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Chlorpromazine이 백서 해마에서 전기경련 충격에 의한 MAPK 타이로신 인산화에 미치는 영향
주연호,정성훈,전송희,강웅구,김용식,김상욱,박주배 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.2
Object : In order to examine the interaction mechanisms of electroconvulsive shock(ECS) and antipsychotic drug at the level of molecular biology, we observed the effect of chlorpromazine pre-treatment on the activation of mitogen activated protein kinase(MAPK) induced by electroconvulsive shock(ECS) in rat hippocampus Method : Male Sprague-Dawley rats were divided into 2 groups. To the experimental group chlorpromazine(20㎎/㎏) was given intraperitoneally, and to the control distilled water was given instead. Thirty minutes later, ECS was given and the hippocampus was dissected out 2 minutes thereafter. Immunoblotting with antiphosphotyrosine antibody was carried out, and the signal intensity at 42kDa band was quantitized using densitometer. The obtained result was compared by student t-test between the experimental and the control group. The absolute amount of MAPK was measured by immunoblotting with anti-MAPK antibody. Result : The tyrosine phosphorylation of MAPK reached peak at 2 minutes after ECS. However, in the chlorpromazine pre-treated group, the peak level of MAPK tyrosine phosphorylation was significantly attenuated(t=-3.12, df=14, p=0.008) compared to the control. In contrast to this, the absolute amount of MAPK did not differ between the pretreated and the control group. Conclusion : Chlorpromazine attenuated the tyrosine phosphorylation of MAPK by ECS. This finding seems to be related to the fact that chlorpromazine pre-treatment changed the cfos expression by ECS in rat brain. Antipsychotic drug and ECS might interact at the level of MAPK signal transduction system, and this might explained the observed synergistic effect of two treatment modality.
당뇨망막증 환자에서 건강보조제 복용 후 양안 동시에 발생한 망막출혈 1례
이상준,이정주,김수영,김신동 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2
Purpose : This is a report of retinal hemorrhage in a patient suffering from diabetic retinopathy taking 10 days of protein supplements. Method : A 38-year-old female patient who had received a panretinal photocoagulation started taking supplements made of cocoon(cocoon steamed powder, ginseng powder, pepino abstraction powder et al.) for 10 days. Then, the patient went on to suffer from an uncontrollable blood pressure, a general edema and a loss in visual acuity. The patient's vision was counter finger 50cm in both eyes. The fundoscopy revealed vitreous hemorrhage in the right eye and preretinal hemorrhage in the left eye. She was hospitalized in nephrology, We waited to resolve hemorrhages. But hemorrhages was not improvement, we performed a pars plana vitrectomy and laser photocoagulation. Results : After the operation, the corrected vision was 0.8 in the right and 0.63 in the left eye, respectively. The patient's general condition was improved with diuretics. Discussion : The main ingredient of the supplements that the patient took were peptides. So this patient with diabetic renal failure had to reduce renal function which cause a reduction in glomerular filtration rate, a increase in blood creatinine levels, edema due to increased blood pressure and vitreal hemorrhaging in both eyes. In conclusion, one must be careful of health supplements because we cannot be sure of the ingredients and the side effects which could worsen certain illnesses.
2상 스테인리스강의 인장특성에 미치는 오스테나이트상의 함량 및 합금원소의 영향
주동원,성장현,이성근 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.1
The effect of alloying elements addition, austenite content and distributions on the tensile properties and corrosion resistance of duplex and super duplex stainless steels has been investigated by changing heat treatment conditions. With the addition of N and Cu, the austenite content of duplex stainless steels increased. After heat treating the super duplex stainless steel, the austenite content increased above 1200℃ and the ferrite single phase temperature shifted to 50℃ high in comparison to duplex stainless steel. Due to the stored energy induced from cold rolling the super duplex stainless steel. the specimen with fibous structure showed to be increased in austenite content compared to the specimen with dispersed structure. Tensile strengths decreased and elongations increased with increasing austenite content. The super duplex stainless steel with fibrous structure showed superior tensile strengths and elongations to the fibrous duplex stainless steel and super duplex stainless steel with dispered structure. The effect of Cu and CU+W addition on tensile properties was small. The passive current density and critical current density of high alloyed super duplex stainless steel showed value in comparison to duplex stainless steel. The Cu+W added super duplex stainless steel appeared the highest corrosion resistance among all specimens.
成周昊 홍익대학교 산업기술연구소 2002 産業技術 Vol.12 No.-
The aim of this paper is to compare the fundmental difference between accounting approach and actuarial approach. For this purpose, we firstly establish the dynamics of pension assets and liablity, respectively in view of accounting approach characterized by the IAS19. Secondly, we build up the actuarial asset and liability dynamic models, respectively. Thirdly, we show that the accounting amortization method is more favorable to the scheme sponsor rather than the scheme members. Lastly, I hope the this paper will contribute to understanding the difference between actuarial approach and accounting approach and furthermore be a turning point of doing reciprocal co-work between accountancy professions and actuarial profession in the field of pension study.
유한 요소법에 의한 절편 회전자를 가진 자기저항전동기의 특성 해석
주수원,한성진,홍정표 東亞大學校 附設 情報通信硏究所 1997 情報通信硏究所論文誌 Vol.5 No.1
This paper deals with improving the characteristics of the reluctance motor with the segmental rotor. These improvements result from incorporating a shallow axial channel in the centre of the air gap face of each segment, filling of this channel with conducting material and shaping of the ends of the segment. To know the characteristics of the distribution of flux, the f.e.m. is applied on the direct-axis so that the ratio of the direct-axis and the quadrature-axis in the test machine is larger than in the conventional machine. The torque has the maximum value at the load angle of 45°as generally is expected.
강주성, 박동원, 안성옥, 김수균 배재대학교 공학연구소 2013 공학논문집 Vol.15 No.1
Using features in the Java Applet game is played on the screen, and web production. Linked using Applet to Database, and will save the record. It also makes the stored data with Statistics screen. What is the problem with him, looking to find ways to solve. For alternative methods are discussed.
Urban Entertainment Center 사업과 지역경제의 파급효과 분석
주수현,허정옥,진금옥,강상주 동의대학교 경제경영전략연구소 2006 經濟經營硏究 Vol.4 No.1
This research is designed for conducing spreading effects of regional economy by analyzing Input-Output Model(i.e. production model, employment model, value model, and income model). These measures of spreading effects in regional economy were determined by precise analyses of feasibility and demands of public businesses. That would be effective and confident polices and supportive for long time in the regional ecinimy. One of the most effectibe analysis on the spreading effects of regional economy is draw up Input-Output Model(IOM). This article, based on 2000 IOM of Busan Area, is focused that how the turbulence level of final demands affected spreading effects of regional economy, such as industrial production, value added, employment, incom etc. Also there were included the analysis of economic analyses of spreading effects on the UEC in the Centum City businesses.
목조건축의 도리결구재의 유형 분류 : 16세기 이전의 건축물을 중심으로 Focused on structures built before the 16th century
주상훈,전봉희 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(계획계)
The purpose of this study is to classify a purlin support type and its materials of Korean wooden structures and Chinese ones and consider it with the times and regions. There are side connecting bace(Takgak), slanting strut(Chasu), connecting beam(Chagyun), curved connecting beam(Charak), purlin-support(Dori-anchogong) and so on besides a basic beam in the type of purlin support forms have several characteristics in accordance with the times and regions. According to this classification. Structures of Koryo have a connection with structures of Song or Won dynasty in China. Periodic and regional characteristics of Korean wooden structure can be found in the use of curved Chasu or decorated Dori-anchogong.