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李重求,李相泰 성균관대학교 기초과학연구소 1994 論文集 Vol.45 No.2
韓國産 잔대屬 植物중 北韓種과 未確認種을 除外한 分類群에 대해 그 동안 混同되었던 種의 限界를 분명히 하기 위하여 總 11種 17分類群의 外部形態學的 特徵을 調査하여 分類學的으로 整理하고 檢索表를 作成하였고, 本 硏究에서 긴당잔대(Adenophora stricta Miq. var. lacifolia Honda)가 未記錄種으로 追加되었다. 韓國産 잔대屬 植物을 Baranov(1963)의 分類體系에 따라 分類하면 다음과 같으며 Remotiflorae節은 Ponomarchuk(1971)이 昇格處理한 結果를 따랐다 : 1) 輪生葉과 가늘고 긴 圓筒形의 蜜盤을 갖는 Platyphyllae節(층층잔대, 털잔대, 좀층층잔대, 가는 층층잔대, 넓은잔대, 외대잔대, 잔대, 왕잔대); 2) 互生葉이며 葉柄이 길고 圓筒形 蜜盤을 갖는 Remotiflorae節(모시대, 그늘모시대, 흰모시대) ; 3) 互生葉이며 葉柄이 없으며, 짧은 圓筒形이 蜜盤을 갖는 Microdiscus節(당잔대, 긴당잔대, 진퍼리잔대, 가는잎잔대); 4) 葉柄이 없는 互生葉과 圓盤型 蜜盤을 갖는 Thyrsanthae節(둥근잔대, 두메잔대). All taxa of the Korean Adenphora except North Korean and dubious ones were morphologically investigated to delimit their taxonomic position. As for 11 species and 17 taxa, a taxonomic treatment and keys to the taxa were made. Adenophora stricta Miq. var. lancifolia Honda was reported as an unrecorded taxon to Korea. According to the Baranov's system (1963) the Korean Adenophora species except Sect. Remotiflorae (Ponomarchuk, 1971) which had been treated as a series in Sect. Microdiscus by Baranov, were classified as follows: Sect. 1. Platyphyllae with whorled leaves and long-thin tubular disc: A. verticiliata, var. abbreviata, var. angustifolia, and for. hirsuta, A. divaricata var. manshurica, A. racemosa, A. triphylla var. japonica, and A. tyosenensis. Sect. 2. Remotiflorae with alternate, long-petiolate leaves and tubular disc: A. remotiflora, var. hirticalyx, and for. leucantha. Sect. 3. Microdiscus with alternate, sessile leaves and short tubular disc: A. stricta, var. lancifolia, A. palustris, and A. liliifolia. And Sect. 4. Thyrsanthae with alternate, sessile leaves and cylindrical disc: A. cornopifolia and A. lamarckii.
Moon, Hyung-In,Lee, Joongku,Kwak, Jong Hwan,Zee, Ok-Pyo,Chung, Jin Ho Pharmaceutical Society of Japan 2005 Biological & pharmaceutical bulletin Vol.28 No.5
<P>Long term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases such as skin cancer as well as photoaging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here we investigated the effect of 2′,4′,7-trihydroxyisoflavone isolated from the whole plants of <I>Viola hondoensis</I> (Violaceae) on the expression of MMPs in UV-irradiated human skin fibroblasts <I>in vitro</I>. 2′,4′,7-Trihydroxyisoflavone markedly reduced UV-induced MMP-1 expression, but not MMP-2, at the both mRNA and protein levels in a dose-dependent manner. Our report is the first description for the ability of 2′,4′,7-trihydroxyisoflavone to regulate MMP-1 expression specifically.</P>
Phytochemical Investigation of Tiarella polyphylla
Guanghai Shen,오세량,민병선,Joongku Lee,Kyung Seop Ahn,김영호,Hyeong-Kyu Lee 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
Seven flavonoids (1-7), two triterpenoids (8 and 9) and four steroids (10, 11, 12 and 13) were isolated from the whole plant of Tiarella polyphylla. Based on the physicochemical and spectroscopic analyses, their structures were identified as myricetin (1), astragalin (2), afzelin (3), quercitrin (4), myricitin (5), nicotiflorin (6), isoquercitrin (7), tiarellic acid (8), 3β-hydroxy- 20(29)lupen-27-oic acid (9), β-sitosterol-3-O-β-D-glucoside (10), stigmasterol-3-O-β-D–glucoside (11), β–sitosterol (12) and ergosterol endoperoxide (13). All 13 compounds, with the exception of tiarellic acid were isolated for the first time from T. polyphylla. In the anti-complementary assay, the steroids (12 and 13) exhibited potent activities; whereas, the flavonoids (1 to 7) showed weak or no activities, but even the triterpenoids (8 and 9) and steroidal saponins (10 and 11) evoked hemolysis.
Moon, Hyung In,Lee, Joongku,Zee, Ok Pyo,Chung, Jin Ho Pharmaceutical Society of Japan 2005 Biological & pharmaceutical bulletin Vol.28 No.6
<P>Isolation of the ethyl acetate soluble fraction from aerial parts of <I>Viola hondoensis</I> W. B<SMALL>ECKER</SMALL> <I>et</I> H. B<SMALL>OISSIEU</SMALL> yielded one major isoflavonoid glycoside, tectoridin-4′-<I>O</I>-β-<SMALL>D</SMALL>-glucoside. The structure of the compound was certainly determined by chemical analyses, as well as 1D- and 2D-NMR spectroscopy. The compound exhibited potent inhibitory activity against the expression of matrix metalloproteinase-1 caused by UV-irradiation in cultured human skin fibroblasts.</P>
Kim, Soo-Young,Kim, Chan-Soo,Lee, Joongku,Bang, Jae-Wook Korean Society of Genetics 2008 Genes & Genomics Vol.30 No.2
Using meiosis and mitosis chromosomes, we have karyotyped and physically mapped of Humulus japonicus. The somatic metaphase chromosome numbers were 2n = 2x = 14 + XX in female, 2n = 2x = 14 + XY<SUB>1</SUB>Y<SUB>2</SUB> in male and 2n = 3x = 21 + XXX in triploid. The 5S and 45S rDNA genes were physically mapped on the metaphase chromosomes using fluorescence in situ hybridization (FISH). One pair of 5S rDNA gene was detected on the short arm of chromosome 4 and two pairs of 45S rDNA gene were observed on the terminal regions of the short arms of chromosome 5 and 7 in both female and male plants. In addition, three pairs of two rDNAs were detected on the chromosome 4, 5 and 7 of triploid. At meiosis, a trivalent chromosome figure was clearly seen, of which Y<SUB>1</SUB> and Y<SUB>2</SUB> could be distinguished from X by their premature condensation and three chromosomes, Y<SUB>1</SUB>-X-Y<SUB>2</SUB>, the forms associated by terminal chiasmata.
Neuroprotective and Free Radical Scavenging Activities of Phenolic Compounds from Hovenia dulcis
Gao Li,Byung-Sun Min,Changji Zheng,Joongku Lee,Sei-Ryang Oh,Kyung-Seop Ahn,Hyeong-Kyu Lee 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.7
The EtOAc-soluble fraction from a methanolic extract of Hovenia dulcis Thunb. exhibited neuroprotective activity against glutamate-induced neurotoxicity in mouse hippocampal HT22 cells. The neuroprotective activity-guided isolation resulted in 8 phenolic compounds (1-8), such as vanillic acid (1), ferulic acid (2), 3,5-dihydroxystilbene (3), (+)-aromadendrin (4), methyl vanillate (5), (-)-catechin (6), 2,3,4-trihydrobenzoic acid (7), and (+)-afzelechin (8). Among these, compounds 6 and 8 had a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells. Furthermore, compound 6 had a DPPH free radical scavenging effect with an IC50 value of 57.7 µM, and a superoxide anion radical scavenging effect with an IC50 value of 8.0 µM. Both compounds 6 and 8 had ABTS cation radical scavenging effects with IC50 values of 7.8 µM and 23.7 µM, respectively. These results suggest that compounds 6 and 8 could be neuroprotectants owing to their free radical scavenging activities.
Anticomplement Activity of Compounds Isolated from the Roots of Euphorbia kansui
Gao Li,Jung-Hee Kim,Guanghai Shen,Joongku Lee,Hyeong-Kyu Lee,오세량 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.2
The anticomplement activity-guided fractionation of the methanol extract of Euphorbia kansui L. resulted in isolation of three diterpenes, two triterpenes, and two sterols (1-7) from ethyl acetate fraction. By spectroscopic analysis, their chemical structures were elucidated as: β-amyrin (1); kansuiphorin C (2); 3-O-(2'E,4'Z-decadienoyl)-ingenol (3); 3-O-(2,3-dimethylbutyryl)-13-O-ndodecanoyl-13-hydroxyingenol (4); β-sitosterol (5); α-euphol (6); β-sitosterol-3-O-β-Dglucopyranoside (7). These compounds were investigated in vitro for their anticomplement activity against the classical pathway of the complement system, with compounds 2-4 exhibiting significant anticomplement activity with respective 50% inhibitory concentration values of 44.1±3.8, 89.5±5.5, and 152.1±6.2 μM.