중국거주 조선족 여성의 영적 안녕정도가 정신건강에 미치는 영향

정성덕,이종범,김진성,서완석,배대석,박순재,주열,염형욱,김승원,김구묘,안영록,황대홍,표미자,조창열,정태길 영남대학교 의과대학 2004 Yeungnam University Journal of Medicine Vol.21 No.2

자아초월 정신의학이 체계화되면서 영성(spirituality)은 인성의 한 부분이라는 이론이 대두되었는데 이 영성은 정신건강에 큰 영향을 미친다고 했다. 인간의 성향 중 영적 안녕 정도를 파악하여 그 정도가 정신건강 중 허위성 경향, 정신병적 경향 및 불안과 우울 경향 등에 어떠한 영향을 미치는지를 조사하고저 본 연구를 실시하였다. 대상은 중국의 연변 조선족 자치구에 거주하는 여성 400명을 대상으로 하여 한국판 영적 안녕척도를 사용하여 영적 안녕정도를 파악하였다. 영적 안녕척도의 총점과 이 척도의 2개 하위 척도인 종교적 안녕과 실존적 안녕 척도 양자로 평가한 성적이 불안-우울통합척도와 정신분열증 척도 및 허위성 척도로 평가한 성적에 미치는 영향을 검증하기 위하여 상관관계분석 및 회기분석을 실시하였다. 그 결과는 다음과 같다. 1) 영적 안녕척도로 평가한 조선족 여성의 총점은 68.29로 한국의 기독교 여성이 평가한 100.65보다 훨씬 낮은 점수였다. 2) 불안·우울통합척도로 평가한 총점은 44.88로 연변노인이 평가한 점수와 일개지역의 한국농촌주민이 평가한 점수와 비슷한 결과였다. 3) 허위성 척도로 평가한 성적은 평균 74.57로 70점 이상이 86%(344명)이었으나 영적 안녕 성적과 허위성 성적 간에는 유의한 상관이 없었다. 4) 영적 안녕총점은 정신분열증 척도로 평가한 정신병적 경향에 유의한 영향을 미치지 않았으나 종교적 안녕하위척도의 성적은 정신병적 경향을 높여준데 비하여 실존적 안녕하위척도의 성적은 정신병적 경향을 낮게 해주었다. 5) 영적 안녕척도의 총점 및 두 하위척도인종교적 안녕과 실존적 안녕은 불안과 우울에유의한 상관을 보였는데 영적 안녕총점이 높을수록 불안·우울 총점이 다소 낮아지는 경향을 보였다. 6) 종교적 안녕 하위척도와 불안과 우울과의 관계는 종교적 안녕점수가 높을수록 불안과 우울을 각각 다소 유의하게 높여주었으며 이에 비하여 실존적 안녕하위척도와 불안과 우울과의 관계는 실존적 안녕정도가 높을수록 불안 및 우울점수는 유의하게 낮아졌다. 이와 같은 성적을 미루어볼 때 연변에 거주하는 조선족 여성이 평가한 영적 안녕정도는 정신병적 경향과 불안 및 우울에 유의한 상관을 보였으면 이 척도의 하위 척도인 종교적 안녕정도는 정신건강에 부정적인 영향을 미치는 반면 실존적 안녕정도는 정신건강에 긍정적 영향을 미친 결과로 평가되었다. 이러한 결과는 공산주의 사회에서 실존적 안녕은 긍정적인 가치관으로 평가되는 반면 종교적 안녕은 정신건강에 부정적으로 작용한 것을 입증해 주었다고 하겠다. Background: Spirituality has been an important part of Transpersonal Psychology and is believed to have a large effect on the mental health because it has been systematized. The aim of this study was to determine the level of spiritual disposition on human beings along with its effects on one's mental health. Materials and Methods: The study targeted 400 women residing in Youn-Gil city of JiLin Prov., which is a district of the Cho-Sun tribe in China. Their spiritual well-being was studied using the Spiritual Well-being Scale-Korean Version. The spiritual well-being scale consists of 2 sub-scales of religious well-being and existential well-being. The study was evaluated using a lie scale, psychotic trend, and a combined anxiety-depression scale. The results were considered to be factors of one's mental health. The correlation between the spiritual well-being and each tendency was analyzed by regression analysis. Results: The total score of the Cho-Sun tribal women according to the spiritual well-being scale was 68.29 which was much less than the 100.65 of Korean Christian women. There was no significant correlation between the spiritual well-being and the Lie trend. However, it was found that 86%(344) of Cho-Sun tribal women scored above 70 in the Lie trend with a mean score of 74.57 which is higher than normal populations. Regarding the correlation between the spiritual well-being and psychotic trend, the psychotic trend became significantly higher when the religious well-being was at a high level. On the other hand, the psychotic trend became significantly lower when the existential well-being was at a high level. Regarding the correlation between the spiritual well-being and anxiety, the anxiety was significantly higher when the religious well-being was at a high level. However, the anxiety level was significantly low when the existential well-being was at a high level. Regarding the correlation between the spiritual well-being and depression, the depression level was somewhat significantly high when the religious well-being was at a high level. However, the depression level was significantly low when the existential well-being was at a high level. Conclusion: This study evaluated the effects of spiritual well-being on a person's mental health among Cho-Sun tribal women in Youn-Gil city of JiLIn Prov., P.R. of China. The results found that the religious well-being, which is a sub-scale of spiritual well-being, had negative effects while the existential well-being had positive effects on the mental health. These results proved that a person's religious disposition had negative effects on their mental health in a communitarian society.

Mite and Booklouse Fauna From Vacuumed Dust Samples From Beijing

Jin-Lu Sun,Lian Shen,Jun Chen,Jin-Miao Yu,Jia Yin 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.3

A significant-source of allergens come from house dust that contain particles derived from arthropods, molds, and pet dander. This study evaluatedmite and booklouse fauna from vacuumed dust samples in Beijing China (a temperate zone). Our survey was carried out in Beijing in the homes ofmite allergic patients who visited our Allergy Department. In total, 38 homes were selected for the collection of dust samples by vacuuming, fromDecember 2008 to January 2010. The flotation method was used to isolate mites from house dust. Permanent slides were prepared for mite specimensand mites were identified and counted under a microscope. In total, 1,798 separate mite and insect specimens were found in 345 dust samplestaken from 38 homes. A total of 95 individual Dermatophagoides (D) siboney were detected in 35 dust samples from 19 homes (representing5.3% of all mite and insect species found in house dust); in addition, this mite was found to co-exist with D. farinae (Hughes, 1961) in 33 dust samples. Our results demonstrated the presence D. siboney that co-existed with D. farinae in house dust in Beijing China (a temperate zone).

Prediction Value of XRCC 1 Gene Polymorphism on the Survival of Ovarian Cancer Treated by Adjuvant Chemotherapy

Miao, Jin,Zhang, Xian,Tang, Qiong-Lan,Wang, Xiao-Yu,Kai, Li Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

Objective: We conducted a prospective study to test the association between three amino acid substitution polymorphismic variants of DNA repair genes, XRCC1 (Arg194Trp), XRCC1(Arg280His) and XRCC1 (Arg399Gln), and clinical outcome of ovarian cancer patients undergoing adjuvant chemotherapy. Methods: 195 patients with primary advanced ovarian cancer and treated by adjuvant chemotherapy were included in our study. All were followed-up from Jan. 2007 to Jan. 2012. Genotyping of XRCC1 polymorphisms was conducted by TaqMan Gene Expression assays. Results: The XRCC1 194 Trp/Trp genotype conferred a significant risk of death from ovarian cancer when compared with Arg/Arg (HR=1.56, 95%CI=1.04-3.15). Similarly, those carrying the XRCC1 399 Gln/Gln genotype had a increased risk of death as compared to the XRCC1 399Arg/Arg genotype with an HR (95% CI) of 1.98 (1.09-3.93). Conclusion: This study is the first to provide evidence that XRCC1 gene polymorphisms would well be useful as surrogate markers of clinical outcome in ovarian cancer cases undergoing adjuvant chemotherapy.

商务汉语教学中的“间性”问题研究

김명자(Jin, Ming-Zi)(金明子),서묘묘(Xu, Miao-Miao)(徐苗苗) 대한중국학회 2020 중국학 Vol.71 No.-

一直以来,商务汉语教学旨在培养语言学习者的语言运用能力、职场沟通能力及跨文化能力,但目前学界关于商务汉语教学的研究多集中于课程体系设置和教学方法的革新等操作性层面,教学过程中的三个“间性”维度却很少有人触碰:即话语间性、主体间性与文化间性。这三个维度分别涉及到文本阅读和语境理解的关系,学习者和教师之间的关系以及语言学习者对不同文化之间的理解方式。在商务汉语的学习目标和学科定位的框架之下对三个“间性”维度进行研究,不仅有助于教育者在商务汉语教学中根据学习者的学习经历,文化背景去采取不同的教育方法和手段,也有利于学习者更为准确的把握文本内涵,进行具有创造性的阅读和写作。 Chinese business teaching aims to train the ability of learners in language applying, workplace communicating and inter-culture communicating. By now, however, most of the researchers have focused on the teaching designing or the method improving. Few of the scholars noticed the three “inter” dimensions in business Chinese teaching: interdiscursivity, intersubjectivity and interculturality. In detail, the interdiscursivity means the relationship between the text reading and the context understanding, while the intersubjectivity refers to the relationship between teachers and learners. Moreover, the concept “Interculturality” means the way learners understand the different kinds of culture. The study on those three “inter” dimensions in business Chinese teaching could not only help teachers in method applying in business Chinese teaching, but also provide a more efficient way in reading, writing and understanding.

CPT考试中商务话语的体裁及其测试维度分析

金明子(Jin, Ming-Zi),徐苗苗(Xu, Miao-Miao) 대한중국학회 2017 중국학 Vol.59 No.-

近年来,商务话语在CPT考试的阅读题和语意理解题中常以广告语、公司会议报告以及应聘记录 等体裁出现.其中广告话语多以营销语和打折信息的形式出现;公司会议报告则以正式的会议记录 或非正式的年会祝词形式出现;应聘记录则主要以招聘启事的形式出现。本文以CPT考试真题中听 力和阅读理解部分出现的商务汉语为研究对象,将商务汉语划分为广告语、公司会议报告以及招聘 通知等三种商务话语体裁,并基于真题分析来探究这三种体裁对于汉语学习者在知识、能力和素质 三个维度的测试内容。 Recently, the business discourse has constituted an important part in the CPT, especially in the Readings. The forms of business discourse includes: Advertisement discourse, reports in the Company meetings and records in interviewing. This essay studies on the Chinese about the business discourse in the reading comprehension and listening comprehension in the CPT. In this essay, advertisement, meeting reports and interviewing notes are the three genres constituting the Chinese about business discourse. The study is basing on the exam questions in the CPT, researching the text dimensions, including the knowledge, ability and the quality.

A novel composition of ticagrelor by solid dispersion technique for increasing solubility and intestinal permeability

Kim, Sung-Jin,Lee, Hong-Ki,Na, Young-Guk,Bang, Ki-Hyun,Lee, Hye-Jin,Wang, Miao,Huh, Hyun-Wook,Cho, Cheong-Weon Elsevier 2019 International journal of pharmaceutics Vol.555 No.-

<P><B>Abstract</B></P> <P>The aim of this study is to improve the bioavailability of ticagrelor, BCS class 4 drug, using solid dispersion technique, and to evaluate the potential of ticagrelor loaded-solid dispersion, as a new formulation. The solid dispersion formulation was prepared via solvent evaporation method using ethanol. TPGS and Neusilin® US2 selected via screening studies were used for preparing formulation. The results of scanning electron microscopy, differential scanning calorimetry and powder X-ray diffraction showed that the crystallinity of the ticagrelor was completely transformed to an amorphous form and maintained in the solid dispersion formulation. The released amount of the optimized solid dispersion significantly increased by 2.2- and 34-fold in comparison with physical mixture (Ticagrelor:TPGS:Neusilin® US2 = 1:2:2, w/w/w) and commercial product (Brilinta®) in distilled water at 90 min, respectively. The absorptive permeability was improved (1.4-fold) and the efflux ratio was decreased (0.45-fold) by formulation containing TPGS acting as a P-gp inhibitor compared to pure drug. The solid dispersion formulation improved the peak plasma concentration (C<SUB>max</SUB>) and relative bioavailability compared to that of pure drug as 238.09 ± 25.96% and 219.78 ± 36.33%, respectively, after oral administration in rats. Thus, we successfully prepared the solid dispersion formulation for enhancing oral bioavailability of ticagrelor, and then this formulation would be recommended as a practical oral pharmaceutical product.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

<i>Loose Plant Architecture1</i> ( <i>LPA1</i> ) determines lamina joint bending by suppressing auxin signalling that interacts with C-22-hydroxylated and 6-deoxo brassinosteroids in rice

Liu, Jing Miao,Park, Soon Ju,Huang, Jin,Lee, Eun Jin,Xuan, Yuan Hu,Je, Byoung Il,Kumar, Vikranth,Priatama, Ryza A.,Raj K, Vimal,Kim, Sung Hoon,Min, Myung Ki,Cho, Jun Hyeon,Kim, Tae Ho,Chandran, Anil K Oxford University Press 2016 Journal of experimental botany Vol.67 No.6

<P>Lamina inclination is a key agronomical character that determines plant architecture and is sensitive to auxin and brassinosteroids (BRs). <I>Loose Plant Architecture1</I> (<I>LPA1</I>) in rice (<I>Oryza sativa</I>) and its Arabidopsis homologues (<I>SGR5/AtIDD15</I>) have been reported to control plant architecture and auxin homeostasis. This study explores the role of <I>LPA1</I> in determining lamina inclination in rice. <I>LPA1</I> acts as a positive regulator to suppress lamina bending. Genetic and biochemical data indicate that <I>LPA1</I> suppresses the auxin signalling that interacts with C-22-hydroxylated and 6-deoxo BRs, which regulates lamina inclination independently of <I>OsBRI1</I>. Mutant <I>lpa1</I> plants are hypersensitive to indole-3-acetic acid (IAA) during the lamina inclination response, which is suppressed by the brassinazole (Brz) inhibitor of C-22 hydroxylase involved in BR synthesis. A strong synergic effect is detected between <I>lpa1</I> and <I>d2</I> (the defective mutant for catalysis of C-23-hydroxylated BRs) during IAA-mediated lamina inclination. No significant interaction between <I>LPA1</I> and <I>OsBRI1</I> was identified. The <I>lpa1</I> mutant is sensitive to C-22-hydroxylated and 6-deoxo BRs in the <I>d61-1</I> (rice <I>BRI1</I> mutant) background. We present evidence verifying that two independent pathways function via either BRs or <I>BRI1</I> to determine IAA-mediated lamina inclination in rice. RNA sequencing analysis and qRT-PCR indicate that <I>LPA1</I> influences the expression of three <I>OsPIN</I> genes (<I>OsPIN1a</I>, <I>OsPIN1c</I> and <I>OsPIN3a</I>), which suggests that auxin flux might be an important factor in <I>LPA1</I>-mediated lamina inclination in rice.</P>

Beneficial effects of natural Jeju groundwaters on lipid metabolism in high-fat diet-induced hyperlipidemic rats

Yan-chao Wang,Jin-miao Lu,Hui-zi Jin,Ai-niu Ma,Jin-yang Zhang,Nian Gong,Qi Xiao,Bin Zhu,Ying-fang Lv,Na Yu,Wei-dong Zhang,Yong-xiang Wang 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.2

BACKGROUND: Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (SamdasooTM), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, serum lipids and lipoproteins, and liver histopathology in high-fat diet-induced hyperlipidemic rats. MATERIALS/METHODS: Rats were randomly and equally divided into 6 groups. Different water samples were supplied to the hyperlipidemic rats as their daily drinking water and the widely-used anti-hyperlipidemic drug simvastatin was used as a positive control. Body weight, serum lipids and lipoproteins were measured weekly. Liver weight, liver index and liver histopathology were examined after the execution of the rats. RESULTS: After drinking Jeju groundwaters for two months, S2 but not S3 significantly reduced weight growth and serum triglycerides levels and increased high density lipoprotein-C (HDL-C) without affecting total cholesterol or LDL-C. S1 and particularly S2 significantly reduced the severity of liver hypertrophy and steatosis. All Groundwaters had much higher contents of vanadium (S3>S2>S1>>tap water) whereas S1 and S2 but not S3 markedly blocked autoxidation of ferrous ions. CONCLUSION: Jeju Groundwater S1 and particularly S2 exhibit protective effects against hyperlipidemia and fatty liver and hypothesize that the beneficial effect of Jeju Groundwaters may be contributed from blockade of autoxidation of ferrous ions rather than their high contents of vanadium.

Strategic approach to developing a self-microemulsifying drug delivery system to enhance antiplatelet activity and bioavailability of ticagrelor

Na, Young-Guk,Byeon, Jin-Ju,Wang, Miao,Huh, Hyun Wook,Son, Gi-Ho,Jeon, Sung-Hoon,Bang, Ki-Hyun,Kim, Sung-Jin,Lee, Hye-Jin,Lee, Hong-Ki,Cho, Cheong-Weon Dove Medical Press 2019 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.14 No.-

<P><B>Background</B></P><P>Ticagrelor (TCG) is used to inhibit platelet aggregation in patients with acute coronary syndrome, but its poor solubility and low bioavailability limit its in vivo efficacy. The purpose of this study was to manufacture an optimized TCG-loaded self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability and antiplatelet activity of TCG.</P><P><B>Materials and methods</B></P><P>Solubility and emulsification tests were conducted to determine the most suitable oils, surfactants, and cosurfactants. Scheffé’s mixture design was applied to optimize the percentage of each component applied in the SMEDDS formulation to achieve optimal physical characteristics, ie, high solubility of TCG in SMEDDS, small droplet size, low precipitation, and high transmittance.</P><P><B>Results</B></P><P>The optimized TCG-loaded SMEDDS (TCG-SM) formulation composed of 10.0% Capmul MCM (oil), 53.8% Cremophor EL (surfactant), and 36.2% Transcutol P (cosurfactant) significantly improving the dissolution of TCG in various media compared with TCG in Brilinta<SUP>®</SUP> (commercial product). TCG-SM exhibited higher cellular uptake and permeability in Caco-2 cells than raw TCG suspension. In pharmacokinetic studies in rats, TCG-SM exhibited higher oral bioavailability with 5.7 and 6.4 times higher area under the concentration–time curve and maximum plasma concentration, respectively, than a raw TCG suspension. Antiplatelet activity studies exhibited that the TCG-SM formulation showed significantly improved inhibition of platelet aggregation compared with raw TCG at the same dose of TCG. And, a 10 mg/kg dose of raw TCG suspension and a 5 mg/kg dose of TCG-SM had a similar area under the inhibitory curve (907.0%±408.8% and 907.8%±200.5%⋅hours, respectively) for antiplatelet activity.</P><P><B>Conclusion</B></P><P>These results suggest that the developed TCG-SM could be successfully used as an efficient method to achieve the enhanced antiplatelet activity and bioavailability of TCG.</P>

Normal Estimation for Mass Point Clouds of Irregular Model in the 3D Reconstruction based on Fuzzy Inference

Liu Yan-ju,Jiang Jin-gang,Miao Feng-juan,Tao Bai-rui,Zhang Hong-lie 보안공학연구지원센터 2014 International Journal of Grid and Distributed Comp Vol.7 No.5

This paper presents a fuzzy normal estimate for mass point clouds of irregular models in reconstruction. The irregular model is complex object that some part is smooth and some parts are irregular including sharp features. Therefore, we put kNN and curvature of mass point clouds to fuzzy inference system to divide the kind of point clouds and the output of FIS can determine which part of tooth point clouds belong to. For different kinds point clouds, corresponding algorithm is given. Point clouds in the smooth area are estimated normal by PCA directly and ones in other regions of thin or sharp area are estimated by checker and attach points. This method is simpler than those complex methods used on the whole point clouds directly. The experiment results show that much time is saved and surface reconstruction is very fine than PCA and WLOP.