Exploring New Applications for Rhodiola rosea: Can We Improve the Quality of Life of Patients with Short-Term Hypothyroidism Induced by Hormone Withdrawal?

Jose´ M. Zubeldia,Hani A. Nabi,Miguel Jimenez del Rio,Jorge Genovese 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6

Patients treated for differentiated thyroid cancer (DTC) are subjected to periodic surveillance that includes serum thyroglobulin measurements followed by radioiodine administrations for diagnostic and therapeutic purposes if necessary. Both procedures require adequately elevated blood levels of thyroid-stimulating hormone (TSH), which can be achieved by two approaches: parenteral administration of recombinant human TSH (rhTSH) or stopping thyroid hormone replacement until optimal levels of endogenous TSH are achieved. Although rhTSH administration does not require hormone withdrawal, it is not inexpensive and carries the risk of secondary effects. The latter option is simpler but induces a profound state of hypothyroidism, which results in physical and mental complaints that may interfere severely with the patient’s activities of daily living. Rhodiola rosea is a popular plant in traditional medical systems in Eastern Europe and Asia with a reputation for stimulating the nervous system, decreasing depression, enhancing work performance, and eliminating fatigue,all features of clinical hypothyroidism. Investigators have also suggested additional benefits such as cardioprotection or even tumor growth inhibition. Here, we propose R. rosea as a viable alternative treatment for the symptoms of short-term hypothyroidism in patients with DTC who require hormone withdrawal.

Los verbos ser y estar en la clase de E/LE

JOSE 한국스페인어문학회 2012 스페인어문학 Vol.0 No.63

Estos dos verbos son de los más evaluados en las pruebas de competencia del español como lengua extranjera (E/LE). El motivo parece obvio: el español es una de los pocos idiomas de amplia difusión con una distinción semejante y, a pesar de las dificultades que entraña para muchos alumnos de E/LE, los hispanohablantes no parecen mostrar divergencias considerables en los dialectos que componen su comunidad. En otras palabras, se asume que un error reiterado en la utilización de uno u otro verbo indica que el hablante no ha alcanzado un determinado nivel de competencia comunicativa, según la secuenciación del Plan Curricular del Instituto Cervantes. Este trabajo intenta ser una reflexión sobre este tema. Hemos dividido el artículo en 3 partes principales: en la primera sección, resumiremos la visión que se ha tenido de estas formas verbales en la tradición gramatical española y revisaremos conceptos como ‘permanente’ frente a ‘accidental’, ‘general’ frente a ‘particular’ o ‘delimitado’ frente a ‘no delimitado’. En la segunda sección, resumiremos la secuenciación que se hace en el Plan curricular de estos dos verbos (anexo 1) y analizaremos sus consecuencias basándonos en una encuesta (anexo 3) realizada a estudiantes de español en el nivel B2 o bien personas que han alcanzado ese nivel por otros medios (permanencia en el extranjero,por ejemplo). En la última sección, presentaremos nuestra propuesta, en la línea de los estudios sobre el aspecto léxico.

Cytotoxicity Screening of Several Tomato Extracts

Jose´ Luis Guil-Guerrero,Rebeca Ramos-Bueno,Ignacio Rodríguez-García,Cristóbal López-Sánchez 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1

The cytotoxic effects of extracts of the tomato variety “Racimo” have been evaluated through the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay at several concentrations. Three extracts—ethanol–water, petroleum ether, and in vitro digested tomato—exhibited in vitro cytotoxicity against the proliferation of the cultured cancer cell line HT-29. The concentration that caused 50% inhibition of cancer cell growth occurred (GI50) of the different extracts for HT-29 cells was 62.5μg/mL for the petroleum ether extract and 87.0μg/mL for the digested tomato extract. For the ethanol–water extract, it was not possible to determine this parameter at the assayed extract concentrations. These results clearly indicate that after the digestion process, the less polar substances, such as carotenoids and sterols, are bioavailable as active species against cancer cells. The GI50 levels for tomato extracts are similar to those values reported for medicinal plants. The results of the MTT assay on nonmutagenic CCD-18 cells showed a lack of negative effect on cell growth, which indicates that tomato extracts act selectively on HT-29 tumor cells. ^1H-Nuclear magnetic resonance spectra confirmed the presence of known compounds with accepted cytotoxic activity against tumor lines (lycopene and β-carotene). The high cytotoxicity for HT-29 cells showed by the petroleum ether extract might be due to the simultaneous presence in the extract of both carotenoids and glyceryl esters of fatty acids. The results of this work clearly indicate the importance of carotenoid consumption on colon tumor proliferation and prevention, and also the importance of the dietary fats in carotenoid bioavailability.

Korea’s Candlelight Protests in Context: Evidence from the Asian Barometer Survey and Global Events Data

José Alemán 고려대학교 평화와 민주주의연구소 2019 평화연구 Vol.27 No.1

2016-2017 witnessed the Candlelight Revolution, a series of protests in which 16 million South Koreans peacefully and successfully demanded the end of Park Geun-hye’s presidency. This paper probes what this event says about the strength of South Korea’s democracy. Scholars have argued that popular mobilization is positively associated with commitment to and support for democracy in East Asia. Using survey and events data, I study the factors driving protest participation in Korea and compare the Candlelight Revolution to previous protest cycles there. I also compare protest and repression in South Korea to domestic conflict in other Third Wave democracies. My research yields two important findings: political protest has become both more routine and less violent in South Korea, and genuine concerns about the quality of democracy rather than dissatisfaction with the political system have driven citizens to partake in protests in recent years. These findings imply that the Candlelight Revolution, the most recent manifestation of popular contention in Korea, reflects and is concerned with the quality of the country’s democracy.

Hay' problemas

Jose‘ Mari‘a Areta Ayuso 한국스페인어문학회 2004 스페인어문학 Vol.0 No.33

Estudiamos en este trabajo la sintaxix del verbo haber como existencial. Para ello, nos basamos tanto en los ejemplos en los que este verbo concuerda con su complemento nominal como en los que no existe tal concordanci´a (los normativos). Discutimos la hipo´tesis de que este verbo sea un verbo inacusativo y la rechazamos segu´n criterios sinta´cticos como la posicio´n del argumento. Planteamos despune´s la hipo´tesis de que este verbo impersonal existencial en realidad proyecta dos argumentos, uno LOCATIVO y otro nominal. Aunque ha habido autores que han defendido el CASO PARTITIVO para este complemento, nosotros creemos que es ACUSATIVO, incluso en las ocasiones en que se produce su concordancia con el verbo, ya que se producen en espan~ol casos simiares, como con el verbo ser en oraciones como son las dos. Por u´ltimo, intentamos extender nuestra hipo´tesis a todos los verbos impersonales del espan~ol, y en esta clase incluimos dos subcategori´as, los impersonales le´xicos, como haber, estar, ser, existir, etc, y los impersinales sinta´cticos estructuras que se convierten en impersonales so´lo si aparece un argumento espacio-temporal. Aunque parece que no es necesario en todos los casos que el sintagma espacio-temporal este´ en una posicio´n argumental, si´ es necesario que estev presinte o, al menos, sea interpretable contextualmente.

Management of esophageal neoplasms by endoscopic submucosal dissection: experience over 100 consecutive procedures

Josué Aliaga Ramos,Yoshinori Morita,Takashi Toyonaga,Danilo Carvalho,Moises Salgado Pedrosa,Vitor N. Arantes 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.5

Background/Aims: Endoscopic submucosal dissection (ESD) is currently considered the first-line treatment for the eradication of superficialneoplasms of the esophagus in Eastern countries. However, in the West, particularly in Latin America, the experience withesophageal ESD is still limited because of the high technical complexity required for its execution. This study aimed to present the resultsof the clinical application of ESD to manage superficial esophageal neoplasms in a Latin American center in over 100 consecutivecases. Methods: This retrospective study included consecutive patients who underwent endoscopic ESD for superficial esophageal neoplasmsbetween 2009 and 2022. The following clinical outcomes were assessed: en bloc, complete, and curative resection rates, local recurrence,adverse events, and procedure-related mortality. Results: Esophageal ESD was performed mainly for squamous cell carcinoma (66.6%), high-grade intraepithelial neoplasia (17.1%),and adenocarcinoma (11.4%). En bloc and complete resection rates were 96.2% and 81.0%, respectively. The curative resection rate was64.8%. Adverse events occurred in six cases (5.7%). Endoscopic follow-up was performed for an average period of 29.7 months. Conclusions: ESD performed by trained operators is feasible, safe, and clinically effective for managing superficial neoplastic lesions ofthe esophagus in Latin America.

A novel quantitation method for phthalates in air using a combined thermal desorption/gas chromatography/mass spectrometry application

Jo, S.H.,Kim, K.H.,Kim, Y.H. Elsevier Pub. Co 2016 Analytica chimica acta Vol.944 No.-

In this study, a novel quantitation method was developed to facilitate the simple and effective sampling and analysis of phthalates in air based on a sorbent tube-thermal desorption-gas chromatography-mass spectrometry system combination. The performance of the thermal desorption-based analysis was assessed using three different sorbent combinations [1]: quartz wool (QW) [2], glass wool (GW), and [3] quartz wool plus Tenax TA (QWTN) in terms of relative recovery in reference to a direct injection method. There was no significant difference in the average recovery rate for seven target phthalates based on sorbent tube type (QW, 70.2 +/- 4.28; GW, 73.2 +/- 8.8; and QWTN, 72.5 +/- 5.02%). However, the recovery rate of phthalates in each sorbent tube type was distingusihed by physicochemical properties of the target compound (e.g., molecular weight and boiling point). The recovery rate of the QW tube was high for dimethyl phthalate and diethyl phthalate compared to other sorbent tubes, while that of the GW tube exhibited greater values for dibutyl phthalate, benzyl butyl phthalate, di(2-ethylhexyl) adipate, di(2-ethylhexyl) phthalate, and di-n-octyl phthalate. The simple sorbent tube-thermal desorption approach is feasible for the quantitation of seven phthalates present at 0.45-24.5 ng m<SUP>-3</SUP> levels in actual air samples (20 L).

Synthesis and investigation of random-structured ionomers with highly sulfonated multi-phenyl pendants for electrochemical applications

Jo, S.G.,Kim, T.H.,Yoon, S.J.,Oh, S.G.,Cha, M.S.,Shin, H.Y.,Ahn, J.M.,Lee, J.Y.,Hong, Y.T. Elsevier Scientific Pub. Co 2016 Journal of membrane science Vol.510 No.-

Poly(p-phenylene)-based random copolymers with locally and densely sulfonated multi-phenyl pendants, which are promising candidates for hydrocarbon-based electrolyte membrane materials for fuel cells, were synthesized using Ni(0)-catalyzed cross-coupling polymerization. The synthesized ionomers, SPPFPB-o, showed outstanding dimensional changes and proton conductivity. The SPPFPB-5.5 membrane in particular had the highest ion exchange capacity (IEC) (2.58meq/g) among the SPPFPB-o series. It exhibited smaller dimensional changes toward the in-plane direction (@?l) than that of the Nafion® 212 membrane, in spite of a higher water uptake (WU) value, which seemed to be derived from the rigid backbone structure. Moreover, the SPPFPB-5.5 membrane showed excellent fuel cell performance and long-term stability comparable or superior to those of Nafion® 212 under fully and partially hydrated conditions.

Characterization of a modified Bosch-type process for silicon mold fabrication

Jo, S.-B.,Lee, M.-W.,Lee, S.-G.,Lee, E.-H.,Park, S.-G.,O, B.-H. SLACK INCORPORATED 2005 Journal of Vacuum Science & Technology. A Vol.23 No.4

Development of a sampling method for carbonyl compounds released due to the use of electronic cigarettes and quantitation of their conversion from liquid to aerosol

Jo, S.H.,Kim, K.H. Elsevier 2016 Journal of chromatography Vol.1429 No.-

<P>In this study, an experimental method for the collection and analysis of carbonyl compounds (CCs) released due to the use of electronic cigarettes (e-cigarettes or ECs) was developed and validated through a series of laboratory experiments. As part of this work, the conversion of CCs from a refill solution (e-solution) to aerosol also was investigated based on mass change tracking (MCT) approach. Aerosol samples generated from an e-cigarette were collected manually using 2,4-dinitrophenylhydrazine (DNPH) cartridges at a constant sampling (puffing) velocity of 1 L min(-1) with the following puff conditions: puff duration (2 s), interpuff interval (10 s), and puff number (5,10, and 15 times). The MCT approach allowed us to improve the sampling of CCs through critical evaluation of the puff conditions in relation to the consumed quantities of refill solution. The emission concentrations of CCs remained constant when e-cigarettes were sampled at or above 10 puff. Upon aerosolization, the concentrations of formaldehyde and acetaldehyde increased 6.23- and 58.4-fold, respectively, relative to their concentrations in e-solution. Furthermore, a number of CCs were found to be present in the aerosol samples which were not detected in the initial e-solution (e.g., acetone, butyraldehyde, and o-tolualdehyde). (C) 2015 Elsevier B.V. All rights reserved.</P>