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Manganese single-atom nanostructures for highly efficient tumor therapy
Jiaping Pei,Hui Dou,Chencai Liu,Tushuai Li 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-
The single-atom attracts growing interests in various fields and provides a new strategy for tumor therapyby inspiring chemodynamic-photothermal therapy (CPT) effects owing to its excellent catalytic properties. We synthesize the Folic acid@single atomic manganese (Mn) nanoparticles (FA@SAMn NPs) withmesoporous carbon sphere structure by the coordination aided polymerization assembly method. Antitumor therapeutic effect studies were carried out in vitro and in vivo. This hierarchical nanostructurepossesses a high surface area, large pore, and rich N that provide higher catalytic activity, and it also exhibitsexcellent activity and stability in the oxygen reduction reaction. With its accumulation in the specifictumor microenvironment, the FA@SAMn NPs could generate reactive oxygen species (ROS), which wouldmediate a series of 4 T1 cell damage and inhibit tumor propagation (56% mortality rate). Moreover, theFA@SAMn NPs possess an excellent photothermal effect under near infrared-II (NIR-II) laser irradiation. This leads to a local hyperthermia situation in the tumor area and contributes to tumor inhibition (91%mortality rate). In sum, FA@SAMn catalysts effectively suppressed tumor growth and significantlyincreased the survival time. This work aims to provide new potential single-atom-coordinated carbonnetworks that possess efficient biocatalytic sites and photothermal effects, inspiring a series of advancesin ROS and photothermal-related biological applications across broad biomedical fields.
Stability, Fairness, and Performance: A Flow-Level Study on Nonconvex and Time-Varying Rate Regions
Jiaping Liu,Proutiere, A.,Yung Yi,Mung Chiang,Poor, H.V. IEEE 2009 IEEE transactions on information theory Vol.55 No.8
<P>The flow-level stability and performance of data networks with utility-maximizing allocations are studied in this paper. Similarly to prior works on flow-level models, exogenous data arrivals with finite workloads are considered. However, to model many realistic situations, the rate region, which constrains the feasibility of resource allocation, may be either nonconvex or time-varying. When the rate region is fixed but nonconvex, sufficient and necessary conditions are characterized for stability for a class of <I>alpha</I>-fair allocation policies, which coincide when the set of allocated rate vectors have continuous contours. When the rate region is time-varying according to a Markovian stationary and ergodic process, the precise stability region is obtained. In both cases, the size of the stability region depends on the resource allocation policy, in particular, on the fairness parameter <I>alpha</I> in <I>alpha</I>-fair utility maximization. This is in sharp contrast with the substantial existing literature on stability under fixed and convex rate regions, in which the stability region coincides with the rate region for many utility-based resource allocation schemes, independent of the value of the fairness parameter. It is further shown that for networks which consist of flows from two different classes under <I>alpha</I>-fair allocations, there exists a tradeoff between the stability region and the fairness parameter <I>alpha</I>. Moreover, the impact of this fairness-stability tradeoff on the system performance, e.g., average throughput and mean flow response time, is studied, and numerical experiments that illustrate the new stability region and the performance versus fairness tradeoff are presented.</P>
Tunable Shape Memory Polyurethane Networks Cross-Linked by 1,3,5,7-Tetrahydroxyadamantane
Shuqin Fu,Jiaping Zhu,Shaojun Chen 한국고분자학회 2018 Macromolecular Research Vol.26 No.11
As a new type of smart polymers, the shape memory polyurethanes attract increasing attention because of their wide use in various applications. Herein, a serials of novel thermo-responsive shape memory polyurethane networks were developed by chemical cross-linking of polycaprolactone with 1,3,5,7-tetrahydroxyadamantane. The polyurethane networks were characterized in relation to their microstructure, cross-linking density, surface appearance, thermal properties, static and dynamic mechanical properties, and shape memory behavior. It was found that the prepared polyurethane networks can exhibit excellent thermo-responsive shape memory properties at body temperature by controlling the molar ratio of 1,3,5,7- tetrahydroxyadamantane and polycaprolactone. Moreover, the incorporation of 1,3,5,7-tetrahydroxyadamantane substantially improved the mechanical properties of the final polyurethane networks. The versatility of the synthesized polyurethane networks is reflected by its dual- and triple-shape memory performance. It can be anticipated that the synthesized polyurethane networks could be used as smart materials for applications involving shape memory polymers.
Ridong Fan,Jiaping Liu,Songyu Liu,Yanjun Du,Martin Liu,Sunan You 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.9
An empirical equation was proposed to predict compression index (Cc) of saturated reconstituted contaminated clays. Experimental data from 464 oedometer tests from literature were analyzed, aiding to develop a method for predicting the Cc of saturated reconstituted contaminated clays. The predictive capacity of three existing empirical equations of Cc with either liquid limit (wL), plasticity index (PI) or initial porosity (n0) was assessed. It was found that these equations previously used for clean soils roughly predict the Cc value of saturated reconstituted contaminated clays. To better predict the Cc, a series of empirical equations were established by regression analysis of the experimental data. Finally, the “best” equation was determined by an assessment of goodness of fit.
Effects of Fermented Rapeseed Meal on Growth Performance and Serum Parameters in Ducks
Fazhi, Xu,Lvmu, Li,Jiaping, Xu,Kun, Qian,Zhide, Zhang,Zhangyi, Liang Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.5
A trial was performed to study the effects of feeding a diet containing solid-state fermentation rapeseed meal (FRSM) replaced soybean meal (SBM) on growth performance and serum biochemistry parameters of ducks and then to determine the appropriate proportion of soybean meal replacement. The 75% rapeseed meal and 25% blood meal were mixed and inoculated with the Lactobacillus plantarum and Bacillus subtilis. Over the 21-day fermentation, isothiocyanates were reduced from 72.7 to 14.1 mmol/kg. A total of 1,280 fifteen-day-old Cherry Valley ducks were randomly allocated into 4 dietary treatments, 4 replicate groups of 80 ducks each for a 30-day feeding trial. In four treatment groups, fermentation rapeseed meal replaced soybean meal at 0, 33, 67 or 100%, respectively. Results showed that feed intake of ducks fed 100% FRSM was greater (p<0.05) than SBM and partial FRSM in both the finishing period (31-45 d) and entire feeding period (15-45 d). Daily gain increased gradually in the three treatment groups with augmenting FRSM over in the whole study period. In the growing period (15-30 d), compared with the SBM group, phosphorus and calcium content in serum from the FRSM group was improved (p<0.05). Total protein concentration was lower in ducks fed 100% FRSM than SBM and 33% FRSM (p<0.05). Concentrations of IgM were dramatically higher for animals fed 100% FRSM than in the SBM, 33% FRSM and 67% FRSM groups. In the finishing trail stage (31-45 d), only serum IgG content in 100% FRSM group was improved (p<0.05). Therefore, rapeseed meal fermented with Lactobacillus plantarum and Bacillus subtilis is a promising alternative protein source and fermented rapeseed meal can completely replace soybean meal in duck diet and potentially reduce the cost of duck production.