종양과 구강각질세포주에서 Celecoxib과 Indomethacin의 Cyclooxygenase-2 비의존적 기전에 의한 억제 효과

노종렬,성명훈,김광현,김동영,하정훈,박찬일 충남대학교 암연구소 2005 암연구소 업적집 Vol.4 No.-

Background and Objectives : Overexpression of cyclooxygenase-2 (COX-2), a rate-limiting enyme in the generation of prostanoids from arachidonic acid, has known to be closely related to tumorigenesis, tumor growth, angiogenesis, and metastasis. Selective or non-selective COX-2 inhibitors have been used for the growth inhibition of cancers with preventative intents ; however, it has been suggested recently that cancer cells have COX-2-independent mechanisms. Materials and Method : Using MTT assat and cell counts, we observed the growth inhibition of SCC VII, CT-26 and B16F10 murine cancer cell lines when treated by celecoxib and indomethacin. SNU-1041 and HOK 16B were used as controls for comparing with the murine cell lines. The COX-2 expression of these cell lines was analyzed by western blotting and compared with the degree of inhibition by the drugs. Results : The growth inhibition of the cell lines by the drugs was clearly demonstrated in a concentration-dependent manner and depended on the type of cell lines and test drug. The in vitro viability assay revealed that CT-26 expressing COX-2 protein was slightly inhibited but SCC Vn and B16F10 without COX-2 expression were moderate-to-highly inhibited by the drug treatment. Celecoxib and indomethacin appeared to have no close relation with the COX-2 expression of cell lines in their growth inhibition, HOK 16B showed a resistance by concentrations less than 25 μM of celecoxib, which implies that celecoxib has a more selective effect on tumor cells and is safer than indomethacin Conclusion : The growth of cancer cells was inhibited by celecoxib and indomethacin treatment, which depends on the type of cancer, treated drug, and its concentration. Their suppressive effect is not closely related to the COX-2 expression of cancer cells. (Korean J Otolaryngol 2004;47:562-8)

종양과 구강각질세포주에서 Celecoxib과 Indomethacin의 Cyclooxygenase-2 비의존적 기전에 의한 억제 효과

노종렬,성명훈,김광현,김동영,하정훈,박찬일 충남대학교 암공동연구소 2005 암공동연구소 업적집 Vol.4 No.

Background and Objectives : Overexpression of cyclooxygenase-2 (COX-2), a rate-limiting enyme in the generation of prostanoids from arachidonic acid, has known to be closely related to tumorigenesis, tumor growth, angiogenesis, and metastasis. Selective or non-selective COX-2 inhibitors have been used for the growth inhibition of cancers with preventative intents ; however, it has been suggested recently that cancer cells have COX-2-independent mechanisms. Materials and Method : Using MTT assat and cell counts, we observed the growth inhibition of SCC VII, CT-26 and B16F10 murine cancer cell lines when treated by celecoxib and indomethacin. SNU-1041 and HOK 16B were used as controls for comparing with the murine cell lines. The COX-2 expression of these cell lines was analyzed by western blotting and compared with the degree of inhibition by the drugs. Results : The growth inhibition of the cell lines by the drugs was clearly demonstrated in a concentration-dependent manner and depended on the type of cell lines and test drug. The in vitro viability assay revealed that CT-26 expressing COX-2 protein was slightly inhibited but SCC Vn and B16F10 without COX-2 expression were moderate-to-highly inhibited by the drug treatment. Celecoxib and indomethacin appeared to have no close relation with the COX-2 expression of cell lines in their growth inhibition, HOK 16B showed a resistance by concentrations less than 25 μM of celecoxib, which implies that celecoxib has a more selective effect on tumor cells and is safer than indomethacin Conclusion : The growth of cancer cells was inhibited by celecoxib and indomethacin treatment, which depends on the type of cancer, treated drug, and its concentration. Their suppressive effect is not closely related to the COX-2 expression of cancer cells. (Korean J Otolaryngol 2004;47:562-8)

제 1형 신경섬유종증 환자의 총상신경초종에서 발생한 악성 말초신경초종

윤여훈,노종렬 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Malignant peripheral nerve sheath tumor (MPNST) is defined as a malignant tumor arising from cells of the peripheral nerve sheath. The patients with neurofibromatosis type 1 (NF1) have the highest probability of developing MPNST. Even with wide surgical excision and adjuvant chemoradiation, the prognosis of MPNST is generally poor. We experienced a case of MPNST in a 38-year-old man with a long-standing NF1. He had a painless, infraauricular mass of 1 month duration. The patient underwent excision of the mass followed by total parotidectomy and modified neck dissection. Permanent pathologic sections confirmed MPNST. We report this case with a review of the literature.

부갑상선 선종 절제 후 발생한 골기아증후군 1예

구본석,노종렬 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

One of the common complications of parathyroid surgery is the development of postoperative hypocalcemia. Hypocalcemia may result from the redistribution of serum calcium as well as the insufficient supply of parathyroid hormone from the parathyroid tissues remaining after the parathyroidectomy. Hungry bone syndrome is postoperative hypocalcemia that takes place due to rapid redistribution of serum calcium to the bone and requires a long-term medical management. We have experienced a 34-year-old man who presented brown tumor in the left humerus and developed hungry bone syndrome after resection of a parathyroid gland adenoma. We report this case with a review of the literature.

부갑상선 선종 절제 후 발생한 골기아증후군 1예

구본석,노종렬 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

One of the common complications of parathyroid surgery is the development of postoperative hypocalcemia. Hypocalcemia may result from the redistribution of serum calcium as well as the insufficient supply of parathyroid hormone from the parathyroid tissues remaining after the parathyroidectomy. Hungry bone syndrome is postoperative hypocalcemia that takes place due to rapid redistribution of serum calcium to the bone and requires a long-term medical management. We have experienced a 34-year-old man who presented brown tumor in the left humerus and developed hungry bone syndrome after resection of a parathyroid gland adenoma. We report this case with a review of the literature.

제 1형 신경섬유종증 환자의 총상신경초종에서 발생한 악성 말초신경초종

윤여훈,노종렬 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Malignant peripheral nerve sheath tumor (MPNST) is defined as a malignant tumor arising from cells of the peripheral nerve sheath. The patients with neurofibromatosis type 1 (NF1) have the highest probability of developing MPNST. Even with wide surgical excision and adjuvant chemoradiation, the prognosis of MPNST is generally poor. We experienced a case of MPNST in a 38-year-old man with a long-standing NF1. He had a painless, infraauricular mass of 1 month duration. The patient underwent excision of the mass followed by total parotidectomy and modified neck dissection. Permanent pathologic sections confirmed MPNST. We report this case with a review of the literature.

외상성 하인두-경부 식도 손상

이강진,성명훈,박범정,성원진,노종렬,정산신,이승신,김광현 대한이비인후과학회 2001 대한이비인후과학회지 두경부외과학 Vol.44 No.11

재발성 호흡기 유두종증의 임상양상과 보조 치료의 유용성

성명훈,최병윤,진정욱,성원진,박범정,노종렬,김대우,원태빈,김광현 대한이비인후과학회 2001 대한이비인후과학회지 두경부외과학 Vol.44 No.12

Prediction of Difficult Laryngeal Exposure in Patients Undergoing Microlaryngosurgery

Roh, Jong-Lyel,Lee, Yong-Won 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Objectives: Although difficult laryngeal exposure (DLE) is a common problem encountered during microlaryngosurgery, reliable predictors of DLE and grading systems of laryngeal exposure have been scarcely suggested in the field of laryngology. We propose a new classification of laryngeal exposure focusing on the extent of glottic visualization. Methods: We investigated physical parameters that could predict DLE; 73 patients underwent a physical examination including 15 parameters. During endotracheal intubation and suspension laryngoscopy, Cormack-Lehane and laryngeal exposure scores were obtained for each patient and compared with the parameters. Results: The patients' ages ranged from 23 to 77 years. The iaryngeal exposure score was correlated with the Cormack-Lehane score (p<.001, r=0.469). Of all parameters, body mass index, neck circumference, thyroid-mental distance, and horizontal thyroid-mental distance showed significant correlation with the laryngeal exposure score (p < .05). From analysis of the candidate parameters in 13 patients with DLE and the non-DLE group, we found that the cutoff values for predicting DLE were a body mass index of >25.0 kg/㎡, a neck circumference of>39.5 cm, a thyroid-mental distance of <5.5 cm, and a horizontal thyroid-mental distance of<4.0 cm. Conclusions: According to the proposed classification of laryngeal exposure, patients with obesity, a muscular neck, or retrognathia are likely to present DLE, and prcoperative measurement of the predictors may be useful in preparing for microlaryngosurgery.

Removal of infratemporal fossa schwannoma via a transmandibular transpterygoid approach

Roh, Jong-Lyel 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Trigeminal schwannomas are commonly located in the intracranium, and extracranial schwannomas limited to the infratemopral fossa (ITF) are extremely rare. Trigemina! mandibular schwannoma was found in the left ITF of a 48-year-old man who presented with a 1-year history of left facial pain and trismus. The schwannoma was completely removed by a transmandibular transpterygoid approach with no major complications. This case is discussed with a review of the literature on this rare occurrence, focusing on the surgical approach.