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Jinsook Kim,Kieun Lee,Eunsung Lee 한국청각언어재활학회 2020 Audiology and Speech Research Vol.16 No.4
Purpose: This study was to determine the effects of response tasks, such as button pressing and mental counting, and handedness on N100, N200, and P300 auditory event-related potential (AERP). Methods: A total of 50 normal-hearing young adults with the average age of 21.6 (±1.5) years participated in this study. Among them, 15 men and 15 women were right-handed and 10 men and 10 women were left-handed. An oddball paradigm was used to deliver 30 stimuli of 2 kHz target tone bursts and 120 stimuli of 1 kHz nontarget tone bursts. The stimuli were presented at 70 dB sound pressure level with the rate of 1/s. Results: The button pressing task elicited significantly smaller N100 and larger P300 amplitudes than the mental counting task. N200 latency was significantly lower and P300 amplitude was higher in left-handed participants than those who are right-handed. Appearance percentages of right-/left-handed participants for N100, N200, and P300 were 80/95%, 85/85%, and 75/75% for the button pressing task and 80/90%, 80/80%, and 70/70% for mental counting task, respectively. Conclusion: The significant difference in appearance percentage between response tasks supported that P300 was a strong endogenous potential. N100 and N200 were thought to have both endogenous and exogenous characteristics. A more sensitive approach in selecting the task of response for the target stimuli and careful consideration for the handedness is necessary for AERP recordings.
Verbal Routines in a Blind Korean Child’s Language Acquisition
Jinsook Kim 한국언어학회 2013 언어 Vol.38 No.3
This study investigates the strategies that a blind child uses to learn language in the absence of visual input. For the last several decades, numerous studies on blind children’s language learning have reported that many blind children use formulaic expressions and verbal routines in their speech; these expressions are composed of several unanalyzed chunks and are used as whole utterances. In this study, the data were collected from one visually impaired Korean child between 24 and 30 months. The child was audio- and video-recorded, and all data were transcribed. The Korean blind child used many verbal routines and formulaic expressions. The results support the ‘use first, analyze later’ strategy (Peters, 1987) in that the child used verbal routines creatively in different conversational contexts and became aware of meaning and the usage of formulaic expressions. This study shows that blind children can be actively involved in their own language learning and that through verbal routines, they learn not only linguistic structures but also social interactions.
( Jin Sook Kim ),( Sook-kyung Lee ),( Joong-won Park ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Tyrosine kinase inhibitors (TKIs), such as sorafenib and regorafenib, were approved as effective treatments for patients with advanced hepatocellular carcinoma (HCC). However, primary resistance towards these agents is observed in approximately 50% of patients and secondary resistance is expressed 3-4 months after treatment in many patients. Moreover, sorafenib provides a lower survival rate for patients having high serum alpha-fetoprotein (AFP) levels. AFP is a diagnostic marker, and also has a variety of biological functions. This study investigated whether AFP inhibition enhanced the anti-proliferative effects of TKIs in human HCC cell lines. Methods: AFP-producing human HCC cell lines, Huh-7 and Hep3B, and non-AFP-producing SNU-series cell lines were used in this study. AFP expression was suppressed via AFP siRNA transfection. Cellular growth was analyzed via MTS assay and kinase signaling pathways were examined via immunoblot analysis. Results: Lenvatinib, regorafenib, dasatinib, and sorafenib inhibited HCC cellular growth. Huh-7 and Hep3B cells were more susceptible to sorafenib and regorafenib than the other drugs. After AFP siRNA transfection, sorafenib or regorafenib treatments showed a synergistic anti-proliferative effect in Huh-7 and Hep3B cells. This growth inhibition was associated with the suppression of Akt phosphorylation Conclusions: AFP suppression increases the anti-proliferative effect of sorafenib and regorafenib in human HCC cells. These results suggest that AFP silencing may play a synergistic role in the anti-tumor effect of some TKIs in human HCC cells.