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최천집(Choi, Cheon-jip) 한국어문학회 2016 語文學 Vol.0 No.131
This paper was written for the purpose of configuration and you want to reveal the creative intention of “eunaejeon(은애전)” The emphasis on the parts exposed in the previous discussion paper Sanya as starting it looked that has a certain meaning to point out one of the work essence is to say the author through the work, and the hidden intentions of this work trying to identify something It was. Things I did not say that, not only means that you have to see this work is revealed or concealed raise the issue to find something and looked out to find it. Summarizing the discussion in this paper obtained as follows. Belongs to the creative work done by passive command of the king. Such a point is already present at the start of the works, and is another factor to determine the basic nature of the work. Part of this process with the emerging debate waged cheogyeol on the case of the management layer that is described in the following events eunae are giving clear framework to conduct confined to literature rather than the basic direction of the work. This part is sought through a literary author has a certain practical relevance and acts as an element to have the opportunity to realize it. As a result, work is gatgido the opportunity to work through the author can play a role with the opportunity to speak you can do in reality. Work is structured into three parts. The first case corresponds to a section takes place in eunae. Eunae has a tree as punishment intended to spread a rumor unfaithful he did not commit the murder of Manda and the old lady next door. The response in this case is that the viscosity of a woman wearing a framed unfair happened to be in the process of what is expected to raise the issue of work has to be constant. The second example, on the grounds that the portable shrine ships one day maiden to in order to realize the will to virtue is toward showing the controversial process of leaving waged will make any cheogyeol for the murder of the ruling class is eunae holding a reason of ways The emphasis on that. Because to find a good reason for them to work toward in order to persuade it has been established that the logic of the tank towards the cheogyeol murder for what happened as an important basis of their political action. The third part is itgido suggests that the author of the leedeokmu(이덕무) is to assess the meaning of this event is part of the idea of the author as well as for the case where he is the ultimate goal oriented and we want through them. Creative intent of this work sikineunde imprint that all this through the course of processing the work of eunae balhyeoseo that chastity is performing well the office of a king, the people live a life that conforms to the medieval ideology is given when going to compensate you know have. As a result, the tank will be conducted and evaluated as well the political action haejun out the unfair things people seonggun beautiful. However, the author has the virtue to give a twirl king of identity go beyond unfair limitations on their opportunities for political speech that would be awesome if this makes the correct cheogyeol achieved through this work. In the form that it is hidden but it revealed that it lies with the intention of creation of the work. The work in the political life of leedeokmu do not have the opportunity to seize the opportunity of the remarks of political speech and deliver it to the king, while hiding the intent to deliver a uniform solution provided for seoeol identity and should be recognized as a problem. Work also has revealed a hidden intention, as well as intended. To the creative intention of this work has the intention to expose the party to inform soksajeong not known whether virtue is one balhyeoseo How well do the office of a king over the course of processing the work of eunae. The result is evaluated by virtue of well performing political acts of unfair things out of people who will be seonggun beautiful. However, t
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Ji, P.,Schachtschneider, K.M.,Schook, L.B.,Walker, F.R.,Johnson, R.W. Academic Press 2016 Brain, behavior, and immunity Vol.54 No.-
Although poorly understood, early-life infection is predicted to affect brain microglial cells, making them hypersensitive to subsequent stimuli. To investigate this, we assessed gene expression in hippocampal tissue obtained from a previously published study reporting increased microglial cell activity and reduced hippocampal-dependent learning in neonatal piglets infected with porcine reproductive and respiratory syndrome virus (PRRSV), a virus that induces interstitial pneumonia. Infection altered expression of 455 genes, of which 334 were up-regulated and 121 were down-regulated. Functional annotation revealed that immune function genes were enriched among the up-regulated differentially expressed genes (DEGs), whereas calcium binding and synaptic vesicle genes were enriched among the down-regulated DEGs. Twenty-six genes encoding part of the microglia sensory apparatus (i.e., the sensome) were up-regulated (e.g., IL1R1, TLR2, and TLR4), whereas 15 genes associated with the synaptosome and synaptic receptors (e.g., NPTX2, GABRA2, and SLC5A7) were down-regulated. As the sensome may foretell microglia reactivity, we next inoculated piglets with culture medium or PRRSV at PD 7 and assessed hippocampal microglia morphology and function at PD 28 when signs of infection were waning. Consistent with amplification of the sensome, microglia from PRRSV piglets had enhanced responsiveness to chemoattractants, increased phagocytic activity, and secreted more TNFα in response to lipopolysaccharide and Poly I:C. Immunohistochemical staining indicated PRRSV infection increased microglia soma length and length-to-width ratio. Bipolar rod-like microglia not evident in hippocampus of control piglets, were present in infected piglets. Collectively, this study suggests early-life infection alters the microglia sensome as well as microglial cell morphology and function.
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( Young Jip Kim ),( Soon Sun Kim ),( Da Mi Lee ),( Hyo Jin Lee ),( Mi Yeon Lee ),( Jae Youn Cheong ),( Sung Won Cho ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: The ideal treatment duration of HBeAg negative chronic hepatitis B is not well known. Relapse has been reported after stopping NUC therapy in the majority of chronic HBeAg negative hepatitis patients. However APASL guideline suggest that if undetectable HBV-DNA has been documented on three occations 6 months apart, discontinuation of treatment can be considered. We investigate the frequency of relapse rate in HBeAg negative CHB patients receiving NUC therapy. Methods: The NUC therapy was discontinued at least three times undetectable level of HBV DNA leave a 6 months space with in 45 patients. (25 with entecavir, 14 with lamivudine, 6 with adefovir.) All patients had follow up at least 1 year after stopping NUC therapy. They were monitored their symptoms, serum AST, ALT and HBV DNA level. Clinical relapse was defined HBV DNA>2,000IU and at least one of the AST, ALT is more than 2 times of upper limit of that. Virologic relapse was defined only HBV DNA>2,000IU regardless their AST, ALT. Results: Clinical relapse developed in 16 (35.6%) and 24 (53.3%) patients after stopping therapy at 6 months and 12 months off therapy, respectively. Virologic relapse developed 22 (48.9%) and 33 (73.3%) patients at 6 months and 12 months off therapy. The factors such as age, gender, cirrhosis, baseline AST, ALT, HBV DNA levels, treatment duration, and consolidation duration were analyzed to investigate the predictive factors associated with 1year sustained response. Of these factors, baseline HBV DNA (92.3% in those with baseline HBV≥108 copies/ml, 63.3% in HBV<108 copies/ml.) and cirrhosis (86.1% in CHB, 22.2% in LC) were significantly associated with 1 year virologic relapse. Conclusions: Virologic relapse developed in the majority (73.3%) of patients and clinical relapse developed in the half (53.3%) patients at 1 year off therapy. Baseline HBV DNA level (<108 copies/ml) and LC were found associated with the low rate of virologic relapse.
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( Young Jip Kim ),( Ki Chan Kim ),( Sun Hyuk Hwang ),( Soon Sun Kim ),( Dami Lee ),( Jae Youn Cheong ),( Sung Won Cho ) 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.3
Background/Aims: Relapse has been reported after stopping nucleos(t)ide (NUC) therapy in the majority of chronic HBeAg negative hepatitis patients. However, the ideal treatment duration of HBeAg negative chronic hepatitis B (CHB) is not well known. We investigated the frequency of relapse in HBeAg negative CHB patients receiving NUC therapy. Methods: The NUC therapy was discontinued at least 3 times undetectable level of HBV DNA leave 6 months space in 45 patients. Clinical relapse was defined as HBV DNA >2,000 IU/mL and alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >2 times of upper limit of normal range. Virological relapse was defined as HBV DNA >2,000 IU/mL. Results: Clinical relapse developed in 16 (35.6%) and 24 (53.3%) patients after stopping therapy at 6 months and 12 months off therapy, respectively. Virological relapse developed 22 (48.9%) and 33 (73.3%) patients at 6 months and 12 months off therapy. The factors such as age, gender, cirrhosis, baseline AST, ALT, HBV DNA levels, treatment duration, and consolidation duration were analyzed to investigate the predictive factors associated with 1 year sustained response. Of these factors, cirrhosis (86.1% in CHB, 22.2% in LC) was significantly associated with 1 year virological relapse rate. Baseline HBV DNA and total treatment duration tended to be associated with virological relapse. Conclusions: Virological relapse developed in the majority (73.3%) of HBeAg negative CHB patients and clinical relapse developed in the half (53.3%) of patients at 1 year off therapy. Cirrhosis may be associated with the low rate of virological relapse. (Clin Mol HepatoI2013;19:300-307)
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