WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation

JiSheng Hu,ShangJing Pi,MingRui Xiong,ZhongYing Liu,Xia Huang,Ran An,TongCun Zhang,BaiYin Yuan 한국분자세포생물학회 2020 Molecules and cells Vol.43 No.8

The migration, dedifferentiation, and proliferation of vascular smooth muscle cells (VSMCs) are responsible for intimal hyperplasia, but the mechanism of this process has not been elucidated. WD repeat domain 1 (WDR1) promotes actin-depolymerizing factor (ADF)/cofilin-mediated depolymerization of actin filaments (F-actin). The role of WDR1 in neointima formation and progression is still unknown. A model of intimal thickening was constructed by ligating the left common carotid artery in Wdr1 deletion mice, and H&E staining showed that Wdr1 deficiency significantly inhibits neointima formation. We also report that STAT3 promotes the proliferation and migration of VSMCs by directly promoting WDR1 transcription. Mechanistically, we clarified that WDR1 promotes the proliferation and migration of VSMCs and neointima formation is regulated by the activation of the JAK2/STAT3/WDR1 axis.

Interfacial chemistry and electronic structure between GaN and Al₂O₃ studied by X-ray photoelectron spectroscopy

Jisheng PAN 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Capillary Water Absorption Properties of Steel Fiber Reinforced Coal Gangue Concrete under Freeze-Thaw Cycles

Qiu, Jisheng,Zheng, Juanjuan,Guan, Xiao,Pan, Du,Zhang, Chenghua Materials Research Society of Korea 2017 한국재료학회지 Vol.27 No.8

The service life of coal gangue concrete(CGC) strongly depends on the capillary water absorption, this water absorption is susceptible to freeze-thaw cycles. In this paper, the cumulative water absorption and sorptivity were obtained to study the effects of 0, 0.5, 1.0, and 1.5 % steel fiber volume fraction added on the water absorption of CGC. Sorptivity and freeze-thaw tests were conducted, and the capillary water absorption was evaluated by the rate of water absorption(sorptivity). Three prediction models for the initial sorptivity of steel fiber reinforced coal gangue concrete(SFRCGC) under freeze-thaw cycles were established to evaluate the capillary water absorption of SFRCGC. Results showed that, without freeze-thaw cycles, the water absorption of CGC decreased when steel fiber at 1.0 % volume fraction was added, however, the water absorption increased with the addition of 0.5 or 1.5 % steel fibers. Once the SFRCGC specimens were exposed to freeze-thaw cycles, the water absorption of SFRCGC significantly increased, and 1.0 % steel fiber in volume fraction added to CGC caused the lowest water absorption, except for the case of the sample without steel fibers added. The CGC with steel fiber at 1.0 % volume fraction performed better. The SFRCGC has a strong response to freeze-thaw cycles. Results also showed that the linear function prediction model is practical in the field of engineering because of its simple form and a relatively high precision. Although the polynomial prediction model presents the highest computation precision among the three models, the complicated form and too many coefficients make it impractical for engineering applications.

Design of a DSP-Based Real-Time Control Device for Railway Vehicle Simulation

Yuan Yuan,Wenjun Meng,Jisheng Hu 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.10

A real-time control device for railway vehicle simulation is designed in this study according to the experimental requirements of a railway vehicle electric traction and electric braking system. The device uses the high-speed processing characteristic of DSP and runs on the basis of both DSP and the corresponding experimental platform. The simulation experiment for a different power grade traction system is achieved through control of the device. Full static and dynamic simulation of the operating condition of the train electric traction and braking system is attained in the case of no commissioning.

중국, 한국, 일본의 도시고형폐기물 매립지에서의 침출수 관리 시스템

( Sotaro Higuchi ),( Masataka Hanashima ),( Jisheng Long ),( Yukihisa Sakata ),( Nam-hoon Lee ),( Wenlong Xu ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2

본 연구의 목적은 아시아의 기후와 매립되는 폐기물의 성상 따른 적절한 매립지 관리방법을 건설하기 위한 것이다. 이 연구의 시작부분에서 매립지, 폐기물 관리 및 매립지 관리와 같은 매립지의 특성을 아시아 국가와 유럽국가 비교를 실시했다. 각각의 국가들은 매립지 관리에 대한 각국의 기본적인 개념을 가지고 있어, 매립지 liner구조물들은 다르게 건설되었다. 아시아의 고형폐기물 소각율이 높아짐에 따라, 강우량 등과 같은 여러 기후조건이 비슷한 중국, 일본, 한국 같은 아시아 국가들은 특히 기술 교환으로 각 국가와 함께 협력을 해야 할 것이다. The objective of this study is to construct a suitable landfill management method for Asian climate and quality of landfilled waste. In the beginning of this study, comparison of the Asian countries and European countries in their characteristics such as land, waste management and landfill management. Each country has own basic concept on the landfill management, therefore liner structures of the landfill differ from each other. With solid waste incineration rate rising in Asia, it could be concluded that Asian countries such as China, Korea and Japan, which have similar climate in precipitation amount and so on, should corporate each other especially in technical exchange.

Co-adsorption of Irreversibly Adsorbing Sb and Te on Pt(111)

이충균,김태곤,정창훈,Jisheng Zhao,Bonseong Ku 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.5

Presented is a voltammetric study of co-adsorption of irreversibly adsorbing Sb and Te on Pt(111). When a layer of Sb and Te was formed via simultaneous adsorption, the reduction peak of Te was observed at 0.30 V in the initial cathodic scan. In contrast, sequential adsorption of Sb followed by Te adsorption led to a Te reduction peak at 0.50 V in the initial scan. As the voltammetric scan was continued, in addition, the voltammogram of the simultaneously co-adsorbed layer changed, while that of the sequentially co-adsorbed layer did not. These observations are discussed in terms of formation of a homogeneously mixed layer and a layer consisting of heterogeneously separated domains of Sb and Te. Also, the difference in the adsorption strength of Sb and Te was observed.

LEACHATE MANAGEMENT SYSTEM ON MSW LANDFILL SITE IN CHINA, KOREA AND JAPAN

( Sotaro Higuchi ),( Masataka Hanashima ),( Jisheng Long ),( Yukihisa Sakata ),( Nam-hoon Lee ),( Wenlong Xu ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.1

The objective of this study is to construct a suitable landfill management method for Asian climate and quality of landfilled waste. In the beginning of this study, comparison of the Asian countries and European countries in their characteristics such as land, waste management and landfill management. Each country has own basic concept on the landfill management, therefore liner structures of the landfill differ from each other. With solid waste incineration rate rising in Asia, it could be concluded that Asian countries such as China, Korea and Japan, which have similar climate in precipitation amount and so on, should corporate each other especially in technical exchange.

Wind characteristics in the high-altitude difference at bridge site by wind tunnel tests

Mingjin Zhang,Jinxiang Zhang,Yong-Le Li,Jisheng Yu,Jingyu Zhang,Lianhuo Wu 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.30 No.6

With the development of economy and construction technology, more and more bridges are built in complex mountainous areas. Accurate assessment of wind parameters is important in bridge construction at complex terrain. In order to investigate the wind characteristics in the high-altitude difference area, a complex mountain terrain model with the scale of 1:2000 was built. By using the method of wind tunnel tests, the study of wind characteristics including mean wind characteristics and turbulence characteristics was carried out. The results show: The wind direction is affected significant by the topography, the dominant wind direction is usually parallel to the river. Due to the sheltering effect of the mountain near the bridge, the wind speed and wind attack angle along the bridge are both uneven which is different from that at flat terrain. In addition, different from flat terrain, the wind attack angle is mostly negative. The wind profiles obey exponential law and logarithmic law. And the fitting coefficient is consistent with the code which means that it is feasible to use the method of wind tunnel test to simulate complex terrain. As for turbulence characteristics, the turbulence intensity is also related to the topography. Increases sheltering effect of mountain increases the degree of breaking up the large-scale vortices, thereby increasing the turbulence intensity. Also, the value of turbulence intensity ratio is different from the recommended values in the code. The conclusions of this study can provide basis for further wind resistance design of the bridge.

Agronomic improvements through the genetic and physiological regulation of nitrogen uptake in wheat (Triticum aestivum L.)

Lingan Kong,Fahong Wang,Luis Lo´pez-bellido,Jose Maria Garcia-mina,Jisheng Si 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.2

Nitrogen (N) uptake is the first step in nitrateassimilation, and efficient N uptake is essential for plantgrowth, especially for protein biosynthesis and photosyntheticactivities. In cereals, improved N uptake is closelycoupled with an increase in nitrogen use efficiency (NUE)and yield improvements. Because wheat (Triticum aestivumL.) is a leading crop worldwide, a better understandingof N uptake regulation in wheat is vital toimproving NUE and developing sustainable agriculturalsystems. However, detailed information regarding thebiological mechanisms that are responsible for the moreefficient uptake of ambient N by wheat is limited. Thisreview presents recent developments in the biologicalmechanisms of N uptake in wheat, including plant growthregulations, fundamental roles of root systems, interactionsbetween N species, and genetic controls. Specifically, thispaper provides a number of potential strategies that can beused to increase wheat N uptake. The information providedhere may guide N fertilizer management during wheatproduction and further elucidate the plant regulatorymechanisms that are involved in N uptake, which canthereby increase wheat NUE.

Co-adsorption of Irreversibly Adsorbing Sb and Te on Pt(111)

Ku, Bon-Seong,Kim, Tae-Gon,Jung, Chang-Hoon,Zhao, Jisheng,Rhee, Choong-Kyun Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.5

Presented is a voltammetric study of co-adsorption of irreversibly adsorbing Sb and Te on Pt(111). When a layer of Sb and Te was formed via simultaneous adsorption, the reduction peak of Te was observed at 0.30 V in the initial cathodic scan. In contrast, sequential adsorption of Sb followed by Te adsorption led to a Te reduction peak at 0.50 V in the initial scan. As the voltammetric scan was continued, in addition, the voltammogram of the simultaneously co-adsorbed layer changed, while that of the sequentially co-adsorbed layer did not. These observations are discussed in terms of formation of a homogeneously mixed layer and a layer consisting of heterogeneously separated domains of Sb and Te. Also, the difference in the adsorption strength of Sb and Te was observed.