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Cyclosporin A 반복투여에 의한 랫드 간장의 조직학적 변화
윤화중,손무호,장병준,권구범 건국대학교 동물자원연구센터 1998 動物資源硏究誌 Vol.19 No.-
This study was carried out to investigate the histological changes of rat liver by repeated treatment of cyclosporin A that has been widely used for treating some autoimmune diseases and immunosuppressive drug in organ transplantation. 70 Sprague-Dawley rats were kept in experimental circumstances for 2 weeks and 50mg/kg B.W of cyclosporin A was injected once a day subcutaneously for 7 days and sacrificed at 1 hour, 1 day, 3 days, 7 days, 14 days, 28 days after the last injection. Histological changes were observed by H & E, Oil red O, and Masson trichrome stains and the results obtained were as follows. 1. 26 percent of animals has died during the treatment of cyclosporin A, and the animals survived were observed to be dull and inactivated. 2. The mild cytoplasmic changes of hepatocytes in portal area were observed by H & E stain in 1 hour lapse group and this finding was recovered with time lapse. 3. The lipid accumulation in periportal areas was observed in 1 hour and 1 day lapse groups and this finding was recovered with time lapse. 4. Although the cytoplasmic changes and lipid accumulation were started in the portal area and moved to intermediated and central areas, the changes in the intermediate and central areas were not as severe as that of portal area. 5. No specific increase of connective tissue was observed in all groups. 6. Histological changes of rat liver induced by cyclosporin A were recovered with time lapse, and the entire recovery was observed in 28 days lapse group after the last injection.
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이종호,정중재,정종철,서구종 大韓顎顔面成形再建外科學會 1992 Maxillofacial Plastic Reconstructive Surgery Vol.14 No.4
Osteopetrosis is a rare skeletal disease of unknown etiology. Osteomyelitic changes in the jaw bones are frequently seen in this disease, especially in the mandible and may follow upon tooth extractioin. A case is reported of a 31-year-old male who was seen because of intraorally exposed bony spicule and chronic dull pain. Radiographic and haematological investigations led to the diagnosis of osteopertrosis with osteomyelitis. The striking radiologic findings were pathologic mandibular fracture and generalized skeletal thickening. The present case could be grouped under the benign form, type II osteopetrosis. With the conservative and minimally invasive modes of treatment including administration of penicillin G sodium, curettage and closed reduction, we could successfully manage the osteomyelitis and pathologic fracture associated osteopetrosis.
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감마선 조사가 조미오징어의 저장 중 품질특성에 미치는 영향
노정은,김병근,김현구,권중호 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.5
This study was conducted to investigate the changes in the quality of gamma-irradiated seasoned cuttle during storage. Seasoned cuttle packed in PVC film (0.06 mm) was stored at 15±1℃ for 6 months after treatment with doses of 0 to 7 kGy. Microbial populations of seasoned cuttle were 1.6×10^5 CFU/g in total aerobic bacteria, 10⁴~10^5 CFU/g in yeasts & molds, and negative in coliforms, which were effectively reduced by 3 kGy or higher up to the undetectable level(〈20 CFU/g). The pH and moisture content of the samples were not changed with irradiation, but moisture was some decreased during storage. The instrumental color (especially Hunter b value), pigments (lipophilic & hydrophilic) and TBA value of the samples increased with storage time as well as irradiation dose more than 3 kGy. The influence of storage condition, however, were more significant. Irradiation did not induce any changes in volatile basic nitrogen (VBN) and trimethylamine (TMA) contents, thereby maintaining their contents lower than those of the non-irradiated samples during storage by reducing the microbial load.
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이중혈류유발 심폐소생술이 심정지를 유발한 개의 단기 생존율에 미치는 영향
황성오,조준휘,강구현,김성환,문중범,이강현,이승환,윤정한,최경훈,홍은석 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3
Background and Objectives: We previously reported that, compared with standard cardiopulmonary resuscitation(S-CPR), better hemodynamic effects could be achieved by simultaneous sterno-thoracic cardiopulmonary resuscitation(SST-CPR) in which we compressed the sternum and constricted the thorax circumferentially during the systolic period by using a device. This study was designed to assess whether SST-CPR, compared with S-CPR, improve the survival rate of dogs with cardiac arrest. Subjects and methods: Twenty-five mongrel dogs(19∼31㎏) were enrolled in this study. After four minutes of ventricular fibrillation induced by an AC current, animals were randomized to resuscitate with either S-CPR(n=13) or SST-CPR(n=12). Epinephrine(1 ㎎) was injected into the right atrium every three minutes after the beginning of CPR. Defibrillation was attempted after 6 minutes of CPR. Standard advanced cardiac life support was started if defibrillation was not successful. Results: SST-CPR resulted in significantly(p<0.001) higher systolic arterial pressure(91±47 vs 47±24 ㎜ Hg), diastolic pressure(43±24 vs 17±10 ㎜ Hg), coronary perfusion pressure(35±25 vs 13±9㎜ Hg), and end tidal CO2 tension(9±4 vs 3±2 ㎜ Hg). Two of 13 animals(15 %) resuscitated with S-CPR and six of 12 animals(50%) resuscitated with SST-CPR survived until 12 hours after cardiac arrest(p<0.05). Donclusion: SST-CPR, compared with S-CPR, improves the short-term survival rate in canine cardiac arrest.
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홍중구(Joong-ku Hong),손재영(Jae-young Son) 건국대학교 부동산도시연구원 2017 부동산 도시연구 Vol.9 No.2
고령화는 인구구조 변화와 함께 국가 경제환경에 미치는 영향도 크다, 인구구조 변화는 생산가능 인구의 감소로 이어져, 노인가구에 대한 부양문제를 부각시키고 있다. 경제적 측면에서 노인가구는 근로소득의 감소로 가계 재무 관리의 어려움을 겪게 된다. 근로소득의 감소분은 공적,사적 이전소득과 함께 보유자산을 통한 소득으로 일부 보완되고 있다. 증가하는 중고령가구의 재정적 건전성 확보는 국가 경제안정에 미치는 영향도 크다. 본 연구는 중고령가구의 가계수지 건전성 여부에 따른 인구학적, 경제적요소 차이를 확인하고, 경제적요소가 가계수지 건전성에 미치는 영향을 분석하였다. 분석 결과 자산요소에서 부동산자산과 부채는 가계재정수지 건전성에 음(-)의 영향을 미치고 있으며, 총소득과 금융자산은 가계재정수지 건정성에 양(+)의 영향을 미치고 있다. 이는 가계재정수지 건전성 확보를 위해서는 보유자산의 유동화가 중요하다는 것을 시사하고 있다. Ageing, along with changes in the population structure, has a great impact on the national economic environment. Changes in the population structure leads to a decrease in the working-age population, bringing about the problem of supporting the aged households. For the aged household, household financial management is more important due to the reduction in earned income. Decrease in earned income is somewhat supplemented by income from asset management as well as public and private transfer income. This study attempts to find out a difference in demographical and economic elements according to financial balance of middle-to old-age households and to analyze the effect of the economic element on the soundness of household financial balance. Results of analysis showed that real estate assets and debts had a negative effect on the soundness of household financial balance and that total income and financial assets had a positive effect on the soundness of household financial balance. This suggests that the liquid asset is important to secure the soundness of household financial balance.
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Shin, Joong-Ho,Kim, Kyoung-Hwa,Kim, Su-Hwan,Koo, Ki-Tae,Kim, Tae-Il,Seol, Yang-Jo,Ku, Young,Rhyu, In-Chul,Chung, Chong-Pyoung,Lee, Yong-Moo Blackwell Publishing Ltd 2010 Journal of Clinical Periodontology Vol.37 No.3
<P><I>Shin J-H, Kim K-H, Kim S-H, Koo K-T, Kim T-I, Seol Y-J, Ku Y, Rhyu I-C, Chung C-P, Lee Y-M</I>. Ex vivo <I>bone morphogenetic protein-2 gene delivery using gingival fibroblasts promotes bone regeneration in rats. J Clin Periodontol 2009; 37: 305–311. doi: 10.1111/j.1600-051X.2009.01522.x</I>.</P><P>Abstract</P><P>Aim</P><P>The aim of the present study was to investigate bone regeneration following ex vivo bone morphogenetic protein-2 (BMP-2) gene delivery using human gingival fibroblasts (HGFs) in rat calvarial defects.</P><P>Materials and Methods</P><P>An 8 mm craniotomy defect was created in Sprague–Dawley rats. The animals were divided into four groups: (1) non-grafted group, the defect was left empty; (2) collagen matrix group, the defect was filled with collagen matrix only; (3) HGF group, the defect was filled with non-transduced HGFs on collagen matrix; (4) BMP-2/HGF group, the defect was filled with BMP-2 gene-transduced HGFs on collagen matrix. Animals were sacrificed at 2 and 4 weeks after surgery, and micro-computed tomographic and histologic observations were performed.</P><P>Results</P><P>The BMP-2/HGF group showed promoted osseous healing of calvarial defects, as compared with the other groups. At both 2 and 4 weeks, regenerated bone area was significantly greater in the BMP-2/HGF group than the other three groups. Quite a few number of transplanted HGFs were observed within the regenerated bone tissues.</P><P>Conclusions</P><P>The results of this study suggest that ex vivo BMP-2 gene delivery induces prominent bone regeneration in vivo and HGFs may be useful as target cells for ex vivo gene therapy.</P>
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홍중구(Hong Joong Ku),손재영(Son Jae Young) 한국주거환경학회 2016 주거환경(한국주거환경학회논문집) Vol.14 No.4
Interests in middle-and advanced-age households are mounting due to the rapid aging of our society. Their proportion in total households is on the increase, and their consumption is gradually exerting an increasing effect on the home market. Accordingly, this study attempted to analyze influences on household consumption such as the income element, the asset element and the demographical element by dividing the households of houesholders aged above their 50s by age group. As a result, it was found that earned income as the income element had the greatest effect on household consumption. But there was a difference in income from real estate and financial income according to the age group. Income from real estate had the greater effect on consumption expenditure on non-durable goods than financial income, whereas financial income had a greater effect on consumption expenditure on social participation than income from real estate. The households of the householders ranging from 50 to 64 years had a significant negative value in both consumption on non-durable goods and on social participation in terms of transfer income(both private and public), and the households of those aged above 75 years had a significant positive value. And property assets had a much greater effect on household consumption than financial assets in terms of the asset element. This study has the following implication : Retired hoseholders would need jobs for earned income. So there is a need to change the direction of assets from property assets occupying most of the assets of middle- and advanced-age households to financial income in order to revitalize their consumption on social participation. And the social-security policy for the elderly would be more effective for the super-aged household. The consumption of middle- and advenced-age households would contribute to the development of national economy by revitalizing the home market.
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