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Novel microfluidic platform for modeling and evaluating osteoconduction of 3D printed scaffold
( Jinsub Han ),( Sangbae Park ),( Jae Eun Kim ),( Jae Woon Lim ),( Hyunmok Son ),( Kyoung-je Jang ),( Jong Hoon Chung ) 한국농업기계학회 2021 한국농업기계학회 학술발표논문집 Vol.26 No.1
Using scaffold in bone regenerative treatment for efficient osteoconduction to induce the bone healing is still challenging. Thus, the aim of the study was to develop scaffold-on-a-chip device that comprises a 3D environment and fluid shear stress. The chip is composed with space for scaffold in the center and a microfluidic channel which encircles the scaffold area. This structure can allow real time monitoring of cell adhesion, proliferation, differentiation and migration. The design of chip model focused on minimizing bubble and controlling of cell seeding area, both verified using computational fluid dynamics (CFD). Different channel coatings were compared to enhance cell adhesion on the chip and coating with 200 μg/ml of fibronectin was applied on the chip. MC3T3-E1 cells were cultured in the chip device for 7 days and investigated using immunocytochemical staining. Results demontrated that the cells were successfully cultured and differentiated in the chip. Fabricated scaffold-on-a-chip has a potential to help our understanding of scaffold-tissue interaction and provide an alternative to animal and clinical studies for scaffold development.
Jinsub Kim,Seok Chan An,Yojong Choi,Tae Kuk Ko,Yong Chu IEEE 2017 IEEE transactions on applied superconductivity Vol.27 No.4
<P>A quench detection system for Korea Superconducting Tokamak Advanced Research (KSTAR) Poloidal Field (PF) coils is indispensable against the occurrence of a normal zone due to frequently variable current operation and an enormous amount of stored energy. The co-wound conductive strips and Wheatstone bridges have been adopted in KSTAR to detect abnormal voltage signal caused from quench. Those voltage detection methods have sufficient capability to detect quench occurrence, but additional cancelling out of mutual induction by adjacent coils would improve stability and reliability of quench detection system. A new voltage detection concept, using central difference averaging (CDA) and mutual inductance compensation (MIK) simultaneously, as an advanced technique to compensate the mutual inductive voltage, has been suggested and studied for this study. The CDA and MIK methods were practically adapted to the KSTAR PF 1 coil for the feasibility study. Test results show that the inductance matrix calculated by the FEM tool should be revised because of a revealed discrepancy between measured CDA voltage and calculated MIK voltage. In this study, the inductance matrix was revised by using the “Genetic algorithm” optimization method to reduce the discrepancy between CDA and MIK effectively. The adoption of the MIK revised inductance matrix was consistent with CDA voltage; mutual inductive voltage was expected to be successfully eliminated.</P>
Jinsub Shin,Sung Hwan Cho,Bon Sung Koo,Yang Hoon Chung 순천향대학교 순천향의학연구소 2017 Journal of Soonchunhyang Medical Science Vol.23 No.1
Hypoglossal nerve palsy is a rare complication of endotracheal intubation. The mechanism of nerve palsy is mainly attributed to stretching or compression of the nerve during airway manipulation. The cuff pressure can also contribute to the occurrence of hypoglossal nerve palsy. Since it is often accompanied by other cranial nerve palsies, meticulous overall cranial nerve examination is necessary. The main treatment is supportive with respiratory monitoring. The prognosis is favorable. Majority of patients achieve nearly full recovery of nerve function. Here, we report a case of unilateral hypoglossal nerve palsy following usual, uneventful endotracheal intubation and review the literature.
Conferencing Service Interworking in Peer-to-Peer and IMS Networks
( Jinsub Sim ),( Younghan Kim ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.9
The growth of Internet technologies and the widespread use of mobile devices have been paving the way for the increasing use of conferencing services. Two types of systems have been designed to provide conferencing services: 1) a conferencing system using session control over a peer-to-peer (P2P) network and 2) an IP Multimedia Subsystem (IMS) conferencing system. The IMS conferencing system was developed to adapt to a server-based centralized system, whereas the benefits of the P2P operational model in providing such conference services are widely acknowledged. However, each system provides conferencing services only to its own users. Therefore, in this paper, we propose an interworking model to support multimedia conferencing service between the P2P environment and IMS networks. We also introduce protocol architecture and some service scenarios. To verify this system model and the design architecture, we perform an actual implementation and show experienced test results.
Jinsub Kim,Hyungjun Kim,Jeyull Lee,Tae Kuk Ko Institute of Electrical and Electronics Engineers 2016 IEEE transactions on applied superconductivity Vol.26 No.4
<P>Recently, superconducting power applications by using the high-temperature superconducting (HTS) tape have been widely researched due to the development of the HTS tape. In particular, the HTS coils cowound with insulation materials have been dominantly used for the power applications. However, the insulated HTS coil has low thermal stability at overcurrent operation, which causes much likely to be damaged. To relieve this issue, other insulation methods such as insulation-free or partial insulation have been investigated. These methods have good thermal stability; however, they have weaknesses such as magnetic field saturation and charge-discharge delay as well. In particular, charge-discharge delay is a significant obstacle for superconducting magnetic energy storage due to a frequently variable current operation. Therefore, a quasi-insulation (QI) coil that compensates the disadvantages has been proposed. In this paper, two QI coils according to the width of the insulation tape were fabricated since the performance of this winding method is affected by the exposure area to the coolant. In addition, insulation-free coil and partial insulation coil were fabricated and tested as the control group. The terminal coil voltage and center magnetic field were measured to compare the characteristics of each coil. The experimental result shows the QI coil has good thermal stability at overcurrent operation without magnetic field saturation and degradation. In addition, cooling effect is proportional to the exposed area to the coolant and adjustable with a different width of insulation tape.</P>