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Bhamore, Jigna R.,Jha, Sanjay,Singhal, Rakesh Kumar,Park, Tae Jung,Kailasa, Suresh Kumar Elsevier 2018 Journal of molecular liquids Vol.264 No.-
<P><B>Abstract</B></P> <P>In this work, we synthesized fluorescent carbon dots (CDs) using <I>Pyrus pyrifolia</I> (pear) fruit <I>via</I> hydrothermal method at 180 °C for 6 h without using any further treatment or surface passivating agents. The synthesized CDs possess intense blue fluorescence under UV lamp at 365 nm and exhibit emission peak at 471 nm when excited at 390 nm. Because of specific surface functional groups, the synthesized CDs showed high selectivity to detect Al<SUP>3+</SUP> ion through chelation enhanced fluorescence (CHEF) mechanism. The emission peak intensity of CDs at 471 nm was gradually enhanced with increasing concentration of Al<SUP>3+</SUP> ion, thereby Al<SUP>3+</SUP> ion was quantified by plotting calibration curve over the range of 0.005–50 μM with a detection limit of 0.0025 μM (2.5 nM). The nanoprobe was subsequently evaluated by assaying Al<SUP>3+</SUP> ion from spiked water samples, signifying the utility of nanoprobe for assaying of Al<SUP>3+</SUP> ion real samples. Furthermore, we also demonstrate that the bioimaging ability of CDs for imaging of <I>Bacillus subtilis</I> bacterial cell, suggesting that the nanoprobe can be used for cell imaging applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fluorescent carbon dots are derived from <I>Pyrus pyrifolia</I> (pear) fruit. </LI> <LI> Al<SUP>3+</SUP> ion was detected <I>via</I> chelation enhanced fluorescence mechanism. </LI> <LI> Al<SUP>3+</SUP> ion detection limit is 0.0025 μM (2.5 nM). </LI> <LI> The CDs acted as probes for imaging of <I>Bacillus subtilis</I> bacterial cells. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Schematic representation for fabrication of CDs using pear fruit and sensing of Al<SUP>3+</SUP> ion <I>via</I> chelation enhanced fluorescence mechanism.</P> <P>[DISPLAY OMISSION]</P>
Bhamore, Jigna R.,Jha, Sanjay,Park, Tae Jung,Kailasa, Suresh Kumar Elsevier 2018 Sensors and actuators. B Chemical Vol.277 No.-
<P><B>Abstract</B></P> <P>In this work, we explored the use of <I>Acacia concinna</I> seeds (shikakai) as a green precursor for the fabrication of ultra-small fluorescent carbon dots (CDs). The synthesized ultra-small fluorescent CDs sense only Cu<SUP>2+</SUP> ion through strong chelation between Cu<SUP>2+</SUP> ion and organic groups of CDs. As a result, highly selective fluorescence “turn-off” probe was developed for assay of Cu<SUP>2+</SUP> ion, causing remarkable fluorescence intensity quenching, which has ability to sense Cu<SUP>2+</SUP> ion even at 0.0043 μM (4.3 nM). Furthermore, the ultra-small fluorescent CDs act as biocompatible probes for multicolour imaging of fungal (<I>Penicillium</I> sp.) cells. The practical application of the developed sensor was demonstrated by assaying of Cu<SUP>2+</SUP> ion in spiked water samples, which confirms their significant analytical and bioanalytical applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fabrication of fluorescent shikakai CDs from <I>Acacia concinna</I> fruit. </LI> <LI> Shikakai CDs act as fluorescent sensor for Cu<SUP>2+</SUP> ion sensing. </LI> <LI> Shikakai CDs-based fluorescent platform exhibited higher sensitivity. </LI> <LI> Shikakai CDs act as strong chelator to trap Cu<SUP>2+</SUP> ion, shows detection limit of 0.0043 μM. </LI> <LI> Multi-color fungal cell imaging was carried out using shikakai CDs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Synthesis of fluorescent carbon dots from shikakai for fluorescence detection of Cu<SUP>2+</SUP> ion and fungal cell imaging.</P> <P>[DISPLAY OMISSION]</P>
Vaghela, Jitendra H.,Shah, Jigna H.,Patel, Jaladhi H.,Purohit, Bhargav M. The Korean Dental Society of Anesthsiology 2020 Journal of Dental Anesthesia and Pain Medicine Vol.20 No.1
Background: Surgical extraction of third molars is associated with postoperative pain and swelling at the extraction site. Pain is commonly managed using non-steroidal anti-inflammatory drugs (NSAIDs). Postoperative pain is usually moderate to severe in the first 12 h postoperatively and lasts for 3-5 days. However, with NSAIDs, these symptoms usually subside within 24 h. Diclofenac sodium and etodolac are NSAIDs, more selectively cyclooxygenase-2 inhibitors, with good analgesic efficacies. Methods: We compared the safety and analgesic efficacy of diclofenac sodium with etodolac peroral after surgical extraction of third molars in a double-blind, double-dummy, parallel-group study. The subjective pain improvement and pain relief after 2, 6, 24, 48, and 72 h using the visual analogue scale were measured as the study outcome. Results: Etodolac was equivalent to diclofenac sodium in pain alleviation at all postoperative time periods. No significant differences were found between diclofenac sodium and etodolac groups (P > 0.05). Both study medications were well tolerated and safe with mild adverse effects in only a few participants. Conclusion: Diclofenac sodium and etodolac are comparable in terms of analgesic efficacy and safety after surgical removal of third molars.
Adenosine Deaminase - a Novel Diagnostic and Prognostic Biomarker for Oral Squamous Cell Carcinoma
Kelgandre, Deepak Chandrakant,Pathak, Jigna,Patel, Shilpa,Ingale, Pramod,Swain, Niharika Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: The number of patients with oral cancer in India is increasing gradually (especially in younger people). Although the diagnostic modalities and therapeutic management of oral cancer are improving, the treatment outcome and prognosis of oral cancer remain poor. The absence of definite early warning symptoms for most head and neck cancers suggests that sensitive and specific biomarkers are likely to be important in screening for high-risk patients. Aims: To analyze serum adenosine deaminase (ADA) levels in oral squamous cell carcinoma (OSCC) cases who reported to our institute. Materials and Methods: A prospective study was performed on 100 histopathologically proven cases of OSCC (study group) and 100 normal healthy individuals (control group). Independent sample and one sample t-tests and one way ANOVA followed by Tuckey's POST HOC test were conducted for analysis. Results: Statistically significant increase in serum ADA levels was observed in OSCC cases compared to the control group. Also serum ADA level increased significantly with the histopathological grade. Conclusions: Serum ADA levels in OSCC may be a useful diagnostic and prognostic biomarkers in clinical practice and our findings suggest that a large-scale study is warranted to confirm clinical utility as a prognostic and diagnostic biomarker.
Rana, Kirankumar,Bhamore, Jigna R.,Rohit, Jigneshkumar V.,Park, Tae-Jung,Kailasa, Suresh Kumar The Royal Society of Chemistry 2018 NEW JOURNAL OF CHEMISTRY Vol.42 No.11
<P>In this study, we explore ligand exchange reactions on citrate-gold nanoparticles (citrate-Au NPs) for facile and rapid parallel colorimetric identification of six pesticides including three organophosphorus pesticides (acephate, phenthoate, and profenofos), neonicotinoid (acetamiprid), chloronitrile (chlorothalonil) and thiocarbamate (cartap) in water and vegetable samples. The citrate-Au NPs acted as probes for a parallel colorimetric assay of six pesticides based on the significant red-shifts in their surface plasmon resonance (SPR) bands, which was due to the aggregation of Au NPs <I>via</I> ligand exchange reactions. Under optical conditions, the probe exhibited good linearity in the micromolar concentration range for the six pesticides. Importantly, the sensing system showed lower detection limits at nanomolar range for the six pesticides and exhibited good selectivity in the presence of commonly found inorganic species. The potential of the method was assessed by analyzing six pesticides in spiked water and food samples, which suggested that this simple method exhibited good recoveries and can be practically applied in on-site and real-time parallel colorimetric sensing of the six pesticides.</P>
Characterization of Blackberry Extract and Its Antiproliferative and Anti-Inflammatory Properties
Russell J. Mumper,Jin Dai,Jigna D. Patel 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
Blackberries are rich in polyphenols, including anthocyanins. Polyphenols are hypothesized to have biologi-cal activities that may impact positively on human health. In these studies, an anthocyanin-rich extract from Hull blackber-ries grown in Kentucky was obtained and fully characterized in terms of total anthocyanin and phenolic content, polymericcolor, anthocyanin composition, and total antioxidant capacity. In vitrocell culture studies showed that the blackberry extractinhibited HT-29 colon tumor cell growth in a concentration-dependent manner with 49.2 .g of total anthocyanins/mL in-hibiting HT-29 cell growth up to 66% at 72 hours. Likewise, in a concentration-dependent manner, total anthocyanin con-centrations in the range of 040 .g/mL suppressed both high-dose (10 .g/mL) and low-dose (0.1 .g/mL) lipid A-inducedinterleukin-12 release from mouse bone marrow-derived dendritic cells. These results suggest that Hull blackberry extract(HBE) has potent antioxidant, antiproliferative, and anti-inflammatory activities and that HBE-formulated products may havethe potential for the treatment and/or prevention of cancer and/or other inflammatory diseases.
Koduru, Janardhan Reddy,Kailasa, Suresh Kumar,Bhamore, Jigna R.,Kim, Ki-Hyun,Dutta, Tanushree,Vellingiri, Kowsalya Elsevier 2018 Advances in colloid and interface science Vol.256 No.-
<P>Silver nanoparticles (Ag NPs) have recently emerged as promising materials in the biomedical sciences because of their antimicrobial activities towards a wide variety of microorganisms. Nanomaterial-based drug delivery systems with antimicrobial activity are critical as they may lead to novel treatments for cutaneous pathogens. In this review, we explore the recent progress on phytochemical-mediated synthesis of Ag NPs for antimicrobial treatment and associated infectious diseases. We discuss the biological activity of Ag NPs including mechanisms, antimicrobial activity, and antifungal/antiviral effects towards various microorganisms. The advent of Ag NP-based nanocarriers and nano-vehicles is also described for treatment of different diseases, along with the mechanisms of microbial inhibition. Overall, this review will provide a rational vision of the main achievements of Ag NPs as nanocarriers for inhibition of various microbial agents (bacteria, fungus, and virus). (C) 2018 Elsevier B.V. All rights reserved.</P>