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( Jin Ho Bae ),( Ji Yeoun Shin ),( Ga Hee Jung ),( Young Lip Park ),( Jong Suk Lee ),( Kyu Uang Whang ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Molluscum contagiosum, a self-limiting benign viral skin disease, can be presented as a cutaneous manifestation of HIV/AIDS infections. Because molluscum contagiosum shows ubiquitous distribution and it is frequent especially among the pediatric population, it would manifest in unusual forms when complicated with HIV/AIDS infections. A 50-year-old male patient visited with multiple nonpruritic, yellowish papules and plaques on the whole face, neck and trunk. He has been diagnosed as AIDS over 10 year ago and treated with ART(Anti-Retroviral Therapy), but he was lost to follow up for last 4 years with no ART medication. His laboratory findings revealed a remarkable decrease of CD4 T cells. We did a punch biopsy under the impression of Kaposi’s sarcoma, but the lesions were confirmed as the molluscum contagiosum on histologic examination. Then, his skin lesions were managed with topical 5% imiquimod cream at the beginning, but adverse effects like irritation and erythema were presented. The cryotherapy successfully alleviated the disease after 4-times treatment with an interval of one month. Cutaneous infections by molluscum contagiosum virus in persons with AIDS are sometimes presenting in unusual forms, such as plaque-shaped forms, beard forms, or giant forms. These presentations may be one of the markers for the therapeutic failure. Herein we report a case of unusual disseminated molluscum contagiosum in a patient with AIDS.
FC 2-15 Expression of ARF6 and cytohesin-2 in malignant skin cancers
( Jin Ho Bae ),( Ji Yeoun Shin ),( Ga Hee Jung ),( Sang Hoon Lee ),( Sung Yul Lee ),( Kyu Uang Whang ),( Moon Kyun Cho ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: ARF6(ADP Ribosylation Factor 6) plays an critical role in regulating tumor growth and metastasis. Cytohesin-2 is a GEF for ARF6 and its functions include cell proliferation and migration. The overexpression of ARF6 and cytohesin-2 is prevalent in many human cancers. However, very few studies have been conducted on the expressions and functions of ARF6 and cytohesin-2 in skin cancers. Objectives: This study aims to examine the expression of ARF6 and cytohesin-2 in cutaneous carcinomas including various skin cancers. Methods: 6 normal skin and 18 malignant skin tissue were examined using western blotting method and IHC for ARF6 and cytohesin-2. A cell viability study and cell migration assays were carried out on G361 cells by small interfering RNA transfection. Results: According to the results of western blotting, ARF6 and cytohesin-2 were found to be expressed in all malignant skin tumor tissues but none of them were found in normal skin tissues. The results of IHC examination on ARF6 and cytohesin-2 in skin cancers correspond to those of the western blotting. Compared to when ARF6 and cytohesin-2 were treated with siRNA respectively, the degree of apoptosis markedly increased and cell viability was inhibited in G361 cell when ARF6 and cytohesin-2 were treated with siRNA simultaneously. Conclusion: This study is the first report on the expression of ARF6 and cytohesin-2 in human skin tumors and suggests that ARF6 and cytohesin-2 play an oncogenic role in skin cancers.