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Jianxun Chen,Qizhong Huang 한국탄소학회 2006 Carbon Letters Vol.7 No.4
Carbon/Carbon composite was been manufactured by the technology of warmer-molding process of clutter chopped carbon fiber, using phenolic resin as an adhesive. The degree of graphitization, the microstructure and the friction properties were studied. The results show that the clutter chopped carbon fiber fully scatter in the Carbon/Carbon composite and the degree of graphitization of phenolic resin can reach up to 86.2%, this matrix carbon can form the continuous and stable graphitic thin film on the friction surface during braking process so that the composite has fine friction properties and low wear rate.
Jianxun Chen,Xiang Xiong 한국탄소학회 2007 Carbon Letters Vol.8 No.1
The carbon brake discs were manufactured by densification the carbon fiber preform using PG-CVI technology with Propene as a carbon precursor gas and Nitrogen as a carrier gas. The densities of carbon brake discs were tested at different densification time. The results indicate that the densification rate is more rapid before 100 hrs than after 200 hrs. The CTscanning image and the SEM technology were used to observe the inner subtle structure. CT-images show the density distribution in the carbon brake disc clearly. The carbon brake disk made by PG-CVI is not very uniform. There is a density gradient in the bulk. The high-density part in the carbon brake is really located in the friction surface, especially in the part of inner circle. This density distribution is most suitable for the stator disc.
pH-Responsive Drug Delivery Systems Based on Clickable Poly(L-glutamic acid)-Grafted Comb Copolymers
Jianxun Ding,Xuesi Chen,Chaoliang He,Chunsheng Xiao,Jie Chen,Xiuli Zhuang 한국고분자학회 2012 Macromolecular Research Vol.20 No.3
Five pH-responsive alkyne-poly(2-aminoethyl methacrylate)-graft-poly(L-glutamic acid) (alkyne-PAMA-g-PLGA) comb copolymers were synthesized through the ring-opening polymerization (ROP) of γ-benzyl-L-glutamate N-carboxyanhydride (BLG NCA) and the subsequent deprotection of benzyl group from BLG unit. The chemical structures of copolymers were confirmed by proton nuclear magnetic resonance spectra (1H NMR) and Fourier transform infrared spectroscopy (FTIR). The pyrene-probe-based fluorescence technique and transmission electron microscopy (TEM) measurements revealed that the comb copolymers could spontaneously self-assemble into micellar or vesicular nanoparticles in phosphate buffered saline (PBS) at pH 7.4. Doxorubicin (DOX), an anthracycline anticancer drug, was loaded into nanoparticles as a model anticancer drug. The in vitro release results showed that the release behaviors could be altered by adjusting the composition of the comb copolymer and pH of the release medium. In vitro methyl thiazolyl tetrazolium (MTT) assays demonstrated that the copolymers were biocompatible,and DOX-loaded nanoparticles showed effective inhibition of cellular proliferation. Hemolysis tests indicated that the copolymers were also hemocompatible, and that the presence of the copolymers could reduce the hemolysis ratio (HR) of the DOX significantly. In addition, the comb copolymers could be modified through versatile Cu(I)-catalyzed “click chemistry” between the terminal alkyne group and azide-modified functional agents. These properties indicate that the pH-responsive clickable comb copolymers are promising candidates for multifunctional nanocarriers in cancer diagnosis and therapy.
Failure Mechanisms and Modes of Tunnels in Monoclinic and Soft-Hard Interbedded Rocks: A Case Study
Jianxun Chen,Weiwei Liu,Lijun Chen,Yanbin Luo,Yao Li,Haijiang Gao,Daochuan Zhong 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.4
The issue of large deformation mechanism in soft rock tunnels has puzzled tunnel scholars for decades. Previous studies have not evolved a clear and common understanding. Therefore, detailed on-site measurement, full investigation and statistical analysis have been conducted on the instability and failure of Muzhailing Tunnel since its construction, whose length is beyond 15 km. The study aims at systematically analyzing the failure mechanisms and modes of Muzhailing Tunnel in monoclinic and soft-hard interbedded rock strata. Study results show that the angle between strata strike and tunnel axis greatly determines the magnitude of deformation, the dip direction significantly controls the bias direction and maximum deformation direction, and the dip angle deeply affects the deformation form. The failure modes of surrounding rock mainly include four types: spalling and overturning failure, bending failure, shear slip failure and buckling failure. Large deformation characteristics are summarized from six aspects: failure form, groundwater, sensitivity to influencing factors, deformation degree, deformation speed and deformation duration. The instability modes of primary lining include in-plane (transverse) instability and out-plane (longitudinal) instability. Finally, the causes of large deformation are analyzed from geological, structural, engineering and human factors.
Development of Auto Antigen-specific Regulatory T Cells for Diabetes Immunotherapy
Jianxun Song 대한면역학회 2016 Immune Network Vol.16 No.5
CD4+ regulatory T cells (Tregs) are essential for normal immune surveillance, and their dysfunction can lead to the development of autoimmune diseases, such as type-1 diabetes (T1D). T1D is a T cell-mediated autoimmune disease characterized by islet b cell destruction, hypoinsulinemia, and severely altered glucose homeostasis. Tregs play a critical role in the development of T1D and participate in peripheral tolerance. Pluripotent stem cells (PSCs) can be utilized to obtain a renewable source of healthy Tregs to treat T1D as they have the ability to produce almost all cell types in the body, including Tregs. However, the right conditions for the development of antigen (Ag)-specific Tregs from PSCs (i.e. , PSC-Tregs) remain undefined, especially molecular mechanisms that direct differentiation of such Tregs. Auto Ag-specific PSC-Tregs can be programmed to be tissue-associated and infiltrate to local inflamed tissue (e.g. , islets) to suppress autoimmune responses after adoptive transfer, thereby avoiding potential overall immunosuppression from non-specific Tregs. Developing auto Ag-specific PSC-Tregs can reduce overall immunosuppression after adoptive transfer by accumulating inflamed islets, which drives forward the use of therapeutic PSC-Tregs for cell-based therapies in T1D.
Analysis of dynamic RBC aggregation in microfluidic device using laser backscattering
Hou Jianxun(호우지엔쉰),Yunhee Ku(구윤희),Sehyun Shin(신세현),Jangsoo Suh(서장수) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
The aggregation characteristics of red blood cells (RBCs) play an important role in microvascular flow system and increased RBC aggregation has been observed in various pathological diseases, such as thrombosis and myocardial infarction. This paper presents a novel microfluidic device for evaluating the aggregability of RBCs on the flow of blood by directly measuring aggregating force (critical shear stress) to overcome shearing force due to flow in a microchannel. The device functionality is based on a microfluidic slit rheometry with decreasing pressure-driven flow mechanism with laser light backscattering technique. The present RBC aggregation index shows a higher sensitivity to small changes of aggregation modulated by amount of fibrinogen in blood plasma. The direct measurement of RBC aggregating force represents a new concept for the field of blood rheology and should prove beneficial for basic science and clinical applications.
CONTINUOUS MULTISCALE ANALYSIS ON THE HEISENBERG GROUP
He, Jianxun Korean Mathematical Society 2001 대한수학회보 Vol.38 No.3
In this paper, we study the continuous wavelet transform on the Heisenberg group H$^n$, and describe the related continuous multiscale analysis. By using the wavelet packet transform we obtain a reconstruction formula on L$^2$(H$^n$).
Chen, Jianxun,Xiong, Xiang Korean Carbon Society 2007 Carbon Letters Vol.8 No.1
The carbon brake discs were manufactured by densification the carbon fiber preform using PG-CVI technology with Propene as a carbon precursor gas and Nitrogen as a carrier gas. The densities of carbon brake discs were tested at different densification time. The results indicate that the densification rate is more rapid before 100 hrs than after 200 hrs. The CTscanning image and the SEM technology were used to observe the inner subtle structure. CT-images show the density distribution in the carbon brake disc clearly. The carbon brake disk made by PG-CVI is not very uniform. There is a density gradient in the bulk. The high-density part in the carbon brake is really located in the friction surface, especially in the part of inner circle. This density distribution is most suitable for the stator disc.