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Microwave-assisted Approach for the Rapid Enzymatic Digestion of Rapeseed Meal
Ju-Fang Li,Fang Wei,Lu-Lu Guo,Gang-You Yuan,Feng-Hong Huang,Mu-Lan Jiang,Yuan-Di Zhao,Xu-Yan Dong,Guang-Ming Li,Hong Chen 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.2
This study demonstrates the use of a new microwave-assisted approach for accelerating the enzymatic digestion of rapeseed meal. The effects of different microwave parameters, such as the time, temperature, and power level, on the degree of hydrolysis (DH) were investigated by using response surface methodology (RSM). The maximum predicted DH value (10.2%) was in good agreement with the value obtained experimentally using an alkaline protease, which was 12.57% under optimal conditions. In only 7 min, the microwave-assisted method achieved a DH value similar to that obtained by the conventional enzymatic digestion method (4 hr). Therefore,this new technique for rapid enzymatic digestion will improve the application of rapeseed meal in the preparation of protein hydrolysates for use in food and feed.
Serum Uric Acid Relation for Hearing Threshold Shiftt
Hui-Fang Yang,Tung-Wei Kao,Tao-Chun Peng,Yu-Shan Sun,Fang-Yih Liaw,Chung-Ching Wang,Ju-Ting Hsueh,Wei-Liang Chen 대한이비인후과학회 2017 Clinical and Experimental Otorhinolaryngology Vol.10 No.2
Objectives. The effects of serum uric acid (UA) level on a variety of diseases were found from experimental and observational studies via oxidative stress and anti-oxidants. However, research on the association of UA and hearing thresholds is relatively sparse. We investigated this issue in the U.S. general population to evaluate the relationship of serum UA levels and pure tone threshold of hearing. Methods. Forty four thousand eighty four eligible participants aged 20 to 69 years who have serum UA data and received Audiometry Examination Component were enrolled from the National Health and Nutrition Examination Survey 1999–2004. Hearing thresholds (dB) as a pure tone average at low frequencies (0.5, 1, 2 kHz) and at high frequencies (3, 4, 6, and 8 kHz) were computed. Multivariate linear regression models and tertile-based analysis with an extended-model approach for covariates adjustment were used to assess the correlation between serum UA level and hearing thresholds. Results. In the adjusted mode of tertile-based analysis, the regression coefficients elucidated as the change of log-transformed mean hearing thresholds upon comparing participants in the highest tertile of serum UA to those in the lowest tertile were –0.067 (P=0.023) in high frequency and –0.058 (P=0.054) in low frequency. After adjusting for multiple pertinent covariates, inverse association between tertiles of serum UA and hearing thresholds remained essentially unchanged. The negative trends between serum UA and hearing thresholds were statistically significant (P for trends <0.05) in tertile-based multiple linear regressions. Conclusion. Individuals with elevated UA levels independently were found to be inversely associated with hearing thresholds for pure tone audiometry in a nationally representative sample of U.S. adults.
Li, Zhi-Fang,Wang, Shao-Ming,Shi, Ju-Fang,Zhao, Fang-Hui,Ma, Jun-Fei,Qiao, You-Lin,Feng, Xiang-Xian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Objectives: To investigate the current prevalence and knowledge of cervical cancer, breast cancer and reproductive tract infections (RTIs) in rural Chinese women, and to explore the acceptance and feasibility of implementing a combined screening program in rural China. Methods: A population-based, cross-sectional study was conducted among women aged 30 to 59 years old in Xiangyuan County, Shanxi Province from 2009 to 2010. Socio-demographic characteristics, knowledge of cervical cancer, breast cancer and RTIs, and the attitude toward single or combined screening were collected by an interview questionnaire. Each participant received a clinical examination of the cervix, breast and reproductive tract. Examinations included visual inspection, mammography, laboratory tests and pathological diagnosis. Results: A total of 1,530 women were enrolled in this study. The prevalence of cervical precancerous lesions, suspicious breast cancer, suspicious benign breast disease and RTIs was 1.4%, 0.2%, 14.0% and 54.3%, respectively. Cervicitis, trichomonas vaginitis, and bacterial vaginitis were the three most common RTIs among our participants. Television, radio broadcast, and public education during screening were the major source of healthcare knowledge in rural China. Moreover 99.7% of women expressed great interest in participating in a combined screening project. The affordable limit for combined screening project was only 50 RMB for more than half of the rural women. Conclusion: A combined screening program would be more effective and popular than single disease screening projects, while appropriate accompanied education and a co-pay model for its successful implementation need to be explored, especially in low-resource settings.
A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer
Fang, Zhenghuan,Han, Boreum,Jung, Kyung Hee,Lee, Ju-Hyeon,El-Damasy, Ashraf Kareem,Gadhe, Changdev G.,Kim, Soo Jung,Yan, Hong Hua,Park, Jung Hee,Lee, Ji Eun,Kang, Yeo Wool,Pae, Ae Nim,Keum, Gyochang,H Elsevier 2018 Cancer letters Vol.426 No.-
<P><B>Abstract</B></P> <P>Tropomyosin-related kinase A (TrkA) plays important roles in tumor cell growth and survival signaling and contributes to chemo-resistance in pancreatic cancer. Therefore, we developed KK5101, a novel TrkA target inhibitor and assessed its anti-cancer effects and investigated underlying mechanism of action in pancreatic cancer. KK5101 was characterized to inhibit TrkA selectively and potently by protein binding assay. It effectively inhibited the growth and proliferation of pancreatic cancer cells. Also, KK5101 increased apoptosis with loss of mitochondrial membrane potential, as evidenced by increases of cytochrome <I>c</I> releases. It increased numbers of TUNEL-positive apoptotic cells, and cell death including early and late apoptosis by Annexin V assay. In addition, activation of the TrkA signaling cascades including p-AKT, p-MEK, and p-STAT3 were inhibited by KK5101 treatment <I>in vitro</I>, as well as <I>ex vivo</I> tumor spheroid models, resulting in potent induction of apoptosis. Importantly, KK5101 also significantly attenuated tumor growth of <I>in vivo</I> pancreatic cancer models. These findings indicate that KK5101 may exert antitumor effects by directly affecting cancer cell growth or survival via inhibition of TrkA signaling pathway. We therefore suggest that KK5101 is a novel therapeutic candidate for treating pancreatic cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> KK5101 specifically binds in an allosteric pocket of TrkA. </LI> <LI> KK5101 effectively inhibits survival/proliferation and induced apoptosis in pancreatic cancer. </LI> <LI> KK5101 may be a highly selective inhibitor for TrkA, inhibiting the PI3K/AKT, Raf/MAPK, and STAT3 signaling pathways. </LI> </UL> </P>
Fang-Yi Liu,Kuo-Tan Li,Wen-Ju Yang 한국원예학회 2014 Horticulture, Environment, and Biotechnology Vol.55 No.2
Although many new tomato cultivars with various degrees of heat-tolerance have been released, year-roundtomato production in subtropical lowlands is still challenged by summer heat and an increasing risk from salinity stress. Little information about the simultaneous effects of heat and salinity on growth and fruiting in tomatoes is available. It was hypothesized that cultivars which perform better in high temperatures are also more tolerant to salinity stress. Two highly heat-tolerant cultivars, ‘Tainan ASVEG No. 19’ (TA19) and ‘Taiwan Seed ASVEG No. 22’ (TSA22), andone moderately heat-tolerant cultivar, ‘Hualien ASVEG No. 21’ (HA21), were grown under high temperature conditionsand were irrigated with a 0, 50, 150, or 200 mM NaCl solution for 20 days. Vegetative growth, fruiting behavior,and fruit quality were monitored. Number of leaves, leaf area, shoot fresh and dry weights, and root fresh weightwere generally decreased with increasing level of salinity stress, but root dry weight was not affected, resulting in anincrease in root to shoot ratio in all three cultivars. Yield was also decreased by salinity treatments in all threecultivars due to reduced number of flowers, fruit set, and fruit size. The highly heat-tolerant ‘TA19’ had the lowestvegetative growth and the highest yield under the high temperature condition, but the yield was strongly suppressedby the short-term mild salinity treatment. On the other hand, vegetative growth was little affected and the degree ofyield reduction was less intense with the short-term mild salinity treatment in the moderately heat-tolerant ‘HA21’. The result indicated that effects of heat stress and salinity stress are not additive and differential responses to salinityunder high temperatures exist among cultivars with various degrees of heat-tolerance.