Feasibility and Outcomes of Multivisceral Resection in Locally Advanced Colorectal Cancer: Experience of a Tertiary Cancer Center in North-East India

Joydeep Purkayastha,Pritesh Rajeev Singh,Abhijit Talukdar,Gaurav Das,Jitin Yadav,Srinivas Bannoth 대한대장항문학회 2021 Annals of Coloproctolgy Vol.37 No.3

Purpose: Locally advanced colorectal cancer may require an en bloc resection of surrounding organs or structures to achieve complete tumor removal. This decision must weigh the risk of complications of multivisceral resection against the potential survival benefit. The purpose of this study is to review a single-center experience of feasibility of en bloc multiv- isceral resections for locally advanced colorectal carcinoma and to examine the effect of surgical experience on immediate outcome and rate of R0 resections. Methods: This is a study of 27 patients who underwent multivisceral resection for locally advanced colorectal carcinoma which was performed at our institute from January 2016 to December 2019. Among the 27 patients aged between 21 and 76 years (mean age, 48.67±7.3 years), 13 were males and 14 were females. Overall 18 patients had primary colon carci- noma and 9 had primary rectal carcinoma. All rectal cancer patients received neoadjuvant chemoradiation. All patients underwent surgery with curative intent. All patients underwent open surgery of which 66.7% underwent colectomy, 14.8% underwent anterior resection, 11.1% underwent Miles procedure, and 7.4% underwent pelvic exenteration. Results: The mean operative time was 268.14±72.2 minutes and the median amount of blood units transfused was 2.07 units. The mean hospital stay was 13.67±3.4 days. Histologically, 44.4% of patients had well-differentiated adenocarci- noma and 55.6% had moderately differentiated adenocarcinoma. The final histopathological examinatio n revealed ma- lignant infiltration of the adjacent organs in 19/27 patients (70.4%). Pathological complete response was seen in 2 patients. R0 resection rate achieved was 96.3%. Lymph node metastasis was seen in 66.7% of patients with colon cancer and 11.1% with rectal cancer with overall mean number of harvested lymph nodes being 12.44±3.01. Postoperative complications were identified in 7 patients (25.9%), while mortality was seen in 2 (7.4%). Conclusion: Multivisceral resection for advanced colorectal cancer invading into the adjacent organ may be performed with acceptable morbidity and mortality.

Nonparametric testing under crossover design for ordered categorical response

Joydeep Basu,Uttam Bandyopadhyay,Ganesh Dutta 한국통계학회 2017 Journal of the Korean Statistical Society Vol.46 No.4

This paper uses ridit introduced by Bross (1958) to develop a nonparametric procedure for testing the difference between two treatment effects with ordered categorical outcomes under two period crossover design in which subjects receive same or different treatment during the period of study. The performance of this procedure is compared numerically with that of a procedure obtained from Armitage (1955) in terms of type I error rate and power. The numerical study shows the ridit approach to tend to relatively more efficient in terms of power as the number of categories increases. The procedures are illustrated using the data from Matthews (1989) on crossover trial with two hypertensive agents.

Isolation of a Pseudomonas sp. Capable of Utilizing 4-Nonylphenol in the Presence of Phenol

( Chakraborty Joydeep ),( Tapan K. Dutta ) 한국미생물생명공학회 2006 Journal of microbiology and biotechnology Vol.16 No.11

Development of Large Area Nanostructured Silicon-Hydrogen Alloy Material with Improved Stability for Solar Cell Application by Argon Dilution Method

Arka Dey,Mrinmay Das,Joydeep Datta,Rajkumar Jana,Joydeep Dhar,Sayantan Sil,Debasish Biswas,Chandan Banerjee,Partha Pratim Ray 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.4

Here we have presented the results of large area (30 × 30 cm2) siliconhydrogenalloy material and solar cell by argon dilution method. As analternative to hydrogen dilution, argon dilution method has been appliedto develop single junction solar cell with appreciable stability. Optimization of deposition conditions revealed that 95% argon dilutiongives a nanostructured material with improved transport property andless light induced degradation. The minority carrier diffusion length (Ld)and mobility-lifetime (μτ) product of the material with 95% argondilution degrades least after light soaking. Also the density of states(DOS) below conduction level reveals that this material is lessdefective. Solar cell with this argon diluted material has been fabricatedwith all the layers deposited by argon dilution method. Finally we havecompared the argon diluted solar cell results with the optimizedhydrogen diluted solar cell. Light soaking study proves that it is possibleto develop stable solar cell on large area by argon dilution method andthat the degradation of argon diluted solar cell is less than that ofhydrogen diluted one.

Antibiotic Production by a Marine Isolate (MS 310) in An Ultra-low-speed Rotating Disk Bioreactor

Sreyashi Sarkar,Joydeep Mukherjee,Debashis Roy 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.6

Actinomycin-D production by a biofilm-forming estuarine isolateviz. Streptomyces sp. MS 310 is studied in smallscale shaken cultures, as well as in a 25 L rotating disk bioreactor, (RDBR) which, when operated at a disk rotational speed of 1 revolution/day with 50% disk submergence, mimics the intertidal conditions of the microbe’s niche estuarine habitat- alternating 12 h periods of inundation and exposure. The ideal pH and temperature for antibiotic production are determined (pH 10, 30oC) through a designed experimental study using shaken flasks. Subsequently, operating conditions in the RDBR are investigated employing a 3ⁿ experimental design wherein each of two (n = 2) parameters viz. aeration and disk submergence are considered at three levels viz. high, medium, and low: 9.0, 6.0, and 3.0 L/min for aeration rate; and 75, 50, and 25% for disk submergence, (while maintaining the rotational speed at 1.0 rev/day). The niche-mimic condition along with maximum permissible aeration is found to be most favorable for antibiotic production - peak antibiotic activity (PAA) and peak activity attainment rate (PAAR) simultaneously attaining their highest values: 40 mm and 2.13 mm/h, respectively. Both PAA and PAAR increase with increasing aeration at all operating conditions examined - particularly, at the niche-mimic condition, a threefold increase in aeration rate (3~9 L/min) causes PAA to increase by 33%, whereas PAAR increases by 2.5 times, thus pointing to the strong aeration dependence of this actinomycin-D producer. Again, compared to the best values obtained in the 500 mL shaken flask experiments, corresponding RDBR values are 16% higher for PAA and more than 5 times higher for PAAR - strong evidence for employing these novel bioreactors for cultivation of antibiotic-producer marine microbes Actinomycin-D production by a biofilm-forming estuarine isolateviz. Streptomyces sp. MS 310 is studied in smallscale shaken cultures, as well as in a 25 L rotating disk bioreactor, (RDBR) which, when operated at a disk rotational speed of 1 revolution/day with 50% disk submergence, mimics the intertidal conditions of the microbe’s niche estuarine habitat- alternating 12 h periods of inundation and exposure. The ideal pH and temperature for antibiotic production are determined (pH 10, 30oC) through a designed experimental study using shaken flasks. Subsequently, operating conditions in the RDBR are investigated employing a 3ⁿ experimental design wherein each of two (n = 2) parameters viz. aeration and disk submergence are considered at three levels viz. high, medium, and low: 9.0, 6.0, and 3.0 L/min for aeration rate; and 75, 50, and 25% for disk submergence, (while maintaining the rotational speed at 1.0 rev/day). The niche-mimic condition along with maximum permissible aeration is found to be most favorable for antibiotic production - peak antibiotic activity (PAA) and peak activity attainment rate (PAAR) simultaneously attaining their highest values: 40 mm and 2.13 mm/h, respectively. Both PAA and PAAR increase with increasing aeration at all operating conditions examined - particularly, at the niche-mimic condition, a threefold increase in aeration rate (3~9 L/min) causes PAA to increase by 33%, whereas PAAR increases by 2.5 times, thus pointing to the strong aeration dependence of this actinomycin-D producer. Again, compared to the best values obtained in the 500 mL shaken flask experiments, corresponding RDBR values are 16% higher for PAA and more than 5 times higher for PAAR - strong evidence for employing these novel bioreactors for cultivation of antibiotic-producer marine microbes

Reliability Evaluation of a Microgrid Considering Its Operating Condition

Xufeng Xu,Joydeep Mitra,Tingting Wang,Longhua Mu 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.1

Microgrids offer several reliability benefits, such as the improvement of load-point reliability and the opportunity for reliability-differentiated services. The primary goal of this work is to investigate the impacts of operating condition on the reliability index for microgrid system. It relies on a component failure rate model which quantifies the relationship between component failure rate and state variables. Some parameters involved are characterized by subjective uncertainty. Thus, fuzzy numbers are introduced to represent such parameters, and an optimization model based on Fuzzy Chance Constrained Programming (FCCP) is established for reliability index calculation. In addition, we present a hybrid algorithm which combines scenario enumeration and fuzzy simulation as a solution tool. The simulations in a microgrid test system show that reliability indices without considering operating condition can often prove to be optimistic. We also investigate two groups of situations, which include the different penetration levels of microsource and different confidence levels. The results support the necessity of considering operating condition for achieving accurate reliability evaluation.

Conformally Flat Quasi-Einstein Spaces

DE, UDAY CHAND,SENGUPTA, JOYDEEP,SAHA, DIPTIMAN 대한수학회 2006 Kyungpook mathematical journal Vol.46 No.3

The object of the present paper is to study a conformally flat quasi-Einstein space and its hypersurface.

Measurement of emission current and temperature profile of emissive probe materials using CO_2 LASER

Payal Mehta,Arun Sarma,Joydeep Ghosh,Shwetang Pandya,Santosh Pandya,Paritosh Choudhuri,J. Govindarajan,C. Ionita Schrittwieser,Roman Schrittwieser 한국물리학회 2011 Current Applied Physics Vol.11 No.5

Emissive probes have been used for the direct measurement of plasma potential in many plasma devices. Different approaches have been introduced to measure the plasma potential using emissive probes. But the biggest disadvantage of the emissive probe is short life span due to its self-arrangement and different plasma environment. Few initiations have been made to measure plasma potential by using LASER heated emissive probe. In case of LASER heated emissive probe, mostly graphite and LaB_6 are being used as probe tip to emit electrons by heating with LASER light. However, very little studies have been done to understand the mechanism of heating process of the LaB_6 and graphite materials. The complete heating dynamics of these materials, heated by a CW CO_2 LASER with a maximum 55Wpower have been studied in this work. In-situ temperature of the probe tip has been measured by using an IR camera. Complete theoretical and simulated model have been developed to understand the experimentally measured data. Further, the experimental results are compared with ANSYS simulations. The emission current from the probe with respect to the bias voltage applied to the probe has also been measured.

Biological Response Modifiers Influence Structure Function Relationship of Hematopoietic Stem and Stromal Cells in a Mouse Model of Leukemia

Basu, Kaustuv,Mukherjee, Joydeep,Law, Sujata,Chaudhuri, Samaresh Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Biological response modifiers (BRMs) can alter interactions between the immune system and cancer cells to boost, direct, or restore the body's ability to fight disease. Mice with ethylnitrosourea- (ENU) induced leukemia were here used to monitor the therapeutic efficacy of lipopolysaccaride (LPS), Bacillus Calmette Guerin (BCG) and sheep erythrocytes (SRBC). Flow cytometry based CD34+ positivity analysis, clonogenicity, proliferation and ultrastructure studies using scanning electron microscopy (SEM) of stem cells in ENU induced animals with and without BRMs treatment were performed. BRMs improved the stem-stromal relationship structurally and functionally and might have potential for use as an adjunct in human stem cell therapy.

Reliability Evaluation of a Microgrid Considering Its Operating Condition

Xu, Xufeng,Mitra, Joydeep,Wang, Tingting,Mu, Longhua The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.1

Microgrids offer several reliability benefits, such as the improvement of load-point reliability and the opportunity for reliability-differentiated services. The primary goal of this work is to investigate the impacts of operating condition on the reliability index for microgrid system. It relies on a component failure rate model which quantifies the relationship between component failure rate and state variables. Some parameters involved are characterized by subjective uncertainty. Thus, fuzzy numbers are introduced to represent such parameters, and an optimization model based on Fuzzy Chance Constrained Programming (FCCP) is established for reliability index calculation. In addition, we present a hybrid algorithm which combines scenario enumeration and fuzzy simulation as a solution tool. The simulations in a microgrid test system show that reliability indices without considering operating condition can often prove to be optimistic. We also investigate two groups of situations, which include the different penetration levels of microsource and different confidence levels. The results support the necessity of considering operating condition for achieving accurate reliability evaluation.