아동의 색채개념 발달정도에 관한 연구

이연숙,오승혜,이의준 연세대학교 대학원 1986 延世論叢 Vol.22 No.1

The purpose of this study was to identify developmental phase of the color concept of Korean children according to age, sex. The present experiment was conducted during June, 1985. Subjects were 616children ranged form 3-year old to 15-year old, who were attending to Child Development Research Institute of Y University, E indergarten,E Demonstration Elementary School College of E Womans University, A Middle School. The materials used in the experiment were 24 colored papers selected through a pilot study. The experiment was designed to identify the children's color concepts by presenting the 24 colored papers.

주요우울증이 근로자의 생산성에 미치는 영향 : WHO-HPQ(Health and Work Performance Questionnaire)를 이용한 예비연구

김원,황태연,함병주,이준석,최병휘,김세주,서용진,강은호,우종민 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Major depressive disorder (MDD) causes patients' distress and makes socioeconomic burden, both directly and indirectly. We used the concept of lost productive time (LPT) to estimate the indirect costs and calculated both absenteeism and presenteeism among workers with MDD. Mcthods : Depression group was recruited from workers visiting psychiatric outpatient clinic who had MDD without major physical or mental disorders (N= 106). Age and sex matched healthy control group was also recruited through advertisement (M=100). All participants completed a interview using WHO Health and Work Performance Questionnaire (HPQ), Job Stress Measurement Scale for Korean Employees, and Hamilton Rating Scale for Depression. Statistical analysis was performed with independent t-test or χ² test as characteristics of values (p=0.05). Results : The number of absence (0.94-day/month vs. 0.10-day/month, P=0.015) andthe numberofearly leaving (2.56-day/month vs. 0.24-day/month, P<0.001) were significantly higher in the depression group. Depression group evaluated their Perfor-mance level much lower than controls with significant value (5.16 vs. 7.62, P<0.001). In addition, depression group estimated their performance level during the last 4 weeks lower compared to the level of past 1-year (5.16 vs 6.63, P<0.001). The estimated costs of absenteeism in depression group were higher than controls by 2,520,000 Korean Won per year, and those of presenteeism were also higher by 4,880,000 Korean Won per year. The total costs of LPT in depression group were higher than controls by 7,400,000 Korean Won, which corresponds to 26% ofmean annual salary. In addition, the level of occupational stress, such as high demand and interpersonal conflict, was higher in the depression group. Conclusion : Major depressive disorder costs substantial productivity loss to workers and their company. Presenteeism imposes more time cost than absenteeism. Effectiveness trials are needed to devise cost-effective programs for the early detection and treatment of depression at the workplace.

The Prevalence and Characteristics of Brown Adipose Tissue in an $^{18}F$-FDG PET Study of Koreans

Park, Joon-Yeun,Lim, Jung-Sub,Park, Eun-Young,Cho, A-Ra,Kim, Byeong-Il,Cheon, Gi-Jeong,Choi, Chang-Woon,Lim, Sang-Moo The Korea Society of Nuclear Medicine 2010 핵의학 분자영상 Vol.44 No.3

Purpose The object of this study was to evaluate the prevalence and characteristics of brown adipose tissue (BAT) in Korean subjects using $^{18}F$-fluorodeoxyglucose positron emission tomography ($^{18}F$-FDG PET). Methods Six thousand and five consecutive $^{18}F$-FDG PET/CT scans of 5,115 patients (3,007 females and 2,108 males, mean age 53.5 years) were retrospectively reviewed. We characterized the nature of BAT, such as its location, and we assessed the influence of sex, age, body mass index (BMI), and temperature on BAT. Results The prevalence of BAT in Koreans in a single $^{18}F$-FDG PET/CT scan in average conditions was 1.07%. The BAT detection rate was higher in females than males (1.32% vs 0.73%), and also with younger age (7.94% vs 0.73%), lower BMI (BMI with BAT, 21.1 vs BMI without BAT, 23.15) and cold outdoor temperature (1.65% vs 0.49%). The most frequent location of BAT was the supraclavicular area (left, 0.91%; right, 0.88%) and ventral neck area (left, 0.62%; right, 0.63%). Conclusions The characteristics of BAT in Koreans are not different from those described for Caucasians. However, the low prevalence of BAT in our study might be related to some scan condition like ambient temperature, but further study is needed.

자연소실의 경과를 보인 특발성 종격동 섬유화증

왕준호 ( Joon Ho Wang ),송광선 ( Kwang Seon Song ),김현준 ( Hyun Jun Kim ),송기호 ( Ki Ho Song ),인행환 ( Haing Hwan In ),최수봉 ( Su Bong Choi ),조미연 ( Mi Yeun Joo ),성기준 ( Ki Joon Sung ),신계철 ( Kye Chul Shin ) 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.4

Identification of Genes Differentially Expressed in Oral Squamous Cell Carcinoma

KIM, Joon yeun 慶北大學校 齒科大學 1995 慶北齒大論文集 Vol.12 No.2

암의 형성에 유전자의 구조적 변화가 주된 역할을 하지만 유전자 조절의 변화도 중요한 역할을 한다고 알려져 있다. 본연구는 구강내 악성 편평상피세포종에서 유전자 발현의 변화를 조사할 목적으로 구강내 정상조직과 악성 편평상피세포종 조직에서 376개의 cDNA clone 의 변화를 reverse dot -blot 기법으로 비교하였다 3예의 구강 악성 편평 상피세포종 환자에서 모두 발현이 증가된 유전자는 21 clones는 였다. 이들 21 clones 의 염기서열을 분석하여 Genbank data base 와 homology search를 시행한 결과 이들중 I clone 은 plasminogen activator inhibitor 1 유전자였으며 4 clones는 rat resiniferatoxin-binding protein ,bovine myosin I heavy chain, yeast 4- hydroxybenzoate hexaprenyl transferase 및 human fatty acids omega-hydroxylase 와 염기서열이 유사하였으며 7 clones는 아직 보고되지 않은 유전자이나 Alu repetitive sequence 를 갖고 있었다. 나머지 9 clones는 완전히 새로운 유전자로 밝혀졌다. Using a differential EST screening technique to assay the relative level of expression of each of large numbers of cloned cDNA sequences in oral squamous cell carcinomas, we compared the expression of 376 clones in normal and tumor tissues of oral SCC patients. Comparison of nomal to oral SCCs demonstrated alterations in expression of approximately 5.6% of the cloned sequences. Of 21 cDNA clones which were overexpressed in oral SCCs,one clone was identified as PAI-1(K0377),and four cDNA clones(K0364,K0516,K0595,K0466) revealed homology to genes encoding rat resiniferatoxin - binding protein,bovine myosin heavy chain, yeast 4-hydroxybenzoate hexaprenyl transferase, and human fatty acids omega-hydroxylase, respectively. Seven cDNA clones (K0301,K0312,K0392,K0409,K0442,K0488,K0517)had unknown sequence containing Alu repetitive sequence. Nine cDNA clones (K0055,K0156,K0399,K0491,K0494,K0519,K0529,K0541,K0543) had unknown sequences.

백서에서 술전 스테로이드 투여에 따른 술후 조직 부종의 변화

김준연(Joon Yeun Kim),이상한(Sang Han Lee) 대한구강악안면외과학회 1990 대한구강악안면외과학회지 Vol.16 No.2

The purpose of this study was to determine the most appropriate time to administer dexamethasone presurgically for reduction of experimental postsurgical edema in rats. Total 105 rats, Spargue Dawley Strain, each weighing about 200-300g, were used and divided into 5 groups: control group consisting of 25 rats; Experimental group 1, 2, 3, 4 were administered dexamethasone(1.5㎎/㎏) intramuscularly just before, 6, 12, 18 hours before operation. Edema was produced by the surgical procedures on the mandibular angle in rats. The obtained results were as follows; The mean percent of water in normal tissue was 74.5%. In control group, mean percent of water increased to 77.4% at the 24 hours, 77.9% at the 48 hours, 80.0% at the 72 hours, and 78.5% at the 96 hours postoperatively. Among experimental groups(group 1, 2, 3, 4), the most effective control of postsurgical edema was observed in group 3 and maximum effect was appeared on 72 hours postoperatively. Histopathologically control group showed greater distortion of architecture with a moderate inflammatory infiltrate and vascular disruption than experimental groups. Experimental group 3 showed much less inflammatory infiltrates than any other groups at 72 hours after operation. In the present study, surgically produced swelling peaked between 48 and 72 hours after injury and could be greatly suppressed by the preoperative intramuscular administration of dexamethasone.

Unilateral vocal cord paralysis following a short period of endotracheal intubation anesthesia

Yeun Hee Shin,Dong Ai An,Won Joon Choi,Yun Hong Kim 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.65 No.4

Enhanced transfection efficiency of PAMAM dendrimer by surface modification with <small>L</small>-arginine

Choi, Joon Sig,Nam, Kihoon,Park, Jong-yeun,Kim, Jung-Bin,Lee, Ja-Kyeong,Park, Jong-sang Elsevier 2004 Journal of controlled release Vol.99 No.3

<P><B>Abstract</B></P><P>We designed a novel type of arginine-rich dendrimer, with a structure based on the well-defined dendrimer, polyamidoamine dendrimer (PAMAM). Further characterization was performed to prove that the polymer is a potent nonviral gene delivery carrier. The primary amines located on the surface of PAMAM were conjugated with <SMALL>L</SMALL>-arginine to generate an <SMALL>L</SMALL>-arginine-grafted-PAMAM dendrimer (PAMAM-Arg). For comparison, an <SMALL>L</SMALL>-lysine-grafted-PAMAM dendrimer (PAMAM-Lys) was also generated and compared as a control reagent. The polymers were found to self-assemble electrostatically with plasmid DNA, forming nanometer-scale complexes. From dynamic light scattering experiments, the mean diameter of the polyplexes was observed to be around 200 nm. We used PicoGreen reagent as an efficient probe for assaying complex formation of polymers with plasmid DNA. The complex composed of PAMAM-Arg/DNA showed increased gene delivery potency compared to native PAMAM dendrimer and PAMAM-Lys. The cytotoxicity and transfection efficiencies for 293, HepG2, and Neuro 2A cells were measured by comparison with PEI and PAMAM. In addition, transfection experiments were performed in primary rat vascular smooth muscle cells, and PAMAM-Arg showed much enhanced transfection efficiency. These findings suggest that the <SMALL>L</SMALL>-arginine-grafted-PAMAM dendrimer possesses the potential to be a novel gene delivery carrier for gene therapy.</P>

Original Article : Impact of immunosuppressant therapy on early recurrence of hepatocellular carcinoma after liver transplantation

( Ju Yeun Lee ),( Yul Hee Kim ),( Nam Joon Yi ),( Hyang Sook Kim ),( Hye Suk Lee ),( Byung Koo Lee ),( Hye Young Kim ),( Young Rok Choi ),( Geun Hong ),( Kwang Woong Lee ),( Yung Suk Suh4 ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2

Background/Aims: The most commonly used immunosuppressant therapy after liver transplantation (LT) is a combination of tacrolimus and steroid. Basiliximab induction has recently been introduced; however, the most appropriate immunosuppression for hepatocellular carcinoma (HCC) patients after LT is still debated. Methods: Ninety-three LT recipients with HCC who took tacrolimus and steroids as major immunosuppressants were included. Induction with basiliximab was implemented in 43 patients (46.2%). Mycophenolate mofetil (MMF) was added to reduce the tacrolimus dosage (n=28, 30.1%). The 1-year tacrolimus exposure level was 7.2 ± 1.3 ng/mL (mean ± SD). Results: The 1- and 3-year recurrence rates of HCC were 12.9% and 19.4%, respectively. Tacrolimus exposure, cumulative steroid dosages, and MMF dosages had no impact on HCC recurrence. Induction therapy with basiliximab, high alpha fetoprotein (AFP; >400 ng/mL) and protein induced by vitamin K absence/antagonist-II (PIVKA-II; >100 mAU/mL) levels, and microvascular invasion were significant risk factors for 1-year recurrence (P<0.05). High AFP and PIVKA-II levels, and positive 18fluoro-2-deoxy-d-glucose positron-emission tomography findings were significantly associated with 3-year recurrence (P<0.05). Conclusions: Induction therapy with basiliximab, a strong immunosuppressant, may have a negative impact with respect to early HCC recurrence (i.e., within 1 year) in high-risk patients. (Clin Mol Hepatol 2014;20:192-203)

핀란드 법무보호복지제도 연구

권준성(Joon Sung Kwon),현문정(Mun Jung Hyun),왕세연(Se Yeun Wang) 안전문화포럼 2022 안전문화연구 Vol.- No.19

형벌 중심의 처벌과 구금을 통한 범죄억제 방식은 다수국가에서의 형사정책 연구와 그 실천 속에서 그 한계를 분명히 드러내왔으며, 이는 우리나라에서도 마찬가지 결과를 나타낸다. 즉, 국내에서 2009년 이후 현재까지 교정시설 내 수용인원은 꾸준히 증가하는 추세를 나타내고 있으며, 최근 10년 동안 금고 이상 형을 받은 수형자 중에서 교정시설로 복귀하는 인원은 최소 40%이상으로, 이는 많은 수형자들이 구금이 종료된 이후 사회에 적응하지 못하고 있음을 드러낸다. 더불어 이러한 구금 방식의 경우 구금 대상자뿐만 아니라 그 가족과 주변인들에게까지 막대한 부정적 영향을 미치는 것으로 나타나기에, 이에 전적으로 의존하는 것은 사회통합과 발전을 저해하는 주요 요인으로 지목되어 왔다. 이에, 보다 효율적으로 이를 해결하기 위한 대안으로 주목받은 것이 회복적 사법이다. 회복적 사법이란 피해자와 가해자 및 지역사회구성원 간의 조정과 상호 협의를 통해 범죄자가 사회에 적응하고 그 일원으로 잘 복귀하는 것을 목적으로 하는 재범방지 패러다임이다. 특히 북유럽 국가들의 경우 범죄율이 매해 꾸준히 감소하는 수준에 있을 뿐만 아니라, 치안과 안전에 많은 관심을 갖고 이에 관한 정책을 선구적으로 탐색하고 운영하는 교정의 선진국으로, 이들의 교정정책 및 제도를 탐구하는 것은 우리의 형사사법정책을 운영함에 큰 도움이 될 것으로 판단된다. 그 중 핀란드는 대표적인 회복적 사법 기반 교정정책을 사용하는 국가이자 대표적 복지국가로, 법무보호제도에 관한 안정된 체계와 구체적인 운영방식 및 사례를 갖추고 있다. 따라서 회복적사법 및 법무보호복지제도의 발전을 도모하는 국내 형사정책 연구에서는 이에 대한 연구를 적극 탐구하고 수용해야 할 필요가 있음에도 아직까지 국내에서 이러한 연구가 매우 미진한 실정이다. 이에 본 연구에서는 핀란드의 범죄정책 및 법무보호복지제도 등에 관한 고찰을 통해 국내 법무보호복지제도의 방향성을 탐색하고 미진한 부분에 대한 보완 및 향후 개선방안을 탐색하고자 한다. 이를 위해 본 연구는 핀란드의 보호관찰 제도 및 법무보호복지제도를 소개하는 연구 논문과 국가 보고서, 그리고 정부 통계 등 접근 가능한 문헌을 통해 핀란드의 법무보호복지제도 운영 방식 및 사례를 소개함과 더불어 이들과 우리의 차이를 검토하고 이를 통해 우리의 법무보호복지제도의 현 실태 및 향후 나아갈 방향을 제언할 것이다. The method of crime suppression through punishment-oriented punishment and detention has clearly revealed its limitations in criminal policy research and practice in many countries, which is the same in Korea. In Korea, the number of people in correctional facilities has been steadily increasing since 2009. In addition, among prisoners sentenced to imprisonment or higher in the last 10 years, at least 40% return to correctional facilities, which reveals that many prisoners have not been able to adapt to society since the end of their detention. In addition, in the case of this type of detention, it appears to have a huge negative impact on not only the detainees but also their families and neighbors, so relying entirely on it has been pointed out as a factor that hinders social integration and development. Accordingly, it is restorative justice that is attracting attention as an alternative to solving this problem more efficiently. Restorative justice is a paradigm for preventing recidivism that aims to help criminals adapt to society and return to their members through coordination and mutual consultation between victims, perpetrators, and community members. In particular, the crime rate is steadily decreasing every year in Nordic countries, and it is considered that exploring their correctional policies and systems will be of great help to operate our criminal justice policy. Among them. Finland is a country and a representative welfare state that uses a representative restorative justice-based correctional policy, and has a stable system for the legal protection system, specific operational methods, and examples. Therefore, although domestic criminal policy research promoting the development of the restorative justice and legal protection welfare system needs to be actively explored and accepted, such research is still very insufficient in Korea. Therefore, this study seeks to explore the direction of the domestic legal protection welfare system through a review of Finland's criminal policy and legal protection welfare system, and to find ways to supplement and improve the deficiencies in the future. So, this study introduces Finland's legal protection and welfare system through research papers, national reports, and government statistics, and reviews our differences and suggests the current status and future direction of our legal protection and welfare system.