Serum level changes of long chain-polyunsaturated fatty acids in patients undergoing periodontal therapy combined with one year of omega-3 supplementation: a pilot randomized clinical trial

Gisele Lago Martinez,Josely Correa Koury,Marcela Anjos Martins,Fernanda Nogueira,Ricardo Guimarães Fischer,Anders Gustafsson,Carlos Marcelo S Figueredo 대한치주과학회 2014 Journal of Periodontal & Implant Science Vol.44 No.4

Purpose: We aimed to investigate the impact of nonsurgical periodontal treatment combined with one-year dietary supplementation with omega (ω)-3 on the serum levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and arachidonic acid (AA). Methods: Fifteen patients with chronic generalized periodontitis were treated with scaling and root planing. The test group consisted of seven patients (43.1±6.0 years) supplemented with ω-3, consisting of EPA plus DHA, three capsules, each of 300 mg of ω-3 (180-mg EPA/120-mg DHA), for 12 months. The control group was composed of eight patients (46.1±11.6 years) that took a placebo capsule for 12 months. The periodontal examination and the serum levels of DPA, EPA, DHA, and AA were performed at baseline (T0), and 4 (T1), and 12 (T2) months after therapy. Results: In the test group, AA and DPA levels had been reduced significantly at T1 (P<0.05). AA and EPA levels had been increased significantly at T2 (P<0.05). The ΔEPA was significantly higher in the test compared to the placebo group at T2–T0 (P=0.02). The AA/EPA had decreased significantly at T1 and T2 relative to baseline (P<0.05). Conclusions: Nonsurgical periodontal treatment combined with ω-3 supplementation significantly increased the EPA levels and decreased the AA/EPA ratio in serum after one year follow-up. However, no effect on the clinical outcome of periodontal therapy was observed.

Serum level changes of long chain-polyunsaturated fatty acids in patients undergoing periodontal therapy combined with one year of omega-3 supplementation: a pilot randomized clinical trial

Martinez, Gisele Lago,Koury, Josely Correa,Martins, Marcela Anjos,Nogueira, Fernanda,Fischer, Ricardo Guimaraes,Gustafsson, Anders,Figueredo, Carlos Marcelo S. Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.4

Purpose: We aimed to investigate the impact of nonsurgical periodontal treatment combined with one-year dietary supplementation with omega (${\omega}$)-3 on the serum levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and arachidonic acid (AA). Methods: Fifteen patients with chronic generalized periodontitis were treated with scaling and root planing. The test group consisted of seven patients ($43.1{\pm}6.0$ years) supplemented with ${\omega}$-3, consisting of EPA plus DHA, three capsules, each of 300 mg of ${\omega}$-3 (180-mg EPA/120-mg DHA), for 12 months. The control group was composed of eight patients ($46.1{\pm}11.6$ years) that took a placebo capsule for 12 months. The periodontal examination and the serum levels of DPA, EPA, DHA, and AA were performed at baseline (T0), and 4 (T1), and 12 (T2) months after therapy. Results: In the test group, AA and DPA levels had been reduced significantly at T1 (P<0.05). AA and EPA levels had been increased significantly at T2 (P<0.05). The ${\Delta}EPA$ was significantly higher in the test compared to the placebo group at T2-T0 (P=0.02). The AA/EPA had decreased significantly at T1 and T2 relative to baseline (P<0.05). Conclusions: Nonsurgical periodontal treatment combined with ${\omega}$-3 supplementation significantly increased the EPA levels and decreased the AA/EPA ratio in serum after one year follow-up. However, no effect on the clinical outcome of periodontal therapy was observed.

Cytotoxicity Screening of Several Tomato Extracts

Jose´ Luis Guil-Guerrero,Rebeca Ramos-Bueno,Ignacio Rodríguez-García,Cristóbal López-Sánchez 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1

The cytotoxic effects of extracts of the tomato variety “Racimo” have been evaluated through the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay at several concentrations. Three extracts—ethanol–water, petroleum ether, and in vitro digested tomato—exhibited in vitro cytotoxicity against the proliferation of the cultured cancer cell line HT-29. The concentration that caused 50% inhibition of cancer cell growth occurred (GI50) of the different extracts for HT-29 cells was 62.5μg/mL for the petroleum ether extract and 87.0μg/mL for the digested tomato extract. For the ethanol–water extract, it was not possible to determine this parameter at the assayed extract concentrations. These results clearly indicate that after the digestion process, the less polar substances, such as carotenoids and sterols, are bioavailable as active species against cancer cells. The GI50 levels for tomato extracts are similar to those values reported for medicinal plants. The results of the MTT assay on nonmutagenic CCD-18 cells showed a lack of negative effect on cell growth, which indicates that tomato extracts act selectively on HT-29 tumor cells. ^1H-Nuclear magnetic resonance spectra confirmed the presence of known compounds with accepted cytotoxic activity against tumor lines (lycopene and β-carotene). The high cytotoxicity for HT-29 cells showed by the petroleum ether extract might be due to the simultaneous presence in the extract of both carotenoids and glyceryl esters of fatty acids. The results of this work clearly indicate the importance of carotenoid consumption on colon tumor proliferation and prevention, and also the importance of the dietary fats in carotenoid bioavailability.

Los verbos ser y estar en la clase de E/LE

JOSE 한국스페인어문학회 2012 스페인어문학 Vol.0 No.63

Estos dos verbos son de los más evaluados en las pruebas de competencia del español como lengua extranjera (E/LE). El motivo parece obvio: el español es una de los pocos idiomas de amplia difusión con una distinción semejante y, a pesar de las dificultades que entraña para muchos alumnos de E/LE, los hispanohablantes no parecen mostrar divergencias considerables en los dialectos que componen su comunidad. En otras palabras, se asume que un error reiterado en la utilización de uno u otro verbo indica que el hablante no ha alcanzado un determinado nivel de competencia comunicativa, según la secuenciación del Plan Curricular del Instituto Cervantes. Este trabajo intenta ser una reflexión sobre este tema. Hemos dividido el artículo en 3 partes principales: en la primera sección, resumiremos la visión que se ha tenido de estas formas verbales en la tradición gramatical española y revisaremos conceptos como ‘permanente’ frente a ‘accidental’, ‘general’ frente a ‘particular’ o ‘delimitado’ frente a ‘no delimitado’. En la segunda sección, resumiremos la secuenciación que se hace en el Plan curricular de estos dos verbos (anexo 1) y analizaremos sus consecuencias basándonos en una encuesta (anexo 3) realizada a estudiantes de español en el nivel B2 o bien personas que han alcanzado ese nivel por otros medios (permanencia en el extranjero,por ejemplo). En la última sección, presentaremos nuestra propuesta, en la línea de los estudios sobre el aspecto léxico.

Exploring New Applications for Rhodiola rosea: Can We Improve the Quality of Life of Patients with Short-Term Hypothyroidism Induced by Hormone Withdrawal?

Jose´ M. Zubeldia,Hani A. Nabi,Miguel Jimenez del Rio,Jorge Genovese 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6

Patients treated for differentiated thyroid cancer (DTC) are subjected to periodic surveillance that includes serum thyroglobulin measurements followed by radioiodine administrations for diagnostic and therapeutic purposes if necessary. Both procedures require adequately elevated blood levels of thyroid-stimulating hormone (TSH), which can be achieved by two approaches: parenteral administration of recombinant human TSH (rhTSH) or stopping thyroid hormone replacement until optimal levels of endogenous TSH are achieved. Although rhTSH administration does not require hormone withdrawal, it is not inexpensive and carries the risk of secondary effects. The latter option is simpler but induces a profound state of hypothyroidism, which results in physical and mental complaints that may interfere severely with the patient’s activities of daily living. Rhodiola rosea is a popular plant in traditional medical systems in Eastern Europe and Asia with a reputation for stimulating the nervous system, decreasing depression, enhancing work performance, and eliminating fatigue,all features of clinical hypothyroidism. Investigators have also suggested additional benefits such as cardioprotection or even tumor growth inhibition. Here, we propose R. rosea as a viable alternative treatment for the symptoms of short-term hypothyroidism in patients with DTC who require hormone withdrawal.

Hay' problemas

Jose‘ Mari‘a Areta Ayuso 한국스페인어문학회 2004 스페인어문학 Vol.0 No.33

Estudiamos en este trabajo la sintaxix del verbo haber como existencial. Para ello, nos basamos tanto en los ejemplos en los que este verbo concuerda con su complemento nominal como en los que no existe tal concordanci´a (los normativos). Discutimos la hipo´tesis de que este verbo sea un verbo inacusativo y la rechazamos segu´n criterios sinta´cticos como la posicio´n del argumento. Planteamos despune´s la hipo´tesis de que este verbo impersonal existencial en realidad proyecta dos argumentos, uno LOCATIVO y otro nominal. Aunque ha habido autores que han defendido el CASO PARTITIVO para este complemento, nosotros creemos que es ACUSATIVO, incluso en las ocasiones en que se produce su concordancia con el verbo, ya que se producen en espan~ol casos simiares, como con el verbo ser en oraciones como son las dos. Por u´ltimo, intentamos extender nuestra hipo´tesis a todos los verbos impersonales del espan~ol, y en esta clase incluimos dos subcategori´as, los impersonales le´xicos, como haber, estar, ser, existir, etc, y los impersinales sinta´cticos estructuras que se convierten en impersonales so´lo si aparece un argumento espacio-temporal. Aunque parece que no es necesario en todos los casos que el sintagma espacio-temporal este´ en una posicio´n argumental, si´ es necesario que estev presinte o, al menos, sea interpretable contextualmente.

Korea’s Candlelight Protests in Context: Evidence from the Asian Barometer Survey and Global Events Data

José Alemán 고려대학교 평화와 민주주의연구소 2019 평화연구 Vol.27 No.1

2016-2017 witnessed the Candlelight Revolution, a series of protests in which 16 million South Koreans peacefully and successfully demanded the end of Park Geun-hye’s presidency. This paper probes what this event says about the strength of South Korea’s democracy. Scholars have argued that popular mobilization is positively associated with commitment to and support for democracy in East Asia. Using survey and events data, I study the factors driving protest participation in Korea and compare the Candlelight Revolution to previous protest cycles there. I also compare protest and repression in South Korea to domestic conflict in other Third Wave democracies. My research yields two important findings: political protest has become both more routine and less violent in South Korea, and genuine concerns about the quality of democracy rather than dissatisfaction with the political system have driven citizens to partake in protests in recent years. These findings imply that the Candlelight Revolution, the most recent manifestation of popular contention in Korea, reflects and is concerned with the quality of the country’s democracy.

우리는 왜 가난한가?

시오닐 호세/안경환 전남대학교 법률행정연구소 공익인권법센터 2008 인권법평론 Vol.- No.3

Reflections on the Lack of Consideration of Ethnic Ancestry to Stratify Clozapine Dosing

Jose de Leon(Jose de Leon ) 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.3

This review article argues against trusting standard clozapine references, including the US package insert, because they do not include advances in the sciences of pharmacokinetics and pharmacovigilance and ignore the effects of ethnic ancestry on therapeutic dosing. The minimum therapeutic dose leading to the minimum therapeutic concentration of 350 ng/mL in serum/plasma can be used to compare individuals/groups with treatment-resistant schizophrenia. The US clozapine package insert recommends targeting doses of 300-450 mg/day and, subsequently, increments of up to 100 mg with a maximum dose of 900 mg/day. Ethnic ancestry is defined by DNA ancestry group. Asians (people with ancestry ranging from Pakistan to Japan) and Indigenous Americans are similar in clozapine dosing; their average clozapine minimum therapeutic dose ranged from 166 mg/day (female non-smokers) to 270 mg/day (male smokers). For those with European ancestry, average clozapine minimum therapeutic doses ranged from 236 mg/day (female non-smokers) to 368 mg/day (male smokers). Based on limited studies, Black (African sub-Saharan ancestry) patients may be treated with typical US doses (300-600 mg/day), assuming no poor metabolism (PM) status. Ancestry’s impact on clozapine lethality in four countries is discussed (two countries with highly homogenous populations, Denmark and Japan, and two countries with increasingly heterogenous populations due to immigration, Australia and the UK). An international guideline with 104 authors from 50 countries/regions was recently published, providing 6 personalized clozapine titration schedules for adult inpatients (3 ancestry groups and PM/non-PM schedules) and recommending c-reactive protein monitoring at baseline and weekly for 4 weeks.

Numerical study of a new constructive sequence for movable scaffolding system (MSS) application

Teran, Jose Ramon Diaz de,Haach, Vladimir Guilherme,Turmo, Jose,Jorquera, Juan Jose Techno-Press 2016 Advances in concrete construction Vol.4 No.3

This paper consists in a study of a new contructive sequence of road viaducts with Movable Scaffolding System (MSS) using numerical tools based on finite element method (FEM). Traditional and new sequences are being used in Spain to build viaducts with MSS. The new sequence permits an easier construction of one span per week but implies some other issues related to the need of two prestressing stages per span. In order to improve the efficiency of the new sequence by reducing the number of prestressing stages per span, two solutions are suggested in this study. Results show that the best solution is to introduce the 100% of the prestressing force at the self-supporting core in order to improve the road viaduct construction with movable scaffolding system by reducing execution time without increasing economic costs.