http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jong-Hwan Lim,Myoung-Seok Kim,Byung-Kwon Park,Youn-Hwan Hwang,Mi-Hyun Hwang,Seung-Chun Park,Hyo-In Yun 한국독성학회 2005 Toxicological Research Vol.21 No.4
The aim of the present study was to evaluate systemic bioavailability of surfactin and to determine its pharmacokinetic profiles. The stability of surfactin to pH, temperature and protease was evaluated. Surfactin was resistant to high temperature, a wide range of pH and the action of hydrolytic enzymes. The pharmacokinetic natures of surfactin which were shown the short half-life, rapid clearance and poor bioavailability. The results of study should provide preliminary data of surfactin for further dose-finding studies and for the design of application forms. It is also be important to a context of the safety of surfactin.
Genotoxic Evaluation of Surfactin C in Chinese Hamster Lung Cell Line
Jong Hwan Lim,In Bae Song,Byung Kwon Park,Myoung Seok Kim,Youn-Hwan Hwang,Hyo In Yun 한국독성학회 2009 Toxicological Research Vol.25 No.1
To investigate the mutation inducibility of surfactin C, we performed the chromosome aberration assay with Chinese hamster lung cells in vitro. The colorimetric MTT screening assay was carried out to determine the cytotoxicity index (IC??) of surfactin C. The IC?? value was 125 ㎍/㎖. For the chromosome aberration test of surfactin C, the maximum concentration was employed as 125 ㎍/㎖, followed by 62.5 and 31.25 ㎍/㎖ for the lower concentrations, with or without metabolic activation (S9). Cyclophosphamide and mitomycin C were used as positive controls in the presence and absence of S9 metabolic activation, respectively. These results showed that surfactin C was not capable of inducing chromosome aberration, as measured by the chromosome aberration test using Chinese hamster lung cell line. There is no evidence for surfactin C to have a genotoxic potential.
Jong-Hwan Lim,Byung-Kwon Park,Myoung-Seok Kim,Man-Hee Rhee,Seung-Chun Park,Hyo-In Yun 한국독성학회 2004 Toxicological Research Vol.20 No.4
This study provides more information about the potential toxicological risk of Bacillus sp. A9184 isolated from soybean paste. The evaluation was based on the guidelines of acute oral toxicity/pathogenicity for microbial pesticide and was to get more comprehensive understanding on the acute toxicity of the potential probiotic in Sprgue-Dawley rats. No dead animal was observed in rats after single oral administration with bacteria (10^8 CFU per animal). There were neither no treatment-related changes in clinical signs, nor changes in body weight and body temperature as compared with the untreated group. All tested animal showed the increase in body weight with time. The results obtained in this study suggest that the potential probiotic, Bacillus sp. A9184, is nontoxic for rat.