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Moon,,Jong-Ho,Lee,,Dong-Ho,Ryu,,Ho-Jung,Park,,Young,Cheol,Jo,,Sung-Ho,Jin,,Gyoung,Tae,Lee,,Jong-Seop,Min,,Byoung-Moo The Society of Chemical Engineers Japan 2018 Journal of chemical engineering of Japan Vol.51 No.8
김종직은 性情의 陶治와 風敎의 實現을 문학이 성취해야 할 목표로 삼았다. 그리고 이를 위해 經術을 중시하고 理勝한 문예를 지향해 나갔다. 그는 훈구 계가 지도하고 있던 관각문예의 폐단을 발견하고 이를 수정하고자, 문예의 두 차원인 형식과 내용을 일치시키면서 내용의 합리성을 우위에 두고자 하는 문학관을 제출했다. 당시 관각문예가 점차 형식을 지나치게 존중하면서 내용이 점차 부실해져 가는 경향을 보이고 있다고 판단했기 때문이다. 김종직의 수정 노선은 사후에 그의 문집을 읽고 그의 유풍을 접하며 자라난 후속 사림들에 의해 계승되고 발전되어, 16세기 사림파 문예의 성립을 가져왔다. 후대의 이황과 이이는 김종직의 문집을 읽고 자라난 세대여서 그의 영향을 받지 않을 수 없었다. 그러나 그들은 주자성리학에 대한 심화된 이해를 바탕으로 문예를 성리학적인 관점에서 해석하는 능력이 김종직보다 뛰어났다. 이들은 나중에 김종직이 제시한‘경술문장일치론'을 주자의‘道文合一論'을 수용하는 차원으로 이해한 것으로 보인다. 김종직은 문예의 작용을 말하면서‘성정을 다스리고 풍교를 창달한다.'고 하였을 뿐 다른 형이상학적 논리를 개입시키지 않았다. 육경이란 텍스트에 충실한 그리고 그로부터 수렴된 문학관을 가지고 있었기 때문이다. 이황과 이이는 육경을 다시 해석한 주자의 이론으로부터 문학관을 구축하였다. 그들의 문학관도 형이상학적 용어로 조직되었다. 사실 이황과 이이의 문학관과 미의식은 김종직에게서 출발을 본 조선 성리학의 착근을 입증하는 표지인 것이다. It's Kim Jong-jik's goal to cultivate Sungjong and realize Punggyo. So he esteemed Kyungsul and aimed for Liseung in literature. Kim Jong-jik need to change negative effect of Kwangak arts leading by Hungu group. Kwangak arts are getting worse in contents according to having a high sense of conventions. Post Sarim who read his anthology and contact his custom succeed to Kim's changing line after his death. Therefore literary ideas of 16th Sarim group was finally established. But they show excellent ability to interpret arts from a Sunglihak's perspective. So they figured out unity of Kyungsul-Munjang as unity of Do-Mun. Kim Jong-jik only said that literal arts cultivate Sungjong and realize Punggyo, and he avoided mentioning such as a metaphysical logics. Because he have a literary ideas being a faithful to the text of six Confucianism scriptures. Then Li Hwang and Lee Yi reinterpret six Confucianism scriptures from a Juja's theory, and built up their literary aspects to be organized by metaphysical terms. Actually, ILi Hwang and Lee Yi's literary aspects and aesthetic consciousness comes from Kim'shis experience, that is a sign to prove taking a root of Chosun Sunglihak.
Activation of peroxisome proliferator-activated receptor (PPAR) serves as a key factor in the proliferation and invasion of breast cancer cells and is a potential therapeutic target for breast cancer. However, the mechanisms underlying this effect remain largely unknown. Heme oxygenase-1 (HO-1) is induced and overexpressed in various cancers and is associated with features of tumor aggressiveness. Recent studies have shown that HO-1 is a major downstream target of PPAR. In this study, we investigated the effects of induction of HO-1 by PPAR on TPAinduced MMP-9 expression and cell invasion using MCF-7 breast cancer cells. TPA treatment increased NF-B /AP-1 DNA binding as well as MMP-9 expression. These effects were significantly blocked by 15d-PGJ2, a natural PPAR ligand. 15d-PGJ2 induced HO-1 expression in a dose-dependent manner. Interestingly, HO-1 siRNA significantly attenuated the inhibition of TPA-induced MMP-9 protein expression and cell invasion by 15d-PGJ2. These results suggest that 15d-PGJ2 inhibits TPA-induced MMP- 9 expression and invasion of MCF-7 cells by means of a heme oxygenase-1-dependent mechanism. Therefore, PPAR/HO-1 signaling- pathway inhibition may be beneficial for prevention and treatment of breast cancer.
Activation of peroxisome proliferator-activated receptor γ (PPARγ) serves as a key factor in the proliferation and invasion of breast cancer cells and is a potential therapeutic target for breast cancer. However, the mechanisms underlying this effect remain largely unknown. Heme oxygenase-1 (HO-1) is induced and over-expressed in various cancers and is associated with features of tumor aggressiveness. Recent studies have shown that HO-1 is a major downstream target of PPARγ. In this study, we investigated the effects of induction of HO-1 by PPARγ on TPA-induced MMP-9 expression and cell invasion using MCF-7 breast cancer cells. TPA treatment increased NF-κB /AP-1 DNA binding as well as MMP-9 expression. These effects were significantly blocked by 15d-PGJ<sub>2</sub>, a natural PPARγ ligand. 15d-PGJ<sub>2</sub> induced HO-1 expression in a dose-dependent manner. Interestingly, HO-1 siRNA significantly attenuated the inhibition of TPA-induced MMP-9 protein expression and cell invasion by 15d-PGJ<sub>2</sub>. These results suggest that 15d-PGJ<sub>2</sub> inhibits TPA-induced MMP-9 expression and invasion of MCF-7 cells by means of a heme oxygenase-1-dependent mechanism. Therefore, PPARγ/HO-1 signaling-pathway inhibition may be beneficial for prevention and treatment of breast cancer.
Choi,,Seunghwan,Kim,,Joohwan,Kim,,Ji-Hee,Lee,,Dong-Keon,Park,,Wonjin,Park,,Minsik,Kim,,Suji,Hwang,,Jong,Yun,Won,,Moo-Ho,Choi,,Yoon,Kyung,Ryoo,,Sungwoo,Ha,,Kwon-Soo,Kwon,,Young-Guen,Kim,,Young-Myeong Nature Publishing Group 2017 Experimental and molecular medicine Vol.49 No.11
<P>Heme oxygenase-1-derived carbon monoxide prevents inflammatory vascular disorders. To date, there is no clear evidence that HO-1/CO prevents endothelial dysfunction associated with the downregulation of endothelial NO synthesis in human endothelial cells stimulated with TNF-α. Here, we found that the CO-releasing compound CORM-2 prevented TNF-α-mediated decreases in eNOS expression and NO/cGMP production, without affecting eNOS promoter activity, by maintaining the functional activity of the <I>eNOS</I> mRNA 3′-untranslated region. By contrast, CORM-2 inhibited MIR155HG expression and miR-155-5p biogenesis in TNF-α-stimulated endothelial cells, resulting in recovery of the 3′-UTR activity of <I>eNOS</I> mRNA, a target of miR-155-5p. The beneficial effect of CORM-2 was blocked by an NF-κB inhibitor, a miR-155-5p mimic, a HO-1 inhibitor and siRNA against HO-1, indicating that CO rescues TNF-α-induced eNOS downregulation through NF-κB-responsive miR-155-5p expression via HO-1 induction; similar protective effects of ectopic HO-1 expression and bilirubin were observed in endothelial cells treated with TNF-α. Moreover, heme degradation products, except iron and <I>N</I>-acetylcysteine prevented H<SUB>2</SUB>O<SUB>2</SUB>-mediated miR-155-5p biogenesis and eNOS downregulation. These data demonstrate that CO prevents TNF-α-mediated eNOS downregulation by inhibiting redox-sensitive miR-155-5p biogenesis through a positive forward circuit between CO and HO-1 induction. This circuit may play an important preventive role in inflammatory endothelial dysfunction associated with human vascular diseases.</P>
Dyeing and washing fastness properties of polyurethane-impregnated polyester (PU-impregnated PET), and tIhe distribution of two disperse dyes between PET and PU film were studied to investigate the effect of PU portion to exhaustion and washing fastness. Dyeing properties of PU-impregnated PET were quite different with those of PET: PU-impregnated PET absorbed dispersec dye linearly from the early stage of dyeing to equilibrium, and it exhibited excellent build-up property up to 4 %owf dyeing. The absorbed dye on PU film at early dyeing stage migrated to morre substantive PET at the temperature higher than 115℃. The amount of exhausted dye on PET portion was larger than on PU film and the distribution ratio was 2.08~-2.34. The grade of washing fastness of PU-impregnated PET was the same as or lower by 0.5~-1 grade than PU film whose washing fastness was lower by 0.5~1 than PET.
Jong,S.,Kim,Yeon-Jung,Kim,Kyung,Bok,Lee,Jae-Kwan,Cha,Jong-Moo,Park,Yang-Ha,Hwang,Eung-Gyu,Kim,Joung-Ho,Rha,Jaseong,Koo,Jei,Kim,Yong-Jae,Kim,Woo-Keun,Seo,김동억,Thompson,G.,Robinson,Richard,I.,Lindley,Xia 대한뇌졸중학회 2018 Journal of stroke Vol.20 No.1
Background and Purpose Following the positive results from recent trials on endovascular therapy (EVT), bridging therapy (intravenous alteplase plus EVT) is increasingly being used for the treatment of acute ischemic stroke. However, the optimal dose of intravenous alteplase remains unknown in centers where bridging therapy is actively performed. The optimal dose for eventual recanalization and positive clinical outcomes in patients receiving bridging therapy also remains unknown. Methods In this prospective Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) sub-study, we explored the outcomes following treatment with two different doses (low- [0.6 mg/kg] or standard-dose [0.9 mg/kg]) of intravenous alteplase across 12 Korean centers where EVT is actively performed. The primary endpoint was a favorable outcome at 90 days (modified Rankin Scale scores 0 to 1). Secondary endpoints included symptomatic intracerebral hemorrhage (ICH) in all patients, and the recanalization rate and favorable outcome in patients who underwent cerebral angiography for EVT (ClinicalTrials.gov, number NCT01422616). Results Of 351 patients, the primary outcome occurred in 46% of patients in both the standard- (80/173) and low-dose (81/178) groups (odds ratio [OR], 1.14; 95% confidence interval [CI], 0.72 to 1.81; P=0.582), although ICHs tended to occur more frequently in the standard-dose group (8% vs.3%, P=0.056). Of the 67 patients who underwent cerebral angiography, there was no significant difference in favorable functional outcome between the standard- and low-dose groups (39% vs.21%; OR, 2.39; 95% CI, 0.73 to 7.78; P=0.149). Conclusions There was no difference in functional outcome between the patients receiving different doses of alteplase in centers actively performing bridging therapy.
Maize is expected to be planted in June after harvest of winter barley for the double cropping of forage maize-barley. But maize yield tends to be reduced rapidly with late planting after mid-May, so the pre-requisite of maize variety for the double cropping of maize-barley is less reduction of growth and yield at the condition of late planting in June. In order to select domestic forage maize variety adapted to late planting in June after barley harvest, Kwangpyeong-ok, Gangda-ok and Jangda-ok in 2007 and Kwangpyeong-ok, Gangda-ok and Cheongan-ok in 2008 were planted on June 13 and June 21, and plant growths and yields were compared with early planting on April 24 and May 31, respectively. In 2007, Ear number per plant was as high as 0.98 at Kwangpyeong-ok compared to 0.89 and 0.56 of Gangda-ok and Jangda-ok, respectively, at late planting on June 13. TDN and grain yield of Kwangpyeong-ok were the highest among three variety as 1,037 and 710 kg/10a, and yield reduction of Kwangpyeong-ok compared to early planting were 24% and 28 %, which were 7% and 8% lower than Gangda-ok and 22% and 50% lower than Jangda-ok, respectively. In 2008, TDN and grain yield at late planting on June 21 of Kwangpyeong-ok were also the highest among three varieties as 1,157 and 854 kg/10a at late planting on June 24, and yield reduction of Kwangpyeong-ok by late planting were 21% and 19%, which were 10% and 11% lower than Gangda-ok and 22% and 50% lower than Jangda-ok, respectively. It was concluded that proper maize variety adapted to late planting for the double cropping of forage maize-barley was Kwangpyeong-ok because of its higher ear bearing, less reduction of TDN and grain yields at the condition of late planting.