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Lovastatin의 암세포에 대한 항증식 효과에 관한 연구
이환봉,장정순 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1
Background: Lovastatin which is a potent inhibitor of HMG-CoA reductase has antiproliferative effect on cancer cells. We investigated the cell cycle regulatory mechanism of anti-proliferative effect of lovastatin and its therapeutic value on cancer treatment. Methods: MDA-MB-231, an ER negative breast cancer cell line and PC-3-M, an androgen independent prostate cancer cell line were grown up to use. We checked expression pattern of cell cycle regulatory proteins such as cyclins, cdk inhibitors including p21, cdks, RB and RB family protein p107 with lovastatin by Western blot analysis and immunoprecipitation. Results: The proliferative tendency of breast cancer and prostate cancer cells was decreased with 10 μM lovastatin. Cyclin D1 was decreased, however p21, a cdk inhibitor was increased with lovastatin. There is no change in the protein level of cyclin E, cdk4 and cdk2. After 36 h incubation with lovastatin, RB and p107 were dephosphorylated and showed increased binding with transcription factor E2F1 and E2F4 respectively. Conclusion: These results show that lovastatin has antiproliferative effects on breast and prostate cancer cells. The cell cycle regulatory effects of lovastatin come to G1 phase and those are mediated by cyclin D1 depression, p21 induction and decreased activity of cdk4. In accordance with them RB dephosphorylation and its sucessive binding with E2F1 seem to have important role in growth inhibitory effect of lovastatin. These data suggest that growth inhibitory activity of lovastatin by way of cell cycle regulation supports the therapeutic value for cancer treatment.
經口的 慢性暴露에 의한 白鼠의 Methyl 水銀 中毒時 마늘의 豫防效果에 關한 硏究
黃正一,裵恩相,車喆煥 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1
Many researches on the various chemical compounds which containes -SH radicals including BAL and penicillamine have been undertaken in order to develop proper ways of treatment and protection from methyl mercury poisoning. However, BAL and penicillamine which have been used for these purposes, are still remained as a pending issue because of the side effects, and the studies on their derivatives hare been conducted to clarify whether these chemical compounds of -SH radical bring about protective effect to brain and kidney: the target organs of mercury phoning although still uncertain. Therefore, the authors tried to inquire into the protective effects of the Korean garlic against the methyl mercury poisoning. The Korean garlic has been known as a vegetation which has a protective effect and contains a large amount of diallyldisulfide with -S-S and -SH radicals such as glutathione, cysteine, homocysteine and etc.. The garlic was put into pellet by various concentrations, and methyl mercury was mixed in drinking water by 4 ppm concentration. These mixture were fed to albino rats for 10 weeks. A close observation was made to see the histopathological changes and amount of mercury accumulation in brain and kidney. At the same time, the amount of mercury accumulation in liver and erythrocyts n-ere compared with control gorup. The results of the experiment were as follows; 1. In simultaneously-dosed group with 6.7% garlic and methyl mercury, concentrations of mercury in organs were lower than those in methyl mercury-only-dosed group by 33.1% in erythrocyte, 32.2% in brain, 22.3% in liver and 29.1% in kidney. The group with 8.0% of gallic and methyl mercury also showed lower concentration by 38.6%, 41.9%, 39.5% and 34.3% in those organs respectively, whereas there was PO significant difference between the group with 2.35% of garllic and methyl mercury and that of methyl mercury-only-dosed group. 2. The simultaneously-dosed group with 3.35% of garlic and methyl mercury didn't show a remarkable difference to the group treated with methyl mercury-only in histopathological findings of brain and kidney. However, for the group with 6.7% of garlic and methyl mercury, a slight demyelinization in cerebellar white matter and degenerative change of Punkinje cells were found. In addition, a little degeneration on epithelium of proximal tubules in kidney and a small amount of- tubular casts were found. The-group with 8.0% of garlic and methyl mercury has shown a loss of small amount of demyelinization in cerebellar white matter, but kindey was remained in normal architecture. Accordingly, simultaneous administration of garlic with methyl mercury caused decrease. of mercury accumulation in erythrocytes, brain, liver and kidney and it also has shown protective effect in histopathological changes in brain and kidney. The result also makes us. to believe that there exists some evidence of dose-response relationship between the amount. of Korean garlic dosed and its protective effects on methyl mercury.
학교급식 식자재 공급업체 선정요인의 우선순위에 관한 연구
박명주,김석환,이정실 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4
The purpose of this study is to examine how nutritionists, principals and parents evaluated the importance and priorities of different selection factors for food materials suppliers in an attempt to suggest how to ensure the best supplier choice, since the selection of the best supplier was mandatory for the successful TQM of school food services. This study especially aims to develop priority alternatives based on relative rather than absolute assignments on selection of suppliers for school food service materials. To apply AHP, the selection factors of a food materials suppliers were grouped into five categories, which included quality, service, reliability, hygiene and price. And the five categories involved 28 elements. As the result, quality was considered most crucial on the whole, followed by service, reliability, hygiene and price; and food labeling in the category of quality evaluated as that of first priority in the totality evaluation elements.
Joung Whan Park,이남근,김병용,Hye Kyung Kim,Ki Ok Kwon,함영태 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.2
In this study, traditionally fermented Korean soybean paste, eoyukjang, was characterized and its microorganisms were isolated. The contents of amino-type and ammonia-type nitrogens in the pastes we examined were 89.60 to 98.93mg/% and 0.32 to 0.30mM, respectively. Antioxidant activity increased during ripening, with antioxidant activities in 1- and 4-year-old pastes measured at 9.80 and 13.84 μmol of Trolox equivalents/g, respectively. Twenty-two and 19 microorganisms were isolated from soybean pastes under aerobic and anaerobic conditions,respectively. After identification, Bacillus amyloliquefaciens,Bacillus subtilis, and Bacillus vallismortis were dominant. In the enzyme activities, protease and lipoxygenase activities were observed from 0.065 to 0.733 unit/mg protein and 0.016 to 0.19 unit/mg protein, respectively. Amylase activity was, however, broad between 43.1 to 571.8 unit/mg protein.
Joung Whan Moon,Jin Wan An,Yeon Kyun Oh,Du Young Choi,Chang Woo Lee,Seung Taek Yu 조선대학교 의학연구원 2016 The Medical Journal of Chosun University Vol.41 No.4
Diagnosis of scrub typhus is difficult because of its unspecific symptoms. The authors studied the correlation between serum adenosine deaminase (ADA) levels and scrub typhus, with the aim of aiding diagnose of the disease. The medical records of 64 children, who visited Wonkwang University Hospital from 2005 to 2015 for fever of undetermined origin, were analyzed retrospectively. Serum ADA levels were measured and indirect immunofluorescence antibody (IFA) assays were conducted. The patients were divided into two groups based on diagnosis of scrub typhus. Of 64 febrile patients, 39 were confirmed to have scrub typhus. Mean serum ADA level in the scrub typhus group (58.54±2.82 IU/L) was significantly higher than that in the non-scrub typhus group (29.30±4.03 IU/L, p<0.05). In the 25 non-scrub typhus patients, mean serum ADA level was significantly higher (50.24±8.52 IU/L) in patients with Mycoplasma infection than that in those with other diseases (19.46±1.39 IU/L, p<0.05). The study shows that in patients with only fever who are difficult to diagnose, serum ADA levels substantially aid the diagnosis of scrub typhus. Ed:- please consider carefully
정진환(Joung Chin-Whan) 한국교육행정학회 2005 敎育行政學硏究 Vol.23 No.3
지난날 국가의 관심이 미흡했던 평생학습은 최근 들어 이에 대한 국민적 관심 고조와 전 세계적인 인적자원개발 및 국가경쟁력 향상이라는 흐름에 힘입어 점차 그 틀을 구축해 가고 있다. 이는 국민들에게 보다 많은 평생교육의 기회를 제공해 줄 수 있다는 점에서 매우 바람직한 현상이다. 그러나 보다 중요한 것은 국민의 평생학습과 관련된 사회적 여건을 바꾸는 것이 시급하며, 평생교육 진흥정책이 해결해야 할 가장 중요한 과제는 평생학습체제를 강화하는 것이라 하겠다.<br/> 현행 평생학습 추진체제의 문제점은 범정부적 차원의 통합적인 평생학습 추진계획의 미비, 체계적인 평생학습 지원체제의 결여, 전담기구의 조직적 취약성, 지역교육청 및 지방자치단체의 평생학습지원체제의 행ㆍ재정적 취약성 등을 들 수 있다. 이러한 문제점을 해결하기 위한 향후 방향 및 과제로는 평생학습시설의 확충과 육성, 평생교육지원기구 운영의 내실화, 평생학습의 전문화, 지역평생교육의 활성화, 정보화, 재정지원의 확충 노력, 성인학습 기회의 확대와 관련 프로그램 개발 보급, 공공성 보장 등이라 하겠다. In the past the nation didn't pay much attention to the lifelong education. But recently the national concern about it is increasing because the human resource development and the national competitiveness in the world are being enhanced. Owing to these the lifelong education has been built its frame more and more. It is a desirable phenomenon in the point of supplying more lifelong education chances to people. There are two important things. One is to change urgently the social environment related to people's lifelong education. the other is to enhance lifelong education system that is the most important problem for the lifelong education promotion policy to solve.<br/> Today we have many problems of lifelong education promotion system. Those are the insufficiency of the integral lifelong education promotion policy in the whole government level, the lack of systematic lifelong education support, the organizational vulnerableness of the exclusive charge, the administrative and financial vulnerableness of the local government and the local educational authority' lifelong education promotion system.<br/> There are some direction and tasks to solve these problems. Those are the enhancement and promotion of the lifelong education facilities, the specialization of lifelong learning, the revitalization of the local lifelong education, the information, the effort to enhance the financial support, the expansion and program development of adult learning, the reinforcement of publicity.
학교장의 자부심(self-esteem)과 교사의 조직헌신도(organizational commitment)와의 상호성
정진환(Joung Chin-Whan),심태은(Shim Tae Eun) 한국교육행정학회 2005 敎育行政學硏究 Vol.23 No.4
본 연구는 교사가 학교장 자부심 수준이 높다고 지각되면, 교사의 조직헌신 수준도 높을 질 수 있으므로, 효율적인 학교운영 방안을 위한 조직헌신도 고양 방안의 자료로 교육헌장에 도움을 주고자 하는 것이 목적이다. 이때 교사가 바라본 학교장의 사회적·전문적·직업적 자부심 수준을 알아보고 이러한 학교장의 자부심이 교사의 조직헌신도 즉 학교조직에 대한 충성심, 자발성의지, 가치수용 등에 어떠한 상관관계를 미치는가를 알아보도록 하였다. <br/> 그 결과 교사가 바라본 학교장의 자부심 수준과 교사의 조직헌신도와의 상호성을 보았을 때, 학교장의 자부심이 높을수록 교사들은 학교조직이 추구하는 목표나 가치에 대하여 강한 신뢰와 수용하려는 의사가 높았다고 볼 수 있었다. 그 다음으로 학교조직에 대하여 애착심을 갖고 조직의 발전을 위해 최대한 노력하려는 의사와 상관관계가 있다는 것을 볼 수 있었다. 그러므로 학교장은 자신의 자부심을 향상시키기 위하여 노력해야할 것이다. The purpose of this study was to provide for some basic data useful to enhancement of teachers' organizational commitment to an efficient operation of school, on the assumption that they would be more committed to their school organization when they perceive that their principal's may be highly self-esteemed. For this purpose, the researcher surveyed teachers for their perception of principal's social, professional and vocational self-esteem, and thereby, analyzed the correlation between principal's self-esteem and teachers' loyalty to school organization, their voluntary efforts and accommodation of value.<br/> As a result, it was found that teachers' perceived principal's self-esteem was correlated with their organizational commitment. Namely, the higher a principal's self-esteem was, teachers accommodated school goals and value as well as their affection of school and commitment to development of their organization. Such findings suggest that principals are obliged to endeavor to enhance their self-esteem.
鄭鎭環,玄鍾九 敎育硏究院 東國大學校 1996 교육문제연구 Vol.11 No.--
According to the Article 1 of the Private School Acts "The purpose of the Act is to promote the sound development of the privates schools through ensuring the autonomy and encouraging the publicity." However it seems that there are more restrictions and regulations by the government in the operation of the Act. In this sense, this study reviews some articles and clauses of the Act on the following subjects. 1. Authorization and Dissolution of Foundation of the Private Schools. The private schools can be established under the Article to 10 of the Act but the Minister can order the school foundation to break up the school if a school infringe the act. However it could be vicious act because there are no explicit phrases on the conditions of the official sanction and the inability to accomplish the purpose of the school foundation. 2. School Management and the Operation for Profitable Business. The school foundation can operate profitable business under the Clause 1, Article 6 of the Act. But the Article 5 of the School Asset Provision stipulates that the foundation should allot 80% of the profit to the school operational expenses. However the Act stipulates the particulars even to the profit account or the admission fee. Therefore the government make the management or budget of the school adjusted automatically if we consider the fact that the major sources of revenue is the tuition & fees only from students. 3. The Operation of School Affairs. Even though the purpose of school foundation is stipulated under the Article 1 of the Act, the Selection of Students(Article 96, 103, 107, 111), the Revenue of the School(Article 62), the Establishment and Operation of Departments(Article 155), the Books and Publications(Article 157) are stipulated under the separate, too. The above particulars are too restrictive for the foundations to operate the schools according to the Provision on the Purpose of the School foundation(Article 1). It would be desirable to entrust the school managements to the foundation. 4. The Personnel Management of Private Schools The provision on the school personnel is stipulated in the Act on the Government Employee and the Act on the Private Schools. The staff appointment of the private schools should be followed according to the Decree of President. The provisions on the staff appointment should be adjusted according to the characteristics of the privates schools so that the school foundations can select the staff on their will. 5. The Taxation Systems on the Private Schools. The private schools also can get the same taxation advantages corresponding to public schools. Therefore government should try to practice the reduction of and exemption from the various taxes for the private schools. In spite of such conditions, Korean private schools do not enjoy the satisfactory tax advantages