods: Sixty-six patients (78 hips) with osteonecrosis of the femoral head were evaluated after primary total hip arthroplasty between January 2001 and December 2004, using an S-ROM proximal modular femoral stem. The average follow-up was 77 months (range, 60 to 122 months) and all patients were followed for more than five years. Results: The average Harris hip score improved from 53 points to 88.5 points at the final follow-up. At the latest radiologic evaluation, sixty-seven stems had bony ingrowth stability, and 10 stems had stable fibrous ingrowth. However, one stem had diffuse extensive osteolysis and loosening, which was revised at 9 years. Postoperative complications included 4 cases of heterotrophic ossificiation, 1 case of linear fracture after insertion of the femoral stem, 1 case of dislocation, 2 cases of infection, and 1 case of extensive osteolysis and loosening. There were 3 cases of revision and Kaplan-Meier survivorship analysis with revision estimated at a 95.7% chance of survival for the femoral component during 122 months. Conclusion: Our study showed that total hip arthroplasty using the S-ROM modular system with metal-on-metal articulation or ceramic-on-ceramic articulation had favorable clinical and radiological mid- to long-term results.

농촌지역 주민의 건강관련 행위와 질병이환과의 관계

송주복,이부옥,신해림,정갑열,김준연,Song, Jue-Bok,Rhee, Boo-Ouk,Shin, Hai-Rim,Jung, Kap-Yeol,Kim, Joon-Youn 대한예방의학회 1997 Journal of Preventive Medicine and Public Health Vol.30 No.2

This research was carried out to determine the performance rate of health related practices, to measure the agreement between morbidity by doctor's diagnosis and morbidity by subject' self-reported and the degree of association between health related practices and morbidity rate by doctor's diagnosis, to identify their effects on morbidity among rural area populations. The data were gathered by volunteer residents (over the age of 20) of Haman Myeon, Haman Gun, Kyeongsangnam Do in Korea, from June 10, 1993 to June 12, 1993 (369 male and 516 female). Face to face interview, lab, chest P-A, EKG and physical examination were completed. Descriptive statistics, agreement analysis and multiple logistic regression procedures were employed for analyses. The results of the study were summarized as follows : 1) Age adjusted morbidity rates by doctor's diagnosis and self-reported were 38.5% (male:37.3%, female:36.5%), 26.4% (male:33.3%, female:27.5%), respectively. Kappa coefficient between morbidity by doctor's diagnosis and morbidity by self-reported was 0.21 (male:0.21, female:0.22). 2) The frequency of disease by doctor's diagnosis was as follows: hypertension(15.3%), gastritis (9.6%), diabetes mellitus (8.5%), live. disease (8.1%), and degenerative arthritis (6.2%) in the study population. 3) Order of health practice performance rate was as follows: Males-normal body weight (62.1%), non-heavy alcohol consumption (57.5%), 7-8 hours of sleeping (50.1%), non-smoking (21.7%), and exercise (19.8%). Females- non-heavy alcohol consumption (97.3%), non-smoking (84.7%), normal body weight (57.8%), 7-8 hours of sleeping (45.0%), and exercise (9.9%). 4) There was no significant relationship between health related practice and morbidity except exercise among health related practices. 5) Health related practice index which was recategorized by high, medium, and low had effects on the probability of developing morbidity.

Color Flow Mapping과 Doppler Velocimetry를 이용한 태반 혈관종 진단

김윤하 ( Yoon Ha Kim ),박현주 ( Hyun Jue Park ),양진양 ( Jin Yang Yang ),김주리 ( Ju Lee Kim ),김은경 ( Eun Kyung Kim ),송태복 ( Tae Bok Song ) 대한주산의학회 1994 Perinatology Vol.5 No.2