孔子學說在現代生活中的價値

章景明 中國語文硏究會 1988 中國語文論叢 Vol.1 No.-

Phosphorylation of DYNLT1 at Serine 82 Regulates Microtubule Stability and Mitochondrial Permeabilization in Hypoxia

Xue Xu,Yue-sheng Huang,Qiong Zhang,Jiong-yu Hu,Dong-xia Zhang2,Xu-pin Jiang,jie-zhi Jia,Jing-ci Zhu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4

Hypoxia-induced microtubule disruption and mitochondrial permeability transition (mPT) are crucial events leading to fatal cell damage and recent studies showed that microtubules (MTs) are involved in the modulation of mitochondrial function. Dynein light chain Tctex-type 1 (DYNLT1) is thought to be associated with MTs and mitochondria. Previously we demonstrated that DYNLT1 knockdown aggravates hypoxia-induced mitochondrial permeabilization, which indicates a role of DYNLT1 in hypoxic cytoprotection. But the underlying regulatory mechanism of DYNLT1 remains illusive. Here we aimed to investigate the phosphorylation alteration of DYNLT1 at serine 82 (S82) in hypoxia (1% O2). We therefore constructed recombinant adenoviruses to generate S82E and S82A mutants, used to transfect H9c2 and HeLa cell lines. Development of hypoxia-induced mPT (MMP examining, Cyt c release and mPT pore opening assay), hypoxic energy metabolism (cellular viability and ATP quantification), and stability of MTs were examined. Our results showed that phosph-S82 (S82-P) expression was increased in early hypoxia; S82E mutation (phosphomimic) aggravated mitochondrial damage, ele-vated the free tubulin in cytoplasm and decreased the cellular viability; S82A mutation (dephosphomimic) seemed to diminish the hypoxia-induced injury. These data suggest that DYNLT1 phosphorylation at S82 is involved in MTs and mitochondria regulation, and their interaction and cooperation contribute to the cellular hypoxic tolerance. Thus, we provide new insights into a DYNLT1 mechanism in stabilizing MTs and mitochondria, and propose a potential therapeutic target for hypoxia cytoprotective studies.

Investigation on Air Texturing Process for Diacetate Blending with Polyester Filaments

Zhang, Jing,Zhang, Zhilong,Wang, Shanyuan,Qin, Xiaohong The Korean Fiber Society 2007 Fibers and polymers Vol.8 No.4

Influences of processing parameters on tensile property, stability and bulk of core-and-effect air textured yarns of diacetate polyester filaments are mainly examined in this paper. When the air pressure is raised, the tenacity and breaking elongation of textured yarns are reduced, Instability I and II tend to decrease at first and then increase, the core bulk declines markedly at first and then changes slowly, whereas the overall bulk changes little at first and then goes up greatly. With increase in texturing speed, the yarn tenacity and breaking elongation both drop initially then begin to increase, the core bulk and overall bulk are almost linearly increased, while the yarn instability changes with an unclear trend. When the winding underfeed ratio is increased, the yarn tenacity, breaking elongation and core bulk are reduced, but the yarn stability is slightly improved. The wetting of the core component produces higher tenacity, breaking elongation, instability and bulk, compared with that of the effect component or that of both, but the difference is insignificant.

SBD type Silicide-Si high current Schottky barrier switching diode and their characteristics

Zhang Jing Jun 대한전자공학회 1991 ICEIC:International Conference on Electronics, Inf Vol.1991 No.8

Properties of Core-and-effect Air Textured Yarns Blended by Diacetate and Polyester Filaments

Zhang, Jing,Zhang, Zhilong,Wang, Shanyuan,Qing, Xiaohong The Korean Fiber Society 2007 Fibers and polymers Vol.8 No.1

In present work, PET FDY has been used to blend with diacetate filaments by air texturing process and core-and-effect air-textured yarns have been produced. The influences of both over-feeds of core and effect components on properties of textured yarns were mainly examined. It was observed that a spun-like effect of diacetate filaments occurred during air texturing and there were a little amount of free fiber ends besides loops on blended air textured yarns, while the number of free fiber ends changed little with variation in over-feeds. The tenacity of textured yarns decreased with increase in over-feeds of effect or core component. The breaking elongation increased with increase in over-feed of effect component, but decreased with increase in over-feed of core component. The yarn stability improves when both over-feeds are increased. The effect of over-feeds on boiling water shrinkage shows no clear trend. The core and average diameters are higher at high over-feed of effect component, but the over-feed of core component exhibits little effect on yarn diameters. The number and size of loops re increase with increased over-feed of effect component.

Cobalt phosphide nanoparticles embedded in nitrogen-doped carbon nanosheets: Promising anode material with high rate capability and long cycle life for sodium-ion batteries

Zhang, Kai,Park, Mihui,Zhang, Jing,Lee, Gi-Hyeok,Shin, Jeongyim,Kang, Yong-Mook Springer-Verlag 2017 NANO RESEARCH Vol.10 No.12

<P>Cobalt phosphide (CoP) nanoparticles which were uniformly embedded in N-doped C nanosheets (CNSs) were fabricated via the simple one-step calcination of a Co-based metal-organic framework (MOF) and red P and exhibited a high capacity, fast kinetics, and a long cycle life. This CoP/CNS composite contained small CoP particles (approximately 11.3 nm) and P-C bonds. When its electrochemical properties were evaluated by testing CoP/Na coin cells, the composite delivered a Na-storage capacity of 598 mAh center dot g(-1) at 0.1 A center dot g(-1) according to the total mass of the composite, which means that the capacity of pure CoP reached 831 mAh center dot g(-1). The composite also exhibited a high rate capability and long-term cyclability (174 mAh center dot g(-1) at 20 A center dot g(-1) and 98.5% capacity retention after 900 cycles at 1 A center dot g(-1)), which are commonly attributed to robust P-C bonding and highly conductive CNSs. When the reaction mechanism of the CoP/CNS composite was investigated, a conversion reaction expressed as CoP + 3Na(+) + 3e(-) a dagger' Co + Na3P was observed. The outstanding Na-storage properties of the CoP/CNS composite may suggest a new strategy for developing high-performance anode materials for Na-ion batteries.</P>

Simulation Analysis on Hysteretic Performance of Cross-type Rigid Node for Steel Frame Based on Abaqus

Jing Ji,Bing Li,Wenfu Zhang,Yingchun Liu,Chaoqing Yuan,Fei Xing 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1

In order to study the cross-type rigid steel frame node hysteretic behavior of components, the axial compression ratio, H type steel column web thickness, girder section and stiffener as design parameters, 8 steel frame cross-type rigid joints and a T-type rigid joint are designed. Based on simplified mechanical model and constitutive relations of material, using ABAQUS software the corresponding finite element model is established and the hysteretic performance analysis is carried out. Through comparison between given T-type node test results and analysis results, both are in good agreement, thus the rationality of the finite element model established in this paper is verified. Simulation analysis of cross-type node is developed in further, load -displacement hysteretic curve of nodes, skeleton curve, envelope figure and the stress nephogram are extracted and comparative analysis is conducted, influence regularity of four parameters on the seismic behavior of the joints is obtained. The corresponding design suggestion for the axial compression ratio and column web and flange thickness ratio is proposed, design limit value of axial compression ratio of column should be taken as 0.5 and limit value of column web and flange thickness ratio is taken as 0.75,and these can provide reference for actual engineering design.

Preparation of Octadecylamine-Graphene/MgCl₂-Supported Ziegler-Natta Catalyst and Its Application in Ethylene Polymerization

Zhang, Hao,Liu, Jing-Sheng,Zhang, He-Xin,Ko, Eun-Bin,Park, Jae-Hyeong,Moon, Young-Kwon,Shin, Byeong-Kwang,Zhang, Xue-Quan,Yoon, Keun-Byoung American Scientific Publishers 2018 Journal of nanoscience and nanotechnology Vol.18 No.4

<P>A facile coagglomeration method for preparing a long alkyl chain modified graphene oxide (MGO)/MgCl2-supported Ti-based Ziegler-Natta catalyst was reported. The effects of MGO on the catalyst morphology and activity for ethylene polymerization were examined. The resultant polyethylene (PE)/MGO nanocomposites exhibited a layered morphology, with the MGO fillers being well dispersed and exhibiting strong interfacial adhesion to the PE matrix. The thermal stability and mechanical properties of the PE were significantly enhanced with the introduction of a small amount of the MGO filler. Thus, this work provides a facile approach to the production of high-performance PE.</P>

Transcriptome profiling identifies immune response genes against porcine reproductive and respiratory syndrome virus and Haemophilus parasuis co-infection in the lungs of piglets

Jing Zhang,Jing Wang,Xiong Zhang,Chunping Zhao,Sixuan Zhou,Chunlin Du,Ya Tan,Yu Zhang,Kaizhi Shi 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.1

Background: Co-infections of the porcine reproductive and respiratory syndrome virus (PRRSV) and the Haemophilus parasuis (HPS) are severe in Chinese pigs, but the immune response genes against co-infected with 2 pathogens in the lungs have not been reported. Objectives: To understand the effect of PRRSV and/or HPS infection on the genes expression associated with lung immune function. Methods: The expression of the immune-related genes was analyzed using RNA-sequencing and bioinformatics. Differentially expressed genes (DEGs) were detected and identified by quantitative real-time polymerase chain reaction (qRT-PCR), immunohistochemistry (IHC) and western blotting assays. Results: All experimental pigs showed clinical symptoms and lung lesions. RNA-seq analysis showed that 922 DEGs in co-challenged pigs were more than in the HPS group (709 DEGs) and the PRRSV group (676 DEGs). Eleven DEGs validated by qRT-PCR were consistent with the RNA sequencing results. Eleven common Kyoto Encyclopedia of Genes and Genomes pathways related to infection and immune were found in single-infected and co-challenged pigs, including autophagy, cytokine-cytokine receptor interaction, and antigen processing and presentation, involving different DEGs. A model of immune response to infection with PRRSV and HPS was predicted among the DEGs in the co-challenged pigs. Dual oxidase 1 (DUOX1) and interleukin-21 (IL21) were detected by IHC and western blot and showed significant differences between the co-challenged pigs and the controls. Conclusions: These findings elucidated the transcriptome changes in the lungs after PRRSV and/or HPS infections, providing ideas for further study to inhibit ROS production and promote pulmonary fibrosis caused by co-challenging with PRRSV and HPS.

Experimental Application of Pitting Formation for 20MnCr5 Carburized Gear Tooth

Jing Zhang,류성기,Qi Zhang,Changhong Wu,Zhe-Zhu Xu 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

Gear tooth contact analysis and a FZG gear test rig were applied to study and analyze gear contact fatigue in this paper. Under therange of operating conditions, experiments were performed in the test rig by using standard FZG type C spur gear test specimenswhich were made from 20MnCr5 gear steel. Test rig, spur gear test specimens, the properties of the gear material were alsointroduced. After the test, pitting formation was investigated using scanning electron microscopy. Two kinds of fatigue spallings causedby subsurface fatigue failure and surface fatigue failure were investigated. And energy spectral analysis for two kinds of fatiguepositions were analyzed by the EDS detector, the materials of subsurface fatigue failure are the oxide Al2O3 and the carbide, and theblack textures of surface fatigue failure are the oxide and the non-martensitic material. Through the mechanism analysis of this gearcontact fatigue failure, it is founded that reducing the oxygen content in the material, can effectively reduce the oxide inclusions inthe steel. It would provide a reliable reference study for 20MnCr5 carburized gear.